miR-9
1
0 1 2 4 6 8 10 - -- - - + + + ++ + ++ + ++ + + ++ + ++ + miR-9 0 1 2 4 6 8 10 - - - - - + + + ++ + +- + ++ ++ ++ + ++ + 0 1 2 4 6 8 10 - -- - - + + +- +- -+ + ++ + + ++ + +- + 0 2 4 6 8 10 *36.8% (7/19) Relative expression (/ C20 normal liver) - - - - - + + + ++- -- + ++- + ++ +-- + *33.3% (6/18) *46.2% (6/13) miR-503 Methylation Methylation miR-9-1 miR-9-3 Methylation Methylation Methylation *26.7% (4/15) miR-137 Methylation *0% (0/15) Methylation *7.7% (1/13) miR-149 - -- - - + + - ++ + ++ - -- + + + - + ++ + 12 14 -- -- -- + ++ ++ ++ -- - + +++ ++ ++ 0 1 2 4 6 8 10 miR-196b C20 C40 LC08N LC07N LC11N cHc4 Hep 3B Hep G2 Hep-KANO HLE HLF huH-1 HuH-6 Huh7 JHH-1 JHH-2 JHH-4 JHH-5 JHH-6 JHH-7 Li7 PLC/PRF/5 sK-Hep-1 Hep-TABATA HCC cell lines 0 1 2 4 6 8 10 *35.3% (6/17) + - -- --+ + + + + +- + ++ + + ++ + + - + miR-129 Relative expression (/ C20 normal liver) Supplementary Fig. S1 Relative expression (/ C20 normal liver) Relative expression (/ C20 normal liver) Relative expression (/ C20 normal liver) Relative expression (/ C20 normal liver) Relative expression (/ C20 normal liver) 0 0.2 0.4 0.6 0.8 1.0 1.2 - -- - - + + +++ + +- + ++- + + + +- ++ *75.0% (12/16) miR-596 1.4 1 13.4 12.2 23.4 22.9 14.7 10.3 71.2 11.8 25.2 109 135 556 38.5 55.8 285 394 229 336 23.2 77.4 45.9 35.1 744 56.9 27.7 388 88.7 343 186 92 52 11 21.6 38.8
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Supplementary Fig. S1. 23.4. miR-503. 22.9. 13.4. 12.2. 10. 8. 6. Relative expression (/ C20 normal liver). 4. 2. 1. 0. -. -. -. -. -. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. *36.8% (7/19). Methylation. 71.2. miR-9. 14.7. 11.8. 10.3. - PowerPoint PPT Presentation
Transcript of miR-9
012
4
6
8
10
- - - - - + + + + + + + + + + + + + + + + + + +
miR-9
012
4
6
8
10
- - - - - + + + + + + + - + + + + + + + + + + +
012
4
6
8
10
- - - - - + + + - + - - + + + + + + + + + + - +
0
24
68
10
*36.8% (7/19)
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
- - - - - + + + + + - - - + + + - + + + + - - + *33.3% (6/18)*46.2% (6/13)
miR-503
Methylation
MethylationmiR-9-1miR-9-3
Methylation
Methylation
Methylation *26.7% (4/15)
miR-137
Methylation *0% (0/15)
Methylation *7.7% (1/13)
miR-149
- - - - - + + - + + + + + - - - + + + - + + + +
1214
- - - - - - + + + + + + + - - - + + + + + + + +012
4
6
8
10
miR-196b
C20
C40
LC
08N
LC
07N
LC
11N
cHc4
Hep
3B
Hep
G2
Hep
-KA
NO
HL
EH
LF
hu
H-1
Hu
H-6
Hu
h7
JHH
-1JH
H-2
JHH
-4JH
H-5
JHH
-6JH
H-7
Li7
PL
C/P
RF
/5sK
-Hep
-1
Hep
-TA
BA
TA
HCC cell lines
012
4
6
8
10
*35.3% (6/17)+- - - - - + + + + + + - + + + + + + + + + - +
miR-129
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
Supplementary Fig. S1
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
Rel
ativ
e ex
pre
ssio
n
(/ C
20 n
orm
al li
ver)
0
0.2
0.4
0.6
0.8
1.0
1.2
- - - - - + + + + + + + - + + + - + + + + - + + *75.0% (12/16)
miR-5961.4
1
13.4 12.223.4 22.9
14.710.371.2
11.8
25.2 109135
55638.555.8
285394
229
33623.2 77.4
45.935.1
74456.927.7
38888.7
343186 92 52
11
21.638.8
