Neocate® is the most hypoallergenic type of formula1,2

EXCLUSIVE RESOURCES FOR PARENTS & FAMILIES

Amino acid-based formula

Extensively hydrolyzed formula (eHF)

TYPE OF FORMULAPROTEIN STRUCTURES

IN FORMULAS

Partially hydrolyzed formula*

Co

w M

ilk-B

ased

Cow milk-based formula

Neocate®

(100% amino acid based)

Neocate is 100% milk-free using non-allergenic amino acids.

HYP

OA

LLER

GEN

IC

NO

N-A

LLER

GEN

ICM

OST

ALL

ERG

ENIC

* Partially hydrolyzed formulas are not hypoallergenic.1,4

Only Neocate provides your patients complete nutritional and real life support at every step of their food allergy journey

• Neocate is 100% milk-free, using non-allergenic amino acids

• eHFs contain peptides derived from milk3

Neocate.com/footsteps

0-

12 months 6+ months

Nutra

1+ years

Junior with or without prebioticsInfantSyneo® Infant

1+ years

Splash

7Red Flag Indicators for using an amino acid-based formula,such as Neocate, to manage cow milk allergy

© 2018 Nutricia North America

9497350-30732

XXXXX 01/18

1. du Toit G, et al. Identifying and managing cow’s milk protein allergy. Arch Dis Child Educ Pract Ed. 2010;95:134-44. 2. Host A, et al. Dietary products used in infants for treatment and prevention of food allergy. Joint Statement of the European Society for Paediatric Allergology and Clinical Immunology (ESPACI) Committee on Hypoallergenic Formulas and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee on Nutrition. Arch Dis Child. 1999;81:80-4. 3. Host A, et al. Hypoallergenic formulas--when, to whom and how long: after more than 15 years we know the right indication! Allergy. 2004;59 Suppl 78:45-52. 4. American Academy of Pediatrics Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics. 2000;106:346-9. 5. Vandenplas Y, et al. Guidelines for the diagnosis and management of cow’s milk protein allergy in infants. Arch Dis Child. 2007;92:902-8. 6. Koletzko S, et al. Diagnostic approach and management of cow’s-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines. J Pediatr Gastroenterol Nutr. 2012;55:221-9. 7. Venter C, et al. Diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy - a UK primary care practical guide. Clin Transl Allergy. 2013;3:23. 8. Ludman S, et al. Managing cows’ milk allergy in children. BMJ. 2013;347:f5424. 9. Fiocchi A, et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) Guidelines. Pediatr Allergy Immunol. 2010;21 Suppl 21:1-125. 10. Hill DJ, et al. The efficacy of amino acid-based formulas in relieving the symptoms of cow’s milk allergy: a systematic review. Clin Exp Allergy. 2007;37:808-22.

* Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436.

Nutricia North America supports the use of breast milk wherever possible.

Neocate is a medical food for use under medical supervision.

FPO

WHEAT EGG PEANUT

TREE NUTS

MILK FISH SHELLFISH

SOY

Severe colic (irritability) Infant with GI upset(e.g. re�ux, vomiting)

Infant with eczema1 2 3 4 5 6 7*

Severe GI symptoms6-9

Symptoms not resolved on eHF5-8

Failure to thrive7,8

Severeeczema7,10

Multiple food allergies6,10

Symptoms while breastfeeding7,8,10

Anaphylaxis9