Mitosis What is it? Why is it Important? What do I need to know?
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Transcript of Mitosis What is it? Why is it Important? What do I need to know?
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MitosisWhat is it?Why is it Important?
What do I need to know?
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What is Mitosis?MITOSIS: division of the nucleus into two identical daughter cells
http://fairmanstudios.com/als.htm
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Why is mitosis important? Eukaryotes use
cell division to create new cells
Growth, Maintenance and Repair of body cells
Asexual cell division
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What makes up the cell cycle?
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MITOSIS isaboutorganizing anddistributing
CHROMOSOMES
≠ Chromosome made of a DNA and protein complex: chromatinFollowing DNA replication, a chromosome contains two sister chromatids attached by a centromere
Sister
Chromatids
Centromere
Chromosome
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What happens in INTERPHASE? Cells are in interphase
90% of the time G1 = Gap 1 (cell
growth) S =chromosome
synthesis (duplication) G2 = Gap 2 (cell
growth) M = Mitosis
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INTERPHASE:
nuclear envelope
clearly visible
chromatin, NOchromosomes,yet
nucleolus (if any) still visible
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PROPHASE
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PROPHASE
chromosomesbecome visible
nuclear envelopedisappears
nucleolusdisappears
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PROPHASE
Centrioles migrate & form spindle.
Centrioles
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Kinetochore (centromere)
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Mitosis produces identical offspring (2N---2N)
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Why some cells stop mitosis…differentiation
Muscle cells… Nerve cells… Critical functions
might be disrupted Adaptations to this
condition
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Importance??? Growth Replacement Cancer Regeneration of…
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Cancer? Unregulated
mitosis Benign Malignant/
metastasis How does it begin?
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Normal cycle controls Internal signals External signals:
growth factorsfibronectin,etccarcinogens
Apoptosis Immune functions And…
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Cell immortilization!! Hayflick limit?? Hela cells Contact inhibition Increased
telomerase activity = immortalization!
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Immortalization??? If you replaced… Why not??…look at
your shoestrings? Telomerase &
telomeres & …? Recently… Implications???
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Mitosis quiz Use two words to describe the
importance of mitosis Draw and label the cell cycle…
include G1, S, G2, M and cytokinesis…what happens at each stage?
Why might telomerase be important? What disease is associated with
mitosis? Are all organisms limited to 50 mitotic
divisions?
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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Name stage of mitosis
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These are bacteria Watch the clip What kind of
reproduction is shown here?
What advantage does this confer on the organism?