Mr Geoff Herd - gpcme.co.nzgpcme.co.nz/pdf/2017 South/Sat_Room1_0945_Herd... · Geoff Herd South...
Transcript of Mr Geoff Herd - gpcme.co.nzgpcme.co.nz/pdf/2017 South/Sat_Room1_0945_Herd... · Geoff Herd South...
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Mr Geoff HerdPoint-of-Care Testing Coordinator
Northland District Health Board
Whangarei
9:45 - 10:15 Point of Care Testing
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Point-of-Care Testing
in Rural and General Practice
Geoff Herd
South GPCME Conference
12 August 2017
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Introduction
• Definitions and Applications of POCT:
– History lesson(!)
– POCT & With-Patient Testing
• Quality & Risk Management
• Community POCT Experience
– Scope & Scale of POCT in GP
– Optimising the Patient Journey
– Cost effectiveness
– Improving access to care
in the Hokianga
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POCT: the Oldest Form
of Clinical Laboratory Medicine
• 1500 BC Indian physicians: ants attracted to
urine from patients with boils (?diabetes)
• 1350 BC Ancient Egyptians: pregnancy test
urine B-hCG germinates barley or wheat (!)
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Uroscopy:colourodourturbidityvolumeviscositytastesweetness
Middle Ages Uroscopy Wheel
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Dr’s Personal Travelling Kit
Clinitest
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Point-of-Care or With-Patient Testing
• medical lab testing with the patient
(bedside or decentralised testing)
• reduces Therapeutic TAT e.g.:
– critical care: blood gas analysis, glucose
– emergency care: Lactate, cTN, B-hCG
– clinics & GP: CRP, HbA1c, BNP, INR, etc
• POCT is complementary to medical lab testing
– should be integrated with clinical pathways
– varies between hospitals & between countries
• POCT can help to improve access and outcomes
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OR/Theatre
Blood Gases TEG
GP / Clinic:
HbA1c;
Alb/Cr ratio
GP/ED
Troponin BNP
GP / Pharmacy
Lipids / INR
GP/Home
Glucose
GP/ ED B-hCG
Creatinine
POCT = WITH patient testing
Whole of life Instant
Testing for Health
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PATIENT
SELF-
ADVOCACY
MIDDLE CLASS
GROWTH
ADVANCES IN
TECHNOLOGY
URBANIZATIONCHRONIC
DISEASES
AGING
POPULATIONS
21st Century Health Trends and Drivers for POCT
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Key question for any POCT proposalNZPOCTAG Best Practice Guidelines for POCT;2014
“What is the clinical problem that needs to be solved by point of care testing that cannot be solved by conventionallaboratory testing?”
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Solving a Clinical Problem
POC INR Testing Prior to Surgery – 5 min
Assessment
Collect blood & test INR
Check ResultsINR <1.5
SurgeryRecovery
Patient re-starts warfarin
Day of SurgeryTravel to hospital
Home
GP
Pre-Op
Clinic
Optimising the Patient Journey
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Pre & Post Analytical POCT Error
Poor quality Sample
Poor Quality Results
Transcription Error
Good quality sample
Patient Harm
Best Quality POCT Device or Analyser
Best Quality POCT Device or Analyser
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Quality Management Systems
• Patient safety is paramount
• Governance provides executive authority
to implement POCT supported by QMS1,2
• QMS in health is a strategic tool to
improve patient outcomes
• QMS for POCT comprises -– Quality Control: Sampling, IQC, EQA, ILCP,
– Quality Assurance: Staff Training; Accreditation
– Continuous Quality Improvement : clinical audit, PDSA
• QMS is A Sustainable POCT Risk Management System
(1) Musaad and Herd NZMJ 2013; 126: No1383(2) Herd and Musaad NZMJ 2015; 128: No1471
QMS
QA
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NDHB POC HbA1c Waikato EQA Results:
Siemens DCA Vantage x5 OPD Locations
Sample Site NDHB Waikato
Number Date BOI CHC DLC DRG KTA mean Median
101 Mar-14 97 99 95 100 100 98.2 102
102 Apr-14 98 96 93 93 91 94.2 93
103 May-14 82 80 81 80 81 80.8 81
104 Jun-14 77 74 75 74 75 75 75
105 Jul-14 87 84 80 79 82 82.4 81
106 Aug-14 82 75 77 74 77 77 77
107 Sep-14 97 97 97 100 103 98.8 100
108 Oct-14 69 68 66 69 62 66.8 68
109 Nov-14 73 75 77 79 78 76.4 76
110 Dec-14 65 70 65 67 70 67.4 66
Mean 83 82 81 82 82 82 81.9
