N on H omologous E nd J oining
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Non Homologous End Joining
description
N on H omologous E nd J oining. Homologous Recombination. Non Homologous End Joining. Differences between HR and NHEJ :. Error- free / Error- prone Cell cycle regulated Varies between species. plants. yeast. mammals. NHEJ. HR. HR. NHEJ. Cell-induced Double Strand Brakes. - PowerPoint PPT Presentation
Transcript of N on H omologous E nd J oining
Non Homologous End Joining
Homologous Recombination
Non Homologous End Joining
Differences between HR and NHEJ:
• Error- free / Error- prone• Cell cycle regulated • Varies between species
HR NHEJ
yeast mammalsplants
HR NHEJ
MHC rearrangementMeiosis
Cell-induced Double Strand Brakes
V(D)J recombination
NHEJ Defects
• SCID (Severe Combined Immune Deficiency).
• Cancer – genome instability: rearrangements, deletions, amplifications.
Ku 70/80 heterodimer
Ku has a role in telomeres
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KU 70/80
Ku is critical for telomere maintenance
Ku Plays Several Roles at Telomeres
Telomere addition
Telomeric silencing
Ku is a multifunctional protein
HR
NHEJ
