NCI-NCTN Imaging and Radiation Oncology Core Michael V ... · NCI Clinical Trial Efforts NCI...

Neuroradiology Education and Research

(NER) Foundation Symposium 20006

NEW CONTRAST AGENTS

Michael V. Knopp, MD., PhD

E-Mail: [email protected] 1

IROCNCI-NCTN Imaging and Radiation Oncology Core

Michael V. Knopp, MD. Ph.D.

Professor of Radiology and Novartis Chair of Imaging Research

PI / Director, Wright Center of Innovation in Biomedical Imaging (WCIBMI)

and the Ohio Imaging Research and Innovation Network (OIRAIN)

Co-PI, NCI Imaging and Radiation Oncology Core (IROC)

E-Mail: [email protected]

Educational Exhibit Presented at RSNA 2013



NEW CONTRAST AGENTS



NCI Clinical Trial Efforts

For over 50 years, NCI has supported a standing

infrastructure - the NCI Clinical Trials Cooperative Group

Program - to conduct large scale cancer clinical trials across

the nation, with successful completion of many important

trials that have led to new treatments for cancer patients.

More than 25,000 patients and thousands of clinical

investigators participate in the program's clinical trials

annually. It is NCI’s vision and responsibility to ensure that

the Cooperative Groups are optimally situated and well-

prepared to design, enroll and complete state-of-the-art trials

for cancer patients.


In recent years stakeholders have expressed concerns that the

program is falling short of its. As a result, NCI asked the Institute of

Medicine (IOM) to assess the state of clinical cancer trials, review the

Cooperative Group Program, and provide advice on improvements.

This review was completed and 4 major goals highlighted:

1.Improve speed and efficiency of design, launch, and conduct of trials

2.Incorporate innovative science and trial design into cancer trials

3.Improve prioritization, selection, support, and completion of trials

4.Incentivize the participation of patients and physicians in trials



NEW CONTRAST AGENTS




NCI Director, Harold Varmus, MD summarized the efforts in 2010 as:

This is not just about getting the clinical trial groups properly retrofitted.., it’s

about injecting a new kind of science into the way we do clinical trials.



NEW CONTRAST AGENTS





NEW CONTRAST AGENTS




The NCI National Clinical Trial Network

will be guided by the CTAC Clinical Trials

Strategic Planning Subcommittee which

will have representation from all

stakeholders in the network. The next

organizational component are the NCI

Disease / Imaging Steering committees

which will be tasked to evaluate and

prioritize clinical trials going forward.

Reproducibility / Validation / Efficacy

Number 3

Avoid using advanced imaging technologies — PET, CT,

and radionuclide bone scans — to monitor for a cancer recurrence in patients who have finished initial treatment and have no signs or symptoms of cancer

PET and PET/CT, which are

"expensive," have not been proven as

surveillance tools to improve outcomes,

said Dr. Schnipper

These scans can also give false-positive

results, which can cause a patient to

undergo additional unnecessary or invasive

procedures or treatments or to be exposed

to additional radiation, said Dr. Schnipper.Slide courtesy J. Dye



NEW CONTRAST AGENTS



ACRIN

Core Lab

RTOG

QA Office

Alliance and SWOG

Imaging Core Lab

at Ohio State

Image Guided

Therapy Center

at Wash U

Radiological

Physics Center

(RPC)

Quality

Assurance

Review Center

(QARC)

IROC

Philadelphia

Imaging

IROC

Philadelphia

RT

IROC

Ohio

IROC

St. Louis

IROC

Houston

IROC

Rhode

Island

IROC Mission

Provide integrated imaging and radiation

oncology quality control programs in

support of the NCI’s NCTN Network thereby

assuring high quality data for clinical trials

designed to improve the clinical outcomes

for cancer patients worldwide



NEW CONTRAST AGENTS





NEW CONTRAST AGENTS



IROC’s Five General NCTN Core Services

Trial

Design

Support

Case

Review

Data

(pre-review)

Management

CredentialingSite

Qualification

Data

(post-review)

Management

1. Site Qualification

(FQs, ongoing QA, proton approval, resources)

2. Trial Design Support/Assistance

(protocol review, templates, help desk, key contact QA centers)

3. Credentialing

(tiered system to minimize institution effort)

4. Data Management

(pre-review, use of TRIAD, post-review for analysis)

5. Case Review

(Pre-, On-, Post-Treatment, facilitate review logistics for clinical reviews)

IROC’s Data Upload Strategy

IROC is building upon ACR investment

into TRIAD software to expand it to serve

as a efficient tool to upload imaging and

radiation therapy data sets for Quality

Assurance and Analytical Processing for

NCTN trials. This is an evolutionary

process that will occur over the next years

as IROC develops more efficient and

effective workflows.



NEW CONTRAST AGENTS



ICL Trial Implementation Pipeline

Trial InitiativeProtocol Proposal

Protocol Amendment

Site Credentialing

Equipment Validation

Protocol Refresher

(Virtual) Site Visit

Site Specific Manual

Trial Performance

Data Management

Quality Control

Real-time Image Review

Trial Report & Update

Trial Assessment

Blind Central Review

Endpoint Analysis

Summary & Report

Semi-automatic Image QC



NEW CONTRAST AGENTS



ICL PET/CT Quality Check Weighted-Scoring System

Category # QC ItemsWeight

(100)Green Weight Yellow Weight Red Weight

1 Timing Point of PET/CT (BL, C2, C6, 6) 10 within 10 < 7days diff 6 >7days 1

2 Emission Uptake Time 15 60-80 min 15 50-90 8 <50 or >90 0

3 Consistency of Emission Uptake Time btw F&B 15 <15min diff 15 15-20min diff 8 >20 0

4 Completeness of Imaging Data 3 complete 3 most complete 2 incomplete 0

5 Data format (DICOM, jpg, bmp, films, ...) 10 DICOM 10 secondary DICOM 3 non-dicom 0

6 Consistency of PET/CT Scanner 15 same 15 n/a different 5

7 Consistency of Arm Positioning 5 same 5 different 3 n/a

8 Consistency of Scan Direction 5 same 5 different 3 n/a

9 Injection Site 3 no extravasation 3 clear extrvasation 1 n/a

10 De-identification 2 De-identified 2 not de-identified 1 n/a

11 Image Resolution 3 meet protocol 3 1mm diff 1 >1mm diff 0

12 CRFs 2 complete 2 incomplete 1 n/a

13 Fasting (e.g., > 4 hours) 2 >4 2 n/a <4 0

14 Glucose level (e.g., <200 mg/dL) 5 <200 5 n/a >= 200 1

15 FDG Dosage (e.g., 7-15 mCi) 5 7-15 5 5-17 4 <5 or >17 1

Study: (Green) Compliant: >=80; (Yellow) Acceptable: 70-80; (Red) Non-compliant: <70

Patient: (Green) Compliant: >=85; (Yellow) Acceptable: 75-85; (Red) Non-compliant: <75

Weight Score Criteria of Data Compliance (SWOG0816)

Timing

Data

Patient

Phase II Trial of Response Adapted Therapy of Stage III-lV

Hodgkin Lymphoma Using Early Interim FDG-PET Imaging

M D018 219282 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2unknown 1 5 95

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 17 . 69 4 98

W A069 220207 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 91. 33333

C2 10 56 8 - 22 0 3 10 15 5 5 3 1 3 2 2 5 16 . 23 4 76

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231437 BL 10 53 8 15 3 10 15 5 5 3 1 3 2 2 5 15 . 78 4 91 95. 66667

C2 27 da ys 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

MI014 220153 BL 1058 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 89. 33333

C2 1094 min 8 36 0 3 10 15 5 5 3 1 3 2 2 5 5 77

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

220938 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99223396 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98 92. 33333

