N-Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional...

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2006 Antiinflammatory activity X 0130 N-Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional 2-Hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) Benzenesulfon- amide Class of COX-2 Inhibitors. — The conversion of potent COX-2 inhibitors, inactive in vivo, to potent antiinflammatory drug candidates is demonstrated by means of a prodrug approach. Prodrugs (I) are identified as potential agents for oral as well as parenteral administration. — (SINGH*, S. K.; VOBBALAREDDY, S.; KALLEDA, S. R.; CASTURI, S. R.; MULLANGI, R.; RAMANUJAM, R.; YELESWARAPU, K. R.; IQBAL, J.; Bioorg. Med. Chem. Lett. 16 (2006) 15, 3921-3926; Chem.-Discovery Res., Dr. Reddy's Lab. Ltd., Hyderabad 500 049, India; Eng.) — H. Hoennerscheid 45- 219

Transcript of N-Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional...

Page 1: N-Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional 2-Hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) Benzenesulfonamide Class of COX-2 Inhibitors.

2006

Antiinflammatory activityX 0130 N-Acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional

2-Hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) Benzenesulfon-amide Class of COX-2 Inhibitors. — The conversion of potent COX-2 inhibitors, inactive in vivo, to potent antiinflammatory drug candidates is demonstrated by means of a prodrug approach. Prodrugs (I) are identified as potential agents for oral as well as parenteral administration. — (SINGH*, S. K.; VOBBALAREDDY, S.; KALLEDA, S. R.; CASTURI, S. R.; MULLANGI, R.; RAMANUJAM, R.; YELESWARAPU, K. R.; IQBAL, J.; Bioorg. Med. Chem. Lett. 16 (2006) 15, 3921-3926; Chem.-Discovery Res., Dr. Reddy's Lab. Ltd., Hyderabad 500 049, India; Eng.) — H. Hoennerscheid

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Pyrazol-5-ones to 3-Methyl-4-nitro-5-alkenylisoxazoles ... · Organocatalytic Asymmetric Synthesis of Compounds Bearing both Isoxazole and Pyrazole Moieties via 1,6-Addition of Pyrazol-5-ones

Pyrazol-5-ones to 3-Methyl-4-nitro-5-alkenylisoxazoles ... · Organocatalytic Asymmetric Synthesis of Compounds Bearing both Isoxazole and Pyrazole Moieties via 1,6-Addition of Pyrazol-5-ones

Synthesis of a Pyrazol-3-ylidene Palladium Complex, Pyrazolium …znaturforsch.com/s67b/s67b0359.pdf · 2016-06-28 · Synthesis of a Pyrazol-3-ylidene Palladium Complex, Pyrazolium

Synthesis of a Pyrazol-3-ylidene Palladium Complex, Pyrazolium …znaturforsch.com/s67b/s67b0359.pdf · 2016-06-28 · Synthesis of a Pyrazol-3-ylidene Palladium Complex, Pyrazolium

Acylated Flavonoid Glycosides are the Main Pigments that ... · such as flavonoids (flavonol glycosides, isoflavonoids and anthocyanins), phenolic derivatives, tannins, and triterpenes

Acylated Flavonoid Glycosides are the Main Pigments that ... · such as flavonoids (flavonol glycosides, isoflavonoids and anthocyanins), phenolic derivatives, tannins, and triterpenes

Bioorganic & Medicinal Chemistry - fac.ksu.edu.safac.ksu.edu.sa/sites/default/files/2_49.pdf · In fact we have prepared a large number of thioureas incorporating benzenesulfonamide

Bioorganic & Medicinal Chemistry - fac.ksu.edu.safac.ksu.edu.sa/sites/default/files/2_49.pdf · In fact we have prepared a large number of thioureas incorporating benzenesulfonamide

4 (2 Aminoethyl)Benzenesulfonamide

4 (2 Aminoethyl)Benzenesulfonamide

MASTER OF SCIENCE - İYTElibrary.iyte.edu.tr/tezler/master/kimya/T000252.pdf · Synthesis and Spectroscopic Characterization of Some New [tris(3,5-dimethyl-pyrazol)borato] Molybdenum

MASTER OF SCIENCE - İYTElibrary.iyte.edu.tr/tezler/master/kimya/T000252.pdf · Synthesis and Spectroscopic Characterization of Some New [tris(3,5-dimethyl-pyrazol)borato] Molybdenum

RSC CC C2CC38433G 1. - SKKUorgmedichem.skku.edu/erp/erpmenus/professor_thesis/... · 2013-01-25 · position furnished the acylated product 3g,albeitprovidingthe regioisomers at C

RSC CC C2CC38433G 1. - SKKUorgmedichem.skku.edu/erp/erpmenus/professor_thesis/... · 2013-01-25 · position furnished the acylated product 3g,albeitprovidingthe regioisomers at C

