MOLES, MELANOMA and SKIN CANCER Mary C. Martini, MD, FAAD Associate Professor Dermatology Director,...
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Transcript of MOLES, MELANOMA and SKIN CANCER Mary C. Martini, MD, FAAD Associate Professor Dermatology Director,...
![Page 1: MOLES, MELANOMA and SKIN CANCER Mary C. Martini, MD, FAAD Associate Professor Dermatology Director, Melanoma and Pigmented Lesion Clinic Northwestern University.](https://reader036.fdocuments.in/reader036/viewer/2022062421/56649dc85503460f94abd25e/html5/thumbnails/1.jpg)
MOLES, MELANOMA and SKIN CANCER
Mary C. Martini, MD, FAADAssociate Professor Dermatology
Director, Melanoma and Pigmented Lesion ClinicNorthwestern University
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MOLES Everyone gets
moles They can get
bigger and darker due to sun burns and heavy sun exposure
Some families make “atypical” or irregular moles
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MOLES
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MOLES Benign or healthy
moles
Irregular moles-”dysplastic”
Melanoma
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Dysplastic Nevus Multicolored Asymmetric
pigment deposition
Asymmetric contour-macular and papular
Indistinct margins
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Atypical mole syndrome-(Dysplastic nevus
syndrome) >100 melanocytic
nevi 1 or more nevi
>8mm in diameter
1 or more dysplastic nevi on exam
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Atypical Mole Syndrome has a 10 year risk of developing melanoma of 14%
Wang et al.JAAD 2005;50:15-20
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Management of the Dysplastic Nevi Patient
Close monitoring- full body exams every 6 months
Dermoscopy of all atypical appearing nevi
Whole Body Photos Excision of any changing or
markedly atypical nevi
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Body Mapping Studio
positioning stage indexed monostandbalanced cross-lighting
high resolution digital camera
body mapping software
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The Body Map
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At Home Exam
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Dermoscopy The magnified visualization of pigmented skin
lesions beyond what would be visible by the physician
Increases diagnostic accuracy by 10-20%
Dermlite.com
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Benign Nevireticulated pattern
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Dysplastic Nevi
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Asymmetric pigment pattern
Irregular depigmentation
Irregular edge
Dysplastic Nevi
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Melanoma
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Melanoma
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Changes in Overall Cancer Mortality (1975-2000)
Prostrate -5% Breast -15% Colorectal -25% MELANOMA +28%
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Melanoma
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Melanoma
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Tumor Thickness- Breslow level
Level 5yr survival
<0.75mm 97.9%
0.76-1.49mm 91.7%
1.5-3.99mm 72.8% >4mm 57.5% Barnhill et al,Cancer 1996
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Incidence of melanoma 1900 - 1 in 2000 2004 - 1 in 70 Major cause is ultraviolet exposure
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Tanning bed use before the age of 35 increases the risk
of skin cancer by 75%
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SUN DAMAGE
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PHOTOAGING Sun damage
Pollution
Heredity
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LENTIGOS “Sunspots or big
freckles” Increase in size
and color with more sun exposure
Areas with these growths may be areas that develop skin cancer years later
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Lentigo
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Lentigo
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Photodamage
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Actinic Keratosis
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SKIN CANCER Basal cell
carcinoma
Squamous cell skin cancer
Melanoma
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Basal Cell Carcinoma Most common skin cancer Never metastasizes Sun damage is the major cause
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Basal Cell Carcinoma
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Basal Cell Carcinoma
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Squamous Cell Carcinoma Second most common form of skin
cancer Can metastasize if neglected and
continues to grow Sun damage plays a major role
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Squamous Cell Carcinoma Can occur in preexisting burn and
traumatic scars Can occur on lower lip due to
smoking or chewing tobacco in addition to actinic damage
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Squamous Cell Carcinoma
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Benign Lesions
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Warts Caused by a virus Spread by shedding
skin Treated by “cryo”, 5FU or salicylic acid
plaster-oral/genital warts
linked to cervical and oral/throat cancer
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WARTS
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Angiomas
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Seborrheic Keratosis
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Dermatofibromas
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Sebaceous Hyperplasia
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SUNSCREENS Facial everyday sunscreens SPF 15-25: Eucerin
facial, Oil of Olay facial, Purpose
Chemical free- titanium dioxide and zinc oxide- Blue Lizard and Neutragena
Waterproof sunscreens SPF 35-70: Coppertone sport, Neutragena with helioplex, Blue lizard, in Canada or Europe sunscreens with Mexoryl
Reapply every 2 hours if swimming or sweating
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Skin Cancer Prevention Skin protection involves use of
sunscreens including reapplication Wear sun screen containing
clothing and hats Avoid prolonged sun exposure
from 11 am to 3 pm
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