Natural products and ecological interactionsAdaptive evolution (i.e. “rapid”)

Scents Colours Flavours

Pests Pathogens Allelopathy

The gene cluster is close to the telomere

15 kb Sad1 probe

Where synteny breaks down…

• Rapidly evolving regions of genomes• Conserved motifs shared by co-regulated

genes• Determining the sequence of evolution of

members of multigene families• Determining the sequence of evolution of

combinations of genes

Wish list

• Reliable ORF designations; reliable sequence information

• Sceptical of text annotation – prefer using a set of “probe” sequences or Pfam domains

• Positional information – Genomic context• Searchable gene expression data

(Genevestigator-like)

• Recombination frequencies• Degree of divergence across

accessions/species/broader