The most comprehensive, up-to-date, reference on diseases of thenervous system currently available. Now in its third edition, the two-volume text is packed with details on the clinical presentations ofneurological disorders with a focus on the underlying mechanismsthat lead to these disorders – pathology, pathophysiology, molecularand cellular dysfunction.

Transcranial magnetic stimulation(TMS) is a non-invasive andpainless technique that has opened up completely new andfascinating avenues to study neural plasticity. Current knowledge ofall these exciting possibilities is brought together in this book,written by the world’s leading experts in the field, it is an essentialcompendium on plasticity of the human brain in health and disease.

DISEASES OFTHE NERVOUSSYSTEMClinical Neuroscienceand TherapeuticPrinciples3rd editionEdited by Arthur K. AsburyUniversity of PennsylvaniaSchool of Medicine, USAGuy M. McKhannThe Johns Hopkins UniversitySchool of Medicine and The Zanvyl Krieger Mind and Brain Institute, USAW. Ian McDonaldInstitute of Neurology, University College London, and Royal College ofPhysicians, London, UKand Justin C. McArthurDepartments of Neurology and Epidemiology, The Johns Hopkins UniversitySchool of Medicine, USA

2002 2194pp 825 illus

0 521 79351 3 Hardback 2 volume set £295.00 / $375.00

ContentsPart I. Introduction and General Principles; Part II. Disorders of Higher Function; PartIII. Disorders of Motor Control; Part IV. Disorders of the Special Senses; Part V.Disorders of Spine and Spinal Cord; Part VI. Disorders of Body Function; Part VII.Headache and Pain; Part VIII. Neuromuscular Disorders; Part IX. Epilepsy; Part X.Cerebrovascular Disorders; Part XI. Neoplastic Disorders; Part XII. AutoimmuneDisorders; Part XIII. Disorders of Myelin; Part XIV. Infections; Part XV. Trauma and ToxicDisorders; Part XVI. Degenerative Disorders; Part XVII. Neurological Manifestations ofSystemic Conditions.

Features● Fully revised and updated with greater emphasis on therapeutic

principles● In two volumes, it is easily the most comprehensive, scientific

account of clinical neurology● Generously illustrated with diagrams, tables, clinical photographs and

scans. Each volumes contains a colour plate section – all designed toenhance the readers understanding of the material being presented.

New Edition

PLASTICITY IN THE HUMANNERVOUS SYSTEMInvestigations withTranscranial MagneticStimulationEdited by Simon BonifaceAddenbrooke’s Hospital, Cambridge, UKand Ulf ZiemannJohann Wolfgang Goethe-UniversitätFrankfurt, Germany

June 2003 328pp 56 illus

0 521 80727 1 Hardback £65.00 / $95.00

Contents1. The nature and mechanisms of plasticity; 2. Techniques of transcranial magneticstimulation; 3. Developmental Plasticity of the corticospinal system; 4. Practiceinduced plasticity in the human motor cortex; 5. Skill learning; 6. Stimulation inducedplasticity in the human motor cortex; 7. Lesions of cortex and post-strokereorganisation; 8. Lesions of the periphery and the spinal cord; 9. Functionalrelevance of cortical plasticity; 10. Therapeutic uses of rTMS; 11. Rehabilitation;12. New questions.

Features● Brings together two key areas in clinical neuroscience, plasticity

and TMS● Contributors are world leaders in the field● Of essential interest to neuroscientists and clinicians

New

NEW AND FORTHCOMING BOOKS IN

NEUROLOGY and

CLINICAL NEUROSCIENCE

THE SELF INNEUROSCIENCE ANDPSYCHIATRYEdited by Tilo KircherEberhard-Karls-Universität Tübingen, Germanyand Anthony DavidInstitute of Psychiatry, London, UK

In recent years neuroscience has contributed importantinsights to the concept and construction of the selffrom conditions, such as schizophrenia, in which theself becomes disordered. This book focuses onneuropsychiatric models of self-consciousness, setagainst introductory essays describing thephilosophical, historical and psychological approaches.

