Neonatal Sepsis Sepsis neonatorum is the term used to describe any systemic bacterial infection any...
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Transcript of Neonatal Sepsis Sepsis neonatorum is the term used to describe any systemic bacterial infection any...
Neonatal Sepsis
Armanian Amir Mohammad , MDNeonatologist
Assistant Professor of Isfahan Faculty of Medicine
Sepsis neonatorum is the term used to describe
any systemic bacterial infection
documented by a
Positive blood culture in the first month of life .
SYMPTOMS AND SIGNS
•The signs and symptoms of neonatal
sepsis often are nonspecific
CLINICAL MANIFESTATIONS •level of Activity
CLINICAL MANIFESTATIONS •Pattern of Feeding
Abdominal distention / lavage… /
•muscle Tone
CLINICAL MANIFESTATIONS
CLINICAL MANIFESTATIONS
•level of Alertness
respiratory status or effort (Breathing)
CLINICAL MANIFESTATIONS
CLINICAL MANIFESTATIONS
•Peripheral Perfusion
CLINICAL MANIFESTATIONS •level of Activity
•Pattern of Feeding
•muscle Tone
•level of Alertness
•respiratory status or effort (Breathing)
•Peripheral Perfusion
•The negative predictive value (NPV) of this scoring system was 96%
•Thus, although observational findings alone cannot replace the physical examination and
laboratory studies, they are an important aspect of the evaluation.
•Temperature elevation in full-term infants is
uncommon .• Temperature elevation is infrequently
associated with systemic infection when only a single elevated temperature occurs .• Temperature elevation that is sustained
longer than an hour is frequently associatd with infection .• Temperature elevation without other signs of
infection is infrequent
Early-onset disease•GBS, E. coli and other gram-negative enteric bacilli, and
L. monocytogenes:
ampicillin + an aminoglycoside (gentamicin)
Multidrug-resistant bacteria: tobramycin and amikacin. (Ampi + Amika )
If meningitis is suspected: cefotaxime, for better CNS penetration.
( Ampi + Amika + Cefo)
ampicillin - g
entamicin
)
late-onset disease ( community acquired)
•Empirical therapy for late-onset disease acquired in the community should provide coverage for
the same neonatal pathogens of early onset and for potential community
acquired pathogens, such as S. pneumoniae ,N.meningitidis & H.influenza.
Because meningitis frequently is a component of late-onset sepsis, antibiotics with good CNS
penetration should be selected. Ampicillin and a third-generation cephalosporin
(e.g., cefotaxime) are commonl recommended.( Ampi + cefo)
Ampicillin - Cefotaxime
late-onset disease (nosocomial acquired)
•CONS, enterococci, gram-negative enteric bacilli (including drug-resistant strains), and fungi:
•Vancomycin generally is active against all staphylococcal species, streptococci, and most enterococci.
•Vancomycin and gentamicin are commonly used for initial therapy: (Vanco + genta or Amika )
•when gram-negative meningitis is a concern:
(Vanco + Cefo) Cefotaxime does not have activity against Pseudomonas, enterococci ,L.
monocytogenes. : PEL
Ceftazidime (Vanco + Cefta )
Vancomycin-Cefotaxime