My Way in Biopsychology

Donald F. SmithTranslational Neuropsychiatry Unit

Institute of Clinical MedicineAarhus University

https://www.youtube.com/watch?v=2Ox1Tore9nw

As the snow fliesOn a cold and gray Chicago mornin'A poor little baby child is bornIn the ghetto

And his mama criesCause if there's one thing that she don't needIt's another hungry mouth to feedIn the ghetto

People, don't you understandThe child needs a helping handOr he'll grow to be an angry young man some day

My house

Ghetto

Stock Yards = Slaughterhouse

Downtown

Briefly describe the US Public School System1950 - 1963

Horace Mann Grammar School South Short Public High School

James Dewey Watson was born in Chicago, Ill., on April 6th, 1928. Young Watson's entire boyhood

was spent in Chicago where he attended Horace Mann Grammar School (1933 – 1941) and

South Shore High School (1941 – 1943). He then received a tuition scholarship to the

University of Chicago, and in the summer of 1943 entered their experimental four-year college.

In 1947, he received a B.Sc. degree in Zoology. From September 1950 to September 1951 he spent his

first postdoctoral year in Copenhagen as a Merck Fellow of the National Research Council.

The Nobel Prize in Physiology or Medicine 1962Francis Crick, James Watson, Maurice Wilkins

http://www.nobelprize.org/nobel_prizes/medicine/laureates/1962/watson-bio.html

Mention Alfred J. Lewy ("Sandy Lewy“), Russ Chadwick and Ray Cahnman

1963

University of IlliniosPsychology 101

Turning-Point LectureDemo

Thorndike’s Law of Effect:

”Organisms tend to repeat and learn responses that lead to tension reduction and the

completion of motivated activity.”

Learning and MotivationPavlovian Classical Conditioning

Thorndike’s Operant Conditioning

Edward L. ThorndikeColumbia University

Ivan PavlovMilitary Medical Academy

Institute of Experimental MedicineSt. Petersburg

1963

1965

Robert P. Erickson & familyDuke University – 1969Psychology Department

Mention Discussion of Neurogenesis

The neural code for taste

Robert P. Erickson et al. Brain Research, Volume 23, Issue 3, 1970,428–432

‘Across-Fiber Pattern' analysis of populations of individual neurons

Physiological Psychology

Robert Erickson & wifeca. 2014

LiCl

KCl

KClNaCl

NaCl

Physiological Psychology

Understand and describe behavior by the laws of physics and chemistry

1963

1965

1967

BSc

1967

1963

1965

1967

BSc

1967

Edward StrickerPhysiological PsychologyMcMaster UniversityUniversity of Pittsburgh since 1971

1. Smith DF, Stricker EM. The influence of need on the rat's preference for dilute NaCl solutions. Physiol Behav 1969:4:407-410.

2. Smith DF, Stricker EM, Morrison GR. NaCl solution acceptability by sodium deficient rats. Physiol Behav 1969:4:239-243.

1963

1965

1967

BSc

1968

University of Chicago, Department of Biopsychology, Pritzker School of Medicine

The Spirit at the U of C

Heinrich Klüver

Biopsychology examines the interaction between biological systems and behavior.

Physiological Basis of Motivational Processes

Central Molecular Mechanisms Governing Eating and Drinking

Sebastian P. Grossman Head of Department

Saul BalaguraBiopsychology Dept.University of Chicago

Reminder: Myer Lubran statement on next slide

”He who follows the masters, will always follow the masters!”

Dr. Myer LubranHead of Clinical Chemistry

Medical SchoolUniversity of Chicago Hospital

Louis SeidenPsychopharmacologyUniversity of Chicago

John A. HarveyNeuropsychopharmacology University of Chicago

Dwight J. IngleHead of Physiology DepartmentPritzker Medical SchoolUniversity of Chicago

Chief Editor of American Journalof PhysiologyFounder of ”Perspectives in Biologyand Medicine”

3. Smith DF, Balagura S. The role of oropharyngeal factors in LiCl aversions. J Comp Physiol Psychol 1969:69:3O8-31O.

4. Smith DF, Balagura S, Lubran M. Some effects of adrenalectomy on LiCl intake and excretion in the rat. Am J Physiol 197O:218:751-754

5. Smith DF, Balagura S, Lubran M. "Antidotal thirst": A response to intoxication. Science 197O:167:297-298.

6. Balagura S, Smith DF. Role of LiCl and environmental stimu li on generalized learned aversion to NaCl in the rat. Am J Physiol 197O:219:1231-1234

7. Smith DF, Balagura S, Lubran M. Antidotal thirst and lit hium excretion in rats with hypothalamic lesions. Physiol Behav 1971:6:2O9-213.

8. Smith DF, Balagura S. Sodium appetite in rats given lithium. Life Sci 1972:11:1O21-1O29.

9. Smith DF, Balagura S. A method to study lithium, sodium, and potassium ions in rat CSF. Physiol Behav 1972:9:261-262.

10. Smith DF, Balagura S. Taste and physiological need in vitamin C intake by guinea pigs. Physiol Behav 1975:14:545-549.

