MSC : Changing Paradigm The New Medicine
-
Upload
dr-pradeep-mahajan -
Category
Healthcare
-
view
64 -
download
0
Transcript of MSC : Changing Paradigm The New Medicine
![Page 1: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/1.jpg)
![Page 2: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/2.jpg)
Outline of TalkGlobal perspectiveNeed of Hour: MSC as a drug moleculeDrugs ≠ Regeneration thus Stem CellsWhat is Regenerative MedicineStem Cells are the main streamMSC- as drug
![Page 3: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/3.jpg)
India
![Page 4: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/4.jpg)
Innovations are required…new treatment therapies are required………..
“We can’t solve the problem by using the same kind of thinking we used when we created them”
- Albert Einstein
![Page 5: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/5.jpg)
A Paradigm Shift in HealthcareHeading towards cure from signs and symptoms
suppressionAssure complete safety and minimum side effectsAlso ensure long-term benefits
Need of the hour….
![Page 6: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/6.jpg)
![Page 7: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/7.jpg)
“Cells are not single molecular agents but are rather, site-regulated, adaptive agents capable of very complex functions involving a multitude of bioactive factors and reactivities.”
MSC: A complete genome for healing is available
Drug: A single molecule with limited applications
![Page 8: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/8.jpg)
Repair
![Page 9: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/9.jpg)
Stem Cell Potential..RepairRejuvenateReplaceRestoreMaintainEnhance…. This is regardless of any cause for the injury
to the cell or tissue or organ….
![Page 10: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/10.jpg)
Stem Cells Applications : Hype or Hope
“ Imagine if a doctor says to you that you are diagnosed with an untreatable condition and you have to live with it and die with it ….what will be your state !!!!!”
A story from fiction to facts
![Page 11: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/11.jpg)
![Page 12: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/12.jpg)
“I have thought a lot about stem cells , and I am sure that when the historians will look back at the 20th century…the greatest scientific achievement will not be from the field of space technology or computer technology but will be from the tissue engineering and genetic medicine.”
-Michael Goulian-ABC Scientific News Reporter,
29-9-1999.
![Page 13: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/13.jpg)
Are we churning the old wheel again??
![Page 14: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/14.jpg)
YOU ARE ALIVE….
Blood Every Second
Skin Every 2 Weeks
Bones Every 20 Years
Your Innate Regenerative Capacity
![Page 15: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/15.jpg)
![Page 16: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/16.jpg)
![Page 17: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/17.jpg)
![Page 18: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/18.jpg)
Regenerative Medicine
Tissue Engineering
![Page 19: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/19.jpg)
MSCs and PericytesChang’s hypothesisPericytes are present on the capillaries and micro-
vesselsThese pericytes appear to be getting recruited by
body’s intelligence upon any injury…Pericytes also appear to understand the injury
process as well as the required repair mechanism…
They are the mechanics, getting all the spare parts in place..or may be working just as bio-catalysts
![Page 20: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/20.jpg)
All MSCs are pricytes…but all pericytes are not MSCs….
![Page 21: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/21.jpg)
![Page 22: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/22.jpg)
![Page 23: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/23.jpg)
MSC as antibacterial activity, antibacterial protein
Human CAP-18/LL37
![Page 24: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/24.jpg)
This calls for a new thought… Are MSCs merely MSCs or…they actually are..“Medicinal Signaling Cells” …?
A complete regenerative micro-environment created…Act like an injury-specific drug store!!
![Page 25: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/25.jpg)
![Page 26: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/26.jpg)
![Page 27: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/27.jpg)
![Page 28: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/28.jpg)
![Page 29: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/29.jpg)
![Page 30: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/30.jpg)
![Page 31: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/31.jpg)
Trophic Factors
![Page 32: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/32.jpg)
![Page 33: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/33.jpg)
![Page 34: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/34.jpg)
![Page 35: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/35.jpg)
![Page 36: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/36.jpg)
![Page 37: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/37.jpg)
Over-all drug-like actions of MSCsImmuno-modulatory: control immune function in
facvour of bodyAnti-inflammatory: reduce unwanted
compensatory mechanismsAnti-apoptotic: Allow regenerationCell differentiation: all functions regainedProtein and cytokine synthesis (through mRNA
activation): Micro-environment enrichmentAngiogenic: assurance of continued effectAnti-Bacterial activity & Release micro verticals
transporting functional mRNA & micro RNA
![Page 38: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/38.jpg)
One MSC….ALL ACTIONS!!
![Page 39: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/39.jpg)
What is MSC exactly???Mesenchymal Stem Cell??
Mesenchymal Stromal Cell??
Medicinal Signaling Cell??
![Page 40: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/40.jpg)
ISCT definitionA cell that adheres to plasticExpresses CD 105, 90, 73Does not express CD 34, 45 and 13HLA DR is absent
All these virtues of this MSC make them interesting, innovative drug molecule…
![Page 41: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/41.jpg)
Additional features…MSCs can be customized as per need…
The immunomodulating action can be modified as per need…
TLR 4 priming…. Pro-inflammatory---MSC1TLR3 priming….immuno-suppressive…MSC2
![Page 42: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/42.jpg)
How about tumorogenicity??Autologous MSCs Allogenic MSCsDNA garbage
accumulationMutationsSenescenceTelomer e shorteningMalignancy not possible
Xeno in nature..Hence, preferential
elimination by the recipient body
No scope for any malignancy
This very fact makes Allogenic-MSCs as best choice future drugs!!
![Page 43: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/43.jpg)
![Page 44: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/44.jpg)
![Page 45: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/45.jpg)
![Page 46: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/46.jpg)
![Page 47: MSC : Changing Paradigm The New Medicine](https://reader035.fdocuments.in/reader035/viewer/2022062310/5873a3451a28aba3548b45c5/html5/thumbnails/47.jpg)
“ You carry your own repairing kits in your body”