Nerissa Wu, MPH, Ph.D. Robert Voss, MPH California ... · 3 Program funding 2015-16 budget includes...
Transcript of Nerissa Wu, MPH, Ph.D. Robert Voss, MPH California ... · 3 Program funding 2015-16 budget includes...
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Nerissa Wu, MPH, Ph.D. Robert Voss, MPH
California Department of Public Health
Biomonitoring California Scientific Guidance Panel Meeting
July 16, 2015 – Oakland, CA
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Program updates/announcements Project updates Measuring Analytes in Maternal Archived Samples
(MAMAS) Project overview Round 1 data presentation
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Program funding 2015-16 budget includes $800K two-year augmentation Biomonitoring California budget comprised of:
Permanent state funding CDC cooperative agreement 2014-16 augmentation 2015-17 augmentation
Biomonitoring team updates
Dr. Yu-Chen Chang joined EHL
Program Announcements
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Biomonitoring Staff
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Pilot BEST On-going data analyses Evaluation of results return Posted results on website for: PCBs, PAHs, organochlorine
pesticides, pyrethroid pesticide metabolites Expanded BEST
Received lab results for 2nd set of chemicals: environmental phenols, PAHs, phthalates, pesticides, and metals (in urine), and POPs (in serum)
Round 2 results return planned for August Data analyses (metals, PFCs)
Project Updates
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Flame Retardant and Environmental Exposure Study (FREES): Collaboration with the UC Davis, Environmental Working
Group, Green Science Policy Institute, and Silent Spring Couch and Foam Cushioning Replacement Study
Participants will remove or replace flame retardant-containing foam in the home
UC Davis study will look at FR levels in dust
Biomonitoring California will look at FR levels in blood and urine
Proposed Studies
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Asian/Pacific Islander Community Exposures (ACE) Project Collaboration with APA Family Services Community-based study to biomonitor Chinese,
Vietnamese, Filipino, and Lao populations in San Francisco and conduct education and outreach related to safe fish consumption
Project will fill data-gap related to specific Asian sub-populations
Proposed Studies (2)
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Review of Biobank MAMAS-1 pilot sampling MAMAS-2 statewide expansion Benefits and challenges
Measuring Analytes in Maternal Archived Samples (MAMAS)
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Biobank counties: Fresno, Kern, Kings, Madera, Tulare, Orange and San Diego
California Biobank Genetic Disease Screening Program (GDSP)
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MAMAS Pilot Study
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MAMAS – Phase II samples will be pulled from four geographic regions: Los Angeles County; San Bernardino & Riverside Counties; Contra Costa & Alameda Counties; and the Northern Tier
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• Pregnant women • San Diego and Orange Counties
• Selected by race/ethnicity • Asian subgroups with n>30:
Chinese, Filipino, Vietnamese
• Consistent second trimester sampling
Measuring Analytes in Maternal Archived Samples (MAMAS): Demographics
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MIEEP: Maternal and Infant Environmental Exposure Project
• Metals • Perfluorochemicals (PFCs) • Persistent Organic Pollutants (POPs): Organochlorine pesticides (OCPs) Polychlorinated biphenyls (PCBs) Polybrominated diphenyl ethers (PBDEs)
MAMAS chemicals
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14 *Description of PFCs: http://biomonitoring.ca.gov/chemicals/perfluorochemicals-pfcs
CTS: California Teachers Study FOX: Firefighter Occupational Exposures Project
PFC detection frequencies
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15 * NHANES is females, all ages.
PFHxS and PFOS in MAMAS and NHANES*
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16 * NHANES is females, all ages.
PFHxS and PFOS in MAMAS and NHANES*
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17 * NHANES is females, all ages.
PFHxS and PFOS in MAMAS and NHANES* (2)
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• Currently can report Hg, Mo, Se, Sr, and Tl
• Metal contamination in collection tubes
• Two blank studies completed • Affects As, Cd, Co, Cr, Mn, Pb,
Sb, U, and possibly others
Metals results
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19 Note: NHANES 2011-12, total blood mercury for all females.
Mercury by race in MAMAS and NHANES
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20 Note: NHANES 2011-12, total blood mercury for all females.
Mercury by race in MAMAS and NHANES (2)
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21 Note: *NHANES 18-45 year aged, overall and pregnant subgroups.
• Congeners shown were detected in at least 40% of samples
• DFs and GMs were less than NHANES (2003-04)*
POPs detected in MAMAS
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22 Note: *NHANES 18-45 year aged, overall and pregnant subgroups.
• Congeners shown were detected in at least 40% of samples
• DFs and GMs were less than NHANES (2003-04)*
• Exception: BDE-183 • DFs in CTS and FOX < 5%
POPs detected in MAMAS (2)
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*Values shown for context only; not statistically valid due to low DF **DF not reported
PBDEs: Consistent with recent studies
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MAMAS: 3 POPs by race
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Challenges Serum only, limited sample
volume Limited representation of CA:
pregnant women Additional, specific bias:
Only those achieving pregnancy Likely omits higher risk
pregnancies Omits older and younger
women No exposure histories possible No control over sampling
protocol
Benefits Inexpensive Representative racially and
geographically Samples can be fairly large Continuous sampling stream
might facilitate timely surveillance (limited by other project timelines)
MAMAS: Potential for state-wide sampling
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Next steps: Combine with MAMAS II Continue to assess metals strategy
Future possibilities: Changes over time in California Sentinel monitoring of emerging chemicals Retrospective investigation in Biobank counties
Future directions for MAMAS