Steve Jobs Quotes That Could Change Your Life

"Your work is going to fill a large part of your life, and the only way to be

truly satisfied is to do what you believe is great work. And the only way to do

great work is to love what you do. If you haven't found it yet, keep looking.

Don't settle. As with all matters of the heart, you'll know when you find it.“

https://www.linkedin.com/pulse/7-steve-jobs-quotes-could-change-your-life-jeff-haden?midToken=AQEwnyih2fp2PQ&trk=eml-b2_content_ecosystem_digest-recommended_articles-183-null&fromEmail=fromEmail&ut=20c0WB5mAyB6I1

1971PhD

Quebec

Aarhus

11. Smith DF. Diurnal variations of lithium clearance in the rat. Int Pharma copsychiatry 1973:8:99-1O3.12. Smith DF, Smith HB. The effect of prolonged lithium admini stration on ac tivity, reactivity, and endurance in the rat. Psychopharmacology (Berlin) 1973:3O:83-88.13. Smith DF, Thomsen K. Renal lithium clearance in adrenalec tomized rats. Am J Physiol 1973:225:159-161.14. Smith DF. The effect of exercise and pain-stress on renal clearance of lithium, sodium, potassium and creatinine in the rat. Int Pharmacopsychia try 1973:8:217-22O.15. Smith DF. The effect of NH4Cl on polyuria and polydipsia during prolonged lithium administration in the rat. Acta Pharmacol Toxicol (Copenh) 1974:34:121-129.16. Smith DF. Renal lithium clearance during dehydration and rehydration with water or O.9 % NaCl in the rat. Acta Physiol Scand 1974:9O:427-43O.17. Smith DF. NH4Cl acceptability in the rat. Physiol Behav 1974: 12:513-514.18. Smith DF, de Jong W. Renal lithium, sodium, potassium and water excretion and plasma renin activity in rats in the cold. Pharmacopsychiatria 1975:8:132-135.19. Smith DF. Biogenic amines and the effect of short-term lithium administra tion on open field activity in rats. Psychopharmaco logy (Berlin) 1975:41:295-3OO.20. Smith DF. The role of sodium in the effect of food intake on renal lithium clearance in the rat. J Toxicol Appl Pharmacol 1975:33:276-28O.21. Smith DF. The role of alpha- and beta-adrenergic effects in the action of adrenaline on renal lithium elimination in adrenalectomized rats. Eur J Pharmacology 1976:36:49-54.22. Smith DF. Lithium orotate, carbonate and chloride: Pharmacokinetics, polydipsia and polyuria in rats. Br J Pharmacol 1976:56:399-4O2.

23. Smith DF. Reexamination of vertical activity in rats trea ted with lithium chloride. Experientia 23. 1976:32:132O-1321.

24. Smith DF, Shimizu M. Effect of posture on renal lithium clearance. Clin Sci 1976:51:1O3-1O5.25. Smith DF. Antagonistic effect of lithium chloride on L-dopa-induced loco motor activity in rats. Pharmacol

25. Res Commun 1976:8:575-579.26. Smith DF. Effects of tranylcypromine stereoisomers, clorgyline and deprenyl on open field activity during

long-term lithium administration in rats. Psychopharmacology (Berlin) 1976:50:81-84.27. Smith DF, Shimizu M, Schou M. Lithium absorption, distribution and clearance and the body temperature in

rats given lithium plus haloperidol. Pharmacology 1977:15:337-34O.28. Smith DF. Locomotor activity and plasma, red blood cell and cerebral cor tex lithium concentration in inbred

mice given lithium carbonate. Pharma col Biochem Behav 1976:5:379-382.29. Smith DF, Shimizu M. Effects of alpha methyltyrosine and parachlorophenylanine on open field behavior

in rats given tranylcypromine stereoisomers and lithium carbonate. Pharmacol Biochem Behav 1976:5:515-518.

30. Smith DF, Shimizu M. Aggression in groups of rats given tranylcypromine stereoisomers: Effect of alpha-methyltyro sine and parachlorophenylalanine. Agressologie 1977:18:17-19.

31. Smith DF, Shimizu M. Toxic interaction between disulfiram and tranylcypro mine stereoisomers in rats. J Pharm Pharmacol 1976:28:858.

32. Smith DF. The effects of lithium on behavior: Critical analy sis of a school-of-thought. Compr Psychiatry 1977:18: 449-452.

33. Shimizu M, Smith DF. Salivary and urinary lithium clearance while recumb ent and upright. Clin Pharmacol Ther 1977:21:2 12-215.

34. Smith, DF. Studies on hyperactivity in rats given tranyl cypromine stereo isomers and reserpine. Arch Int Pharacodyn Ther 1977:229:129-132.

35. Smith DF. Learned aversion and rearing movement in rats given LiCl, PbCl2 or NaCl. Experientia 1978:34:12OO-12O1.

36. Shimizu M, Smith DF. Relationship between clearance of lit hium, potassium and sodium in human mixed saliva. Int Pharma copsychiatry 1978:13:34-38.