C2 1058 min 8 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 91

Bi og r aph40 vs 1 068C6 10 15 15 3 10 1 5 5 5 3 1 3 AGm ADS 1 2 5 5 88

223560 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98 97

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 3 1 3 2 2 5 5 94229135 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

230003 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100231358 BL 1057 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 92. 33333

C2 21 da ys 6 15 15 3 10 15 3 5 3 2 3 2 2 5 5 94

C6 1057 min 8 15 3 10 15 3 5 3 2 3 2 2 5 5 91

232041 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 1057 min 8 15 5 10 15 3 5 3 2 3 2 2 5 5 93

234565 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 33333C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

Bi og r aph40 vs Di s co v er yC6 10 59 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

235710 BL 10 59 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 66667

Bi og r aph40 vs Di s co v er yC2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

Biog raph 40C6 10 59 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

235786 BL 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 90. 33333C2 1083 min 8 27 m in 0 3 10 15 5 5 3 2 3 2 2 5 5 78

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

237108 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

239166 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 5

C2 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93C6

IL 147 220208 BL 1048 min 0 15 3 10 15 5 5 3 3 2 2no r ec o rd 1 5 79 81

C2 28 da ys 6 15 16 8 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 16 . 03 4 86STE v s STC6 1050 min 8 15 3 10 1 5 5 3 3 1 3 AGm ADS 1 2 5 15 . 36 4 78

223551 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 16 . 11 4 97 96. 66667

C2 10 15 15 3 10 15 5 3 3 1 3 2 2 5 5 97

C6 10 15 15 3 10 15 5 3 3 1 3 2 2 5 15 . 46 4 96

227667 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 15 . 76 4 97 98. 0

C2 10 15 15 3 10 15 5 5 3 2 3 AGm ADS 1 2 5 15 . 83 4 98C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 24 4 99

228006 BL 1054 min 8 15 3 10 15 5 5 3 2 3 AGm ADS 1 2 5 15 . 53 4 91 88. 66667

C2 1049 min 0 15 3 10 15 5 5 3 2 3 AGm ADS 1 2 5 15 . 31 4 83

C6 10 15 16 8 3 10 15 5 5 3 2 3 2 2 5 15 . 98 4 92

IL094230041 BL 1050 min 8 15 3 10 15 5 5 3 2 3 no fo rms 1 2 5 5 92 95

C2 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

234005 BL 1053min 8 15 3 10 15 5 5 3 2 3 2 2 5 16 . 78 4 92 95. 33333

C2 10 15 15 3 10 15 3 5 3 2 3 2 2 5 15 . 09 4 97

C6 10 15 15 3 10 15 3 5 3 2 3 2 2 5 15 . 09 4 97

236417 BL 10 55 8 15 3 10 15 5 5 3 2 3 2 2 5 15 . 76 4 92 86Di sc o ve r y 6 90 v s STEC2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

Dis c ov e ry STEC6 10 53 8 - 17 8 3 10 1 5 5 5 3 2 3 2 2 5 5 76

OH027 227841 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98 96

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 1001094 vs b i og r aphC6 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

230085 BL 1059 min 8 15 3 10 15 5 5 3 2 3 2 2 5 6 .1 1 89 93

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

234735 BL 10 15 15 3 10 15 5 5 3 1 3 no fo rms 1 2 5 5 98 93. 5

1094 vs b i og r aphC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 0238350BL 1082 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 92

C2 10 15 - 18 8 3 10 15 5 5 3 1 3 2 2 5 5 92

C6 0

238558BL 10 10 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 10 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6

WA011 / 221174 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 N/ A 0

223078 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667

C2 27 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95C6 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

224338 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231447 BL 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 94. 5

C2 21 da ys 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96C6 UNK 0 15 15 3 10 15 5 5 3 2 3 2 UNK 0UNK 0 5 83

232563 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 63 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

233005 BL 1049 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 86. 5

STE v s STC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 0233371 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

233534 BL 1054 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 96. 66667

C2 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99236542 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

TX035 221288 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98. 5

C2 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98C6 N/ A 0

221481 BL 1094 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 79

C2 1054 min 8 - 40 0 3 10 1 5 5 5 3 1 3 AGm ADS 1 2 5 5 66

C6 N/ A 0

222248 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 89. 33333

C2 1055 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92

C6 1089 min 8 -29 min 0 3 10 15 5 5 3 1 3 2 2 5 5 77223980 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98 87

C2 30 da ys 182 min 8 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 82

C6 UNK 059 min 15 15 3 10 15 5 5 3 1 3 1 UNK 0UNK 0 5 81

224111 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98 76. 33333

C2 7 da y s 155 min 8 25 min 0 3 10 1 5 5 5 3 1 3 AGm ADS 1 2 5 5 57

RX v s . STE?C6 10 15 -20 min 8 3 10 1 5 5 5 3 1 3 2 2 5 5 74224225 BL 1096 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 83. 33333

C2 10 15 -27 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 74

C6 10 15 -23 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84

226920 BL 1055 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 87. 33333

C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 UNK 0 15 15 3 10 15 5 5 3 1 3 1 UNK 0UNK 0 5 81

227063 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 93. 66667C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

RX v s . STE?C6 1058 min 8 15 3 10 1 5 5 5 3 2 3 2 2 5 5 83

227347 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 86. 33333

RX v s . STE?C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

RX v s . STE?C6 UNK 0 15 15 3 10 1 5 5 5 3 1 3 1 UNK 0UNK 0 5 71

228056 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 66667RX v s . STE?C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

C6 10 15 15 3 10s amr b as e li ne 15 5 5 3 2 3 2 2 5 5 100

229259 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95

RX v s . STE?C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

C6 0

229468 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 94. 33333C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 ~16 week s p o s t chemo0 59 8 15 3 10 15 5 5 3 2 3 2 2 5 5 83

230649 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C2 W ITHDREWW ITHDREWWI THDREW WITHDREWWITHDREW WITHDREWWITHDREWWITHDREWWITHDREWW ITHDREWW ITHDREW W ITHDREWWI THDREWWI THDREWWI THDREW W ITHDREWWI THDREWWI THDREWWI THDREWWI THDREWWI THDREWWITHDREWWITHDREWWITHDREWWITHDREWW ITHDREWW ITHDREWW ITHDREWWI THDREW WITHDREW 0

C6 W ITHDREWW ITHDREWWI THDREW WITHDREWWITHDREW WITHDREWWITHDREWWITHDREWWITHDREWW ITHDREWW ITHDREW W ITHDREWWI THDREWWI THDREWWI THDREW W ITHDREWWI THDREWWI THDREWWI THDREWWI THDREWWI THDREWWITHDREWWITHDREWWITHDREWWITHDREWW ITHDREWW ITHDREWW ITHDREWWI THDREW WITHDREW 0

233704 BL 1085 min 8 15 3 10 15 5 5 3 2 3 no ADS 1 UNK 0UNK 0 5 85 82. 33333

STE v s RX C2 UNK 0 15 15 3 10 1 5 5 5 3 2 3 no ADS 1 UNK 0UNK 0 5 72STE C6 6m pos t chemo 0 15 15 3 10 15 5 5 3 2 3 2 2 5 5 90

236798 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95

RX vs . STE? C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

C6 0

237024 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95

RX vs . STE? C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90C6 0

FL020 232717 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 92 4 98 98

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 42 4 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 65 4 98

221954 BL 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 17 . 99 4 97 97. 66667C2 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98

C6 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 98

MO011 222513 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

222975 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

225943 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 95. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

1094 vs . b as e li ne 1023C6 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89228117 BL 1094 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 88. 66667

C2 1082 min 8 15 3 10 15 5 5 3 1 3 2 2 5 18 4 91

C6 1068 min 15 -26 min 0 3 10 15 5 5 3 1 3 2 2 5 16 .2 4 83

228412 BL 1052 min 8 15 3 10 15 5 5 3 2 3 2 2 5 15 .4 4 92 96

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .9 4 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .8 4 98228721 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .4 4 98 95. 33333

d if f b i og raphsC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 .3 4 99

