MRI evaluation of TMJ internal derangement: Degree of ... · MRI evaluation of TMJ internal...

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ORIGINAL ARTICLE MRI evaluation of TMJ internal derangement: Degree of anterior disc displacement correlated with other TMJ soft tissue and osseous abnormalities Nahla Mohamed Ali Hasan a, * , Tarek Elsayed Ftohy Abdelrahman b a Department of Diagnostic Radiology, Sohag Faculty of Medicine, Sohag University, Egypt b Department of Maxillofacial Surgery. Sohag Faculty of Medicine, Sohag University, Egypt Received 12 January 2014; accepted 24 March 2014 Available online 21 April 2014 KEYWORDS MRI; TMJ dysfunction; Anterior disc displacement Abstract Objective: To evaluate the relationship between anterior disc displacement (ADD) degree and other temporomandibular joint (TMJ) soft tissues and osseous abnormalities in symp- tomatic TMJ dysfunction based on magnetic resonance imaging findings. Patients and methods: MR images of 106 TMJs in 53 patients, presented with symptomatic TMJ dysfunction were included. Degree of ADD was detected and its relationship to joint effusion, ret- rodiscal layer integrity, thickness of lateral pterygoid muscle (LPM) attachments, degenerative changes and condylar position and translation as well as clinical manifestations was studied. Results: Compared with normal disc position, risk of joint effusion and degenerative changes were significantly increased with increased degree of ADD (p < 0.05). LPM attachment thickening and retrodiscal layer abnormalities are significantly associated with an advanced degree of ADD (p < 0.05). Risk of ADD is significantly increased with posterior position of the condyle within the fossa. Conclusion: There is a direct relationship between the ADD degree and other TMJ soft tissues and bone abnormalities as well as the severity of clinical manifestations, so early MRI detection and reporting of ADD degree and other MRI findings might help clinicians in full assessment and deter- mining strategy of management of TMJ dysfunction. Ó 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society of Radiology and Nuclear Medicine. 1. Introduction Temporomandibular joint (TMJ) dysfunction is a common problem and affects up to one-third of all adults at some stage in their life (1). The most frequent cause of TMJ dysfunction is internal derangement which refers to an alteration in the normal pathways of motion of the TMJ that largely involves * Corresponding author. Tel.: +20 1006892117; fax: +20 934602963. E-mail addresses: [email protected] (N.M.A. Hasan), tarekf- [email protected] (T.E.F. Abdelrahman). Peer review under responsibility of Egyptian Society of Radiology and Nuclear Medicine. The Egyptian Journal of Radiology and Nuclear Medicine (2014) 45, 735–744 Egyptian Society of Radiology and Nuclear Medicine The Egyptian Journal of Radiology and Nuclear Medicine www.elsevier.com/locate/ejrnm www.sciencedirect.com 0378-603X Ó 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society of Radiology and Nuclear Medicine. http://dx.doi.org/10.1016/j.ejrnm.2014.03.013 Open access under CC BY-NC-ND license. Open access under CC BY-NC-ND license.

Transcript of MRI evaluation of TMJ internal derangement: Degree of ... · MRI evaluation of TMJ internal...

Page 1: MRI evaluation of TMJ internal derangement: Degree of ... · MRI evaluation of TMJ internal derangement 737. 2.2.6. Position of the condyle. Position of the condylar head in relation

The Egyptian Journal of Radiology and Nuclear Medicine (2014) 45, 735–744

Egyptian Society of Radiology and Nuclear Medicine

The Egyptian Journal of Radiology andNuclearMedicine

www.elsevier.com/locate/ejrnmwww.sciencedirect.com

ORIGINAL ARTICLE

MRI evaluation of TMJ internal derangement:

Degree of anterior disc displacement correlated

with other TMJ soft tissue and osseous

abnormalities

* Corresponding author. Tel.: +20 1006892117; fax: +20 934602963.E-mail addresses: [email protected] (N.M.A. Hasan), tarekf-

[email protected] (T.E.F. Abdelrahman).

Peer review under responsibility of Egyptian Society of Radiology and

Nuclear Medicine.

