Muscular Contractions

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Muscular Contractions. Contracting and Relaxing Skeletal Muscle. Anatomy of a Muscle Fiber (Cell). Sarcolemma Myofibril Sarcomere Z line. Anatomy of a Sarcomere. Actin Myosin. Contraction Overview. Lovely artwork courtesy of David Goodsell and the RCSB Protein Data Bank. - PowerPoint PPT Presentation

Transcript of Muscular Contractions

  • MUSCULAR CONTRACTIONSContracting and Relaxing Skeletal Muscle

  • Anatomy of a Muscle Fiber (Cell)SarcolemmaMyofibrilSarcomereZ line

  • Anatomy of a SarcomereActinMyosin

  • Contraction OverviewLovely artwork courtesy of David Goodsell and the RCSB Protein Data Bank

  • Steps of a Muscle ContractionNerve causes release of acetylcholine (ACh)

  • Steps of a Muscle ContractionReception of ACh causes an action potential (electrical nerve signal) in muscle cell

  • Steps of a Muscle ContractionAction potential causes release of calcium in muscle cellMeanwhile

  • Steps of a Muscle ContractionCalcium binds, forming troponin complex and revealing myosin binding sites.

  • Steps of a Muscle ContractionSliding filament theory

  • Contraction OverviewLovely artwork courtesy of David Goodsell and the RCSB Protein Data Bank

  • RelaxationAcetylcholinesterase breaks down AchActive transport prepares the muscle cell for future action potentialsActive transport removes free calcium from muscle cellsATP breaks actin-myosin linkage

  • Relaxation

  • InterferenceBotox & botulism block acetylcholine releaseRigor mortis cant keep calcium out of cells so muscles contract, lack of ATP prevents myosin from releasing actin