Nanbiosensor Working Group, Nov. 19 th, 2002 Convener: Antje Baeumner Participants:+Evangelyn...

Nanbiosensor Working Group, Nov. 19th, 2002

Convener: Antje BaeumnerParticipants: +Evangelyn Alocilja

+Larry Branen+Paul Dawson+Richard Durst+Joseph Irudayari+Zhiko Kounev+Greg McCarty+Jerzy Nowak+Daniel Schmold+Ruixiu Sui+U. Sunday Tim+John Vetelino+Guigen Zhang

www.nseafs.cornell.edu

Background and Rational of Nanobiosensors

-Bioanalytical Nanosensor

- using biology or used for biology

-Collection, interaction, sensor platform, response

- Biosensor system, portable and non-portable


Characteristics of Biosensors:- single use: remote, small, portable, rapid response (real time) and processing,

specific, quantitative

-Laboratory: more specific (i.e. subtyping capability) non-portable, high throughput, quantitative

-Multichannel-Sensitive-Reliable-Accurate-Reproducible

-Robustness-Stability

-6 more slides on background and rational


-6 more slides on background and rational

Pathogen Detection: Foods, Plants, Animals, Fruits & Vegetables

Plant/Animal Production, Transgenics Cloning

BioProcessing, Foods , Industrial Products (BioProcessing, Food Quality + Safety)

BioSensor, (Biosecurity) Agrosecurity

Environmental Processing (Environmental Monitoring)

Sustainable Agriculture (Sustainable Rural Community)

Specific Objectives in Bioanalytical Nanosensors1. Novel nanomaterials adaptable to agricultural & food systems

(limited sample preparation, complex systems (dirty), more robust)

2. Novel recognition mechanisms based on the nanoscale(fundamental studies, non-biomaterials, biomimetics, carbon nanotubes, MIP, recombinant – genetically engineered)

3. Novel integration mechanisms of transducer and recognition element(SAM, Directed/guided assembly, new immobilization (chemical, biological and electrical)

5. Integration of NEMS remote receive/transmit systems (embedded on the chip, satellite interaction, GPS, remote powering biopowering)

4. Novel transduction mechanisms(mechanical, impedance, piezoelectric, optical, electrochemistry, transistor)

Education about Nanotechnology as overall educational topic area for initiative

Potential Outcomes & Impacts in Nanobiosensors

Crosscutting Issues

Collection: Transport, Bioseparation, Microfluidics, Bioselective surface-Sampling – representative sample (statistically significant)

Recognition: Bioselective Surface, Microfluidics, Nanomaterials, Nucleic Acids- specificity (saturation,time, fouling)

Transduction: Bioselective Surface, Microfluidic, Nanomaterial-Integration to bioselective surface

Data Processing: Nanomaterials

Crosscutting Issues (continued)

Drug delivery: Sensing if release is required, where to release

NanoBioprocessing:

Modeling: Models for new nanosensorsnanosensors

Estimated Research Budget for Bioanalytical Nanosensors

Fundamental Theme area Centers of Research Education Totalresearch challenge excellence infrastructure[in million $] (applied) (equipment)

12345

1 1*2 1*3 1*4 1*5 0.4**

* 3 projects per year at $300,000** 2 projects per year at $200,000 $4.4

1 1* 1*2 1* 1*3 1* 1*4 1* 1*5 0.4** 0.4**


1 1* 1* 4 regional2 1* 1* centers3 1* 1* (5 year)4 1* 1* $10/year5 0.4** 0.4**


1 1* 1* 4 regional 1*2 1* 1* centers 1*3 1* 1* (5 year) 1*4 1* 1* $10/year 1*5 0.4** 0.4**


1 1* 1* 4 regional 1* 0.22 1* 1* centers 1* 0.23 1* 1* (5 year) 1* 0.24 1* 1* $10/year 1* 0.25 0.4** 0.4** 0.2


-Biosensors: Definition of Biosensor Systems:-Bioanalytical Nanosensor

- using biology or used for biology-Collection, interaction, sensor platform, response- Biosensor system, portable and non-portable

Characteristics of Biosensors:

-remote, small, portable, rapid response (real time) and processing, single use, Specific, quantitative-Laboratory base more specific (I.e. subtyping capability) non-portable, high throughputquantitative

-Multichannel-Sensitive-Reliable-Accurate-Reproducibility-Robustness-Stability

Pathogen DetectionFoods, Plants, AnimalsFruits & Vegetables

Plant/Animal ProductionTransgenics Cloning

BioProcessingFoods Industrial Products

BioSensor(Biosecurity) Agrosecurity

Environmental Processing

Sustainable Agriculture

Rapid sensor (min or less)SimpleIn-situ (real-time)Detection at farm-level, and throughout food processing and distribution chain,

including consumerNon-invasive (non-destructive)Remote Telemetric -we include FOOD SAFETY-HACCP

Examples:-implanted sensors in farm animals-Monitoring of pathogens throughout the farm for early recognition of disease-Tracing sources of “contamination” (typically done in the lab)-Sample egg wash water, telemetric detection and automatic adjustment of disinfectant-Fish farms-Mycotoxin levels in grains-Toxins from pathogenic organism







- GMO detection throughout processing/distribution including consumer-Detection the function of the immune system in animals to detect disease resistance(production efficiency vs. disease)-rapid screening of clones-“SMART” plants – plants sensor

-Production process:- increase yield, productivity by monitoring the animals and plants-Root/soil interface investigation-(ethylene ripening)-IPM

-Ask experts in this field

-Specifics demanded of biosensors-GMO --- rapid, simple etc.-others fast, but in the lab is sufficient







-BioProcessing, Food Quality + Safety

-Monitoring of Food Quality + Safety-Contamination, physical properties-- heavy metals, pesticides-- oxidation-- metabilites, amonia etc.-- antioxidants-- texture

On-line monitoring of bioprocessing (proteins, cheese)Monitoring imported foods

Characteristics:

- both, portable and lab







-Take everything from Pathogen Detection







-Environmental Monitoring, (quality)

-Water-Surface,- ground, -watershed-Waste water

-Air-Odor-Spores, -particulates-allergens

-Soil-Nutrient monitoring in soils (phosphorus, carbon, nitrogen)

-Characteristics of biosensors neededportableespecially remote monitoring, since geographically dispersed







-Sustainable Rural Community-Environmental Monitoring, (quality)

-Production

-BioProcessing

-ALL OF them fit into this category

-Having nanosensors helping in making decisions, not only for monitoring

-Even opens up opportunities between rural + urban discussions-Agriculture in the classroom-Nanosensors as example of teaching tool, I.e. high tech to Agriculture, to K-12-Decision making community, water, air, waste management

Nanbiosensor Working Group, Nov. 19 th, 2002 Convener: Antje Baeumner Participants:+Evangelyn...

Documents

Transcript of Nanbiosensor Working Group, Nov. 19 th, 2002 Convener: Antje Baeumner Participants:+Evangelyn...