0378-603X � 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society of Radiology and Nuclear Medicine.

http://dx.doi.org/10.1016/j.ejrnm.2014.03.013Open access under CC BY-NC-ND license.

Nahla Mohamed Ali Hasan a,*, Tarek Elsayed Ftohy Abdelrahman b

a Department of Diagnostic Radiology, Sohag Faculty of Medicine, Sohag University, Egyptb Department of Maxillofacial Surgery. Sohag Faculty of Medicine, Sohag University, Egypt

Received 12 January 2014; accepted 24 March 2014Available online 21 April 2014

KEYWORDS

MRI;

TMJ dysfunction;

Anterior disc displacement

Abstract Objective: To evaluate the relationship between anterior disc displacement (ADD)

degree and other temporomandibular joint (TMJ) soft tissues and osseous abnormalities in symp-

tomatic TMJ dysfunction based on magnetic resonance imaging findings.

Patients and methods: MR images of 106 TMJs in 53 patients, presented with symptomatic TMJ

dysfunction were included. Degree of ADD was detected and its relationship to joint effusion, ret-

rodiscal layer integrity, thickness of lateral pterygoid muscle (LPM) attachments, degenerative

changes and condylar position and translation as well as clinical manifestations was studied.

Results: Compared with normal disc position, risk of joint effusion and degenerative changes were

significantly increased with increased degree of ADD (p< 0.05). LPM attachment thickening and

retrodiscal layer abnormalities are significantly associated with an advanced degree of ADD

(p< 0.05). Risk of ADD is significantly increased with posterior position of the condyle within

the fossa.

Conclusion: There is a direct relationship between the ADD degree and other TMJ soft tissues and

bone abnormalities as well as the severity of clinical manifestations, so early MRI detection and

reporting of ADD degree and other MRI findings might help clinicians in full assessment and deter-

mining strategy of management of TMJ dysfunction.� 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society of Radiology and Nuclear

Medicine. Open access under CC BY-NC-ND license.

1. Introduction

Temporomandibular joint (TMJ) dysfunction is a commonproblem and affects up to one-third of all adults at some stage

in their life (1). The most frequent cause of TMJ dysfunction isinternal derangement which refers to an alteration in thenormal pathways of motion of the TMJ that largely involves

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Fig. 1a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows the disc in its normal

position between the condyle and temporal bone and centred in

the intermediate zone (arrow).

736 N.M.A. Hasan, T.E.F. Abdelrahman

the function of the articular disc, therefore, these alterationshave been also referred to as disc derangement (2). Anteriordisc displacement (ADD) is one of the major findings in

TMJ internal derangement. Anterior disc displacement withreduction (ADDWR) and anterior disc displacement withoutreduction (ADDWOR) are the two most common forms of

TMJ disc displacement (3), while posterior displacement is rare(4). State-of-the-art magnetic resonance imaging (MRI) tech-niques allow analysis of disc position in both sagittal and coro-

nal planes, dynamic assessment of condylar translation anddisc movement during opening and closing the mouth (5).Other MRI signs that can suggest a diagnosis of TMJ dysfunc-tion include thickening of lateral pterygoid muscle (LPM)

attachment, rupture of retrodiscal layers or joint effusion (6).Relationship between ADD and joint effusion and degener-

ative changes have been discussed frequently in previous stud-

ies (7–9), while ADD relationship to LPM thickness andretrodiscal layer integrity as well as condylar position withinthe glenoid fossa and condylar translation has not been fre-

quently covered.The purpose of this study was to evaluate ADD in cases of

symptomatic TMJ dysfunction and to investigate the relation-

ship between its degree and other TMJ soft tissues and osseousabnormalities. Also in this study we tried to assess the correla-tion between the degree of disc displacement and the clinicalmanifestations of the patients.

2. Patients and methods

This prospective study included MR images of 106 TMJs in 53

patients (17 males and 36 females, mean age was 25.9 years)were referred to the MRI unit in Diagnostic RadiologyDepartment at a teaching University Hospital from August

2010 to October 2012, presented by symptomatic unilateralor bilateral TMJ dysfunction (TMJ clicking, TMJ locking,restricted movement of the jaw or pain in the TMJ region).

