National Library of Medicine Free Resources

for Biology, Genetics, Public Health

and the Environment

Holly Ann BurtNN/LM-GMR, Outreach & Exhibits Coordinator

2nd Wisconsin Health Information Outreach Summit

August 16, 2006Green Bay, WI

• World’s largest biomedical library

• Provide a wide variety of biomedical resources via free online databases

www.nlm.nih.gov

This program is coordinated by the National Library of Medicine and carried out by a nationwide network of over 4,600 health science libraries and information centers:– 8 Regional Medical Libraries– 156 Resource Libraries

National Network of Libraries of Medicine

Mission of the NN/LM

• To advance the progress of medicine and improve the public health by providing all US health professionals with equal access to biomedical information

• To improve the public's access to information to enable them to make informed decisions about their health

http://nnlm.gov

1:New York University School of Medicine 2: University of Maryland at Baltimore - HSL 3: University of Illinois at Chicago - LHS 4: University of Utah

(800) 338-7657

5: Houston Academy of Medicine, Texas Medical Center Library 6: University of Washington7: University of California - Los Angeles8: University of Massachusetts

www.nlm.nih.gov

MedlinePlus

• User friendly source• Health information for patients and the public• Quality filtered• Credible sources

www.medlineplus.gov

• Links to MEDLINE

searches

MedlinePlus

• Health Topics (700+)

• Information on Drugs and Herbal Supplements

• Medical Encyclopedia

• Dictionary• Publications/News • On-line Tutorials

• Surgery Videos• Hospitals• Doctors/Dentists• Organizations• Databases• Directories• Libraries• Links to MEDLINE

& Genetics Home Reference

Drug & SupplementsInformation

• Drug information comes from MedMaster™ from the American Society of Health System Pharmacists and the USP DI® Advice for the Patient ® from the United States Pharmacopeia

• Information on Herbal Supplements is from Natural Standard©, an international research collaboration on complementary and alternative therapies

www.medlineplus.gov

Medical Encyclopedia

• The A.D.A.M. Health Illustrated Encyclopedia

• Over 4,000 articles, many illustrated

www.medlineplus.gov

Other MedlinePlus Features

• Medical Dictionary– Merriam-Webster

• Current Health News– The latest health news from sources such as

Reuters and UPI

• Directories– You can find doctors, dentist, hospitals, etc.

• Other Resources– Links to other resources that are helpful

MedlinePlus En Español

• MedlinePlus is available in Spanish by clicking on the “español” link

• This is not a “mirror” site, all the materials here are responsive to the language, dietary, and cultural needs of the Hispanic population

• A term typed in English will be translated into an equivalent term in Spanish.

www.medlineplus.gov/spanish

Genetics Home Reference is a website for information about genetic conditions

and the genes responsible for those conditions.

http://ghr.nlm.nih.gov/

Information in GHR

• Genetic Condition Summaries– Each summary explains the condition’s genetic

cause and pattern of inheritance

• Gene Summaries– Each summary provides the official name and

symbol of a gene, its chromosomal location, and an explanation of its normal function and how mutations in the gene cause particular genetic conditions

• Help Me Understand Genetics– This document provides a basic explanation of

how genes work and how mutations cause disorders

• Glossary– A searchable glossary to find definitions of

genetic and medical terms

• Resources for Educators– Classroom activities and guidelines for

teachers.

Information in GHR

The Online Mendelian Inheritance in Man (OMIM) is a continuously updated catalog of

human genes and genetic disorders containing textual information and

references. Contains nearly 17,000 entries of genes and phenotypes.

Searched through NCBI Entrez http://www.ncbi.nlm.nih.gov/entrez/

Online Mendelian Inheritance in Man

• Linked to from the Entrez gateway, the NCBI query bar, and from within several databases

• Contains extensive links to MEDLINE to additional related resources

• Clinical Synopsis is provided for many diseases

• OMIM Gene Map presents the cytogenetic locations of genes

www.nlm.nih.gov

Human Genome Resources• Genes and Human

Health– Gene Database,

OMIM, RefSeq, dbSNP

• Reagents– molecular probes,

cDNA clones• Transcribed

Sequences: – UniGene, SAGEmap,

GEO

• Maps and Markers – Map Viewer, UniSTS,

Electronic PCR

• Genomic Sequence – BLAST, DNA

Sequences, Clone registry

• Comparative Genomics– HomoloGene,

Homology Map

• Cytogenetics– SKY/CGH

www.nlm.nih.gov

http://sis.nlm.nih.gov/enviro.html

http://sis.nlm.nih.gov/

Tox Town

http://toxtown.nlm.nih.gov/

Interactive guide to toxic substances and Interactive guide to toxic substances and environmental healthenvironmental health

What can you find in Tox Town?

