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neoplasia - Weebly · 2019. 10. 1. · •Characterized by: marked cellular atypia, nuclear...
Transcript of neoplasia - Weebly · 2019. 10. 1. · •Characterized by: marked cellular atypia, nuclear...
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neoplasia Robbins pictures
For the lab questions
Doctor 2016
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Colonic polyp/ adenoma
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• The picture in the previous slide shows a polyp from the colon.
• A polyp is a mass projecting above a mucosal surface.
• This particular polyp in the picture is a benign adenoma of the colon.
• Adenoma= benign lesion that is either originating from glandular tissue or forming glands.
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Pleomorphic adenoma from salivary gland
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• The pic in the previous slide is a pleomorphic adenoma
• This is a benign tumor affecting salivary glands, mainly parotid
• It is an example of mixed tumor : that contained epithelial and stromal elements
• The epithelial elements are the glandular structures
• The stromal elements are the myxoid stroma that resemble cartilage.
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Well differentiated squamous cell carcinoma (SCC)
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• The pic in the previous slide shows SCC
• In this example it is well differentiated
• Differentiation means how much the tumor mimics its cell of origin both structurally and functionally
• The differentiation is reported as the grade of the tumor.
• Tumor stage on the other hand is the extent the tumor has spread in the body
• Stage is more important than grade in determining the outcome ( clinical behavior of the tumor)
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anaplasia
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• Anaplasia means dedifferentiation or lack of differentiation
• It s a histologic hallmark of malignancy
• Characterized by: marked cellular atypia, nuclear pleomorphism , hyperchromasia and tumor giant cells
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Atypical mitosis
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• Abnormal mitosis is seen in malignant tumors
• Not seen in benign tumors
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Carcinoma in situ 1
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Carcinoma in situ 2
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• Carcinoma in situ is full thickness atypia= severe dysplasia involving the whole thickness of the epithelium
• is a pre invasive stage of cancer
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Fibroadenoma of the breast
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• Fibroadenoma is benign
• In the pic you notice the well circumscribed, encapsulated lesion
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Breast carcinoma:
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• Previous pic: lesion is infiltrative and lacks a capsule. These are features of malignancy
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Liver with metastatic carcinoma
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• The pic in the previous slide is for a liver. You see several nodules within it
• Usually multiple nodules are metastatic
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