Patients with TMJ fractures, or systemic diseases knownto affect the TMJ, such as rheumatoid arthritis wereexcluded. Also patients with posterior disc displacement were

excluded.

2.1. MRI technique

All MRIs had been obtained by using 1.5-T machine (Philips-

Acheiva), Netherlands using TMJ surface coli. Pulse sequencesincluded sagittal oblique T2-weighted images (T2WI) and pro-ton density (PD) weighted images in close- and open-mouth

positions (TR = 3000/3500 ms, TE = 120/30 ms respectively)and coronal PD weighted images in closed mouth position(TR= 3500 ms, TE = 30 ms). Section thickness was 2 mm

with a 0.2 mm intersection gap. The field of view was 12 cmfor sagittal images and 18 cm for coronal images.

2.2. Image analysis

2.2.1. ADD

The 1st step was evaluation of the disc location in both closed-

and open-mouth positions relative to the condyle and articulareminence.

ADD was assessed in sagittal oblique plane in both closed-

and open-mouth positions and coronal plane in closed mouth

position. According to the degree of ADD, our series was clas-sified into 4 categories.

2.2.2. Category 0

Normal disc position (the thin intermediate zone interposedbetween the condyle and the adjacent temporal bone, wher-ever the two bones are most closely apposed to one another

regardless of whether or not the mouth was open or closed)(Fig. 1) (10). Category I: Partial anterior disc displacementwith reduction (PADDWR); disc displaced anteriorly in

closed mouth up to the posterior band interposed betweenthe two most closely apposed cortical bone surfaces of thecondyle and eminence with disc reduction to normal loca-

tion in open mouth position (Fig. 2). Category II: Partialanterior disc displacement without reduction (PADDWOR);disc displaced anteriorly in closed mouth as described in cat-

egory I, that maintained displaced with mouth opening(Fig. 3). Category III: Complete anterior disc displacementwith reduction (CADDWR); disc displaced anteriorly inclosed mouth up to no disc substance interposed between

the two most closely apposed cortical bone surfaces of thecondyle and eminence with disc reduction to normal loca-tion in open mouth position (Fig. 4). Category IV: Complete

anterior disc displacement without reduction (CADDWOR);disc displaced anteriorly in closed mouth as described in cat-egory III, that maintained displaced with mouth opening

(Fig. 5).

2.2.3. Disc morphology

Normal disc morphology is biconcave structure in sagittal

images with homogenous low signal intensity. Disc deformitiesincluding thickening, irregularity, flattening, folded, degenera-tion, and perforation were reported (Fig. 6).

2.2.4. Joint effusion

Joint effusion was assessed on T2WI manifesting as area ofhyperintensity, which was divided into 3 grades (11). Grade

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Fig. 1b Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows that the disc has maintained

its normal position during condylar movement (arrow).

Fig. 2a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows partial anterior disc dis-

placement with intermediate signal of degeneration (large arrow)

and anterior osteophyte of the condyle (small arrow).

Fig. 2b Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows that the disc has maintained

its normal position during condylar movement (arrow).

Fig. 3a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows (flattened shape) partial

anterior disc displacement (arrow).

Fig. 3b Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows that the disc remains partially

displaced from its normal location (arrow), associated with Grade

I joint effusion.

MRI evaluation of TMJ internal derangement 737

0: None (no bright signal in either joint space). Grade I: Slighteffusion (a bright signal in either joint space that conforms to

the contours of the disc, fossa/articular eminence, and or con-dyle). Grade II: Frank effusion (a bright signal in either jointspace that extends beyond the osseous contours of fossa/artic-

ular eminence, and or condyle and has a convex configurationin the anterior or posterior recesses.

2.2.5. Degenerative changes

TMJ osteoarthritis was diagnosed when more than one of thefollowing changes were noted; fattening of the articular sur-face, subcortical sclerosis or cyst, surface erosion, osteophytes,

and generalized sclerosis for the condylar head and flatteningof the articular eminence, subcortical sclerosis, and surfaceerosions for the fossa (11).

