My Opa Thies
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yopa es Myopathies Muscular Dystrophies Myotonic Dystrophy Congenital Myopathies Metabolic Myopathies Inflammatory Myopathies Ion Channel Myopathies Toxic Myopathies Muscle Biopsy Contraindication/ Low-yield Electrolyte disturbances Most endocrine diseases Malignant hyperthermia Myasthenic syndromes Myotonic disorders Old age Periodic paralysis Poor nutrition Muscle Biopsy Type of Muscles Red Muscles White Muscles Aerobic respiration Numerous mitochondria Capillary density Designed for y Postural y Sustained activity Capable of anaerobic respiration Fewer mitochondria Abundant glycogen Designed for y Sudden action y Intermittent action Fiber Typing Type 1 Type 2 Colour Red White Adenosine TPH Oxidative enzyme Glycogen Phosphorylase Lipid content Distribution (average) 35% 65% Normal Muscle Normal Muscle Nucleus at periphery Normal Muscle (ATPase), pH 9.4 Type 1 Fiber (1) Type 2 Fiber (2) Tendinous Insertion Artifacts Freezing Artifact Vacuolar-like change Contraction Artifact Fiber Atrophy Type 1 Type 2 Myotonic dystrophy Nemaline myopathy Centrinuclear myopathy Cogenital fiber-type disproportion Corticosteroid Rx, Hypercorticoidism Myasthenia gravis Disuse atrophy Acute denervation Paraneoplastic myopathy Morphology Type 2 Atrophy in Malignancy (Myosin immunostain) Neurogenic Atrophy Groupin g of small angular fibers Neurogenic Atrophy (ATPase, pH 9.4) Neurogenic Atrophy (NADPH) Target fibers inner unstained Zero surrounded by a rim of enzyme activity Pathognomonic Chronic Denervation with Reinervation Type grouping
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