Features● Encompasses an extensive review of current

scientific and clinical approaches toconsciousness and self-consciousness

● Focuses on pathological states of self-consciousness, such as in schizophrenia anddisordered mental states

● Written by an international team of leadingexperts from the fields ofneuroscience, psychiatry, psychology and thephilosophy of science

ContentsPart A. Conceptual Background; Part B. Cognitive andNeurosciences; Part C. Disturbances of the Self.

2003 384pp 35 illus 0 521 53350 3 Paperback £29.95 / $33.000 521 80387 X Hardback £80.00 / $90.00

MAGNETIC RESONANCEIMAGING IN STROKEEdited by Stephen DavisRoyal Melbourne Hospital and University ofMelbourne, AustraliaMarc FisherUniversity of Massachusetts, Boston, USAand Steven WarachNational Institute of Mental Health, Bethesda,Maryland, USA

Magnetic resonance imaging provides non-invasiveinformation about the brain’s blood flow, watermovement and biochemical abnormalities followingstroke, and advances in magnetic resonance imaging(MRI) are transforming the investigation and treatmentof cerebrovascular disease. Echoplanar techniques withdiffusion and perfusion weighted imaging, togetherwith developments in magnetic resonance spectroscopyand angiography, are replacing CT scanning as thediagnostic modality of choice.

Features● State of the art coverage of techniques that are

revolutionising the way stroke is investigated● Editors and contributors are world leaders● Profusely illustrated

Contents1. The importance of specific diagnosis in stroke patientmanagement; 2. Limitations of current brain imagingmodalities in stroke; 3. Clinical efficacy of CT in acutecerebral ischemia; 4. Computerized tomographic basedevaluation of cerebral blood flow; 5. Technicalintroduction to MRI; 6. Clinical use of standard MRI;7. MR Angiography of the head and neck: basicprinciples and clinical application; 8. Stroke MRI inintracranial hemorrhage; 9. Using diffusion-perfusion inanimal model for drug development; 10. Localisation ofstroke syndromes using Diffusion-Weighted MRImaging; 11. Magnetic resonance imaging in transientischemic attacks: clinical utility and insights intopathophysiology; 12. Perfusion-weighted magneticresonance imaging in stroke; 13. Perfusion imagingwith arterial spin labelling; 14. Clinical role ofechoplanar MRI in stroke; 15. The ischemic penumbra;16. New MR techniques to select patients forthrombolysis in acute stroke; 17. MRI as a tool in strokedrug development; 18. Magnetic resonancespectroscopy in stroke; 19. Functional magneticresonance imaging and stroke.

2003 280pp 127 illus0 521 80683 6 Hardback £80.00 / $120.00

DISORDERS OF BRAINAND MINDVolume 2Edited by Maria A. RonInstitute of Neurology, London, UKand Trevor W. RobbinsUniversity of Cambridge, UK

The clinical and scientific scope of this authoritativenew book encompasses abnormal and normal mindimaging, genes and behaviour, brain development,consciousness, aggression, dementia, affective illness,and drug use and abuse. It will appeal to anyone whohas a clinical or scientific interest in the mind and itsdisorders.

2002 492pp 40 illus0 521 00456 X Paperback £49.95 / $70.00

INTRODUCTION TOFUNCTIONAL MAGNETICRESONANCE IMAGINGPrinciples and TechniquesR. B. BuxtonUniversity of California, San Diego, USA

Presenting an invaluable introduction to FunctionalMagnetic Resonance Imaging (fMRI), from basicprinciples and underlying physics and physiology, to thelatest techniques such as arterial spin labeling anddiffusion tensor imaging.Now recognised as thestandard tool for mapping activation patterns in thehuman brain, this highly interdisciplinary field involvesneuroscientists and physicists as well as clinicians whoneed to understand the rapidly increasing range,flexibility and sophistication of the techniques.