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Fig. 4a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows (thickened shape) complete

anterior disc displacement (arrow) and associated joint effusion in

both upper and lower joint recesses.

Fig. 4b Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows that the disc (arrow) has

maintained its normal position during condylar movement.

Fig. 5a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows complete anterior disc

displacement (arrow).

Fig. 5b Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows that the disc remains

displaced from its normal location (arrow) and cortical erosion

of the condyle (small arrow). Note the marked restricted mobility

of the condyle apex where it translates to less than the apex of the

articular eminence.

738 N.M.A. Hasan, T.E.F. Abdelrahman

2.2.6. Position of the condyle

Position of the condylar head in relation to the articular fossawas assessed in PD sagittal oblique images in closed mouthposition and was classified as concentric, anterior or posterior

position.

2.2.7. Translation of the condyle

Condyle translation was assessed in PD sagittal oblique imagesin open mouth position as follows; apex of the condyle trans-lates to less than the apex of the articular eminence, apex of thecondyle translates to the apex of the articular eminence, which

is a position many authors consider normal, or apex of thecondyle translates beyond the apex of the articular eminence(11) (Fig. 7).

2.2.8. Thickness of LPM attachments

Thickness of LPM attachments was assessed in closed mouthsagittal oblique PD weighted images and compared with theaverage thickness of LPM attachments in asymptomatic nor-

mal TMJ included in this study (Fig. 8).Integrity and thickness of retrodiscal layers: Integrity of

both superior and inferior retrodiscal layers was assessed in

open mouth sagittal oblique T2-weighted images. Images wereevaluated for thinning, thickening or rupture of either of supe-rior or inferior layer (Fig. 9).

2.2.9. Clinical evaluation

We divided patients into 3 groups according severity of clinicalmanifestation and we found that: Group I. EARLY cases who

presented with painless clicking with No restricted motion.Group II. INTERMEDIATE group who presented with

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Fig. 6a Sagittal oblique spin-echo proton-density–weighted MR

images (closed-mouth position) show abnormal disc morphology:

(a) shows intermediate signal of degeneration within the disc

(arrow).

Fig. 6b Shows fattened, irregular disc with complete anterior

displacement (arrow) associated with osteoarthritic changes and

joint effusion.

Fig. 6c Shows ballooning of posterior disc band with complete

anterior displacement (arrow) associated with osteoarthritic

changes and joint effusion.

Fig. 6d Shows perforated disc with complete anterior displace-

ment (arrow) associated with osteoarthritic changes (cortical

erosion and irregular articular surface of the condyle and small

anterior osteophyte)

Fig. 7a Sagittal oblique spin-echo proton-density–weighted MR

images (open-mouth position) show the translation of the condyle

in relation to the articular eminence (a) the apex of the condyle

(arrow head) translates to the apex of the articular eminence

(asterisk), which is considered normal.

Fig. 7b Shows complete anterior disc displacement without

reduction and restricted mobility of the condyle i.e., the apex of

the condyle (arrow head) translates to less than the apex of the

articular eminence (asterisk).

MRI evaluation of TMJ internal derangement 739

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Fig. 7c Shows normal disc position with hypermobility of the

condyle i.e. the apex of the condyle (arrow head) translates beyond

the apex of the articular eminence (asterisk).

Fig. 8a Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows normal disc position (large

arrow) and normal thickness of inferior LPM insertion (small

arrow).

Fig. 8b Sagittal oblique spin-echo proton-density–weighted MR

image (closed-mouth position) shows complete anterior disc

displacement (arrow) and thickened inferior LPM insertion (arrow

head), compared with (a).

Fig. 9a Sagittal oblique spin-echo proton-density–weighted MR

image (open-mouth position) shows normal intact superior (large

arrow) and inferior (small arrow) retrodiscal layers.

Fig. 9b Sagittal oblique T2-weighted MR image (open-mouth

position) shows thickening of superior retrodiscal layer (large

arrow) and normal inferior retrodiscal layer (small arrow).