229278 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 90. 33333

1094 vs . b aC2 10 15 15 3 10 1 5d iff 3 d iff 3 3 1 3 2 2 5 5 85

1094 vs . b aC6 10 15 15 3 10 1 5d iff 3 5 3 1 3 2 2 5 5 87230456 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 84. 66667

1094 vs . g ua r di an bodyC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 16 .3 4 88

b io g raph 40 v s gua rd ia n b odyC6 1051 min 8 -25 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 67

230524 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667

C2 26 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231538 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .2 4 98 94C2 26 da ys 6 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 85

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

232734 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .1 4 98 96

C2 27 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 16 4 94

C6 0

233858 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 93. 51094 vs 1 080C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 16 .3 4 88

C6 0

234506 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 19 . 79 4 98 91. 33333

1094 vs 1 080C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 17 .4 4 88

1094 vs 1 080C6 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 20 .9 4 88

235117 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 0

237057 BL 38 da ys 1 53 8 15 3 10 15 5 5 3 1 3 2 2 5 4 82 82

C2 10 15 18 .3 4

C6 6 da y s o ve r 6 15 3 10 15 5 5 3 1 3 2 2 5 22 4 79

237516 BL 1050 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 91. 5

C2 1059 min 8 15 3 10 15 5 5 3 1 3 2 2 5 4 91C6

237990 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98

C2 10 15 15 3 10 15a rms up 3 5 3 1 3 2 2 5 5 97

C6

I L036 222146 BL 1085 min 8 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 5 91 91C2 ( tx is sue ) 10 15 - 18 8 3 10 15 5 3 3 2 3 2 2 5 5 91

C6 N/ A 0

223139 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

224477 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 93

C2 10 15 15 3 10 15 3 5 3 1 3 2 2 5 5 92C6 22 da ys 1 15 15 3 10 15 3 5 3 1 3 2 2 5 5 88

226393 BL 1081 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 95. 33333

C2 21 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

226484 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667

C2 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

227024 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

227377 BL 10114 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 84

C2 10 15 0 3 10 15 5 5 3 1 3 2 2 5 5 84C6 10 15 0 3 10 15 5 5 3 1 3 2 2 5 5 84

230025 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

232897 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0233820 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

235652 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 81. 66667

C2 1057 minu te s 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 UNK 0116 min 0 59 min d i ff 0 3 10 15 5 5 3 2 3 None 1 UNK UNK 5 52238985BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6

ND007 222869 BL 10 15 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 98 98

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 17 .1 4 98C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 17 4 98

226665 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

PA055 222032 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 26 4 99 99C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 98

235745 BL 1049 min 0 15 3 10 15 5 5 3 2 3 2 2 5 15 .1 4 84 87

C2 10 15 16 min 8 3 10 15 5 5 3 2 3 2 2 5 4 92

C6 10 82 8 17 8 3 10 15 5 5 3 2 3 2 2 5 17 . 57 4 85

LA017 222942 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667

C2 10 15 15 3 10 15 5n /a 3 3 1 3 2 2 5 5 97

C6 10 15 15 3 10 15 5n /a 3 3 1 3 2 2 5 5 97

226080 BL 1085 min 8 15 3 10 15 5 5 3 1 3 2 2 5 15 .4 4 91 91

C2 26 da ys 686 min 8 15 3 10 15 3n /a 3 3 1 3 2 2 5 5 84

C6 10 15 15 3 10 15 5n /a 3 3 2 3 2 2 5 5 98

DE002 223135 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 66667

C2 1081 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

227096 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99227432 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 09 4 98 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

236612BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 94. 33333

C2 1058 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 14 da ys 0 15 15 3 10 15 5 5 3 2 3 2 2 5 5 90238659BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6

AR029 223209 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95

C2 re do 29 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95 r e sc an

C6 25 da ys 1 15 15 3 10 15 5 5 3 1 3 2 2 5 5 90227324 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 33333

C2 32 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 62 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

HI010 223243 BL 1043 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 83. 66667

C2 10 15 30 min 0 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 83C6 10 15 26 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84

230103 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 3 5 3 2 3 2 2 5 5 98

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

234741 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100C6 0

236190 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 58 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

IL017 223228 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 99 4 98 97. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 16 . 22 4 97C6 10 15 15 3 10 15 5 5 3 1 3 AGm ADS 1 2 5 17 . 44 4 97

232021 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 4 99 99. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

232105 BL 10 15 15 3 10 15 5 5 3 2 3 AGm ADS 1 2 5 15 . 16 4 98 96. 5

C2 21 da ys 6 15 15 3 10 15 5 5 3 2 3 2 2 5 15 . 62 4 95C6 0

M A043 223374 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

223388 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

234607 BL 1051 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 97. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

237931 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 0

238586BL 10 55 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 92

C2 10 55 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92

C6 0

NE003 223882 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 98. 66667C2 10 15 15 3 10 15 5 3 3 2 3 2 2 5 5 98

C6 10 15 15 3 10 15 5 3 3 2 3 2 2 5 5 98

224262 BL 1058 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 89. 66667

C2 1085 min 8 27 min 0 3 10 15 5 5 3 1 3 2 2 5 5 77

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

225519 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 5

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 0

227728 BL 1053 min 8 15 3 10 15 5 5 3 1 3 2 2 5 19 . 19 4 91 90. 33333

RX v s 1 024C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

RX v s 1 024C6 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

229005 BL 10119 min 0 15 3 10 15 5 5 3 1 3 2 2 5 16 .7 4 83 77. 66667

RX v s Bio g raph40C2 10 15 -55 min 0 3 10 1 5 5 5 3 2 3 2 2 5 5 75RX v s Bio g raph41C6 10 15 -55 min 0 3 10 1 5 5 5 3 2 3 2 2 5 5 75

229499 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

229815 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15 . 23 4 99C6 0

230808 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 17 m in 8 3 10 15 5 5 3 1 3 2 2 5 5 92

230977 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

WI029 223950 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 N/ A 0

225365 BL 1053 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 96. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 98C6 10 15 15 3 10 15 5 5 3 2 3 Agm ADS 1 2 5 5 99

226729 BL 10 15 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 98 94

C2 1056 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 91

C6 1059 min (c omp ) 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

227412 BL 1055 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 91 89. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 Agm ADS 1 2 5 5 99

C6 10 82 8 27 min 0 3 10 15 5 5 3 2 3 2 2 5 5 78236848 BL 1054 min 8 15 3 10 15 5 5 3 2 3 2 2 5 6. 6 0 88 81. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 6 .06 0 95

C6 24 day s 0 45 0 -19 8 3 10 15 3 5 3 2 3 2 2 5 0 61

O R037 224057 BL 10 43 0 15 3 10 15 5 5 3 1 3 2 2 5 20 . 72 4 83 79. 66667

C2 10 15 22 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 74C6 10 15 20 min 8 3 10 1 5 5 5 3 2 3 2 2 5 15 .3 4 82

224545 BL 1058 min 8 15 3 10 15 5 5 3 1 3 2 2 5 16 .1 4 91 95. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .2 4 98

C6 10 15 15 3 10 15 5 3 3 2 3 2 2 5 15 . 08 4 97

I L353 224515 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 17 . 16 4 98 98. 66667C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 Re 1059 minu te s 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 49 4 99

238330 BL 1098 minu te s 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 92. 5

C2 1091 minu te s 8 15 3 10 15 5 5 3 2 3 2 2 5558MBq 4 92

C6 0

SC021 224629 BL 1090 min 8 15 3 10 15 5 5 3 3 2 2 5 17 4 90 90. 66667BL r e s bm t 1087 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 17 . 58 4 90 r e sc an