Features● Detailed introduction to the physics and

physiology of fMRI techniques● Extensive treatment of how fMRI works and

what the pitfalls are● CD-ROM of supplementary images to the book

is also available

ContentsPart I. An Overview of Functional Magnetic ResonanceImaging:Part II. Principles of Magnetic Resonance Imaging:Part III. Principles of Functional Magnetic ResonanceImaging:

2001 536 pages 168 illus0 521 58113 3 Hardback £95.00 / $140.000 521 00275 3 CD-ROM £95.00 / $140.000 521 00274 5 Book and

CD-ROM Pack £170.00 / $240.00

New

WOMEN WITH EPILEPSYA Handbook of Health andTreatment IssuesEdited by Martha Morrelland Kerry L. FlynnBoth from Columbia University, New York, USA

Published in association with the Epilepsy Foundationof America, this handbook reviews the special problemsfaced by women with epilepsy. Hormone levels affectseizures and treatments affect fertility, pregnancy andbirth outcomes. The authors aim to inform best practiceand provide women with the information needed foreffective self-advocacy.

Features● Addresses the medical, emotional and social

challenges facing women with epilepsy● Written by a team of experts from the epilepsy

community● A comprehensive information resource, written

to be accessible to a lay-reader

ContentsPart I. The Woman with Epilepsy; Part II. EpilepsyDiagnosis and Treatment; Part III. Hormones and theBrain; Part IV. Health Challenges for Women withEpilepsy; Part V. Family Planning, Pregnancy andParenting; Part VI. Living Well with Epilepsy.

2003 310pp 30 illus0 521 65541 2 Paperback £19.95 / $30.000 521 65224 3 Hardback £55.00 / $80.00

CHILDHOOD EPILEPSYLanguage, Learning and EmotionalComplicationsWilliam SvobodaChildren with epilepsy often have interrelatedlanguage, learning and/or behavior complicationswhich persist beyond seizure control. In thiscomprehensive book, the author distils a lifetime ofclinical experience into three areas which address themain points of difficulty, looking at why the problemsarise and assessing treatments.

Features● Covers epilepsy in childhood specifically● Looks at speech–language associations with

epilepsy● Looks at epileptic intrusions in behavior,

language and learning as they impact ondevelopment and maturation

ContentsPart I. Language Problems; Part II. Learning Problems;Part III. Behavior Problems.

November 2003 672pp0 521 82338 2 Hardback £80.00 / $120.00

EPILEPSY ANDMOVEMENTDISORDERSEdited by Renzo GuerriniAcademic Neuroscience Centre, King’s CollegeHospital, London, UKJean AicardiHôpital Robert-Debré, Paris, FranceFrederick AndermannMontreal Neurological Institute & Hospital,Canadaand Mark HallettNational Institutes of Health, Bethesda MD, USA

The boundaries between epilepsy and movementdisorders are difficult to define. Here, a distinguished,international team of specialists comprehensivelyexamines the clinical, neurophysiological, genetic,pharmacological and molecular factors which underliethe relationships and differences between the twodisorders. They examine the methods for investigatingthe characteristics of epilepsies which resemblemovement disorders; present a scheme forneurophysiological classification; examine the causes ofdiagnostic problems; review the latest genetic findings;and assess the drug treatments available.

Features● First book to link epilepsy and movement

disorders, describing where they differ andwhere they overlap

● A comprehensive overview of the clinicalneurophysiology of paroxysmal motor disorders

● Provides an overview of the genetics of newlyrecognized syndromes featuring multipleparoxysmal neurological manifestations.

2001 586pp 70 illusHardback 0 521 77110 2 £80.00 / $120.00

THE NEUROPSYCHIATRYOF EPILEPSYEdited by Michael R. TrimbleInstitute of Neurology, London, UKand E. Bettina SchmitzHumboldt-Universität, Berlin, Germany

A multi-national team of experts review and explorethe interface between epilepsy and behaviourdisorders. Coverage is broad-ranging and offers both adiagnostic and management perspective. This will beessential reading for all professionals engaged in thetreatment of epileptic patients.

Features● Addresses the interface between neurology

and psychiatry● Practical, and treatment-oriented● Timely and up-to-date

ContentsPart I. Background; Part II. Clinical Aspects; Part III.Cognitive Aspects; Part IV. Non Epileptic Attacks; Part V.Treatment Complications; Part VI. Treatment.

