More than just transport… Blood. Functions of Blood 1.Deliver O 2, nutrients to all body cells...
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Transcript of More than just transport… Blood. Functions of Blood 1.Deliver O 2, nutrients to all body cells...
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More than just transport…
Blood
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Functions of Blood
1. Deliver O2, nutrients to all body cells
2. Transport waste products from cells for elimination
3. Transport hormones4. Maintain body temp (distribute heat)5. Maintain pH (carry buffers)6. Maintain fluid volume7. Prevent blood loss (clotting)8. Prevent infection (WBCs, antibodies)
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Blood Components
Plasma (55%) water (90%), ions,
proteins, gases, nutrients, wastes, hormones
Cells (45%) RBCs, WBCs, platelets Develop from stem
cells in bone marrow
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Blood Cell Formation
Hematopoiesis: blood cell formation
Occurs in red bone marrow
Skull, pelvis, ribs, sternum, humerus, femur
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Erythrocytes
Red blood cells (RBCs) Transport O2 in blood Biconcave discs Anucleate (no nucleus) Hemoglobin: iron-containing protein, binds
to O2
Life span: 100-120 days
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Anemia: decrease in oxygen-carrying ability of blood Low RBC count or deficient hemoglobin
content Sickle-Cell Disease: abnormal hemoglobin
Genetic disorder Carriers of 1 allele are resistant to malaria in
Africa
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Leukocytes
White blood cells (WBCs) Defend body against infection and
tumors Locate areas of tissue damage by
responding to chemicals Types: neutrophils, eosinophils,
basophils, lymphocytes, monocytes
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Leukemia: bone marrow becomes cancerous huge numbers of WBCs
Treatment: chemotherapy, radiation, stem cell transplant
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Platelets
Cell fragments (irregularly-shaped bodies)
Needed for clotting blood
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HemostasisHemostasis = stoppage of bleeding
1. Vascular spasm Constrict damaged blood vessels
2. Platelet plug forms Platelets stick and bind to damaged site Release chemicals to attract more platelets
3. Coagulation Blood clotting Fibrin threads forms mesh that traps RBCs
Time: blood clot normally forms within 3-6 min.
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Disorders
ThrombusThrombus: clot in unbroken blood vessel Coronary thrombosis = heart attack
EmbolusEmbolus: thrombus breaks away from vessel wall and floats freely Cerebral embolus = stroke
HemophiliaHemophilia: hereditary bleeding disorder, lack clotting factors
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Human Blood Groups
Antigen: foreign substance that immune system recognizes
Antibodies: Y-shaped proteins secreted by WBC’s that attach to antigens
Agglutination: clumping caused by antibodies binding to antigens on RBCs
RBC surface proteins: A antigen B antigen Rh antigen
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ABO Blood Groups
42% 12% 3% 43%
Type A: has A antigen on surface of RBC
Type B: has B antigen Type AB: has both A & B antigens Type O: has no antigens on surface
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Rh antigen found on RBC’s in Rhesus monkeys (1940)
Rh+ : 85% Rh- : 15%
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Donors
Blood Type
Can Receive From:
Can Donate To:
AB
ABO
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Donors
Blood Type
Can Receive From:
Can Donate To:
A O, A A, ABB O, B B, AB
AB O, A, B, AB
AB
O O O, A, B, AB
Who is the universal donor? Universal recipient?
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Blood Typing Analysis
Blood sample mixed with 3 antibodies
If blood clumps, antigens are present If no clumps, no antigens are present
Anti-A antibody testAnti-A antibody test
Anti-B antibody testAnti-B antibody test
Rh antibody Rh antibody testtest
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