NCRI 2013 Poster - DECIPHER Health – The clinical and research application for cancer analytics
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BACKGROUND Dundee Edinburgh Cancer Informatics Programme Harnessing Excellence in Research, a collaboration between two health boards and a biomedical informatics company, is a two year, industry-led project nearing completion. There are two main strands: Research Analytics service: secure web-based service for clinical research offering a high performance analytics platform in a controlled environment with role-based access, and audit trail ensuring security, safety and traceability of data. Clinical Analytics application: developing configurable cancer pathway visualisations with integrated analytics. METHODS Development of a Research Analytics platform to support collaborative research on clinical and genetic datasets in a secure online environment. The Clinical Analytics application has seen development of analytics tools to facilitate real-time analysis of the patient journey and automation of the collection and collation of Clinical Performance Indicators, with pathway and clinical metrics designed by Clinical Informaticists and Clinical Specialists. RESULTS A Research Analytics environment for collaborative project based work, providing analytics with SQL, machine learning, R and charting tools on a scalable clustered computing platform. The environment offers managed sharing protocols, cohort selection and de-identification at source and at sharing level with secure data transfer, audit and monitoring tools in a shared hosting infrastructure. Configurable cancer pathways created for breast, lung, prostate, melanoma and ovarian cancer. Ability for service throughput overview, pathway level analytics and pre-defined cancer specific analytics with Quality Performance Indicators for breast and lung cancers. CONCLUSIONS DECIPHER Health provides a scalable informatics platform supporting linked phenotype-genotype datasets from consented patient cohorts across multiple cancer types. The Research Analytics platform enables the analysis of large, complex de-identified datasets, linking clinical, patient, genomic, imaging and treatment outcome data. This platform will form the basis for the Stratified Medicine Scotland Innovation Centre. The Clinical Analytics application enables healthcare professionals to view a cancer-focused view of clinical patient information at different stages of the cancer pathway , including configurable cancer pathways visualisations for breast, lung, prostate, melanoma and ovarian cancer for service level care. © Aridhia Informatics Ltd. All r ights reserved. www.aridhia.com Partners: www.nhstayside.scot.nhs.uk www.aridhia.com www.nhslothian.scot.nhs.uk Lothian www.ed.ac.uk www.dundee.ac.uk Authors: Dr Rachel Knight, Dr Alexander Henzing, Mrs Pamela Brankin, Dr Catherine Kelly CLINICAL RESEARCH ANALYTICS CANCER fo r • • • • and CA125Response Survivalby Histology(Ovarian) ClinicalOutcomeMetrics Yearof diagnosis grade 1 2 3 4 prstatus erstatus 2% <1% 70% 100% 55% 100% 85% 90% 91% 100% 50% 100% 25% 20% PR/ER Status Grade of tumour by year of diagnosis the
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8/13/2019 NCRI 2013 Poster - DECIPHER Health – The clinical and research application for cancer analytics
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