37. Smith DF, Shimizu M. The role of plasma volume, plasma renin and the sym pathetic nervous system in the posture-induced decline in renal lithium clearance in man. Neurop sychobiology 1978:4:328-332.

38. Smith DF. Lithium chloride toxicity and pharmacodynamics in inbred mice. Acta Pharmacol. Toxicol (Copenh) 1978:43:51-54.

39. Smith DF. Irritable aggression and open field behavior in rats given 2-phenylcyclopropylamaines. Eur J Pharmacol 1978:52:297-3O2.

40. Ebara T, Smith DF. A method to determine lithium content in blood platelets. Acta Pharmacol Toxicol (Copenh) 1979:44:2 38-24O.

41. Smith DF. Hindlimb extensor reflex of spinal rats given tranylcypromine stereoisomers. J Neural Transm 1979:44:3O3-3O7.

42. Hoffman C, Smith DF. Lithium and rubidium: Effects on the rhythmic swimming movement of jellyfish (Aurelia aurita). Ex perientia 1979:35:1177-1178.

43. Ebara T, Smith DF. Lithium levels in blood platelets, serum, red blood cells and brain regions in rats given acute or chronic lithium salt treat ment. (Title in Japane se) No To Shinkei (Brain and Nerve) 1979:31:177-183.

44. Ebara T, Smith DF. A method for determination of lithium content in blood platelets. (Title in Japanese) No To Shinkei (Brain and Nerve) 1979:31:289-293.

45. Ebara T, Smith DF. Lithium levels in blood platelets, serum, red blood cells and brain regions in rats given acute or chronic lithium salt treat ment. J Psychiatr Res 1979:15:183-188.

46. Smith DF, Vestergaard P. The role of monoamines for the central effects of baclofen on behavior of rats. J Neural Transm 1979:46:215-223.

47. Smith DF. Central and peripheral effects of lithium on condi tioned taste aversions in rats. Psychopharmacology (Berlin) 198O:68:215-223.

48. Smith DF. Role of monoamines in behavior of reserpinized rats given tranylcypromine stereoisomers. J Neural Transm 1981:5O:193-2OO.

49. Smith DF. Central and peripheral effects of lithium on amphetamine-induced hyperactivity in rats. Pharmacol Bi ochem Behav 1981:14:439-442.

50. Jensen TS, Smith DF. The role of consciousness in stress-induced analgesia. J Neural Transm 1981:52:55-6O.

51. Hjorth M, Bille M, Smith DF. Serum tryptophan levels in alcoholics. Drug Alcohol Depend 1981:7:157-161.

52. Smith DF, Strömgren LS. Influence of unilateral ECT on tryp tophan meta bolism in endogenous depression. Pharmacophychi atria 1981:14:135-138.

53. Smith DF, Amdisen A. Lithium distribution in rat brain after long-term central administration by minipump. J Pharm Pharma col 1981:33:8O5-8O654. .54. Jensen TS, Smith DF. Dopaminergic effects on tail-flick response in spinal rats. Eur J Pharmacol 1982:79:129-133.

55. Smith DF. Effects of age on serum tryptophan and urine indican in adults given a tryptophan load test. Eur J Drug Metab Pharmacokinet 1982:7:55-68.

56. Jensen TS, Smith DF. Effect of emotions on nociceptive threshold in rats. Physiol Behav 1982:28:597-599.

57. Jensen TS, Smith DF. Monoaminergic mechanisms in stress-induced anal gesia. J Neural Transm 1982:53:247-255.

58. Smith DF, Petersen HN. Stereoselective effects of tranylcypromine enantiomers on brain serotonin. Life Sci 1982:31 :2449-2454.

59. Smith DF. Lithium and carbamazepine: Effects on learned taste aversion and open field behavior in rats. Pharmacol Biochem Behav 1983:18:484-488.

60. Hoffmann C, Smith DF. Lithium and rubidium: Effects on loco mo tion of plan aria (Dendrocoelum lacteum). Experientia 1983:39:179-18O.61. Jensen TS, Smith DF. Role of 5-HT and NA in spinal dopaminergic analgesia. Eur J Pharmacol 1983:86:65-70.62. Smith DF, Amdisen A. Central effects of lithium in rats: Lithium levels, body weight and water intake. Acta Pharma col Toxicol 1983:52:81-85.63. Jensen TS, Smith DF. Stimulation of spinal dopaminergic receptors: Differential effects on tail reflexes in rats. Neuropharmacology 1983:22:477-483.

64. Jensen TS, Schrøder HD, Smith DF. The role of spinal path ways in dopamine mediated alteration in the tail-flick reflex in rats. Neuropharmacology 1984:23:149-153.

65. Smith DF. Stereoselectivity of spinal neurotransmission: Effects of baclo fen enantiomers on tail-flick reflex in rats. J Neural Transm 1984:6O:63-67.

66. Smith DF, Strömgren E, Petersen HN, Williams DG, Sheldon W. Lack of effect of tryptophan treatment in demented geron topsychiatric patients. Acta

psychiatr scand 1984:7O:47O-477.