C2 1093 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 91

C6 1082 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 91

226635 BL 1088 min 8 15 3 10 15 5 5 3 1 3 Agm ADS 1 2 5 5 91 96. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

CA141 224725 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .4 4 98 98. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .4 4 98

228441 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 1056 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92229023 BL 1046 min 0 15 3 10 15 5 5 3 1 3 2 2 5 19 . 04 4 83 88

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 36 4 98

C6 10 15 25 min 0 3 10 15 5 5 3 1 3 2 2 5 18 . 12 4 83

231494 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 5

C2 21 da ys 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 0231813 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 85

C2 1048 min -22 min 0 3 10 15 5 5 3 2 3 2 2 5 5 70

C6 0

232624 BL 1051 min 8 15 3 10 15 5 5 3 1 3 2 2 5 17 . 57 4 91 89

C2 26 da ys 650 min 8 15 3 10 15 5 5 3 1 3 2 2 5 19 . 06 4 87

C6 0236041 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 91. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2283m g/ dL 1 5 96

C6 1017 min 8 15 3 10 1 5 5 5 3 2 3 2 2208 mg /dL 1 5 79

NY167 224761 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96

C2 10 15 -18 min 8 3 10 15 3 5 3 1 3 2 2 5 16 4 89

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100226923 BL 1057 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92

C2 0

C6 0

227571 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 88. 33333

C2 28 da ys 6 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 86

C6 26 da ys 1 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 80227771 BL 1086 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 83

C2 10 15 -22 min 0 3 10 1 5 5 5 3 2 3 2 2 5 5 75

C6 10 15 -16 min 8 3 10 1 5 5 5 3 1 3 2 2 5 5 82

227977 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 92. 33333

C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

227976 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 92. 33333C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

229354 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .5 4 98 96. 5

C2 26 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 0

230607 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .1 4 98 98C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .7 4 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .1 4 98

230548 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .2 4 98 98. 5

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

230891 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 3 5 3 1 3 2 2 5 15 .1 4 96

231838 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .1 4 98 98

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .8 4 98

C6 0

231895 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .2 4 98 98

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .2 4 98C6 0

232626 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .2 4 98 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

232770 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 .3 4 98 98. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 15 .4 4 98

233229 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

234355 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 94

Gemi ni v s. Di sc o ve r yC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89C6 0

237015 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

238913BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 91. 5

C2 10 58 8 15 3 10 1 5 5 5 3 2 3 2 2 5 5 83

C6 0

WI020 224859 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 22 da ys 1 15 15 3 10 15 5 5 3 1 3 2 2 5 17 . 66 4 89

232960 BL 1054 min 8 15 3 10 15 5 5 3 1 3 2 2 5 21 .7 4 91 93

C2 10 15 15 3 10 15 3 5 3 2 3 2 2 5 22 .5 1 94C6 10 15 15 3 10 15 3 5 3 2 3 2 2 5 22 . 35 1 94

235497 BL 1049 min 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 85. 5

C2 1055 min 8 15 3 10 15 3 5 3 2 3 2 2UNK 0 5 86

C6 0

236165 BL 10 15 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 95 97. 5

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6238196 BL 10102 min 0 15 3 10 15 5 5 3 1 3 2 2 5 16 . 02 4 83

C2

C6

238955 BL 1042 /48 0 15 3 10 15 5 5 3 1 3 2 DID NOT FAST? 0UNK 0 5 77

C2

C6

11638 225364 BL 10 15 15 3 10 15 5 5 3 2 3 Agm ADS 1 2 5 18 .9 4 98 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 2 3 1 1 2 5 5 99

DC004 226470 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 18 . 31 4 98 86C2 1049 min 0 -29 min 0 3 10 15 5 5 3 1 3 2 2 5 5 69

C6 10 15 -17 min 8 3 10 15 5 5 3 1 3 2 2 5 16 . 04 4 91

M D001 232523 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 19 . 58 4 99 85

b io g raph v s 1 093C2 1090 min 8 24 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 67

C6 684 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 89

235257 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 5C2 21 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 17 . 78 4 94

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

235792 BL 1096 min 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 85

C2 10 59 15 -37 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 0

M N024 226644 BL 10133 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 84

C2 10 15 - 58 0 3 10 15 5 5 3 1 3 2 2 5 5 84

C6 W ithd rew W ith d rew Wi th d rew Wit h dr ew Wit hd r ew Wit h dr ew Wit h dr ew Wit h dr ew Wit hd r ew W it hd r ew W it hd r ew W ith d rew Wi th d rew Wi th d rew Wi th d rew W ith d rew Wi th d rew Wi th d rew Wi th d rew Wi th d rew Wi th dr ew Wit h dr ew Wit h dr ew Wit h dr ew Wit hd r ew W it hd rew W ith d rew W ith d rew Wi th d rew Wit h dr ew W it hd r ew

228771 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

NC002 226592 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 19 . 75 4 98 95. 66667

C2 36 1 15 15 3 10 15 5 5 3 1 3 2 2 5 5 90

C6 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

232631 BL 1085 min 8 15 3 10 15 5 5 3 1 3 2 2 5 15 . 98 4 91 92. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 5 5s k- th ig h 3 3 2 3 2 2 5 18 . 41 4 87

IL042 226687 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 37 4 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 05 4 98

227722 BL 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 15 . 57 4 98 94

C2 10 15 20 min 8 3 10 15 5 5 3 2 3 2 2 5 15 . 37 4 92C6 10 15 20 min 8 3 10 15 5 5 3 2 3 2 2 5 16 . 37 4 92

230023 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 88. 5

C2 1088 min 8 0 3 10 15 5 5 3 2 3 2 2 5 16 . 66 4 77

C6 0

235411 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 24 4 99 88. 66667

C2 10 84 8 20 min 8 3 10 15 5 5 3 2 3 2 2 5 16 . 24 4 85

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 1 UNK 0UNK 0 5 82238074 BL 1059 min 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 24 4 99 95. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 18 4 99

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 2 2 5 17 . 35 4 89

NC049 226799 BL 1056 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 91. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 29 da ys 6 54 8 15 3 10 15 5 5 3 1 3 2 2 5 83

OH007 227317 BL 10 15 15 3 10 15 5 th ig h -s k 5 3 1 3 2 2 5 5 99 97. 66667

C2 10 15 15 3 10 15 5s k- th ig h 3 3 1 3 2 2 5 5 97

C6 10 15 15 3 10 15 5s k- th ig h 3 3 1 3 2 2 5 5 97

228278 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15 . 22 4 99 97. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 61 da ys 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

228515 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16 . 35 4 99 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 22 4 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

229177 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16 . 29 4 98 98. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

236598BL 10 15 15 3 10 15 5 5 3 1 3 2 2UNK 0 5 94 96. 5

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

O H131 227416 BL 10 15 15 3 10 15 5 5 3 1 3 1 1 2 5 5 98 97. 66667C2 10 15 15 3 10 15 5 5 3 2 3 1 1 2 5 5 99

C6 28 da ys 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

NM 004 227457 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15 .4 4 99 87

C226 days 6

15 15 3 10 15 5 5 3 2 3 2 2 5 15.5 4 95

C6 1037 min 0 -37 min 0 3 10 15 5 5 3 2 3 2 UNK 0 5 17. 13 4 67

IA034 227466 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99C2 0

C6 0

KS017 227467 BL 1059 min 8 15 3 10 15 5 5 3 1 3 1 1 2 5 18.4 4 90 88. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 1 1 2 5 4 97

C6 11 days 1 15 20 min 8 3 10 15 5 3 2 3 2 2 5 5 79228753 BL Rejected Rejec ted Rejec ted Rej ec t ed Rej ec t ed Rej ect ed Rej ec t ed Rej ec t ed Rej ec t ed Rej ec ted Rejec ted Rejec ted Rejec ted Reject ed Reject ed Rejec ted Rejec ted Rejec ted Reject ed Reject ed Reject ed Rej ect ed Rej ec t ed Rej ec t ed Rej ec t ed Rejec ted Rejec ted Rejec ted Rejec ted Rej ect ed 0

