MUSCULOSKELETAL BLOCK Pathology OSTEOMYELITIS and SEPTIC ARTHRITIS
MUSCULOSKELETAL BLOCK Pathology Lecture 2: Congenital and developmental bone diseases
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Transcript of MUSCULOSKELETAL BLOCK Pathology Lecture 2: Congenital and developmental bone diseases
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MUSCULOSKELETAL BLOCK
Pathology Lecture 2:
Congenital and developmental bone diseases
Dr. Maha ArafahDr. Abdulmalik Alsheikh, MD, FRCPC
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Diseases of Bones
• Objectives – Be aware of some important congenital and
developmental bone diseases and their principal pathological features
– Understand the etiology, pathogenesis and clinical features of osteoporosis
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Diseases of Bones
• Congenital• Acquired– Metabolic– Infections – Traumatic – Tumors
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Congenital Diseases of Bones
• Localized or entire skeleton• Dysostoses• dysplasias– Osteogenesis imperfecta – Achondroplasia– Osteopetrosis ( rare, defect in osteoclast function)
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Congenital Diseases of Bones
• Osteogenesis imperfecta– Brittle bone disease– Hereditary disorders– Defect in the synthesis of type I collagen– Extreme fragility of skeleton with susceptibility to
fractures– Four main types with different clinical
manifestations – Type 1: blue sclera in both eye, deformed teeth
and hearing loss
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Congenital Diseases of Bones
• Achondroplasia– Dwarfism– Defect in the cartilage synthesis at growth plates– Mutation in Fibroblast growth factor receptor 3
(FGFR3) lead to inhibition of chondrocytes proliferation
– Epiphyseal growth plate expansion is suppressed
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METABOLIC BONE DISESES
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OSTEOPOROSIS
Is a term that denotes increased porosity of the skeleton resulting from reduction in the bone
mass. It may be localized →disuse osteoporosis of a
limb . or
may involve the entire skeleton, as a metabolic bone disease.
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OSTEOPOROSIS
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OSTEOPOROSIS
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Vertebral bone with osteoporosis and a compression fracture
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OSTEOPOROSIS
•Primary •Secondary
PRIMARY: post menopausal Senile
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OSTEOPOROSIS
•Secondary:–Endocrine Disorders–Gastrointestinal disorders–Neoplasia–Drugs
Table 21-1 page 804
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OSTEOPOROSIS
Pathophysiology:•Occur when the balance between bone
formation and resorption tilts in favor of resorption
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OSTEOPOROSIS
• Pathophysiology:– Genetic factors– Nutritional effects– Physical activity– Aging– Menopause
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OSTEOPOROSIS
Pathophysiology:•AGING
– ↓replicative activity of the osteoprogenitor cells– ↓synthetic activity of the osteoblasts.– ↓activity of the matrix bound growth factors.
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OSTEOPOROSIS
•Menopause:– ↓serum estrogen– ↑IL-1,IL-6 levels– ↑osteoclast activity
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OSTEOPOROSIS
• Clinical features– Difficult to diagnose– Remain asymptomatic ----fracture– Fractures• Vertebrae• Femoral neck
– Bone density by radiographic measures
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Diagnosis
• Plain X ray: cannot detect osteoporosis until 30% to 40% of bone mass has already disappeared.
• Dual-emission X-ray absorptiometry (DXA scan): is used primarily to evaluate bone mineral density, to diagnose and follow up pt. with osteoporosis.
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Prognosis
• Osteoporosis is rarely lethal.• Patients have an increased mortality rate due
to the complications of fracture.• E.g. hip fractures can lead to decreased
mobility and an additional risk of numerous complications: deep vein thrombosis, pulmonary embolism and pneumonia
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OSTEOPOROSIS Prevention Strategies•The best long-term approach to osteoporosis is
prevention .•children and young adults, particularly women, with
a good diet (with enough calcium and vitamin D) and get plenty of exercise, will build up and maintain
bone mass.• This will provide a good reserve against bone loss
later in life. Exercise places stress on bones that builds up bone mass