Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted...
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Transcript of Neoadjuvante chemoradiatie: surgery when needed (preSANO) Neoadjuvante chemoradiatie: targeted...
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• Neoadjuvante chemoradiatie: surgery when needed (preSANO)
• Neoadjuvante chemoradiatie: targeted treatment (TRAP)• Neoadjuvante/definitieve chemoradiatie: surgery if
possible (TOR)• Definitieve chemoradiatie: dosisintensificatie (ART-DECO)• Dataregistratie (POCOP)
Blik op de toekomst: lopende en geplande DOCG studies
Dr. Hanneke W.M. van LaarhovenMedische OncologieAcademisch Medische Centrum
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preSANOpre- Surgery As Needed for Oesophageal carcinoma
A single-arm feasibility trial
Primary endpoint•Correlation between the clinical response during CRE-I and CRE-II and the final pathological response in the resection specimen
Secondary endpoints•Serious complications during endoscopic and endosonographic tissue sampling •R0-resection rates for all included patients that undergo resection
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TRAPChemoradiation, TRAstuzumab and Pertuzumab in resectable
HER2+ esophageal carcinomaA single arm feasibility study
Primary endpoint•Withdrawal rate from surgery
Secondary endpoints•pCR•Toxicity•Post-operative complications
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TOR
Chemoradiotherapy followed by resection for patients with gevolgd a T4b oesofagus carcinoma
Primary endpoint•R0 resection (≥ 80% )
Secondary endpoints•Post-operative complications•Mortality•Quality of life
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ART-DECO
A Randomized Trial of Dose Escalation in definitive Chemoradiotherapy for patients with
Oesophageal cancer
Landelijk Platform Radiotherapie voor Gastro Enterologische tumoren
Primary endpoint•Local recurrence rate (≥ 15% difference)
Secondary endpoints•Grade 3-4 toxicity•Survival
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POCOPProspective Observational Cohort Study of
Oesophageal-gastric cancer Patients
Acknowledgments• Joel Shapiro, Bas Wijnhoven, Jan van Lanschot (preSANO)• Maarten Anderegg, Mark van Berge Henegouwen (TOR)• Maarten Hulshof (ART-DECO)• Leonie Haverkamp, Jelle Ruurda (Oesofagus/maag parel)