C2 20 days 6 16. 99 4 10

C6 10 15 n/a 8 3 10 15 5 5 3 2 3 2 2 5 5 93

DC005 227798 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 92

C226 days 6

15 15 3 10 15 5 5 3 2 3 2 2 5 15.3 4 95

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 1 1 UNK 0UNK 0 5 82

229075 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 66667C2 UNK 0 15 15 3 10 15 5 5 3 2 3 2 2 5 5 90

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

233422 BL 10138 minutes 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 89

C2 10 15 -78 mi nut es 0 3 10 15 3 5 3 2 3 2 2 5 5 83

C6 10 15 fr om int er im 15 3 10 15fr om int er im 5 5 3 2 3 1 1 2 5 5 99

CA306 227844 BL 1047 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 87. 33333C2 1058 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 1036 min 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85

230475 BL 10132 min 0 15 3 10 15 5 5 3 2 3 2 2 5 16.7 4 84 81. 33333

C2 32 days 6144 min 0 15 3 10 15 5 3 3 2 3 2 2 5 16. 59 4 78

C6 10138 min 0 15 3 10 15 5 3 3 2 3 2 2 5 16.4 4 82

CA332 236627BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 94. 66667C2 1054 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 1054 min 8 15 3 10 15 5 5 3 2 3 2 UNK 0 5 5 91

CA332 237343BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5

CA192 235993 BL 10 15 15 3 10 15 5UNK 0 3 2 3 2 2 5 5 95 90

C2 10 15 15 3 10 15 5UNK 0 3 2 3 2 2 5 5 95

C6 10 54 8 15 3 10 15 5UNK 0 3 2 3 1 1 UNK 0UNK 0 5 80

BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99

C2 10 15 15 3 10 15 5 3 3 2 3 2 2 5 5 98

C6

I N074 227942 BL 10 15 15 3 10 15 5 5 3 1 3 1 1 2 5 5 98 98. 66667

C2 10 15 15 3 10 15 5 3 3 2 3 2 2 5 5 98

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

228634 BL 10 15 15 3 10 15 5 5 3 2 3 1 1 2 5 5 99 99. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231319 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 98. 66667C2 10 15 15 3 10 15 5 5 3 1 3 1 1 2 5 5 98

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

237292 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

NY061 228119 BL 1056 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 81

C2 1045 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84

C6 0 95 8 50 0 3 10 15 5 5 3 1 3 2 2 5 5 67

228686 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96

C2 29 days 6 15 15 3 10 15 3 5 3 2 3 2 2 5 17. 26 4 93

C6 10 10

W A024 228129 BL 1037 min 0 15 3 10 15 5 5 3 2 3 2 2 5 18.2 4 84 84. 33333

C2 10 15 32 min 0 3 10 15 5 5 3 2 3 2 2 5 16. 59 4 84

C6 10 15 43 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

UT003 228109 BL 10124 min 0 15 3 10 15 5 5 3 2 3 2 2 5 15.1 4 84 84. 66667

C2 10 15 -51 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85C6 10 15 -48 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

228261 BL 10137 min 0 15 3 10 15 5 5 3 2 3 2 2 5 15. 25 4 84 84. 66667

C2 10 15 -63 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 10 15 -63 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

WI087 228456 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 16. 31 4 98 90. 33333C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 17. 08 4 98

C6 UNK 056 min 8 15 3 10 15 5 5 3 1 3 2 UNK 0UNK 0 5 75

PA209 228663 BL 1082 min 8 15 3 10 15 5 5 3 1 3 2 2 5 17. 61 4 91 88. 66667

C2 10 15 15 3 10 1 5 3 5 3 2 3 2 2 5 1 4 87

C6 10 15 15 3 10 1 5 3 5 3 2 3 2 2 5 5 88

235835 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95. 66667C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 1 5 5 3 3 2 3 2 2 5 16.5 4 87

W V025 228681 BL 1085 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 90. 66667

C2 10 15 - 19 min 8 3 10 15 5 5 3 1 3 2 2 5 5 92

C6 10 15 - 19 min 8 3 10 1 5 5 5 3 1 3 2 2 5 5 87239214 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 90. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 73

MI020 228677 BL 1046 min 0 15 3 10 15 5 5 3 2 3 2 2 5 16.8 4 84 83

C2 10 15 33 min 0 3 10 15 5 5 3 1 3 2 2 5677. 06 MBq 4 83C6 10 15 25 min 0 3 10 15 5 3 3 1 3 2 2 5 5 82

230011 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 98. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 24 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

235206 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 5

C2 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 0

I L057 228725 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 89

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10101 minutes 0 21 0 3 10 15 5 5 3 1 3 2 2 5 5 69

229004 BL 10124 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 84

C2 10 15 -54 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84C6 10 15 -55 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84

235915 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 92. 33333

C2 1096 min 8 16 min 8 3 10 15 5 5 3 2 3 2 2 5 5 86

C6 1091 min 8 15 3 10 15 5 3 3 2 3 2 2 5 5 91

238943BL 10 107 0 15 3 10 15 5 5 3 2 3 2 2 5 15.6 4 84 84

C2 10 111 0 15 3 10 15 5 5 3 2 3 2 2 5 15.1 4 84C6

MI021 228733 BL 10 104 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 84. 33333

C2 10 15 -29 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84

C6 10 106 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85

SC008 228927 BL 10 82 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93C2 0

C6 0

235819 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 84. 33333

C2 33 days 092 min 8 31 m in 0 3 10 15 5 5 3 2 3 2 2 5 5 68

C6 10 103 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85

236271 BL 10 119 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 85C2 10 15 42 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 0

239183 BL 10110 minutes 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 56. 66667

C2 10 15 -48 minutes 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 0

M D015 228973 BL 10 51 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 89C2 29 days 6 15 15 3 10 15 5 5 3 1 3 2 2 4 4 93

C6 10 15 28 0 3 10 15 5 5 3 1 3 2 2 4 4 82

234023 BL 10 89 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 95. 5

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

234458 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99C2 10 59 15 15 3 10 15 5unknown 3 3 2 3 2 2 5 5 98

C6 0

KS027 229031 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 17. 55 4 98 96. 66667

C2 10 15 15 3 10 15 5 3 3 1 3 2 2 5 1 4 96

C6 10 15 15 3 10 15 3 5 3 1 3 2 2 5 17.8 4 96229293 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 18. 69 4 99 99

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 21. 54 4 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 18. 92 4 99

235772 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 92. 5

C2 1081 min 8 17 min 8 3 10 15 5 5 3 2 3 2 2 5 18. 55 4 85

C6 1 0

CA249 229168 BL 1017 min 0 15 3 10 15 5 5 3 2 3 2 2 5 16. 29 4 84 75. 33333

C2 1082 min 8 37 min 0 3 10 1 5 3 3 3 2 3 2 2 5 5 64

C6 1054 min 8 15 3 10 1 5 3 3 3 2 3 2 2 5 16. 29 4 78

231331 BL 1083 min 8 15 3 10 15 5 5 3 2 3 2 2 5 22 4 92 86. 66667

C2 UNK 0 15 20 min 8 3 10 15 5 5 3 2 3 2 UNK 0UNK 0 5 76

C6 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 1 4 92231495 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 17. 07 4 99 88. 33333

Di scover y STE vs Discovery STC2 UNK 0 15 15 3 10 1 5 3 5 3 2 3 2 UNK 0UNK 0 5 71

C6 6 15 15 3 10 15 5 5 3 2 3 2 2 5 17. 36 4 95

231893 BL 1083 min 8 15 3 10 15 5 5 3 2 3 2 2 5 15. 09 4 92 96. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 3 5 3 2 3 2 2 5 5 98