2002 360pp 70 illus0 521 00516 7 Paperback £39.95 / $55.000 521 81374 3 Hardback £110.00 / $150.00

Forthcoming

New

UPPER MOTORNEURONE SYNDROMEAND SPASTICITYClinical Management andNeurophysiologyEdited by Michael P. Barnesand Garth R. JohnsonBoth from University of Newcastle upon Tyne, UK

A practical guide for clinicians, therapists, orthotists,bioengineers and all other health professional involvedin the management of spasticity. Provides a thoroughreview, ranging in coverage from physiotherapy,seating, and orthoses, the use of drugs, and theneurophysiology of spasticity, to measurement ofoutcome and the newer treatment techniques.

Features● Covers the most recent treatment techniques

in detail● Straightforward, practical and comprehensive

review for all health professionals● Includes management of children with

spasticity

‘…clear and clinically relevant …a goodfoundation for clinical practice…’Journal of Neurology, Neurosurgery and Psychiatry

Contents1. An overview of the clinical management ofspasticity; 2. Neurophysiology of upper motor neuronesyndrome and spasticity; 3. Measurement of spasticity;4. Physiotherapy approaches to spasticity; 5. Seatingand positioning in spasticity; 6. Orthoses, splinting andcasting in spasticity; 7. Pharmacological managementof spasticity; 8. Chemical neurolysis in the managementof spasticity; 9. The use of botulinum toxin in spasticity;10. Intrathecal baclofen for control of spinal and supraspinal spasticity; 11. Surgical management of spasticity;12. Management of spasticity in children.

2001 328pp 86 illus0 521 79427 7 Paperback £36.95 / $50.00

DISORDERS OFVOLUNTARY MUSCLE7th editionEdited by George KarpatiMcGill University, Montreal, CanadaDavid Hilton-JonesUniversity of Oxford, UKand Robert C. GriggsUniversity of Rochester Medical Center, USA

Foreword by Lord Walton of DetchantTotally rewritten, extensively illustrated and redesignedwith the needs of the clinician and clinical scientist inmind, this seventh edition contains up-to-date scientificand clinical information on the etiology andpathogenesis of diseases of skeletal muscles, includingrecently identified diseases, and emphasises recentprogress in diagnosis and treatment.

Features● Previously under the editorship of John Walton

(now Lord Walton of Detchant), this is thedefinitive text in the field.

● Contains major updates on molecular andgenetic mechanisms and new treatmentapproaches

‘Hands down, this book is the best currentpublication in its category. The seventhedition is well timed to capture the massiveincrease of information since the previousedition of 1994.’ Doody’s Review

ContentsPart I. Scientific Basis of Muscle DiseasePart II. Methods of Investigation of Muscle DiseasePart III. Description of Muscle DiseasePart IV. The Principles of Management of MuscleDisease

2001 790pp 408 illusHardback 0 521 65062 3 £170.00 / $230.00

COMMUNITYREHABILITATION INNEUROLOGYMichael Barnesand Harriet RadermacherBoth from Hunters Moor RegionalNeurorehabilitation Centre, University ofNewcastle upon Tyne, UK

Rehabilitation should not stop when the disabledperson is discharged from hospital, and manyneurological patients require ongoing rehabilitation.This book analyses the needs from many differentperspectives, taking an international view with manyexamples of community rehabilitation schemes, andcase studies are used to highlight the main issues.

Features● First book to look at neurological rehabilitation

in the community● Growing awareness of the importance of post-

discharge rehabilitation● Contributions covering disabled children and

neuropsychological rehabilitation

Contents1. Background to community neurologicalrehabilitation; 2. Neurological rehabilitation: basicprinciples and models of delivery; 3. Models ofdisability; 4. Concepts of community; 5. The views ofdisabled people; 6. Outcome measures and research inthe community; 7. Evidence base for communityneurological rehabilitation; 8. Lessons from the South;9. Other aspects of community neurologicalrehabilitation; 10. Community rehabilitation inchildhood: concepts to inform practice;11. Neuropsychological rehabilitation in thecommunity; 12. The way forward.

