MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome)
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MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon
Cancer(Lynch Syndrome)Kevin Harris
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Some Families are Predisposed to Colon Cancer
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What Genes Cause HNPCC?
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MLH1 Encodes a DNA Mismatch Repair Protein
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Meiotic Pachytene Arrest is Observed in MLH1-Deficient Mice
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MLH1 Mutants Lack MLH1 Protein and Make Many Replication Errors
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Molecular Markers Confirm MLH1 Mutations in HNPCC Patients
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Familial Non-Polyposis Colon Cancer (Lynch Syndrome) Leads to Other Cancers
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Polyps Come in Many Forms
FAP HNPCC
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With HNPCC Additional Screening Visits are Necessary
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A Preemptive Strike Against Cancer
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Sources
http://www.hopkins-gi.org/GDL_Disease.aspxhttps://humana-portal.dnadirect.com/content/physician-site/hereditary-nonpolyposis-colorectal-cancer/index.htmlhttp://www.sciencedirect.com/science/article/pii/S1471491402023596Edelmann, Winfried. "Meiotic Pachytene Arrest in MLH1-Deficient Mice." Cell 85.7 (1996): 1125-134. Print.Pena-Diaz, Javier, and Josef Jiricny. "Mammalian Mismatch Repair: Error Free or Error Prone." Trends in Biochemical Sciences 37.5 (2012): 206-14. Print.http://www.cancernetwork.com/display/article/10165/106278http://www.gastrolab.net/ng030.htmhttp://www.ajronline.org/content/186/6/1611.figures-onlyhttp://my.clevelandclinic.org/disorders/inherited_colon_cancer/dd_hnpcc.aspxhttp://www.gen.vcu.edu/GRADUATE/GeneticCounseling