67. Jensen TS, Smith DF. Selective association in conditioned stress-induced analgesia: Functional differences in inter oceptive and exteroceptive sen sory pathways. Behav Neural Biol 1985:43:218-221.

68. Smith DF. Species differences in the velocity and stereoselectivity of platelet 5-HT-uptake in rats and humans. Acta Pharmacol et Toxicol 1985:57:3O1-3O3.

69. Tuomisto J, Smith DF. Effects of tranylcypromine enantio mers on monoamine uptake and release and imipramine bin ding. J Neural Transm 1986:65:135-145.

70. Smith DF, Pirkle WH. Stereoselective analysis of racemic psychotropic com pounds by HPLC on chiral stationary phase. Psychopharmacology 1986:89:392-

393.

71. Jensen TS, Christensen NJ, Smith DF. Differential effects of apomorphine on spinal reflex activity following 6-Hy droxydopamine or long-term halope ridol

pretreatment. J Neural Transm 1986:65:125-134.

72. Hagensen D, Smith DF. Central lithium injection induces seizures in reserpinized rats: role of serotonin. IRCS Med Sci 1986:14:919.

73. Enig B, Petersen HN, Smith DF, Larsen B. Food preferences, nutrient intake and nutritional status in cancer patients. Acta Oncologica 1987:26:1-5.

74. Smith DF. Lithium attenuates clonidine-induced hypoactivity: Further studies in inbred mouse strains. Psychopharmacology 1988:94:428-43O. 75. Smith DF. Lithium alters the stereoselectivity of monoamine oxidase in rat brain. J Neural Transm 1989:76:2O5-21O.

76. Petersen HN, Smith DF, Enig B. The severity of depression in cancer patients. Scand J Psychol 1988:29:126-128.

77. Smith DF, Hokland M. Love and salutogenesis in late adole scence: A pre limi nary investigation. Psychology - A Journal of Human Behavior 1988:25:44-49.

78. Sterndorff B, Smith DF. Normal values for type A behavior patterns in Danish men and women in potential high-risk groups. Scand J Psychol 1990:31:49-54.

79. Christensen M-K, Smith DF. Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats. J Neural Transm 1990:80:189-194.

80. Smith DF. Effects of lithium and rolipram enantiomers on locomotor activity in inbred mice. Pharmacol Toxicol 1990:66:142-145.

81. Tytgat D, Gelbcke M, Smith DF. Convenient synthesis of chiral 1-phenyl-1,2-propranediamines. Preliminary pharmaco logical results. Pharmacie, 1990:45:835-836.

82. Smith DF. How to study effects of lithium on spatial features in macromolecules: actions on the stereoselectivity of rat brain monoamine oxidase. In: Sandler

M, Dahlström A, Belmaker RH, eds. Progress in Catecholamine Research. Part B: Central Aspects. New York: Alan R. Liss, 1988, 371-375.

83. Smith DF. Molecular mechanisms of action of lithium: effect on the stereoselectivity of rat brain MAO. In: Birch NJ, ed. Inorganic Pharmacology and Psychiatric Use. IRL Press: Oxford, 1988, 333-334.

84. Smith DF, Jensen PN, Poulsen SH, Mikkelsen O, Elbaz E, Glaser R. Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on serotonergic

mechanisms in rats:Locomotor activity, paroxetine binding, monoamine oxidase activity, 5-HT uptake and 5-HT-induced vasocontraction. European J Phar macology 1991:19 6:85-91.

Quebec

Aarhus

1991

2012

Burnout, sense of coherence and sources of salutogenesis in social workers. Baker, Martyn; North, Daniel; Smith, Donald F. Psychology: A Journal of Human Behavior,Vol 34(1), 1997, 22-26.

85. Smith DF, Sterndorff B. Female physicians outscore male physicians and the general public on Type A scales in Denmark. Behavioral Medicine 1991:17:184-189.86. Smith, DF, Jensen PN, Gelbcke M, Tytgat D. Effects of 3,N,N'-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain. Jour nal of Neural Transmission 1992:88:177-185.87. Smith, D.F., Sterndorff, B. Coronary-prone behavior may be declining in Danish men and women. Scand J Psychol 1993:34: 379-383.88. Soerensen, J.B., Smith, D.F. Enhancement of Y-maze learning by piracetam, 2-thio-1- pyrrolidine-acetamide and 2-

thio-1- pyrro lidi ne-thio-acetamide in rats. J. Neural Transm (P-D Sect) 6:139 - 144, 1993.89. Smith, D.F. Type A personalities tend to have low platelet monoamine oxidase activity. Acta Psychiatr Scand. 89: 88-91, 1994.90. Licht, R.W., Larsen, J.O., Smith, D., Brændgaard, H. Effect ofchronic lithium treatment