234343 BL 1090 min 8 15 3 10 15 5 5 3 2 3 2 2 5 20. 86 4 92 93. 66667C2 27 days 8 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 74 4 97

C6 10 83 8 15 3 10 15 5 5 3 2 3 2 2 5 16. 05 4 92

M A025 229167 BL 1057 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 94. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 1055 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

CO 030 229356 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 91. 66667

C2 1055 min 8 -18 min 8 3 10 15 5 5 3 1 3 2 2 5 5 85

C6 14 days 1 15 15 3 10 15 5 5 3 2 3 2 2 5 5 91

M N041 229574 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

NY016 229586 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 92. 33333

C2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

229741 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 0

229776 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

230098 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

230210 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

230483 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97. 66667C2 19 days 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

230560 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 -18 min 8 3 10 15 5 5 3 1 3 2 2 5 5 92

230600 BL 1094 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 80

C2 10 15 30 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 74C6 10 15 -23 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 74

230800 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 96. 66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 17 min 8 3 10 15 5 5 3 1 3 2 2 5 5 92

230812 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231498 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 92

SE vs LS C2 10 15 15 3 10 1 5 3 3 3 1 3 2 2 5 5 85

C6 1058 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92

231566 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2UNK 0 5 94232366 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 88. 66667

C2 1086 min 8 17 min 8 3 10 1 5 5 5 3 1 3 2 2 5 5 75

C6 10 15 -20 min 8 3 10 15 5 5 3 1 3 2 2 5 5 92

233088 BL 1085 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 88. 33333

C2 10 15 -25 min 0 3 10 1 5 5 5 3 1 3 2 2 5 5 74

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99233537 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 91. 66667

BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

BL 10 100 8 31 0 3 10 15 5 5 3 1 3 2 2 5 5 77

233754 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99234817 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

235123 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

235349 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

236324BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

237241BL 10 96 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 91. 66667C2 10 59 15 -37 min 0 3 10 15 5 5 3 1 3 2 2 5 5 84

C6 10 61 15 same int er im 15 3 10 15 5 5 3 1 3 2 2 5 5 99

237968BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99.0 99. 0

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99.0

C6

238302BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99. 0

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

238362BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

239031BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6

TN008 229716 BL 1091 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 85. 33333

C2 1057 min 8 - 34 m in 0 3 10 15 5 5 3 2 3 2 2 5 5 78

C6 10 15 -31 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

230616 BL 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 92. 66667C2 10 15 21 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

233522 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 98

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 95 4 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 95

234019 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 93

C2 1088 min 8 20 min 8 3 10 15 5 5 3 2 3 2 2 5 5 86C6 0

236736 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C2 0

C6 0

237730 BL 10 59 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C2 0C6 0

NY043 230016 BL 1056 min 8 15 3 10 15 5 3 3 2 3 2 2 5 5 91 92

C2 20 days 6 15 -18 min 8 3 10 15 5 3 3 2 3 2 2 5 5 87

C6 10 15 15 3 10 15 5 3 3 2 3 2 2 5 5 98

NY045 230080 BL 1057 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88 88C2 1057 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88

C6 1053 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88

231100 BL 1058 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88 86

C2 26 days 652 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 84

C6 20 days 0 15 15 3 10 1 5 5 5 3 2 3 2 2UNK 0 5 75

231982 BL 1059 min 15 15 3 10 15 5 3 3 2 3 2 2UNK 0 5 93 93C2 1059 min 15 15 3 10 15 5 3 3 2 3 2 2UNK 0 5 93

C6 10 15 15 3 10 15 5 3 3 2 3 2 2UNK 0 5 93

235410 BL 1051 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88 86

C2 1054 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 88

C6 10 50 8 15 3 10 15 5 3 3 2 3 none 0 UNK 0UNK 0 5 82

235676 BL 10 15 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 95 89. 5C2 20 days 657 min 8 15 3 10 15 5 5 3 2 3 2 2UNK 0 5 84

C6 0

AZ017 230447 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

232905 BL 1058 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 88. 33333C2 10 15 21 min 0 3 10 15diff arm 3 5 3 2 3 2 2 5 5 83

C6 1050 min 8 15 3 10 15diff arm 3 3 3 2 3 2 2 5 5 89

236667 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

237432 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 56.3 m Ci 1 96 96C2 10 15 15 3 10 15 5 5 3 2 3 2 2 56.7 m Ci 1 96

C6 0

M N013 230748 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 33333

C2 1082 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99235002 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 57 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

M N014 230598 BL 1059 min 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 66667

C2 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100235980 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 0 5 5 98

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

M N001 231194 BL 10 38 min 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 85

C2 10 15 26 m inut es 0 3 10 15 5 5 3 2 3 2 2 5 5 85C6 10 15 26 m inut es 0 3 10 15 5 5 3 2 3 2 2 5 5 85

235070 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

M T002 230993 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 94. 33333

C2 1086 min 8 20 min 8 3 10 15diff arm 3 5 3 2 3 2 2 5 15.9 4 83C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

NY012 231066 BL 1059 min 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 90

C2 21 days 681 min 15 22 min 0 3 10 15diff arm 3 5 3 2 3 2 2 5 5 79

C6 1052 min 8 15 3 10 15diff arm 3 5 3 2 3 2 2 5 5 91

232546 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

NJ066 231155 BL 1047 min 0 15 3 10 15 5 5 3 2 3 2 2 5 15.9 4 84 83

C2 27 days 6118 min 0 71 min 0 3 10 15 5 5 3 2 3 2 2 5 5 66

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 1 4 99

231398 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 89

C2 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 79

C6 ST vs 1080 0

235169 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 17.2 4 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

CA189 231330 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 20. 08 4 99 98. 33333

C2 1059 min 15 15 3 10 15 5diff dir 3 3 2 3 2 2 5 21. 21 4 97

C6 1059 min 15 15 3 10 15 5 5 3 2 3 2 2 5 19. 73 4 99

231984 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 19. 08 4 99 99

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 20. 52 4 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 20.4 4 99232805 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 20. 87 4 99 93. 33333

C2 1057 min 8 15 3 10 15 5diff dir 3 3 2 3 2 2 5 20. 51 4 90

C6 1056 min 8 15 3 10 15 5diff dir 3 3 2 3 2 2 5 5 91

234896 BL 10 15 15 3 10 15 5 5 3 2 3 1 1 2 5 19. 26 4 98 98. 5

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 18. 04 4 99

C6 0236023 BL 1055 min 8 15 3 10 15 5 5 3 2 3 2 2 5 18.9 4 92 84. 33333

C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

C6 1053 min 8 15 3 10 1 5diff arm 3diff dir 3 3 2 3 no ADS 1 unk 0unk 0 5 71

238971BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 95 97

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 18.7 4 99

C6 0

NY003 231530BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 95. 66667

C2 21 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96C6 13 days 1 15 15 3 10 15 5 5 3 2 3 2 2 5 5 91

231634 BL 1054 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 87

C2 1081 min 8 27 min 0 3 10 15 5 5 3 2 3 2 2 5 5 78

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 2 2 5 5 90

235555 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 87. 66667

C2 1049 min 0 -31 min 0 3 10 15 5 5 3 2 3 2 2 5 5 70C6 10 15 20 8 3 10 15 5 5 3 2 3 2 2 5 5 93

235754 BL 1053 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 96. 33333

C2 26 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

236345 BL 29 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96 96

C2 19 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96C6 0

M A038 232657 BL 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 96. 5

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

232899 BL 10112 min 0 15 3 10 15 5 5 3 2 3 2 2 5UNK 4 84 86

C2 10 15 15 3 10 1 5 3 5 3 2 3 2 2 5 5 88C6 Light Speed vs Advance 0

CA043 231853 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 68 4.0 99 96. 66667

C2 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 18. 58 4.0 92C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 98 4.0 99

232576BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 66667

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0 15 15 3 10 15 5 5 3 2 3 2 2 5 5 90