POCT HbA1c results can be accurate and reliable
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Are POCT results accurate ? Example: whole
blood Creatinine NDHB data July 2015
• i-STAT whole blood v cobas 6000 plasma
• POCT enzymatic v Lab picrate (umol/L)
• n = 31; r2 = 0.9968; slope =0.9119; intercept= 5.8
• Important range for safety decisions is 100 - 150 umol/L
0
100
200
300
400
500
600
700
0 100 200 300 400 500 600
Yo
ur
Va
lue
Reference Value
Result Comparison
Your Value
Through Origin
Slope and Intercept
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Survey POCT in Primary CareTurner et al Fam Pract 2016 Aug;33(4)388-394
• POCT which may help diagnosis
Condition Percentage of all conditions (n)
Percentage of respondents
UTI 12.4 (521) 47.0
PE/DVT 11.4 (478) 43.1
Acute cardiac disease 9.2 (387) 25.4
INR 6.7 (282) 17.9
Pregnancy 4.2 (178) 16.1
Anaemia 3.9 (162) 14.6
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Survey POCT in Primary Care Turner et al Fam Pract 2016 Aug;33(4)388-394
• POCT would help reduce referrals
Condition Percentage of all conditions (n)
Percentage of respondents
PE/DVT 21.4 (517) 46.6
Acute cardiac disease 11.2 (271) 24.4
Diabetes 5.5 (133) 12.0
COPD / Asthma 5.0 (122) 11.0
Heart Failure 4.8 (116) 10.5
INR 4.1 (100) 9.0
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Survey POCT in Primary CareTurner et al Fam Pract 2016 Aug;33(4)388-394
• POCT would help management & monitoring
Condition Percentage of all conditions (n)
Percentage of respondents
INR 16.7 (547) 49.3
Diabetes 16.0 (527) 47.5
Acute & chronicrenal failure
7.0 (230) 20.7
COPD / Asthma 6.8 (223) 20.1
Lipid disorder 4.7 (154) 13.9
Hyper/hypothyroidism 3.7 (121) 10.9
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Barriers to POCT for Rural & GPWONCA SIG 2016
• Cost of devices
• Lack of reimbursement
• Staffing issues, training & time
• Perceptions about test accuracy
• Logistics, space and storage
• Cost of QC & Accreditation requirements
• Lack of knowledge: how to set up POCT?
• (Perceived?) lack of support from suppliers
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Australian POCT in GP TrialRCT 53 Practices 4968 patients
Laurence et al 2010 BJGP 60; e98-e104
• Patient Satisfaction Statements: p value
• Prefer finger prick test < 0.001
• Labs have better hygiene(!) < 0.001
• Confidence in results < 0.010
• No need to travel to lab < 0.009
• Extra time & transport costs 0.510
• Immediate feedback important <0.003
• More motivated with POC Tests <0.001
• Strengthened Pt/GP relationship 0.010
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POCT in GP & the Community Improving Access to Care:
Group A Streptococcus Testing to Help Prevent Rheumatic Fever
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Improving Access to Care:
Rapid Group A Streptococcus Testing in GP
• Urban General Practice in Whangarei
• Social deprivation; high health needs
• Crowding patient follow-up difficult
• Trial POCT Group A Strep testing
– NDHB lab validation completed
– T/S test with QuikRead go
– treat positives with penicillin
– “one stop shop”
– rapid tracing of contacts
– community engagement
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• Evaluation of POCT in Heart Health (EPOCH)
• Research question: can POCT increase the
number of CVD assessments in GP setting?
• Primary Goal to compare numbers of
completed assessments in 20 practices:
– 10 practices use Roche cobas b101
– 10 control practices use lab service
– POC Tests: HbA1c & Lipids
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KaitaiaKaeo
KerikeriKaikohe
Kawakawa
Whangarei(x3)
Waipu
200 km
Kaitaia
Whangarei
Waipu
Roche cobas b101 locations
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QC: Level 1 & Level 2; GP Locations
Level 2 IQC
Test HbA1c Chol Trig HDLmmol/mol mmol/L mmol/L mmol/L
Count 68 68 68 68
Mean 79.62 6.38 4.2 1.8
SD 3.28 0.21 0.12 0.11
CV% 4.12 3.25 2.85 6.16
Level 1 IQC
Test HbA1c Chol Trig HDLmmol/mol mmol/L mmol/L mmol/L
Count 71 69 69 69
Mean 33.21 3.69 1.1 1.03
SD 1.79 0.13 0.06 0.08
CV% 5.38 3.61 5.78 7.32cobas b101
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• POCT usability & acceptability
–“rather than nurses spending two hours in
the afternoon trying to contact patients with
blood test results – then unsure if patient
understands what the nurse is saying. Much
quicker and then finished face to face.”
