Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden &...
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Transcript of Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden &...
![Page 1: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/1.jpg)
Motifs of Protein StructureMotifs of Protein Structure
![Page 2: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/2.jpg)
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 3: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/3.jpg)
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 4: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/4.jpg)
-helix is a dipole moment.
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 5: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/5.jpg)
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 6: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/6.jpg)
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Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 7: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/7.jpg)
antiparallel -sheet
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 8: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/8.jpg)
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 9: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/9.jpg)
parallel -sheet
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 10: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/10.jpg)
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Adapted from “Introduction to Protein Structure” by Branden & Tooze
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Loop regions are at the surface of protein molecules
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 12: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/12.jpg)
myoglobin
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 13: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/13.jpg)
myoglobin triosephosphate isomerase
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 14: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/14.jpg)
Topology diagram
aspartatetranscarbamoylase
flavodoxin:redox protein
plastocyanin:electron carrier
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 15: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/15.jpg)
helix-turn-helix motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 16: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/16.jpg)
Calcium-binding motif
Troponin-C: a muscle proteinAdapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 17: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/17.jpg)
Calcium-binding motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 18: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/18.jpg)
Conformational change of calmodulConformational change of calmodulin upon peptide bindingin upon peptide binding
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-hairpin motif
bovine trypsin inhibitor snake venom erabutoxinAdapted from “Introduction to Protein Structure” by Branden & Tooze
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staphylococcus nuclease
Greek key motif
Adapted from “Introduction to Protein Structure” by Branden & Tooze
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-hairpin motif
Greek key motif
?
Adapted from “Introduction to Protein Structure” by Branden & Tooze
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motif
right hand left handAdapted from “Introduction to Protein Structure” by Branden & Tooze
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Large polypeptide chains fold into several domains
Adapted from “Introduction to Protein Structure” by Branden & Tooze
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domains are built from structural motifs
triosephosphate isomeraseAdapted from “Introduction to Protein Structure” by Branden & Tooze
![Page 25: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/25.jpg)
protein structure
domain
motif
secondary structure
primary structure
P53
DNA-binding domain
sheet-turn-helix
-helix & -sheet & turn
linear chain
![Page 26: Motifs of Protein Structure. Adapted from “Introduction to Protein Structure” by Branden & Tooze.](https://reader036.fdocuments.in/reader036/viewer/2022062314/56649e765503460f94b776e4/html5/thumbnails/26.jpg)
simple motifs combine to form complex motifs
Adapted from “Introduction to Protein Structure” by Branden & Tooze