Name: Dr.S.S.Jadhav Email:!!!ssj@serumins;tute - DCVMN · 2015. 7. 10. · 2.Nebulizer,...
Transcript of Name: Dr.S.S.Jadhav Email:!!!ssj@serumins;tute - DCVMN · 2015. 7. 10. · 2.Nebulizer,...
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Next-‐Genera*on Vaccine Delivery Technology Mee*ng Geneva, Switzerland
Name: Dr.S.S.Jadhav
Email: ssj@serumins;tute.com Title: Execu;ve Director SSI
Date: February 18, 2014
Plenary Session 2: Landscape
Measles Aerosol Vaccine Measles Vaccine, Dry Powder (Inhalable)
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Measles Aerosol Vaccine
Technology Descrip*on: • Respiratory delivery of the currently available freeze dried measles vaccine
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1. Controller 1000 doses without recharging
Operates automa;cally for 30 seconds
4. Plas*c needle syringe for vaccine recons;tu;on
2. Nebulizer Auto-‐disable aPer one working session
3. Disposable mask One per dose administered
Measles Aerosol Vaccine
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Phase 1 measles aerosol vaccine:
No. of adverse events in 145 healthy measles immune volunteers 1- 35 years of age, India - 2007-08
Most AE were mild or moderate Two SAE not vaccine related
No.
of
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ts
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Measles Aerosol Vaccine Phase II / III RCT
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Measles Aerosol Vaccine
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Status: Bench tes*ng
Animal immunogenicity
Animal Toxicity
Phase 1 in healthy adults
Phase II/III in adults
Usability and acceptability
Cost and ICEA
Measles Aerosol Vaccine
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Benefits: • Non injectable, easier to administer • No waste disposal
• Similar cost per dose
Challenges: • Need demonstra*on studies with MR to further document benefits
• Resources to conduct demonstra*on studies
Measles Aerosol Vaccine
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40 children vaccinated
Injectable route Aerosol route
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Measles Aerosol Vaccine: Opportuni*es ¬Way Forward
Global Public Health Challenge:
Insert representa;ve photo / data summary as applicable / video of
ac;on Technology Availability: • Could be available in 3-‐5
years ;me if funding for trial and demonstra;on studies with MR recommended by SAGE were conducted