Microwave-Assisted Chemistry – from HTS to CDdata.biotage.co.jp/pdf/presentations/3004_06ugm... · CCE* library synthesis • Acylated amino-phthalimides • 480-member library

Microwave-Assisted Chemistry – from HTS to CDdata.biotage.co.jp/pdf/presentations/3004_06ugm... · CCE* library synthesis • Acylated amino-phthalimides • 480-member library

SYNTHESIS AND CHARACTERIZATION OXO-IMIDO …...SYNTHESIS AND CHARACTERIZATION OXO-IMIDO [TRIS (3,5 – DIMETHYL – PYRAZOL) BORATE] MOLYBDENUM COMPLEXES A Thesis Submitted to the

SYNTHESIS AND CHARACTERIZATION OXO-IMIDO …...SYNTHESIS AND CHARACTERIZATION OXO-IMIDO [TRIS (3,5 – DIMETHYL – PYRAZOL) BORATE] MOLYBDENUM COMPLEXES A Thesis Submitted to the

pharma.cu.edu.egpharma.cu.edu.eg/.../En/Sahar_Mahmoud_Abou-Seri.docx · Web viewIsatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms

pharma.cu.edu.egpharma.cu.edu.eg/.../En/Sahar_Mahmoud_Abou-Seri.docx · Web viewIsatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms

A Grapevine Anthocyanin Acyltransferase, Transcriptionally … · In cv Pinot Noir, a red-berried grapevine mutant lacking acylated anthocyanins, ... that they also act as protection

A Grapevine Anthocyanin Acyltransferase, Transcriptionally … · In cv Pinot Noir, a red-berried grapevine mutant lacking acylated anthocyanins, ... that they also act as protection

COMPARISON OF MEMBRANE INTERACTIONS OF ACYLATED …membrane.urmc.rochester.edu/sites/default/files/posters... · 2013. 1. 30. · Denise Greathouse1, Tod D. Romo2, Joshua Horn2, Alan

COMPARISON OF MEMBRANE INTERACTIONS OF ACYLATED …membrane.urmc.rochester.edu/sites/default/files/posters... · 2013. 1. 30. · Denise Greathouse1, Tod D. Romo2, Joshua Horn2, Alan

Vol. 4, Issue 3, March 2015 Kinetics and Mechanistic ... · The reduction product of the oxidant, benzenesulfonamide, was extracted with ethylacetate and detected by TLC using petroleum

Vol. 4, Issue 3, March 2015 Kinetics and Mechanistic ... · The reduction product of the oxidant, benzenesulfonamide, was extracted with ethylacetate and detected by TLC using petroleum

Docking of Potent Anticancer Agents; 4-(Pyrazol-4yl)-Pyrimidine ...

Docking of Potent Anticancer Agents; 4-(Pyrazol-4yl)-Pyrimidine ...

Structure analysis and molecular recognition studies of bio ...449093/...functional groups: noradrenaline, phenylboronic-ester, phenylboronic-acid and benzenesulfonamide, are presented

Structure analysis and molecular recognition studies of bio ...449093/...functional groups: noradrenaline, phenylboronic-ester, phenylboronic-acid and benzenesulfonamide, are presented

Docking of Potent Anticancer Agents; 4-(Pyrazol-4yl ...ijcea.org/papers/338-F0001.pdf · inhibitors have been studied for anticancer potential. Here we conducteda docking studyof

Docking of Potent Anticancer Agents; 4-(Pyrazol-4yl ...ijcea.org/papers/338-F0001.pdf · inhibitors have been studied for anticancer potential. Here we conducteda docking studyof

N-Acylated Chitosan- Hydrophobic Matrices for Controlled Drug Release

N-Acylated Chitosan- Hydrophobic Matrices for Controlled Drug Release

Asymmetric Hydrogenation of Heteroarenes with Multiple … · 2020. 8. 28. · 2).11 The enantioselective hydrogenation of fluorinated aromatic pyrazol-5-ols 7 was carried out using

Asymmetric Hydrogenation of Heteroarenes with Multiple … · 2020. 8. 28. · 2).11 The enantioselective hydrogenation of fluorinated aromatic pyrazol-5-ols 7 was carried out using

p-Toluenesulfonamide (Screening Information Data Set - · PDF fileUses 5 CAS Number : 70-55-3 Uses Chemical Name : Benzenesulfonamide, 4-methyl Use Quantity Year Unspecified amount

p-Toluenesulfonamide (Screening Information Data Set - · PDF fileUses 5 CAS Number : 70-55-3 Uses Chemical Name : Benzenesulfonamide, 4-methyl Use Quantity Year Unspecified amount

DUPONT TELAR XP...DuPont Telar® XP herbicide Dry flowable Active Ingredient By Weight Chlorsulfuron 2-Chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl] benzenesulfonamide

DUPONT TELAR XP...DuPont Telar® XP herbicide Dry flowable Active Ingredient By Weight Chlorsulfuron 2-Chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl] benzenesulfonamide