August 2003 200pp 6 illus0 521 80874 X Hardback £45.00 / $70.00

CEREBROVASCULARULTRASOUNDTheory, Practice and FutureDevelopmentsEdited by Michael Hennericiand Stephen MeairsBoth from Ruprecht-Karls-Universität Heidelberg,Germany

This comprehensive text covers the fundamentals ofultrasound physics, new technology, and clinicalapplications of cerebrovascular ultrasound in all ages.Extracranial and intracranial Doppler applications instroke, subarachnoid hemorrhage, and other disordersare presented by leading authorities in the field.Containing extensive illustrations, this is the definitivereference text in cerebrovascular ultrasound.

Features● The most authoritative book on this fast

moving diagnostic technology● Covers intracranial and extracranial

applications, including new technologies suchas functional neurosonology and 3D and 4Dultrasonography

● Covers physics, technical aspects and clinicalapplications

ContentsPart I. Ultrasound Physics, Technology andHemodynamicsPart II. Clinical Cerebrovascular Ultrasound Section 1Atherosclerosis: pathogenesis, early assessment andfollow-up with ultrasoundSection 2. Extracranial cerebrovascular applicationsSection 3. Intracranial cerebrovascular applicationsPart III. New and Future Developments

2001 442pp 302 illus0 521 63223 4 Hardback £160.00 / $210.00

THE CEREBELLUM ANDITS DISORDERSEdited by Mario-Ubaldo MantoCerebellar Ataxias Unit, Free University ofBrussels, Belgiumand Massimo PandolfoCentre Hospitalier de l’Université de Montréal,Canada

Foreword by Sid Gilman, MDPresenting the first major reference on the cerebellumand its disorders published for nearly twenty years.Written by some of the leading internationalauthorities in the field, coverage ranges fromembryology and basic neuroanatomy through to asurvey of the sporadic and hereditary disorders of thecerebellum.

Features● Covers the full range of sporadic and

hereditary disorders● Of interest to basic neuroscientists and

clinicians in a range of disciplines

'This book … constitutes a major referencetext for those primarily interested in thebasic aspects of cerebellar functions anddysfunctions. it brings information in thisdomain up to date in a clear and lucidfashion.'

Developmental Medicine & Child Neurology

ContentsPart I. Introduction Part II. Theories of Cerebellar Control Part III. Clinical Signs and PathophysiologicalCorrelations Part IV. Sporadic Diseases Part V. Toxic Agents Part VI. Advances in Grafts Part VII. Neuropathology;Part VIII. Dominantly Inherited Progressive AtaxiasPart IX. Recessive Ataxias

2001 612pp 354 illus0 521 77156 0 Hardback £160.00 / $230.00

UNCOMMON CAUSESOF STROKEEdited by Julien Bogousslavskyand Louis CaplanAn excellent companion to the second edition of StrokeSyndromes, this comprehensive reference provides in-depth descriptions of many rare and relativelyuncommon causes of stroke. Providing an essentialresource to help physicians diagnose and treat strokepatients who do not fit well into the usual clinicalcategories.

2001 410pp 190 illus0 521 77145 5 Hardback £150.00 / $240.00SAVE £30 / $40!Available as a 2 Volume Boxed Set 0 521 80258 X £280.00 / $450.00

STROKE SYNDROMES Second EditionEdited by Julien BogousslavskyUniversity of Lausanne, Switzerlandand Louis CaplanHavard Medical School and Beth Israel DeaconessMedical Centre, Boston, USA

This revised and updated second edition remains thedefinitive guide to patterns and syndromes in stroke.

‘This comprehensive work will provide itsowner with a ready source of reference for amultitude of questions that might arise inthe evaluation and localization of individualstroke patients.’

European Neurology

2001 770pp 406 illus0 521 77142 0 Hardback £160.00 / $250.00

CATATONIAA Clinician’s Guide to Diagnosis andTreatmentMax FinkState University of New York, Stony Brook, USAand Michael Alan TaylorFinch University of Health Sciences, Chicago, USA

This book, by two leading neuropsychiatrists, describesthe features of catatonia, teaches the reader how toidentify and treat the syndrome successfully, anddescribes its neurobiology. Patient vignettes from theauthors’ practices, and many from the classicalliterature, illustrate the principles of diagnosing andtreating patients with catatonia.