• Everyday locations where you might find toxic chemicals

• Descriptions of chemicals

• Links to selected, authoritative chemical information on the Internet

• How the environment can impact human health

• Internet resources on environmental health topics

Tox Town Neighborhoods

Current neighborhoods• Town• City• U.S. - Mexico Border• Farm

Future neighborhoods• Beach• Ocean

TOXNET

A cluster of databases covering toxicology, hazardous chemicals, environmental health and related areas. TOXNET provides free access to

these databases

www.toxnet.nlm.nih.gov

TOXNET Databases

• HSDB - Hazardous Substances Data Bank

• LactMed - Drugs and Lactation

• IRIS - Integrated Risk Information System

• ITER - International Toxicity Estimates for Risk

• TRI - Toxic Chemical Release Inventory

• CCRIS - Chemical Carcinogenesis Research Information System

• GENETOX - Genetic Toxicology

• ChemIDplus• Haz-Map • Household Products

Database• TOXMAP

TOXNET Bibliographic Databases

• TOXLINE - references from toxicology literature covering the biochemical, pharmacological, psychological, and toxicological effects of drugs and other chemicals

• DART - references from Developmental and Reproductive Toxicology literature

www.toxnet.nlm.nih.gov

Household Products Database

This database from NLM contains information about thousands of household products and their potential health effects

http://householdproducts.nlm.nih.gov

Questions for theHousehold Products Database• What are the chemical ingredients and their

percentage in specific brands?

• Which products contain specific chemical ingredients?

• Who manufactures a specific brand?

• What are the acute and chronic health effects of chemical ingredients?

• What other information is available (like health studies) in related databases?

Household Products Database

This database also links to over 6,000 consumer brands health effects from

Material Safety Data Sheets (MSDS) provided by the manufacturers.

http://householdproducts.nlm.nih.gov

What is an MSDS Sheet?

• A Material Safety Data Sheet is designed to provide workers and emergency personnel with the proper procedure for handling or working with a particular substance.

• MSDS’s include information such as toxicity, health effects, first aid, reactivity, storage, disposal, protective equipment, and spill/leak procedures

Household Products Database Search Methods

• Browse – By product (using brand name, type of product,

and manufacturer) or alphabetically

• Ingredient– Search by chemical name or CAS Registry

ingredients

– MSDS sheet (by health effects of products)

• MSDS sheet

– Search by the health effects of products

Hazardous Substances Data Bank (HSDB)

Focuses on the toxicology of potentially hazardous chemicals. It has information on

human exposure, industrial hygiene, emergency handling procedures, environmental fate,

regulatory requirements, and related areas. Contains information on over 5000 chemicals.

Searched through www.toxnet.nlm.nih.gov

HSDB Category Groupings• Human health effects• Emergency medical

treatment• Animal toxicity

studies• Metabolism/

Pharmacokinetics• Pharmacology• Environmental fate/

exposure• Chemical/physical

properties

• Chemical Safety & handling

• Occupational exposure Standards

• Manufacturing/use information

• Laboratory methods• Special references• Synonyms and

identifiers• Administrative

information

ChemIDplus

A free web-based search system that provides access to structure and

nomenclature authority files used for the identification of chemical substances

Search through www.toxnet.nlm.nih.gov

or use the advanced search option at:http://chem.sis.nlm.nih.gov/chemidplus/

Features of AdvancedChemIDplus

• Structure searching• Direct links to many

biochemical resources

• Nearly 380,000 chemicals records including names, synonyms, and structures

• Advanced Search

Searching ChemIDplus

• Enter a term into the search box– valium

• Has a spell check feature– valeum => valium

• Systematic names– 2H-1,4-Benzodiaz* = valium

http://hazmap.nlm.nih.gov/

Haz-Map is a database designed to link jobs to occupational diseases, to hazardous agents that can cause

disease, and to other job tasks that can cause disease

Haz-Map Features

• Jobs - over 250 different jobs associated with occupational diseases

• Job tasks - nearly 200 job tasks that can cause damage

• Occupational diseases - over 180 diseases

• Agents - over 1,100 hazardous agents

• Symptoms - catalog of occupational diseases

• Industry - over 440 industries are included

• Non-Occupational Activities - 25 activities associated with hazardous agents

• Processes - 50 processes associated with hazardous agents

How do I search Haz-Map?