233985 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

235193BL 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 96

C2 6 15 15 3 10 15 5 5 3 2 3 2 2 5 1 4.0 95

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

HI021 231954 BL 1056 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 97C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 3 5 3 2 3 2 2 5 5 98

236234 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

M D017 231598 BL 1054 min 8 15 3 10 15 5 5 3 1 3 2 2 5 18. 01 4.0 91 89. 33333C2 10 15 15 3 10Di scover RX vs 5 3 5 3 1 3 2 2 5 5 87

C6 >60 days 0 15 15 3 10same as i nt erim 15 5 5 3 2 3 2 2 5 5 90

235381 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 17. 31 4.0 99

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 17. 47 4.0 99

235976 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16. 32 4.0 99 99C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 96 4.0 99

C6 0

238787 BL 1082 min 8 15 3 10Di sc RX 15 5 5 3 2 3 none 0 UNK UNK 5 84 83. 5

C2 10 15 - 20 MIN 8 3 10Di sc LS 5 5 5 3 2 3 2 2 5 5 83

C6 0

NC036 232471 BL 1055 min 8 15 3 10 15 5 5 3 1 3 2 2 5 16. 59 4.0 91 83. 33333

C2 27 days 691 min 8 36 min 0 3 10 15 5 5 3 1 3 2 2 5 5 73

C6 25 days 655 min 8 15 3 10 15 5 3 3 1 3 2 2 5 5 86

VT004 232439 BL 10111 min 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 83

C2 6 15 -34 min 0 3 10 15 5 5 3 2 3 2 2 5 5 81

C6 10 15 0 3 10 15 5 5 3 2 3 2 2 5 5 85237470 BL 10 87 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 85. 5

C2 10 56 8 -31 min 0 3 10 15 5 5 3 2 3 2 2 5 5 78

C6

KY010 232246 BL 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99. 33333

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

234725 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 1059 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

234901 BL 10 15 15 3 10 15 5 5 3 1 3 1 1 2 5 5 98 92. 5

C2 10 15 15 3 10 1 5 5 3 3 1 3 2 2 5 5 87

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

VT019 233011 BL 10116 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 89

C2 1059 min 15 - 57 MIN 0 3 10 15 5 5 3 1 3 2 2 5 5 84

C6 1058 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

238228BL 1054 min 8 15 3 10 15 5 5 3 1 3 2 2 5 4 91 96

C2 1058 min 15 15 3 10 15 5 5 3 1 3 2 2 5 16.5 4 98C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5572. 76 MBq 4 99

W A059 233240 BL 1089 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 76. 33333

C2 10111 min 0 22 min 0 3 10 15 5 5 3 2 3 2 2 5 5 70

C6 1045 min 0 - 44 0 3 10 15 3 3 3 2 3 2 2 5 5 66

MI079 233223 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 19. 21 4 99 96. 33333

C2 10 59 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 over 60 days 1 15 15 3 10 15 5 5 3 2 3 2 2 5 1 4 90

M A036 233334 BL 1059 min 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 98. 66667

C2 27 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

234296 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 01 4 99 98. 33333

C2 26 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

GA020 234347 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 97. 66667C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

234595 BL 46 days 188 min 8 15 PET, DxCT 2 10 15 5 5 3 2 3 2 2 5 16. 87 4 82 77. 5

C2 10 15 - 21 0 3 10 1 5 5 3 3 2 3 2 2 5 5 73

C6

236890 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6

LA002 234593 BL 1053 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 93

C2 1057 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 10104 min 0 47 0 3 10 15 5 5 3 2 3 2 2 5 5 70

O H134 234656 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 96. 5

C2 10 54 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C6 10 15 15 3 10 15 5 3 3 2 3 2 2 5 15. 02 4 97

W I176 231572 BL 10 55 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 95. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100C6 10 57 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

237625 BL

C2

C6

237789 BL

C2 19 4C6 10 15 15 3 10CPS 15 5 5 3 2 3 2 2 5

236202BL 10 49 0 15 3 10 15 5 5 3 2 3 2 2 5 16. 34 4 84 88. 66667

C2 10 15 18 min 8 3 10CPS vs G E discovery 5 5 5 3 2 3 2 2 5 18.5 4 82

C6 10 15 15 3 10CPS 15 5 5 3 2 3 2 2 5 5 100

KS036 234987 BL 10 15 15 3 10 15 5n/a; unkn 3 3 2 3 2 2 5 5 98 96. 33333C2 10 59 15 15 3 10 15 5n/a; unkn 3 3 2 3 2 2 5 5 98

C6 10 15 15 3 10 15 5n/a; unkn 3 3 2 3 2 2unknown 0 5 93

M A011 234642 BL 10 85 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 89

C2 10 15 -23 min 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 10 15 15 3 10 15 5 3 3 1 3 2 2 5 5 97

236879 BL 10 15 15 3 10 15 5 5 3 1 3 1 1 unknown 1unknown 1 5 93 91

C2 21 da ys 6 15 16 min 8 3 10 15 5 5 3 2 3 2 2 5 5 89

C6

238492BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 0

BL 10 15 15 3 10 15 5 5 3 1 3 2 unknown 1unknown 1 18. 87 4 93

C2 0

C6 0

O H282 235146 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C2 W ITHDRAWW ITHDRAWWI THDRAW WITHDRAWWITHDRAW WITHDRAWWITHDRAWWITHDRAWWITHDRAWW ITHDRAWW ITHDRAW W ITHDRAWWI THDRAWWI THDRAWWI THDRAW W ITHDRAWWI THDRAWWI THDRAWWI THDRAWWI THDRAWWI THDRAWWITHDRAWWITHDRAWWITHDRAWWITHDRAWW ITHDRAWW ITHDRAWW ITHDRAWWI THDRAW WITHDRAW 0

C6 W ITHDRAWW ITHDRAWWI THDRAW WITHDRAWWITHDRAW WITHDRAWWITHDRAWWITHDRAWWITHDRAWW ITHDRAWW ITHDRAW W ITHDRAWWI THDRAWWI THDRAWWI THDRAW W ITHDRAWWI THDRAWWI THDRAWWI THDRAWWI THDRAWWI THDRAWWITHDRAWWITHDRAWWITHDRAWWITHDRAWW ITHDRAWW ITHDRAWW ITHDRAWWI THDRAW WITHDRAW 0

OH016 235510 BL 33 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96 96

C2 32 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 0

O H282 235236 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 57 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

O H282 235189 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

CA136 235340 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 94. 33333C2 10 57 8 -19 8 3 10 15 5 5 3 1 3 2 2 5 5 85

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

SC026 235330 BL 10 15 15 3 10 15 5 5 3 2 3 2 UNKNO WN 0UNKNOW N 0 15. 75 4 92 93. 66667

C2 10 59 min 15 15 3 10 15 i nc 3 5 3 2 3 2 UNKNO WN 0UNKNOW N 0 5 91

C6 10 15 15 3 10 15 5UNK 3 3 2 3 2 2 5 5 98

ID011 235334 BL PET ONLY 10 15 15 3 10 15 5 5 3 2 3 1 1 UNKNO WN 0UNKNOW N 0 5 92 91

C2 10 15 15 3 10 1 5 5 5 3 2 3 2 2 5 5 90

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

PA042 235813 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5592 MBq 4 99 95

C2 10 82 8 15 3 10 15 5UNK 3 3 2 3 2 2 5 5 91C6 0

MI080 236684 BL 10 104 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 77

C2 UNK 0 15 40 0 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 69

C6 UNK 0 55 8 15 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 77

236343 BL 10 58 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 91C2 10 59 15 15 3 10 1 5 5 5 3 2 3 2 2 5 15. 26 4 89

C6 0

236615 BL 10 86 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 81

C2 33 days 1 58 8 28 0 3 10 15 5 5 3 2 3 2 0 5 17. 12 4 66

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 84

PA131 235867 BL 10 42 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 85C2 10 15 25 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 0