Contents1. Catatonia: a history; 2. Signs of catatonia areidentifiable; 3. The many faces of catatonia; 4. Thedifferential diagnosis of catatonia; 5. Catatonia ismeasurable and common; 6. Past treatments forcatatonia; 7. Management of catatonia today; 8. Theneurology of catatonia; 9. Back to the future.

2003 274pp 33illus0 521 82226 2 Hardback £50.00 / $70.00

PSYCHIATRIC ANDCOGNITIVE DISORDERSIN PARKINSON’SDISEASESergio E. StarksteinBuenos Aires Neuropsychiatric Center, Argentina

and Marcello MerelloRaul Carrea Insitute of Neurological Research-FLENI, Argentina

A clear and comprehensive account of emotional andcognitive aspects of Parkinson’s disease, based on theneurological and psychiatric assessment of hundreds ofpatients by the authors. It covers psychiatric andcognitive disorders in practical detail, and also reviewsthe behavioural side effects of anti-parkinsoniantreatments.

Features● Eminent authors present their experience

based on hundreds of cases● Practical approach appropriate to clinicians at

all levels● Includes clear guidelines, flow diagrams and

relevant rating scales

Contents1. Introduction; 2. Epidemiological and neurologicalaspects of Parkinson’s disease; 3. ‘Parkinsonism’ andParkinson’s disease; 4. Cognitive deficits in Parkinson’sdisease; 5. Depression in Parkinson’s disease;6. Anxiety, phobias, and pre-morbid personality inParkinson’s disease; 7. Cognitive and psychiatric side-effects of anti-parkinsonism agents; 8. Treatment ofpsychiatric disorders in Parkinson’s disease; Appendix;References.

2002 240pp 43 illus0 521 66305 9 Hardback £47.50 / $75.00

THE VEGETATIVE STATEMedical Facts, Ethical and LegalDilemmasBryan JennettEmeritus Professor of Neurosurgery,University of Glasgow, UK

‘This is a unique book….the author is aninternational authority on the persistentvegetative state. Not only does he writeclearly and authoritatively, but with a deepsense of the historical foundations of thiscontroversial entity that creates significantmedical, ethical, and legal challenges.’

Doody’s Reviews

Contents1. A syndrome in search of a name; 2. Diagnosis;3. Epidemiology - frequency and causes; 4. Pathology ofthe brain damage; 5. Prognosis for recovery andsurvival; 6. Attitudes to the permanent vegetative state;7. Medical management; 8. Ethical issues; 9. Legalissues in the USA; 10. Legal issues in Britain; 11. Legalissues in other countries; 12. Details of some landmarkcases.

2002 242pp 54 illus0 521 44158 7 Paperback £29.95 / $43.00

PRINCIPLES ANDPRACTICE OFEMERGENCYNEUROLOGYHandbook for Emergency PhysiciansEdited by Sid M. ShahMichigan State University, USAand Kevin Michael KellySchool of Medicine, MCP Hahnemann University,Pittsburgh, USA

This symptom-based handbook guides the emergencyphysician in the diagnosis and management ofcommon and complex neurological disorders.Integrating fundamental neurological concepts with thepractical demands and realities of emergency care, thisreference provides succinct, crucial information for allemergency physicians who diagnose and manageneurologic disorders.

ContentsPart I. Neurological Examination and NeurodiagnosticTesting; Part II. Common Neurological Presentations;Part III. Specific Neurological Conditions; Part IV.Neurological Trauma; Part V. Pediatric NeurologicalEmergencies; Part VI. Pregnancy-Related NeurologicalEmergencies; Part VII. Neurotoxicology; Part VIII. BrainDeath.