with or without haloperidol on number and sizes of neurons in rat neocortex. Psychopharmacology,115: 371-374, 1994.91. Jensen, P.N., Smith, D.F., Poulsen, J.H., Møller, H.J., Rosenberg, R. Effect of flunarizine and calcium on serotonin uptake in human and rat blood platelets and rat synaptosomes. Biol.Psychi atry, 36: 118-123, 1994. 92. Wardle, J., Steptoe, A., Smith, H., Groll-Knapp, E., Koller, M., Smith, D., Brodziak, A. Breast self- examination: attitudes and practices among young women in Europe. European J. Cancer Preven tion, 4: 61-68, 1995.93. Chahboun, S., Gelbcke, M., Smith, D.F. Antidepresseurs potentiels: Synthese et stereochimie de 2,3,4,4a,9,9a- hexahydro-9-phenyl-1H-indeno[1,2-b]pyraxines. Bull. Soc. Chim. Belg., 104:613-622, 1995. 94. Gee, A.D., Smith, D., Gjedde, A. The synthesis of [O-methyl-11C]venlafaxine: A potential tracer of the 5-HT reuptake

site. J. Labelled Comp. Radiopharm., 37: 309-310, 1995.95. Smith, D.F., Glaser, R., Gee, A., Gjedde, A. [11C]-Nefopam as a

potential PET tracer of serotonin reuptake sites. Initial findings in living pig brain. In: Quantification of Brain Function Using PET. Myers, R., Cunningham, V.J., Bailey, D.L., Jones, T. (eds). Academic Press, San

Diego, 1996, pp. 49-53. 96. Smith, D.F., Sterndorff, B., Røpcke, G., Gustavsen, E.M., Hansen, J.K. Prevalence and severity of anxiety, depression

and Type A behaviors in angina pectoris. Scand. J. Psychology, 37: 249 – 258, 1996. 97. Gee, A.D., Smith, D.F., Gjedde, A. The synthesis of [O-methyl-11C]venlafaxine: A non- classical, fast-acting

antidepressant. J. Labelled Comp.Radiopharm., 39: 89 - 95, 1997. 98. Licht, R.W., Smith, D.F., Brændgaard, H. The effect of chronic lithium treatment on the calibre of axons and nerve

fibres in the rat sural nerve.Euro. Neuropsychopharm., 7: 95 - 98, 1997. 99. Smith, D.F., Jensen, P.N., Gee, A.D., Hansen, S.B., Danielsen, E., Andersen,F., Saiz, P.-A., Gjedde, A. PET neuroimaging

with [11C]venlafaxine: serotonin uptake inhibition, biodistribution and binding in living pig brain. Euro. Neuropsychopharm., 7: 195 - 200, 1997. 100. Baker, M., North, D., Smith, D.F. Burnout, sense of coherence and sources of salutogenesis n social workers. Psychology, A Journal of Human Behavior, 34: 22 - 26, 1997. 101. Wegener, G., Smith, D.F., Rosenberg, R. 5-HT1A receptors in lithium-induced conditioned taste aversion.

Psychopharmacology, 133: 51-54,1997.

Quebec

Aarhus

102. Poulsen, P.H., Smith, D.F., Østergaard, L., Danielsen, E.H., Gee, A., Hansen, S.B., Astrup, J., Gjedde, A. In vivo estimation of cerebral blood flow, oxygen consumption and

glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose. J. Neurosci. Methods, 77: 199 - 209,

