MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2009
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Transcript of MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2009
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MUSCLE STRUCTURE AND PHYSIOLOGY
J. Rosenbluth, April 2009
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MUSCLE
• Skeletal muscle – Contraction mechanism– Excitation-contraction coupling
• Gross properties of skeletal muscle
• Cardiac, obliquely striated and smooth muscles
• Pathology/Clinical examples
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Skeletal muscle band pattern
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Double “antiparallel” array of myofilamnts (H.E.Huxley)
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Sliding filament model
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Myosin molecules
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Myosin filament formation
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Low-angle X-ray diffraction of skeletal muscle (meridional pattern)
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Actin double helix
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Decorated F-actin
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Decorated F-actin attached to Z-disc
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Double hexagonal array (vertebrate skeletal muscle)
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Low-angle X-ray diffraction of skeletal muscle (equatorial pattern)
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Crossbridge position during relaxation (top) vs contraction (bottom)
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Cross-bridge Cycle
– Attached
– Released
– Cocked
– Force generating
– Attached
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Focal contraction (amphibian skeletal muscle)
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Triads (amphibian)
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Skeletal muscle triad (amphibian)
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Triad model(Franzini-Armstrong, C.)
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Actin filament with Tr and Tm
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Tropomyosin movement
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Pennate Muscles
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Length-Tension
Relationship
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Load-Velocity Relationship
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Twitch vs Tetanic Tension
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Cat Gastrocmenius
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Muscles Have Heterogenous Properties
Twitch Contractions
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Skeletal Muscle Fatigue
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Cardiac muscle
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Obliquely striated muscle (Ascaris), stretched
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Ascaris obliquely striated muscle
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Smooth muscle (“Myoelastic tissue”)
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Smooth muscle (cross section)
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Smooth muscle (Science 148:1337-1339)
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Smooth muscle
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ABRM
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ABRM
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“Pseudohypertrophy” (Duchenne dystrophy)
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Charcot-Marie-Tooth disease
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Spinal muscular atrophy
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