Nanostructured Polymers for Bone Repair
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Nanostructured Polymers for Bone Repair Scientific Achievement Synthesis of a series of novel, injectable and photo-crosslinkable PPF-co-POSS copolymers via a two-step polycondensation. These copolymers exhibit improved stiffness, toughness and biological performance as bone-tissue engineering scaffolds, specifically when 10% wt. POSS is incorporated. (PPF-co-POSS = poly(propylene fumarate)-co- polyhedral oligomeric silsesquioxane) Significance Understanding copolymer microstructure yields a better understanding of how it functions as scaffold for bone implants Research Details • CNMS Capability: Oxygen mapping in energy-filtered TEM (EFTEM) revealed polydispersity and structure at the nanoscale that cannot be seen with regular bright field TEM; thereby providing a structural understanding of this 10% threshold. • Tensile and compressive moduli and facture toughness are enhanced for crosslinked PPF-co-POSS when POSS wt% is 10%, which results in POSS nanocages that are small and well-distributed. The mechanical properties are correlated with in vitro mouse pre-osteoblastic cell functions including cell attachment, spreading, proliferation, differentiation, and gene expression, which all maximize at POSS wt% of 10%. L. Cai , J. Chen, A. J. Rondinone, S. Wang, Advanced Functional Materials, Early View, DOI: 10.1002/adfm.201200457 (2012). CNMS User Project Highlight 100 nm 100 nm Bright Field Oxygen map Fracture Toughness K IC (Mpa*m 1/2 ) Weight% Fraction of POSS 0.6 0.4 0.2 0 0% 5% 10% 15% 20% Toughness as a function of POSS wt% (Top) and EFTEM images of 5 wt% POSS copolymer (Bottom). POSS crystals are small and well dispersed only for wt% less than 10%
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CNMS User Project Highlight. Nanostructured Polymers for Bone Repair. Scientific Achievement - PowerPoint PPT Presentation
Transcript of Nanostructured Polymers for Bone Repair
Nanostructured Polymers for Bone RepairScientific Achievement
Synthesis of a series of novel, injectable and photo-crosslinkable PPF-co-POSS copolymers via a two-step polycondensation. These copolymers exhibit improved stiffness, toughness and biological performance as bone-tissue engineering scaffolds, specifically when 10% wt. POSS is incorporated. (PPF-co-POSS = poly(propylene fumarate)-co-polyhedral oligomeric silsesquioxane)
SignificanceUnderstanding copolymer microstructure yields a better understanding of how it functions as scaffold for bone implants
Research Details• CNMS Capability: Oxygen mapping in energy-filtered TEM (EFTEM)
revealed polydispersity and structure at the nanoscale that cannot be seen with regular bright field TEM; thereby providing a structural understanding of this 10% threshold.
• Tensile and compressive moduli and facture toughness are enhanced for crosslinked PPF-co-POSS when POSS wt% is 10%, which results in POSS nanocages that are small and well-distributed. The mechanical properties are correlated with in vitro mouse pre-osteoblastic cell functions including cell attachment, spreading, proliferation, differentiation, and gene expression, which all maximize at POSS wt% of 10%.
L. Cai , J. Chen, A. J. Rondinone, S. Wang, Advanced Functional Materials, Early View, DOI: 10.1002/adfm.201200457 (2012).
CNMS User Project Highlight
100 nm 100 nm
Bright FieldOxygen map
Frac
ture
Toug
hnes
sK IC
(Mpa
*m1/
2 )
Weight% Fraction of POSS
0.6
0.4
0.2
00% 5% 10% 15% 20%
Toughness as a function of POSS wt% (Top) and EFTEM images of 5 wt% POSS copolymer (Bottom). POSS crystals are small and well dispersed only for wt% less than 10%