1997. 103. Østergaard, L., Smith, D.F., Vestergaard-Poulsen, P., Hansen, S.B., Gee, A., Gjedde, A., Gyldensted, C. Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: Comparison with positron emission tomography values. J. Cereb. Blood Flow Metab., 18: 425 - 432, 1998. 104. Danielsen, E., Smith, D.F., Poulsen, P.H., Østergaard, L., Gee, A., Ishizu, K., Venkatachalam, T.K., Bender, D., Hansen, S., Gjedde, A., Scheel-Krüger, J., Møller, A. Positron emission tomography of living brain in minipigs and domestic pigs. Scand. J. Lab. Anim. Sci. Suppl. 1., 25: 127 – 135, 1998.105. Smith, D.F., Poulsen, P.H., Ishizu, K., Sakoh, M., Hansen, S.B., Gee, A.D., Bender, A.D., Gjedde, A. Quantitative PET analysis of regional cerebral blood flow and glucose and oxygen metabolism in response to fenfluramine in living porcine brain. J. Neurosci. Methods, 86: 17 – 23, 1998. 106. Smith, D.F., Gee, A.D., Hansen, S.B., Moldt, P., Østergaard Nielsen, E., Scheel-Krüger, J., Gjedde, A. Uptake and distribution of a new SSRI, NS2381, studied by PET in living porcine brain. European Neuropsychopharmacology, 9: 351-359, 1999. 107. Danielsen, E.H., Smith, D.F., Gee, A.D., Venkatachalam, T.K., Hansen, S.B., Hermansen, F., Gjedde, A., Cumming, P. Cerebral 6-[18F]fluoro-L-dopa (FDOPA) metabolism in pig studied by positron emission tomography. Synapse, 33: 247-258, 1999. 108. Smith, D.F. Neuroimaging of serotonin uptake sites and antidepressant binding sites in the thalamus of humans and 'higher' animals. European Neuropsychopharmacology, 9: 537- 544, 1999. 109. Simonsen, C.Z., Østergaard, L., Smith, D.F., Vestergaard- Poulsen, P. and Gyldensten, C. Comparison of gradient- and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking. J. Magn. Reson. Imaging, 12: 411-416, 2000. 110. Ishizu, K., Smith, D.F., Bender, D., Danielsen, E., Hansen, S.B., Wong, D.F., Cumming, P. and Gjedde, A. Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release. Synapse, 38: 87-101, 2000.111. Sakoh, M., Østergaard, L., Røhl, L., Smith, D.F., Simonsen,C.Z., Sørensen, J.C., Poulsen, P.V., Gyldensted, C., Sakaki, S., Gjedde, A. Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequen tial multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours after stroke in pigs. J. Neurosurg. 93: 647-657, 2000. 112. Cumming, P., Kretzschmar, M., Brust, P., Smith, D.F. Quantitative radioluminography of serotonin uptake sites in the porcine brain. Synapse, 39: 351-355, 2001. 113. Marthi, K., Bender, D., Smith, D.F. Synthesis of [N-methyl-11C]mianserin: a tetracyclic, atypical antidepressant. J. Labelled Cpd. Radiopharm., 44: 121-126, 2001. 114. Cumming, P., Danielsen, E.H., Vafaee, M., Falborg, L., Steffensen, E., Sørensen, J.C., Gillings, N., Bender, D., Marthi, K., Andersen, F., Munk, O., Smith, D., Møller, A., Gjedde, A. Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. Acta Neurol. Scand., 103: 309-315, 2001. 115. Smith, D.F., Bender, D., Marthi, K., Cumming, P., Hansen, S.B., Peters, D., Østergaard Nielsen, E., Scheel-Krüger, J., Gjedde, A. Synthesis and evaluation of racemic [11C]NS2456

and its enantiomers as selective serotonin reuptake radiotracers for PET. Nuclear Medicine and Biology, 28: 265-270, 2001. 116. Danielsen, E.H., Smith, D.F., Hermansen, F., Gjedde, A., Cumming, P. Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo. Synapse, 41: 172-175, 2001.117. Smith, D.F., Geday, J. PET neuroimaging of clomipramine challenge in humans: focus on the thalamus. Brain Res., 892: 193-197, 2001.

118. Cumming, P., Danielsen, E.H., Vafaee, M., Falborg, L., Steffensen, E., Sørensen, J.C., Gillings, N., Bender, D., Marthi, K., Andersen, F., Munk, O., Smith, D., Møller, A., Gjedde, A. Normalization of markers of dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. Acta Neurol. Scand., 103: 309-315, 2001.119. Smith, D.F., Hansen, S.B., Østergaard, L., Gee, A.D., Danielsen, E., Ishizu, K., Bender, D., Poulsen, P.H., Gjedde, A. [14C]Serotonin uptake and [O-methyl-11C]velafaxine kinetics in porcine brain. Nuclear Medicine and Biology, 28: 633-638, 2001. 120. Sakoh, M., Østergaard, L., Gjedde, A., Røhl, L., Vestergaard-Poulsen, P., Smith, D.F., Le Bihan, D., Sakaki, S., Gyldensted, C. Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. J. Neurosurg. 95: 450- 458, 2001.121. Danielsen, E.H., Smith, D.F., Andersen, F., Gee, A.D., Bender, D., Hansen, S.B., Hermansen, F., Østergaard, L., Cumming, P., Gjedde, A. FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation. J. Neurosci. Methods, 111: 157-168, 2001. 122. Marthi, K., Bender, D., Watanabe, H., Smith, D.F. PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain. Nucl. Med. Biol., 29: 317-319, 2002.123. Marthi, K., Bender, D., Gjedde, A., Smith, D.F. [11C]Mirtazapine for PET neuroimaging: radiosynthesis and initial evaluation in the living porcine brain. Eur.

