National Institutes of Health Update...Pathway to Achieving . Hepatitis B Cure. ... Typhoid fever...

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National Institutes of Health Update Claire Schuster, MPH National Institute of Allergy and Infectious Diseases National Institutes of Health March 2020

Transcript of National Institutes of Health Update...Pathway to Achieving . Hepatitis B Cure. ... Typhoid fever...

Page 1: National Institutes of Health Update...Pathway to Achieving . Hepatitis B Cure. ... Typhoid fever SFTSV bunyavirus E. coli 0157:H7 PNA syndrome H5N6 influenza 2019 Novel coronavirus

National Institutes of Health Update

Claire Schuster, MPHNational Institute of Allergy and Infectious Diseases

National Institutes of Health

March 2020

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AS Fauci/NIAID1

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Novel Coronavirus: SARS-CoV-2

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National Institute of Allergy andInfectious Diseases (NIAID)http://www.niaid.nih.govFebruary 3, 2020

Experimental HIV Vaccine Regimen Ineffective in Preventing HIV

No Safety Concerns Found; NIH and Partners Discontinue Vaccinations

NIAID stopped administration of vaccinations in its HVTN 702 clinical trial of an investigational HIV vaccine

During an interim review, an independent DSMB found:– The regimen did not prevent HIV – No evidence of decreased or increased infection rates – Recommended that no further vaccination be administered– There are no concerns regarding participant safety

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http://www.niaid.nih.gov/
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http://www.nih.govDecember 10, 2019

NIH Strategic Plan Details Pathway to Achieving

Hepatitis B CureCredit: CDC

Strategic Priority 1: Understand Hepatitis B Biology

Strategic Priority 2: Develop Tools and Resources

Strategic Priority 3: Create Strategies to Cure and Prevent Hepatitis B

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http://www.nih.gov/
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Comparative Epidemiology of Highly Pathogenic Avian ......(SDAH). At the LBM level, a sample size of 30 was required for 95% confidence of detection of H5N1 or H5N6, assuming prevalence

Comparative Epidemiology of Highly Pathogenic Avian ......(SDAH). At the LBM level, a sample size of 30 was required for 95% confidence of detection of H5N1 or H5N6, assuming prevalence

RESEARCH Severe Fever with Thrombocytopenia Syndrome Virus … · To investigate the infections of severe fever with throm - bocytopenia syndrome virus (SFTSV) in domesticated ani-mals,

RESEARCH Severe Fever with Thrombocytopenia Syndrome Virus … · To investigate the infections of severe fever with throm - bocytopenia syndrome virus (SFTSV) in domesticated ani-mals,

Genetic Characterization of Avian Influenza A(H5N6) Virus ... · the presence of genetic elements associated with receptor binding properties. A/common gull/Saratov/1676/2018 and

Genetic Characterization of Avian Influenza A(H5N6) Virus ... · the presence of genetic elements associated with receptor binding properties. A/common gull/Saratov/1676/2018 and

Modulation of Potassium Channels Inhibits Bunyavirus ...eprints.gla.ac.uk/114511/1/114511.pdf · diverse range of arthropod vectors, as well as rodents, ... (26). Here, we report

Modulation of Potassium Channels Inhibits Bunyavirus ...eprints.gla.ac.uk/114511/1/114511.pdf · diverse range of arthropod vectors, as well as rodents, ... (26). Here, we report

Systems to establish bunyavirus genome replication in the absence ...

Systems to establish bunyavirus genome replication in the absence ...

Rapid Risk Assessment on the finding of H5N6 HPAI in wild ... · PDF fileThe same strain of virus has now been detected in ... (mallard ducks, mute swans, greylag geese and guinea

Rapid Risk Assessment on the finding of H5N6 HPAI in wild ... · PDF fileThe same strain of virus has now been detected in ... (mallard ducks, mute swans, greylag geese and guinea

Antigenic Variation of Avian Influenza A(H5N6) …Bas B. Oude Munnink, Jie Wu, Lirong Zou, Yi Jing, Jing Lu, Runyu Yuan, Ming Liao, Marion P.G. Koopmans,1 Chang-wen Ke1 Market surveillance

Antigenic Variation of Avian Influenza A(H5N6) …Bas B. Oude Munnink, Jie Wu, Lirong Zou, Yi Jing, Jing Lu, Runyu Yuan, Ming Liao, Marion P.G. Koopmans,1 Chang-wen Ke1 Market surveillance

INFLUENZA H5N6: The Philippine Experience m. galang jr., dvm da rfo 2 09066942159 romeo j. manalili, dvm bai-rvqs 3 ... miriam c. lopez-vito, dvm bai-rvqs 7 09177107178 catherine g.

