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    National Tuberculosis ControlProgram

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    Lesson Objectives To know about the magnitude of TB

    problem

    To know about the evolution of TBcontrol in India

    To learn about the goals, objectivesand strategies

    To know about the achievements andprogress

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    Magnitude of the Problem

    Source: WHO Geneva; WHO Report 2008: Global Tuberculosis Control; Surveillance, Planning and Financing

    Global annual incidence = 9.1 million

    India annual incidence = 1.9 million

    India is 17th among 22High Burden

    Countries (in terms ofTB incidence rate)

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    Global Burden of Tuberculosis TB is one of the leading causes of death

    due to infectious disease in the world

    Almost 2 billion people are infected with M.tuberculosis

    Each year about:

    9 million people develop TB disease

    2 million people die of TB

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    23%

    5.28 m

    Contribution of India to Global TBControl*

    *WHO Global TB Report 2007 & 2008

    ?

    ?

    4.92 m

    23%

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    The Beginning :National Tuberculosis

    Control ProgramBefore the Revised National Tuberculosis

    Program (NTCP) came into force the existingTuberculosis program had the followingobjectives:

    To identify and treat as large a number of TBpatients as possible so that infectious cases arerendered non- infectious.

    To reduce the magnitude of TB problem in thecountry to a level where it ceases to be a publichealth problem.

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    Organization and administration

    Central level Besides the Tuberculosis Division in the Directorate

    General Health services, National Tuberculosis Institute,

    Bangalore and Tuberculosis Research centre at Chennai District level

    A district constitutes a functional unit of the NTCP andis called District Tuberculosis Control Program

    Peripheral level Comprises of chest clinics and Primary Health Centers

    (PHC)

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    Program Implementation( prior to

    RNTCP)Program activities were:

    Case detection

    Case treatment

    Health education

    BCG vaccination

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    Program performance and evolutionof RNTCP

    Despite a nationwide network of facilities , NTCP failed toyield satisfactory results. The situation did not changemuch.

    The case finding efficiency was only 30 of the expectedlevel although the mortality rate decreased to 53/100,00population

    Government of India launched the RevisedNational Tuberculosis Control Program(RNTCP) in1997 encouraged by the results of Pilot studieswere tested in 1993-94

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    Evolution of TB Control in India 1950s-60s Important TB research at TRC and NTI 1962 National TB Programme (NTP) 1992 Programme Review

    only 30% of patients diagnosed; of these, only 30% treated successfully

    1993 RNTCP pilot began 1998 RNTCP scale-up

    2001 450 million population covered 2004 >80% of country covered 2006 Entire country covered by RNTCP

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    Revised National TB Control Program(RNTCP)

    Launched in 1997 based on WHO DOTSStrategy Entire country covered in March06 through an

    unprecedented rapid expansion of DOTS

    Implemented as 100% centrally sponsoredprogram Govt. of India is committed to continue the support till TB

    ceases to be a public health problem in the country

    All components of the STOP TB Strategy-2006 are being implemented

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    Objectives of RNTCP

    To achieve and maintain a cure rate of atleast 85% among newly detected

    infectious (new sputum smear positive)cases

    To achieve and maintain detection of atleast 70% of such cases in the population

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    Strategy1. Augmentation of organizational support at

    the central and state level for meaningfulcoordination

    2. Increase in budgetary outlay

    3. Use of Sputum microscopy as a primarymethod of diagnosis among self reporting

    patients

    4. Standardized treatment regimens.

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    contd.7 Augmentation of the peripheral level

    supervision through the creation of a sub

    district supervisory unit8. Ensuring a regular uninterrupted supply of

    drugs up to the most peripheral level

    9. Emphasis on training, IEC, operationalresearch and NGO involvement in theprogram

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    Core elements of Phase I The core element of RNTCP in Phase I (1997-

    2006)was to ensure high quality DOTS expansion inthe country, addressing the five primary componentsof the DOTS strategy