Neuropsychopharmacol., 12: 427-432, 2002. 124. Jensen, S.B., Bender, D., Smith, D.F., Scheel-Krüger, J., Nielsen, E.Ø., Olsen, G.M., Peters, D., Gjedde, A. Synthesis of ()3-(6-nitro-2-quinolinyl)[9-methyl-11C]-3,9-diazabicyclo- [4.2.1] nonane ([11C-methyl]NS 4194). J. Label. Compd. Radiopharm., 45: 181-189, 2002. 125. Licht, R.W., Larsen, J.O., Smith, D., Braendgaard, H. Chronic lithium treatment with or without haloperidol fails to affect the morphology of the rat cerebellum. Eur. Neuropsychopharmacol., 13: 173-176, 2003. 126. Jensen, S.B., Smith, D.F., Bender, D., Jakobsen, S., Peters, D., Nielsen, E.Ø., Olsen, G.M., Scheel-Krüger, J., Wilson, A., Cumming, P. [11C]-NS 4194 versus [11C]-DASB for PET imaging of serotonin transporters in living porcine brain. Synapse, 49: 170-177, 2003. 127. Marthi, K., Hansen, S.B., Jakobsen, S., Bender, D., Smith, S.B., Smith, D.F. Biodistribution and radiation dosimetry of [N-methyl-11C]mirtazapine, an antidepressant affecting adrenoceptors. Applied Radiation and Isotopes, 59: 175-179,2003. 128. Cumming, P., Rosa-Neto, P., Watanabe, H., Smith, D., Bender, D., Clarke, P.B.S., Gjedde, A. Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain. NeuroImage, 19: 1127-1136, 2003. 129. Marthi, K., Jakobsen, S., Bender, D., Hansen, S.B., Smith, S.B., Hermansen, F, Rosenberg, R, Smith, D.F. [N-methyl-(11)C]Mirtazapine for positron emission tomography neuroimaging of antidepressant actions in humans. Psychopharmacology, 174: 260-265, 2004.130. Bender, D., Olsen, A.K., Marthi, M.K., Smith, D.F., Cumming, P. PET evaluation of the uptake of N-[11C]methyl CP-643,051, an NK1 receptor antagonist, in the living porcine brain. Nuclear Medicine and Biology, 31: 699-704, 2004.131. Davanlou, M., Smith, D.F. Unbiased stereological estimation of different cell types in rat cerebral cortex. Image Anal. Stereol. 23: 1-11, 2004.132. Geday, J., Hermansen, F., Rosenberg, R., Smith, D.F. Serotonin modulation of cerebral blood flow measured with positron emission tomography (PET) in humans. Synapse, 55: 224-229, 2005.

133. Smith, D.F., Marthi, K., Munk, O.L., Cumming, P., Hansen, S.B., Jakobsen, S. PET neuroimaging of [11C]mirtazapine enantiomers in pigs. European

Neuropsychopharmacology, 16: 350-357, 2005.134. Smith, D.F., Dyve, S., Minuzzi, L., Jakobsen, S., Munk, O.L., Marthi, K., Cumming, P.

Inhibition of [11C]mirtazapine binding by α2-adrenoceptor antagonists studied by positron emission tomography in living porcine brain. Synapse, 59: 463-471, 2006. 135. Jakobsen, S., Pedersen, K., Smith, D.F., Jensen, S.B., Munk, O.L., Cumming, P. Detection

of α2-adrenergic receptors in brain of living pig with 11C-yohimbine. Journal of Nuclear Medicine, 47: 2008-2015, 2006. 136. Smith, D.F., Stork, B.S., Wegener, G., Jakobsen, S., Bender, D., Audrain, H., Jensen, S.V.,

Hansen, S.B.,Rodell, A., Rosenberg, R. Receptor occupancy of mirtazapine determined by PET in healthy volunteers, Psychopharmacology, 195: 131-138, 2007 137. Smith, D.F. and Jakobsen, S. Stereoselective neuroimaging in vivo. Eur. Neuropsychopharm. 17:507-522, 2007138. Smith, D.F., Hansen, S.B., Jakobsen, S., Bender, D., Auddrain, H., Ashkanian, M., Stork,

B.S., Minuzzi, L., Hall, H., Rosenberg, R. Neuroimaging of mirtazapine enantiomers in humans. Psychopharmacology, 200: 273-279, 2008139. Smith, D.F. and Jakobsen, S. Molecular tools for assessing human depression by positron

emission tomography. European Neuropsychopharmacology, 19: 611-628, 2009140.Smith, D.F., Stork, B.S., Wegener, G., Ashkanian, M., Jakobsen, S., Bender, D., Audrain,

H., Vase, K.H., Hansen, S.B., Videbech, P., Rosenberg, R. [11C]Mirtazapine binding in depressed antidepressant nonresponders studied by PET neuroimaging. Psychopharmacology, 206:133-140, 2009141. Guidi, S., Bianchi,P., Alstrup, A.K.O., Henningsen, K., Smith, D.F., Bartesaghi, R. Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen minipig. Brain Research Bulletin, 85: 169-179, 2011. 142. Munk, O.L., Smith, D.F. PET kinetics of radiolabelled antidepressant [N-methyl-11C]mirtazapine, in the human brain. European Journal of Nuclear Medicine and Molecular

Imaging Research, 1:36, 2011, Open access. 143. Smith, D.F., Gerdes, L.U. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatrica Scand. 125: 189-193, 2012.