INFLUENZA H5N6: The Philippine Experience m. galang jr., dvm da rfo 2 09066942159 romeo j. manalili, dvm bai-rvqs 3 ... miriam c. lopez-vito, dvm bai-rvqs 7 09177107178 catherine g.

Severe Fever with Thrombocytopenia Syndrome Virus in Dogs ... · SFTSV is primarily transmitted through a tick bite. The Haemaphysalis longicornis tick is the main vector for SFTSV,

Severe Fever with Thrombocytopenia Syndrome Virus in Dogs ... · SFTSV is primarily transmitted through a tick bite. The Haemaphysalis longicornis tick is the main vector for SFTSV,

Reassortant Clade 2.3.4.4 Avian Influenza A(H5N6) Virus in a Wild Mandarin Duck, South ... · fecal sample obtained from a wild bird sampled in South Korea during the fall 2016. We

Reassortant Clade 2.3.4.4 Avian Influenza A(H5N6) Virus in a Wild Mandarin Duck, South ... · fecal sample obtained from a wild bird sampled in South Korea during the fall 2016. We

Efficacy of T-705 (Favipiravir) in the Treatment of ... · without causing body weight loss and reduced the viral load in the serum. Ribavirin also inhibited SFTSV replication. However,

Efficacy of T-705 (Favipiravir) in the Treatment of ... · without causing body weight loss and reduced the viral load in the serum. Ribavirin also inhibited SFTSV replication. However,

Reassortant Clade 2.3.4.4 of Highly Pathogenic …...of Highly Pathogenic Avian Influenza A(H5N6) Virus, Taiwan, 2017 Li-Hsuan Chen, 1 Dong-Hun Lee, Yu-Pin Liu, Wan-Chen Li, David

Reassortant Clade 2.3.4.4 of Highly Pathogenic …...of Highly Pathogenic Avian Influenza A(H5N6) Virus, Taiwan, 2017 Li-Hsuan Chen, 1 Dong-Hun Lee, Yu-Pin Liu, Wan-Chen Li, David

Outbreaks of H5N6 Highly Pathogenic Avian Influenza Virus ...Six-week-old specific-pathogen-free (SPF) chickens (White Leghorn) and 3-week-old SPF ducks (Shaoxin shelduck, a local

Outbreaks of H5N6 Highly Pathogenic Avian Influenza Virus ...Six-week-old specific-pathogen-free (SPF) chickens (White Leghorn) and 3-week-old SPF ducks (Shaoxin shelduck, a local

Bunyavirus: La Crosse Encephalitis Virus

Bunyavirus: La Crosse Encephalitis Virus

OFFLU AVIAN INFLUENZA POST VCM REPORT · H5N6 viruses in Asia, Europe and the Middle East. H5 low pathogenic avian influenza (LPAI) events were also reported in poultry during this

OFFLU AVIAN INFLUENZA POST VCM REPORT · H5N6 viruses in Asia, Europe and the Middle East. H5 low pathogenic avian influenza (LPAI) events were also reported in poultry during this

Insights into bunyavirus architecture from electron ...

Insights into bunyavirus architecture from electron ...

RESEARCH Severe Fever with Thrombocytopenia Syndrome · PDF filebocytopenia syndrome virus (SFTSV) in domesticated ani- ... People’s Republic of China, from April to November 2011.

RESEARCH Severe Fever with Thrombocytopenia Syndrome · PDF filebocytopenia syndrome virus (SFTSV) in domesticated ani- ... People’s Republic of China, from April to November 2011.

CDTR Week 3, 14-20 January 2018 - European Centre for ...€¦ · outbreaks of highly pathogenic avian influenza A(H5N6) have been detected in birds and poultry. Even though no human

CDTR Week 3, 14-20 January 2018 - European Centre for ...€¦ · outbreaks of highly pathogenic avian influenza A(H5N6) have been detected in birds and poultry. Even though no human

Highly Pathogenic Avian Influenza A(H5N6) in …domestic poultry in South Korea (5). The Study The 2016–17 winter season saw epidemics of HPAI A(H5N6) in domestic poultry and wild

Highly Pathogenic Avian Influenza A(H5N6) in …domestic poultry in South Korea (5). The Study The 2016–17 winter season saw epidemics of HPAI A(H5N6) in domestic poultry and wild

Outbreaks of Highly Pathogenic Avian Influenza (H5N6 ...The H5 highly pathogenic avian influenza viruses (HPAIVs) of clade 2.3.4.4 are of great concern because of their global spread

Outbreaks of Highly Pathogenic Avian Influenza (H5N6 ...The H5 highly pathogenic avian influenza viruses (HPAIVs) of clade 2.3.4.4 are of great concern because of their global spread