740 N.M.A. Hasan, T.E.F. Abdelrahman

frequent pain, joint tenderness, headaches, locking restrictedmotion and painful chewing. Group III. LATE cases who pre-sented with trismus, joint crepitus and marked chronic pain.

Clinical manifestations were evaluated and registered andwere correlated to the degree of ADD in MRI.

2.2.10. Data analysis

Statistical analysis of the relationship between degree of ADDand other soft tissue and bone MRI findings was done usinglogistic regression analysis. Odds ratio with p-value <0.05

was considered significant and p-value <0.01 was consideredhighly significant.

3. Results

This study described a series of 106 TMJ in 53 patients, 17males and 36 females with male to female ratio 1:2.1. Their

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Table 1 Basic clinical data.

No. of patients 53

Sex distribution No. (%)

Male 17 (32)

Female 36 (68)

Mean patient’s age (years) 25.9

No. of TMJ 106

Degree of ADD

Category 0 (normal disc position) 34 (32.1)

Category I (PADDWR) 37 (34.9)

Category II (PADDWOR) 5 (4.7)

Category III (CADDWR) 12 (11.3)

Category IV (CADDWOR) 18 (17)

TMJ, temporomandibular joint; PADDWR, partial anterior disc

displacement with reduction; PADDWOR, partial anterior disc

displacement without reduction; CADDWR, compete anterior disc

displacement with reduction; CADDWOR, complete anterior disc

displacement without reduction.

MRI evaluation of TMJ internal derangement 741

ages ranged between 19 and 43 years (mean age: 25.9 years). 34(32.1%) TMJs had normal disc position, while 72 (67.9%) had

ADD, Table 1.Disc deformity (thickening, irregularity, flattening) was

observed in 50% of joints with ADD, with increased frequency

with increasing degree of ADD, from 11% in PADDWR,reaching up to 100% in CADDWOR, while disc perforationwas reported only in 5 TMJs with complete ADD.

Table 2 Degree of ADD correlated to joint effusion grade and deg

Category 0 Category I

Joint effusion

Grade 0 29(85.3) 20(54.1)

Grade I 4(11.8) 10 (27)

Grade II 4 2 (5.9) 7 (18.9)

OR 4.9**

Degenerative changes No. (%)

Positive 10 (29.4) 16 (43.2)

Negative 24 (70.6) 21 (56.8)

OR 1.8

ADD, anterior disc displacement; OR, Odds ratio,* p< 0.05.** p< 0.01.

Table 3 Degree of ADD correlated to LPM and retrodiscal abnor

Category 0 Category I

LPM attachment

Normal 34 (100) 32 (86.5)

Thick – 5 (13.5)

Retrodiscal layers

Normal 34 (100) 37 (100)

Abnormal – –

Ruptured

Thin

Thick

ADD, anterior disc displacement; LPM, lateral pterygoid muscle.

Risk of joint effusion significantly increased with thechange of the disc position, from normal to ADDWR (oddsratio 4.9 for PADDWR and 5.8 for CADDWR) to ADD-

WOR (odds ratio 8.7 for PADDWOR and 9.1 for CADD-WOR). Risk of degenerative changes increased significantlyin joints with ADD compared to joints with normal disc posi-

tion, and increased in frequency with increasing degree ofADD. Compared to normal joints, joints with PADDWR,PADDWOR, CADDWR and CADDWOR had 1.8, 3.6, 4.8

and 6.2 odds ratio, respectively Table 2.Thickening of LPM attachment was significantly observed

with increasing frequency from PADDWR to PADDWORto CADDWR then decreased in CADDWOR, 13.5%, 20%,

41.7%, and 33.3%. respectively. Morphological changes of ret-rodiscal layers were most frequently observed in CADDWOR,followed by PADDWOR, then CADDWR, 88.9%, 60% and

33.3%, respectively Table 3.ADD was observed more frequently in joints with posterior

position of the condyle within the glenoid fossa in closed

mouth position rather than concentric condyle position; witha significantly increased frequency from 27% in joints withPADDWR (3.8 odds ratio) to 72.2% in joints with CADD-

WOR (16.2 odds ratio). Restricted mobility of the condyle inopen mouth (apex of the condyle translates to less than theapex of the articular eminence) was significantly observedmore frequently in CADDWR and CADDWOR while hyper-

mobility (apex of the condyle translates beyond the apex of thearticular eminence) was significantly more detected in PADD-WOR Table 4.

enerative changes.