October 2003 350pp 140 illus0 521 00980 4 Paperback £39.95 / $60.00

New Edition

Forthcoming

FETAL AND NEONATALBRAIN INJURYMechanisms, Management and theRisks of Practice3rd edition

Edited by David K. StevensonWilliam E. Benitzand Philip SunshineAll from Stanford University Medical School, USA

Now in its third edition, this is a comprehensive surveyof fetal and neonatal brain injury arising from hypoxia,ischemia or other causes. The volume spans a broadrange of areas from epidemiology and pathogenesis,through to clinical manifestations and obstetric care,and then on to diagnosis, long-term outcomes, andmedico-legal aspects.

2003 926pp 305 illus0 521 80691 7 Hardback £140.00 / $190.00

TUBEROUS SCLEROSISCOMPLEXFrom Basic Science to ClinicalPhenotypesPaolo CuratoloUniversità degli Studi di Roma 'Tor Vergata', Italy

Tuberous sclerosis complex presents with seizures,cognitive impairments and autism. This up-to-the-minute book enables the paediatrian to recognise,understand and treat the disease most effectively.

‘This is clearly the most authoritative and contemporarystatement of current knowledge yet published.’ fromthe Foreword by H. Sarnat

Features● Comprehensive overview incorporating the

most up-to-date science● Enables better recognition, understanding and

diagnosis of a complex multisystem disorder● Covers clinical management, future and current

research, and most recent findings fromgenetics and related fields

ContentsForeword; Preface; 1. Historical background;2. Diagnostic criteria; 3. Neurological manifestations;4. Seizures; 5. Intellectual and cognitive impairments;6. Autism; 7. Neuroimaging; 8. Positron emissiontomography; 9. Dermatologic and stomatologicmanifestations; 10. Ophthalmologic manifestations;11. Renal involvement; 12. Cardiac and vascularinvolvement; 13. Hepatic, lung, splenic and pancreaticinvolvement; 14. Molecular genetics;15. Neuropathology; 16. Molecular Neurobiology;17. Future directions.

A Mac Keith Press PublicationJuly 2003 230pp 90 illus1 898683 39 5 Hardback £55.00 / $75.00

THE CLINICALMANAGEMENT OFCRANIOSYNOSTOSISEdited by Richard HaywardBarry JonesDavid Dunawayand Robert EvansAll from Great Ormond Street Hospital forChildren, London, UK

Children with craniosynostosis are born with congenitaldeformities of the face and skull. In severe casesassociated problems are common: blindness, deafness,severe learning difficulties and facial deformities. In thisbook, experts in the field introduce the non-craniofacialspecialist to how they can contribute to the child’swelfare.

Features● Written by practising specialists in

craniosynostosis for non-specialists● Shows non-specialists how they can help

improve outcomes of afflicted children

Contents1. The growth of the skull and face; 2. The classificationand clinical diagnosis of craniosynostosis; 3. Themolecular genetics of craniosynostosis; 4. Theepidemiology and incidence of craniosynostosis; 5. Theante-natal diagnosis of craniosynostosis; 6. Imagingand craniosynostosis; 7. Principles of management ofthe child with craniosynostosis; 8. Management ofraised ICP; 9 Management of airway obstruction;10. Management of ophthalmological complications;11. Management of malocclusion and dentalcomplications; 12. Psychological considerations;13. Neurological problems of children withcraniosynostosis and the role of the paediatrician;14. Speech and language development; 15. Hearingdisorders; 16. The management of feeding problems inchildren with complex craniosynostosis; 17. The role ofthe clinical nurse specialist; 18. Anaesthesia and thechild with craniosynostosis; 19. The surgicalmanagement of the child with craniosynostosis; Index.

A Mac Keith Press PublicationJuly 2003 180pp 70 illus1 898683 36 0 Hardback £50.00 / $70.00

DISORDERS OFNEURONAL MIGRATIONEdited by Peter BarthUniversiteit van Amsterdam, Netherlands

Disorders of neuronal migration are causes of mentalhandicap, autism, and epilepsy. Many are geneticallydetermined and need precise diagnosis to providegenetic counselling. This book will help the clinicianaquire proficiency in diagnosis.