    Political and administrative commitment

    Good Quality Diagnosis through sputumMicroscopy

    Directly observed treatment

    Systematic Monitoring and Accountability

    Addressing stop TB strategy under RNTCP

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    RNTCP Phase II( 2006-11)

    The RNTCP phase II is envisaged to:

    Consolidate the achievements of phase I Maintain its progressive trend and effect

    further improvement in its functioning

    Achieve TB related MDG goals while

    retaining DOTS as its core strategy

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    Diagnosis of TB in RNTCP: Smearexamination

    Cough for 3 weeks or More

    3 sputum smears

    1 positive smear

    X- ray

    positive smear negative

    3 Negative

    Antibiotics1-2 weeks

    Symptoms

    persist

    X-ray

    Negative

    For TBPositive

    Smear-Negative TB

    Anti-TB Treatment

    Non-TB

    Smear-Positive

    TB

    Anti-TB Treatment

    3 or 2 positives

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    Classification of Patients in Categoriesfor Standardized Treatment Regimen

    Category Type of Patient Regimen Duration inmonths

    Category I

    Color ofbox: RED

    New Sputum Positive

    Seriously ill sputum negative,Seriously ill extra pulmonary,

    2 (HRZE)3,

    4 (HR)3

    6

    Category II

    Color ofbox: BLUE

    Sputum Positive relapseSputum Positive failure

    Sputum Positive treatmentafter default

    2 HRZES)3,1 (HRZE)35 (HRE)3

    8

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    Contd.

    Category Type of Patient Regimen Durationinmonths

    CategoryIII

    Color ofbox:GREEN

    Sputum Negative,

    extra pulmonary not Seriouslyill

    2(HRZ)3,

    4 (HR)3

    6

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    Types of Drug-Resistant TBMono-resistant Resistant to any one TB treatment

    drugPoly-resistant Resistant to at least any two TB

    drugs (but not both isoniazid and rifampicin)

    Multidrug- resistant(MDR TB) Resistant to at least isoniazid and

    rifampicin, the two best first-line TB treatment drugsExtensively drug-resistant(XDR TB)

    Resistant to isoniazid and rifampicin, PLUS resistant toany fluoroquinolone AND at least 1 of the 3 injectablesecond-line drugs (e.g., amikacin, kanamycin, orcapreomycin)

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    RNTCP Organization structure: Statelevel

    Health Minister

    Health Secretary

    MD NRHM Director HealthServices

    Additional / Deputy / JointDirector

    (State TB Officer)

    State TB CellDeputy STO, MO, Accountant,

    IEC Officer, SA,DEO, TB HIV Coordinator etc.,

    State Training and DemonstrationCenter (TB)

    Director, IRL Microbiologist, MO,Epidemiologist/statistician, IRL LTs etc.,

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    Program innovations

    Creation of sub district level supervisory and monitoringunit TB Unit

    Patient-wise individual drug boxes for entire course of

    treatment Community involvement in DOTs shopkeepers, teachers,

    postmen, cured patients, etc

    Continuous Internal Evaluation of districts

    Monitoring strategy document with checklists

    NGO & PP (Private Provider) schemes

    Task Force mechanism for involvement of Medical colleges

    Web based IEC/ ACSM resource centre

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    Contd.

    District TB Control Society

    Modular training

    Patient wise boxes Sub-district level supervisory staff (STS,

    STLS) for

    Treatment & microscopy Robust reporting and recording system

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    Quality Diagnostic and TreatmentServices

    ~12,500 decentralized designated microscopy

    centers established External Quality Assurance (EQA) system for

    sputum microscopy as per internationalguidelines

    Quality assured anti-TB drugs Patient friendly DOT services

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    Well Defined IEC Strategy

    Web based resource centre

    Communication facilitators provided to support IEC at district level

    Ongoing capacity building of program managers for planning andimplementing need based IEC activities