Category II Category III Category IV

2 (40) 6 (50) 7(38.9)

2 (40) 3 (25) 3(16.7)

1 (20) 3 (25) 8 (44.4)

8.7** 5.8** 9.1**

3 (60) 8 (66.7) 13 (72.2)

2 (40) 4 (33.3) 5 (27.8)

3.6 4.8* 6.2**

malities.

Category II Category III Category IV

4 (80) 7 (58.3) 12 (66.7)

1 (20) 5 (41.7) 6 (33.3)

2(40) 8 (66.7) 2 (11.1)

1 (20) - 2 (11.1)

2 (40) - 11 (61.1)

4 (33.3) 3 (16.7)

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Table 4 Degree of ADD correlated to condylar position and translation.

Category 0 Category I Category II Category III Category IV

Condylar position No. (%)

Concentric 31 (91.2) 27 (73) 2 (40) 5 (41.7) 7 (38.9)

Posterior 3 (8.8) 10 (27) 3 (60) 7 (58.3) 11 (61.1)

OR 3.8 15.5* 14.5** 16.2**

Condylar translation

Less than the apex – 2 (5.4) 1 (20) 3 (25) 11 (61.1).

To the apex 30 (88.2) 30 (81.1) 4 (80) 9 (75) 7 (38.9) -

Beyond the apex 4 (11.8) 5(13.5) - - -

ADD, anterior disc displacement; OR, Odds ratio.* p< 0.05.** p < 0.01.

742 N.M.A. Hasan, T.E.F. Abdelrahman

As regards the clinical classification; 74 (70%) out of 106TMJs were symptomatic and we founded a positive correlation

between the severity of their clinical manifestations and degreeof anterior disc displacement detected in MR images. Group I(39 joints, 53%) had normal disc position or PADDWR,Group II had PADDWOR or CADDWR (17 joints, 23%)

and Group III had CADDWOR (18 joints, 24%).On the other hand, 32 (30%) out of 106 TMJs were asymp-

tomatic, 29 joints of them had normal disc position while 3

joints had PADDWR.

4. Discussion

ADD is considered a major cause of TMJ internal derange-ment and subsequently TMJ dysfunction. MRI has beenreported to be 95% accurate in assessment of disc position

and 93% accurate in assessment of osseous changes (12).Many authors defined normal disc position in closed mouth

by location of the posterior band at the superior or 12 o’clock

position relative to the condyle and the disc position is abnor-mal if the angle between the posterior band and vertical orien-tation of the condyle exceeds 10� (angle of displacement)(13,14). However, according to this definition, disc displace-

ment is detected in about 33% of asymptomatic volunteers(15,16). So, in this study, for assessment of disc position, weused the intermediate zone as a point of reference, emphasizing

its interpretation between the condyle and the temporal bone,not taking into account the angle of displacement of the pos-terior band (10). In this study, ADD was classified into 4

grades according to degree of displacement in closed mouthand the presence or absence of reduction in open mouth andpartial ADDWR was detected in 9% of asymptomatic TMJs.

It is now generally accepted and understood that joint effu-sion occurs with disc displacement (17,18). Changes in thecomposition of the synovial fluid may increase the intra-artic-ular friction, leading to unstable disc motion (19), these bio-

chemical changes may also affect the joint lubrication andnutritional requirements of the articular surfaces (2).

