Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20;...
-
Upload
justina-manning -
Category
Documents
-
view
216 -
download
0
Transcript of Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20;...
![Page 1: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/1.jpg)
Morning Report!
Julie McGregor
1/18/06
![Page 2: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/2.jpg)
Fun with Acid Base! Day of admission:
HCO3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis pCO2= 1.5(20)+ 8 +/-2 = 36-40 pCO2= 39 …appropriate compensation!!! AG 25, delta gap= 25-12/24-20= 3.25 …concominent metabolic
alkalosis!!!!
![Page 3: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/3.jpg)
Osmolal Gap
Calculated Osm: 2(Na) + (gluc/18)+ (BUN/2.8) 280+ 0.72+ 9.6= 290
Measured Osm= 317 Osm Gap= 27
![Page 4: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/4.jpg)
Last Acid Base Page- The next day
HCO3 17; 7.34/29/89/15
Acidemia Metabolic Acidosis pCO2= 1.5(17)+8 +/-2 = 31.5-35.5 pCO2= 28…Compensation plus additional Respiratory alkalosis
Anion Gap of 13 delta gap of 0.14 so there was a Nongap acidosis on day
after admission.
![Page 5: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/5.jpg)
Alcoholic ketoacidosis
Alcoholics- decreased carbohydrate intake reduces insulin secretion and increases glucagon production
Low insulin leads to lipolysis and free fatty acid delivery to the liver
Glucagon excess promotes conversion of free fatty acids into ketoacids in the liver
![Page 6: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/6.jpg)
Additionally…
Alcohol inhibits gluconeogenesis and itself stimulates lipolysis
Metabolism of ethanol into acetaldehyde and then acetic acid contributes to acid production
AKA is the causative factor in 20% of patients presenting with ketoacidosis. (Tanaka, Intern. Med. 2004, Oct, (10): 955-9)
![Page 7: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/7.jpg)
Clinical Presentation
History of alcohol abuse. Infact, AKA only affects chronic alcoholics. Case reports have also shown that “classic” patients are heavy drinkers who have a binge episode followed by abrupt cessation of alcohol consumption (Tanaka, Intern. Med. 2004, Oct, (10): 955-9)
Anion Gap metabolic acidosis Ketonemia Elevated osmolal gap thought to be due to acetone
accumulation and presence of ethanol
![Page 8: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/8.jpg)
Plasma Glucose in AKA
Plasma glucose can be low, normal, or high Hyperglycemia is not well understood
(hyperglycemia should lead to insulin production) Theory that the stress response eventually triggers
hyperglycemia or patients may have undiagnosed DM
Case report of AKA associated hypoglycemia leading to irreversible encephalopathy (Jain, Med Sci Monit. 2002, Nov; 8(11): CS77-9)
![Page 9: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/9.jpg)
Complications of Acid Base in Alcoholic ketoacidosis
Hypoperfusion induced lactic acidosis- present in 50% of cases
Metabolic alkalosis resulting from concurrent vomiting. Acidosis and alkalosis can be of comparable severity leading to a relatively normal pH but an elevated AG marking underlying ketoacidosis.
Chronic respiratory alkalosis induced by underlying hepatic disease
A relatively normal anion gap (compared to fall in bicarb) due to urinary ketoacid anion loss.
![Page 10: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/10.jpg)
Diagnosis
Confirmation with ketonemia or ketonuria (if possible measure b-hydroxybutyrate in the blood)
Differential diagnosis of the alcoholic patient with a high anion gap metabolic acidosis and an osmolal gap: ethanol, methanol, and ethylene glycol toxicity, lactic acidosis and diabetic ketoacidosis
![Page 11: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/11.jpg)
Diagnostic Evaluation
History Assessmet for ketonemia or ketonuria U/A for calcium oxalate crystals Measurement of serum levels of suspected
toxins
![Page 12: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/12.jpg)
Treatment
Dextrose to increase insulin and reduce glucagon secretion
Saline to repair fluid deficit EtOH rehab, MVI, thiamine, folate, CIWA Nutrition consult Acidemia and ketoacidosis largely correct
spontaneously
![Page 13: Morning Report! Julie McGregor 1/18/06. Fun with Acid Base! Day of admission: HCO 3 20; 7.336/39/203/21 Acidemia- pH 7.336 Metabolic Acidosis](https://reader036.fdocuments.in/reader036/viewer/2022082518/56649f045503460f94c19032/html5/thumbnails/13.jpg)
References:
Tanaka, Intern. Med. 2004, Oct, (10): 955-9 Jain, Med Sci Monit. 2002, Nov; 8(11): CS77-9 Up to date!