144. Smith, D.F. Benefits of flavanol-rich cocoa-derived products for mental well-being: A review. Journal of Functional Foods, 5: 10-15, 2013145. Smith, D.F., Noedskov, H., Winterdahl, M., Lund, T.E. Replication attempt to estimate depression severity by fuzzy logic analysis of emotion-focused fMRI. Journal of Magnetic Resonance Imaging, 37: 498-499, 2013146. Smith, D.F., Jakobsen, S. Molecular neurobiology of depression: PET findings on the elusive correlation with symptom severity. Frontiers in Psychiatry, March 4, 2014 (doi: 10.3389/fpsyt.2013.00008147. Smith, D.F. Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk. Frontiers in Psychiatry, June 18, 2013 (doi: 10.3389/fpsyt.2013.00057)148. Winterdahl, M., Audrain, H., Landau, A.M., Smith, D.F., Bonaventure, P., Shoblock, J.R., Carruthers, N., Swanson, D., Bender, D. PET brain imaging of neuropeptide Y2 receptors using N-[11C]methyl-JNJ-31020028 in pigs, Journal of Nuclear Medicine, 55: 1-5, 2014. 149. Smith, D.F. Systematic review of an emerging trend in China: resting-state functional connectivity in major depressive disorder. Journal of Neuroscience and Clinical Neuroscience, 2014: doi: 10.1176/appi.neuropsych.13110343.

Review articles in peer-reviewed journals1. Smith DF. Factors affecting renal lithium elimination. Me dikon 1977:6:6-15.2. Smith DF. Behavior of rats given lithium salts. A review. Pharmacopsychia tria 1977:10:79-88.3. Smith DF. Tranylcypromine stereoisomers, monoaminergic neurotransmission and behavior. A minireview. Pharmakopsychiatr Neuropsychopharmakol 1980:13:130-136.4. Smith DF. Stereopsychopharmacology: Past, present and future. Prog Neuro psychopharmacol & Biol Psychiat 1983:8:3 27-350.5. Smith DF. Stereochemical considerations of the actions of some psychotrop ic drugs. Pharmacopsychiatia 1985:18:225-230.6. Smith DF. The stereoselectivity of serotonin uptake in brain tissue and blood platelets: The topography of the serotonin uptake area. Neurosci Biobehav Rev 1986:10:37-46.7. Smith DF. Wirkung von Lithium auf die Bewegungsaktivität von Versuchs tieren. In: Müller-Oerlinghausen B, Greil W, eds. Die Lithiumtherapie. Nutzen, Risiken, Alternativen. Berlin: Springer-Verlag, 1986, 51-59.8. Smith DF. Common molecular features in antipsychotic drugs and the topo graphy of their binding site. Nord Psykiatr Tidsskr 1987:41:475-481.9. Smith DF. Introduction. In: Smith DF, ed. Handbook of Stere oi somers:Therapeutic Drugs. Boca Raton, Fl.: CRC Press Inc., 1989, pp. 1 -22.10. Smith DF. Psychotropic drugs. In: Smith DF, ed. Handbook of Stereoisomers: Therapeutic Drugs. Boca Raton, Fl.; CRC Press Inc., 1989, pp. 438-456.11. Smith DF. The stereoselectivity of drug action. Pharmacol Toxicol 1989:65:321-331.12. Smith DF. Strategies in behavioral research on affective disorders: principles, problems and pitfalls. Pharmacol Toxicol 1990:66 (Suppl III):139-143.13. Smith, D.F. MAO stereoselectivity. In: Lithium: New Applications. S. Johnson & F.N. Johnson (eds), Marius Press,Lancaster, 1993, pp. 314 - 317.14. Smith, D.F. Negative emotions and coronary heart disease: Causally related or merely coexistent? A review. Scand. J. Psychol., 42: 57-70, 2001. 15. Smith, D.F. Functional salutogenic mechanisms of the brain. Perspectives in Biology and Medicine, 45: 319 – 328, 2002.16. Smith, D.F. and Jakobsen, S. Stereoselective neuroimaging in vivo. Eur. Neuropsychopharm. 17:507-522, 2007.17. Smith, D.F. and Jakobsen, S. Molecular tools for assessing human depression by positron emission tomography. European Neuropsychopharmacology, 19: 611-628, 2009. 18. Smith, D.F. Cognitive Brain Mapping for Better or Worse. Perspect. Biol. Med. 53(3): 321-329, 2010.19. Smith, D.F. and Gerdes, L.U. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatr. Scand. 125(3): 189-193, 2012.20. Alstrup, A.K.O. and Smith, D.F. PET neuroimaging in pigs. Scand. J. Lab. Anim. Sci. 39(1):25-45, 2012.21. Smith, D.F., and Jakobsen, S. Molecular neurobiology of depression: PET findings on the elusive correlation with symptom severity . Frontiers in Psychiatry 4, 1-15, 2013.

What’s the Score?

149 Original research reports in peer-reviewed journals 21 Review articles in peer-reviewed scientific journals

11 Book chapters 2 Handbooks as Chief Editor 3 Books on selected topics

Total: 186 Scientific Publications

Carrier of 45 years (1970 – 2015) = 540 months540 / 186 = 2.9 months per publication

Academic DegreesBSc Psychology Duke University

MA Physiological Psychology McMaster UniversityPhD Biopsychology University of Chicago

MSc Pharmacology Aarhus UniversityDMSc Psychiatry Copenhagen University

Official ”Thanks” to everyone who has ever worked at The Psychopharmacology

Research Unit, The Center for Psychiatric Research, and The Translational

Neuropsychiatry Unit at the Psychiatric Hospital in Risskov

as well as

The PET Center and CFIN at Aarhus University Hospital