Results of this study showed that joint effusion was

observed more frequently in joints with ADD compared tojoints with normal disc position, moreover, its incidence pro-portionally increased from about 5 times in PADDWR to

about 9 times in CADDWOR. Roh et al. (20) after studying254 patients, have also reported that the incidence of joint effu-

sion was nearly twice as likely when there was ADDWR com-pared to normal discs and more than four times as likely in the

presence of ADDWOR.On the other hand, we observed that about 15% of TMJ

with normal disc position showed joint effusion. Similar resultsobtained by Roh et al. in a study included 508 TMJs of 254

patients (20). This could be explained in two ways, first;according to the hypothesis that the presence of synovial fluidis normal in the joint in small amount. Suenaga et al. (21)

reported joint effusion in up to 9% of asymptomatic individu-als. The second way is considering joint effusion is indicative ofsynovial tissue response to an inflammatory stimulus in TMJ

with normally positioned disc (22).In this study, degenerative changes were more frequently

observed in TMJ with ADD than TMJ with normal disc posi-

tion with its increased incidence from about twice in PAD-DWR to about six times in CADDWOR. These results weresupported with those of previous studies that consideredADD as an aetiological factor of osteoarthritis and/or to be

associated with osteoarthritis (23–25).The role of LPM in normal TMJ function is still controver-

sial. Results of this study showed significant incidence of

hypertrophy of inferior LPM attachment in TMJ with internalderangement compared to joints with normal disc position andthere was a parallel increased inferior LPM thickness with

respect to disc displacement degree.This was in agreement with the results of Tomas et al. (6)

and was supported with the results of electromyographic stud-ies, that showed in cases of TMJ internal derangement, inferior

LPM may become hyperactive in specific positions to help sta-bilize and position the condyle and the disc (26).

Other previous studies have demonstrated morphologic and

pathologic changes in LPM in cases of TMJ with internalderangement (27,28).

Retrodiscal layers play an important role in normal disc

displacement. Results of this study showed a significant corre-lation between ADD degree and morphological changes of ret-rodiscal layers, either thickening, thinning or even rupture.

Thinning of retrodiscal layers was identified in TMJ withADD without reduction. This sign may be due to retrodiscallayer atrophy in chronic stages of internal derangement causedby decreased disc vascularity and fibrous transformation

due to continuous compression and shear (29). Thickeningof retrodiscal layers was less frequently reported in thisseries. Thickening of the posterior meniscal attachment

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MRI evaluation of TMJ internal derangement 743

(pseudo-meniscus sign) was identified byManzione et al. (30) insome cases of TMJ with ADD and was explained as a type ofTMJ protective reaction and affected patients may be less

symptomatic than those who do not have this thickening.Tomas et al. (6) described rupture of superior retrodiscal

layer in 2 patients with severe non-reduced disc displacement

and suggested that it may produce significant disc instabilityand in our study, this sign was identified in 3 TMJ with non-reduced ADD, one had partial displacement and two had com-

plete displacement.The correlation between signs and symptoms of tempro-

mandibular joint disorders and condylar position is controver-sial (31,32). Compared to TMJ with normal disc position, the

present study founded a significant association between poster-ior condyle position within the glenoid fossa in closed mouthand ADD, but no significant differences between variable

degrees of displacement. This could be explained as condylarposition posterior to the normal position may lead to deterio-ration in the disc ligaments, TMJ ligament and the disc itself

(33).Limitation of condylar translation in open mouth was

observed in this series only in joints with ADD and signifi-

cantly more frequent in cases of CADDWOR followed byCADDWR, which could be explained as the anteriorly posi-tioned disc may act as a mechanical interference to the anteriortranslation of the condyle to its normal position at the apex of

the articular eminence in open mouth. A previous studyassessed the degree of mandibular mobility in patients with aclinical diagnosis of temporomandibular disorder and healthy

individuals and found a significant difference in the groups ofpatients with muscle disorders and disc displacement withreduction regarding mandibular mobility when compared with

the control group. Nevertheless, the measurements of the 2groups were within the clinically normal values established inthe diagnostic criteria for temporomandibular disorders

(RDC/TMD) (34).

5. Conclusion

ADD is a common finding in TMJ internal derangement. Theresults show a direct relationship between the degree of ADDand MRI findings of other TMJ soft tissues and bone abnor-malities as well as the severity of clinical manifestations, so

early MRI detection and reporting of ADD degree and otherMRI findings might help clinicians in full assessment anddetermining the strategy of management of TMJ dysfunction.

Conflict of interest

We have no conflict of interest to declare.

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