Wells et al 2017 PLoS ONE 12(4):e0174504
cobas b101
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• Nurses in GP : opportunistic screening
– “POCT good for patients who can’t get to a lab”
– “particularly the younger ones, 45-55 yrs,
Maori men loved it - instant result”
– “We loved the tool as we got results back
immediately so could start the conversation”
Wells et al 2017 PLoS ONE 12(4):e0174504
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WDHB: POCT for 11 Rural PracticesMelanie Adriaansen & Stephanie Williams WDHB
• Goal to improve management of acutely unwell patients
• Troponin, D.dimer, INR, FBC
under evaluation
• Improve diagnostic certainty
• Avoid unnecessary ED visits/hospitalisations
• Inform care plans: right care at the right time
• Increase knowledge and skills
• Improve access to lab testing for rural patients
• Reduce anxiety / waiting for test results
• Reduce patients need for travel & treat close to home
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13 Practices
in WDHB…
7 Main Practices:
1. Wellsford Medical Centre2. Kawau Bay Health3. Kowhai Surgery4. Kumeu Village Medical Centre5. The Doctors (Huapai) Limited6. Waimauku Doctors7. Kaipara Medical Centre
6 Satellite Practices: 1. Matakana2. Maungaturoto3. Paparoa4. Snells Beach5. Mangawhai6. Silver Fern Medical
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Challenges for Rural & Community POCT
• Usability of devices
• Acceptability in the clinical setting
• Sustainability needs QMS
– supplier support for devices/QC etc
– novelty value diminishes
– staff changes & workload increases
– willing to use the instrument & do QC
• POCT must be integrated:
– with patient pathway
– results integrated with EMR
• POCT must be affordable &
• POCT must improve the patient experience
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Northland Health Services Plan
2012-2017
“We need to do things
differently to address
the impending tsunami
of escalating demand
for services.
Specifically, we need
to be dealing with
health needs more
effectively ‘upstream’,
in the primary &
community setting.”
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POCT Evaluation in Hokianga• Rawene Hospital 2 hours to Whangarei
• High deprivation; no lab service
• 10 beds + maternity
• GP and clinics
• i-STAT Analyser:– Blood gases Biochemistry, TnI, BNP
– POCT set up with NDHB QMS:
• Staff Training
• QC/QA programme
• Oversight by NDHB
Blattner K, et al. Changes in clinical practice and patient disposition following the introduction of point-of-
care testing in a rural hospital. Health Policy 2010a:96:7–12
Blattner K, et al Introducing point-of-care testing into a rural hospital setting: thematic analysis of interviews
with providers. J Primary Health Care 2010b;2 (1):54–60.
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POCT Evaluation in Hokianga
• Rawene Hospital 2 hours to Whangarei
• High deprivation; no lab service
• 10 beds + maternity
• GP and clinics
Outcome:• Improved patient disposition & diagnostic certainty
• Cost to Rawene $90K incl some longer bed stays
• Net saving to NDHB in reduced transfers/costs $362K
Blattner K, et al. Changes in clinical practice and patient disposition following the introduction of point-of-
care testing in a rural hospital. Health Policy 2010a:96:7–12
Blattner K, et al Introducing point-of-care testing into a rural hospital setting: thematic analysis of interviews
with providers. J Primary Health Care 2010b;2 (1):54–60.
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Nursing Review 2017 Issue 3: 22-24
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Abbott CELL-DYN Emerald 22 Haematology Analyser
• Analyser measures: • Hb, RBC, indices, WBC and Platelets
• 5 Part WBC differential
• WBC differential absolute and % WBC
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Anticipated benefits of POC Haematology at Rawene
• FBC expected to add critical diagnostic information in most emergency patients
• acute cases with potential for deterioration: • paediatrics• any poorly differentiated patient, • possible neutropenic sepsis in chemo patients • gastrointestinal bleeding, • bleeding in a patient on anti-coagulants, • early sepsis
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Patient
Optimised
Controlled
TestingT
C
O
P
Point-of-Care Testing: a new definition, a new paradigm
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“Everything you wanted to know about Point-of-Care Testing in Rural and General Practice
but were afraid to ask!”
• Vast scope & scale of POC testing• Diverse applications & settings• Seek advice about devices, tests & QA• New technologies easy to use & reliable• Assists diagnosis, referral & monitoring• Patients are more engaged & motivated• Improves access & improves outcomes
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Acknowledgements
Dr Peter Chapman-Smith
Organising Committee South
General Practice Conference
and Medical Exhibition
Melanie Adriaansen, WDHB
Stephanie Williams, WDHB