Features● Synthesises the accumulated knowledge of a

rapidly expanding, multi-disciplinary fieldstraddling pediatrics, neurology and clinicalgenetics

● Provides a comprehensive source ofinformation to aid in diagnosis and counselling

Contents1. Introduction; 2. Morphogenesis of the humancerebral cortex; 3. Lissencephaly: the clinical andmolecular genetic basis of diffuse malformations ofneuronal migration; 4. Non-lissencephalic corticaldysplasias; 5. Periventricular gray matter heterotopia: aheterogenous group of malformations of corticaldevelopment; 6. Anomalies of the Corpus Callosum andcortical malformations; 7. Hemimegalencephaly.

A Mac Keith Press Publication2003 160pp1 898683 31 X Hardback £45.00 / $65.00

BEHAVIOURALPHENOTYPES INCLINICAL PRACTICEEdited by Gregory O'BrienUniversity of Northumbria, UK

It is increasingly thought that the behaviours of youngpeople with intellectual disabilities are shaped by therespective causal syndrome. Here an international teamof experts provides a practical resource forinterventions and ongoing care programmes to addressthis within the context of coordinated multimodal caseplanning.

A Mac Keith Press Publication 2002 252pp1 898683 27 1 Hardback £45.00 / $65.00

CHILDHOOD HEADACHEEdited by Ishaq Abu-Arafeh Stirling Royal Infirmary, Scotland, UK

Presenting an up-to-date account of the advancementsin this common complaint. It gives comprehensivereviews of the scientific basis of headache and theclinical issued related to diagnosis, classification andmanagement, as well as identifying areas for futureresearch. Detailed coverage is given to theunderstanding of migraine in children, diagnosticcriteria for tension headache and other causes ofheadache such as those related to serious underlyingneurological disorders.

A Mac Keith Press Publication2002 208pp 25 illusHardback 1 898683 26 3 £45.00 / $65.00

Child Neurology Books from Mac Keith Press

Printed in the United Kingdom at the University Press, Cambridge June 2003

Please order from your local booksellerForthcoming

New for 2004

THE NEUROPATHOLOGY OFDEMENTIASecond EditionMargaret EsiriUniversity of Oxford, UK

John Q. Trojanowski and Virginia M.-Y. LeeBoth from University of Pennsylvania School of Medicine, USA

Completely rewritten and updated, this new edition isalmost twice the size of its predecessor. Illustrated incolour throughout, and with contributions from theworld’s leading authorities, it is the definitive reference onthe neuropathology of dementia. New material includes:

● Three entirely new chapters on neuroimaging,molecular diagnostics, and transgenic models.

● Two chapters on tauopathies under newauthorship.

● A chapter under new authorship onsynucleinopathies, which includes multiplesystem atrophy.

February 2004 672pp 269 illus0 521 81915 6 Hardback £220.00 / $340.00

Related JournalsINTERNATIONAL JOURNAL OFNEUROPSYCHOPHARMACOLOGY

ISSN 1461-1457

JOURNAL OF INTERNATIONALNEUROPSYCHOLOGICAL SOCIETY

ISSN 1355-6177

DEVELOPMENTAL MEDICINE AND CHILDNEUROLOGY

ISSN 0012-1622

For sample copies and ordering information for Journals visithttp//journals.cambridge.org

NEUROCUTANEOUSDISORDERSEdited by E. Steve RoachWake Forest University, North Carolina, USA

and Van S. MillerUniversity of Texas Southwestern Medical Center, Dallas, USA

The neurocutaneous disorders comprise a large groupof neurological syndromes that feature skin lesions andoften eye lesions, central and peripheral nervoussystem tumors, brain malformations, mentalretardation, psychiatric symptoms, or seizures.Neurocutaneous syndromes have been known forcenturies, but recent research into their cellular,biochemical and molecular-genetic basis has pointed to an essential need for a genotypic nosology.

Features● An authoritative overview of the clinicalfeatures, natural history and genetic andmolecular mechanisms of the neurocutaneoussyndromes● Highly illustrated throughout● Essential reading for both neurologists anddermatologists

September 2003 352pp 200 illus0 521 78153 1 Hardback £120.00 / $180.00