• Text Search– Enter a term in the search box and click on either

the Agent, Disease or Job links (Text search is less effective)

• Browse– Click the link of a major category and the tree will

expand to the next level of information– Browse alphabetical listings of agents or diseases,

by adverse effect, by types of job or types of agents, by jobs and related symptoms

TOXMAP

ToxMap is a Geographic Information System (GIS) from the National Library of Medicine

(NLM) that uses maps of the United States to help users visually explore data from the EPA's

Toxics Release Inventory (TRI).

http://toxmap.nlm.nih.gov/

TOXMAP - Types of Maps

• Facilities maps - show all facilities that reported to the EPA’s TRI program

• Releases maps - show color-coded maps for reported chemical releases

• Trends maps - show changes in reported release amounts for a chosen chemical

http://toxmap.nlm.nih.gov/

Creating a map in TOXMAP

• Use Quick Search to search by a city

• Choose the Facilities, Releases, or Trends tab

– Choose a chemical on the search page

– Move the map to the desired area with the navigation tools

Note: mapping is also available from other databases (e.g. HSDB)

http://toxmap.nlm.nih.gov/

www.nlm.nih.gov

www.nlm.nih.gov/databases/

• A central resource for current information on clinical trials for AIDS patients and others infected with HIV

• Rapid access to the latest information on AIDS research, diagnosis, treatment, control and prevention

• Special sections for students

• Spanish resources available

http://aidsinfo.nih.gov/

AIDSInfo

• Guidelines– List of current guidelines for medical management of HIV

• Drugs– Takes you to the AIDSinfo Drug Database

• Clinical Trials– Ways to research latest therapies

• Vaccines– Latest research on preventive and therapeutic vaccines

• Health Topics– Information for patients, researchers and health

professionals

• AIDSInfo Tools– Including a glossary, Live Help, and PDA tools

DailyMed provides information on

over 550 marketed drugs

FDA approved drug label information in DailyMed includes description, clinical pharmacology, indications and usage, contraindications, warnings, precautions, adverse reactions, dosage & administration, and patient counseling information.

http://dailymed.nlm.nih.gov/

www.nlm.nih.gov

• Provides free access to MEDLINE, NLM's database of nearly 16.5 million bibliographic citations

• Links to the full-text of articles at participating publishers' web sites (via PubMed Central)

• New citations are usually added to PubMed Tuesday through Saturday.

www.PubMed.gov

• Use My NCBI– To save searches– To email new searches– To save collections of citations– To set up five personal filters

• Download informational brochures at http://nnlm.gov/gmr/training/resources.html – PubMed Basics– PubMed My NCBI– Searching with MeSH

PubMed Central is a digital archive of life sciences journal literature and aims to fill the role of a world class library in the digital age.

www.PubMedCentral.nih.gov

PubMed Central may also be searched

through www.PubMed.gov

A growing collection of books that allows you to access the full text of the book. The book list is updated frequently and contains

many core biomedical books

Available through PubMed or directly at:

www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books

www.nlm.nih.gov

History of Medicine collection includes print and non-print materials that document the

history of medicine, health, and disease in all time periods and cultures.

The Images from the History of Medicine (IHM) database consists of over 60,000 images of

NLM’s historical prints and photographs collection.

www.nlm.nih.gov/hmd/

History of Medicine

Images from the History of Medicine

• Subjects range from medieval astrology to 19th century slum conditions to World War I hospitals to the international fight against drug abuse and AIDS

• Most images in the collection are from earlier time periods, although 20th century images are included, the majority dating from World War II

Historical Anatomies on the Web

www.nlm.nih.gov/exhibition/historicalanatomies/

Online Syllabus Archive

www.nlm.nih.gov/hmd/collections/digital/syllabi/

The National Library of Medicine’s archival collection celebrates twentieth-century

leaders in biomedical research and public health. It makes the archival collections of

prominent scientists, physicians, and others who have advanced the scientific enterprise available to the public through modern digital

technology.

www.profiles.nlm.nih.gov

The Profiles in Science collection

• Three sections: – Biomedical Research

– Health & Medicine

– Fostering Science & Health

• Narrative exhibit on the scientist’s life and work and a selection of noteworthy documents

• Additional documents from the scientist’s papers available through a search engine and in alphabetical and chronological “views”

www.nlm.nih.gov

• View the history of forensic medicine, the "visible proofs" that can persuade judges, juries, and the public.

• Explore significant cases, technologies, and people; examine artifacts and images

• A variety of education and other resources are available

www.nlm.nih.gov/visibleproofs/

Changing the Face of Medicine

www.nlm.nih.gov/changingthefaceofmedicine/

The Visible Human ProjectThe project was established in 1989 to build a

digital image library of volumetric data representing complete, normal adult male and female anatomy

www.nlm.nih.gov/research/visible/

Questions? Comments?

Holly Ann Burt

haburt@uic.edu

Visit the NLM website

www.nlm.nih.gov

Call your local network office at:

800-338-7657

or Contact us at:

Tammy Maystmays@uic.edu