235986 BL 10 42 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 87

C2 29 days 6 15 24 0 3 10 15 5 5 3 2 3 2 2 UNK 0 5 76

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

O H029 236207 BL 10 15 15 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 94 89

C2 UNK 0 15 15 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 84

C6 0

M I026 236014BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 33333

C2 10 15 15 3 10 15inc 3 5 3 2 3 2 2 5 5 98C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

236967BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6

M I013 236399 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 18. 26 4 99 99

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 15. 19 4 99C6 0

238909 BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C2 0

C6 0

236726BL 10 8 15 3 10 15 5 5 3 2 3 2 2 5 18. 26 4 92 87. 66667M I032 C2 10 15 24 mi nut es 0 3 10 15 5 5 3 2 3 2 2 5 5 85

C6 1089 min 8 19 8 3 10 15 5 5 3 2 3 2 2 5 5 86

OH055 236578BL 10 51 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 88. 33333

C2 10 15 19 8 3 10 15 5 5 3 2 3 2 2 5 1 4 92

C6 10 51 8 19 8 3 10 15 5 5 3 2 3 1 1 unknown 1unknown 1 5 80

LA007 236826BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 1 4 99 99. 33333

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100

C6 10 15 15 3 10 15 5 5 3 2 3 2 2 5 16. 45 4 99

239305BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 99. 5

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 629. 08 4 99

C6 0

TX011 236934BL 10 100 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 83. 5

C2 UNK 0 90 8 15 3 10 15 5 5 3 2 3 2 2 5 1 4 82

C6 0

237473BL 10 91 8 15 3 10 15 5 5 3 1 3 none 0 Unknown 0unknown 0 5 83 85. 5

C2 31 days 6 87 8 15 3 10 15 5 5 3 1 3 2 2 5 5 88C6

237797BL

C2

C6

CT018 237058BL 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100 100

C2 10 15 15 3 10 15 5 5 3 2 3 2 2 5 5 100C6 0

SD004 237398BL 10 47 0 15 3 10 15 5 5 3 2 3 2 2 5 5 85 86. 33333

C2 21 days 6 44 0 15 3 10 15 5 5 3 2 3 2 2 5 5 81

C6 10 50 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

CO035 237912BL 10 39 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 82

C2 10 15 24 mi nut es 0 3 10 15 5 5 3 2 3 2 2unknown 0 5 80

C6

CO035 BL 10 89 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93

C2 0

C6 0

GA005 238962 10 99 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 88C2 C2D7 0 99 8 15 3 10 15 5 5 3 2 3 2 2 5 5 83

0

239036

CO 034 238670

221174 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 N/A 0

223078 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97.66667

C2 27 days 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

C6 10 59 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

224338 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

231447 BL 10 56 min 8 15 3 10 15 5 5 3 2 3 2 2 5 5 93 94.5

C2 21 days 6 15 15 3 10 15 5 5 3 2 3 2 2 5 5 96

C6 UNK 0 15 15 3 10 15 5 5 3 2 3 2 UNK 0 UNK 0 5 83

232563 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 97.66667

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 63 days 6 15 15 3 10 15 5 5 3 1 3 2 2 5 5 95

233005 BL 10 49 min 0 15 3 10 15 5 5 3 1 3 2 2 5 5 84 86.5

STE vs STC2 10 15 15 3 10 1 5 5 5 3 1 3 2 2 5 5 89

C6 0

233371 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

233534 BL 10 54 min 8 15 3 10 15 5 5 3 1 3 2 2 5 5 92 96.66667

C2 10 59 min 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

C6 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

236542 BL 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99 99

C2 10 15 15 3 10 15 5 5 3 1 3 2 2 5 5 99

SWOG0816 Study QC Results

Study: (Green) Compliant: >=80; (Yellow) Acceptable: 70-80; (Red) Non-compliant: <70

Patient: (Green) Compliant: >=85; (Yellow) Acceptable: 75-85; (Red) Non-compliant: <75



NEW CONTRAST AGENTS



SWOG0816 Central Review stats

2 2

75

11

16

23

1715

12

16

26

13

2826

16

242522

25

35

27

22

3229

32

27

44

22

3433

44

21

3130

25

36

282928

11

3

0

5

10

15

20

25

30

35

40

45

50

Nu

mb

er

of

Stu

die

s C

en

tra

lly

Re

vie

we

d

Month

Real-time Central Review- SWOG0816

Monthly Summary (954 as of 03/14/2013)

Central Read Turnaround Time:

24 hours: 70%, 48 – 72 hours: 20%, 10% adjudication etc.

Verification of Reference Calibration

Protons

TLD (OSLD commissioning completed)



NEW CONTRAST AGENTS



Verification of Reference Calibration

•TLD system

26

The only completely independent comprehensive

radiotherapy quality audit in the USA and Canada

with measurements

On-Site Dosimetry Review Visit

1. Identify errors in dosimetry and QA and suggest improvements.

2. Collect and verify dosimetry data for chart review.

3. Improve quality of patient care.



NEW CONTRAST AGENTS



Discrepancies Regarding:Number of InstitutionsReceiving rec. (n = 156)

Review QA Program 115 (74%)

Photon Field Size Dependence (FSD) 62 (40%)

Wedge Factor (WF) 50 (32%)

Off-axis Factors (OAF)/Beam symmetry 46 (29%)

Electron Calibration 27 (17%)

Photon Depth Dose 25 (16%)

Electron Depth Dose 18 (12%)

Photon Calibration 13 (8%)

Discrepancies Discovered (Jan. ’05 – Mar. ’11)

On-Site Dosimetry Review Audit

Monitor Units =Prescription Dose

(calibration) • (FSD) • (WF) • (depth dose) • (OAF)Monitor Units =

Prescription Dose

(calibration) • (FSD) • (WF) • (depth dose) • (OAF)

Chart Review ProcessRadiotherapy records, calculations & films received from study

group

Independent dose recalculation (±5%)

Resolve errors with institution

Discuss results with Group and Study Chair

Facilitate clinical review at meetings, RPC, HQ



NEW CONTRAST AGENTS



Results of Chart Review

• 1% Systematic errorsPotential to impact every patient treated by

institution

• 11% Individual errors– Impacts study groups and institution

• 27% Reporting errors– Impacts study group and institution

Without RPC review 39% of the doses used by

the study group would be incorrect

• Educate

• Improve understanding of protocol

• Evaluate ability to deliver dose with

advanced technologies

• Improve treatment delivery

• Reduce the deviation rate

before credentialing >10%: now at <5%

Purpose of Credentialing



NEW CONTRAST AGENTS



IROC – NCTN Summary

The transformative changes by NCI to innovate its National

Clinical Trial organization are considerable, visionary, and

enabling while consolidating, integrating, and standardizing.

The premier national imaging and radiation oncology quality

assurance and core laboratories have formed a cooperative

under the administrative umbrella of the American College of

Radiology to facilitate the standardization, harmonization

and increased efficiencies to support imaging and radiation

oncology quality assurance, quality control and data

management in an fully integrated, multi-institutional based

effort.

IROC – NCTN Summary

The Imaging and Radiation Oncology Core (IROC)

cooperative will be seeking further coordination with other

national and international efforts as well as alignment with

initiatives such as QIBA.

The IROC effort has the potential to substantially advance

the use of imaging and radiation therapy within clinical trials

and thereby help to further achieve the transformative goals

for the Nations Cancer Trial efforts.

The strategic alignment and collaboration promises to

facilitate better quality and more efficient and appropriate use

of imaging within multi-center trials and will have the

opportunity to help set the future best practice standards and

methodologies for imaging and Radiation Oncology

NCI-NCTN Imaging and Radiation Oncology Core Michael V ... · NCI Clinical Trial Efforts NCI...

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