Micro fluidics in PCB technology
-
Upload
tasha-chase -
Category
Documents
-
view
19 -
download
0
description
Transcript of Micro fluidics in PCB technology
![Page 1: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/1.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Flow injection analysis realized using PCBs S. Gassmann, L. Pagel Faculty of computer since and electronicsInstitute of Electronic Appliances and Circuits, University of Rostock, Rostock, Germany
![Page 2: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/2.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Micro fluidics in PCB technology
Electronic area IC's, resistor, capacitor, plug and socket connection, push-button, display, ...
Fluidic area:
pumps, valves, channels, filter, ... cavities, optical sensors, conductivity measurement, …
Electronic area
Fluidic area
![Page 3: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/3.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
University of RostockPCB-Fluidics
![Page 4: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/4.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Fluidic PCB-Technology
normal PCB
production
drilling milling
![Page 5: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/5.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Fluidic PCB-Technology
normal PCB
production
etching
![Page 6: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/6.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Fluidic PCB-Technology
second PCB stacked
copper lines build channels
gluing
![Page 7: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/7.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Fluidic PCB-Technology
tube connection
channel view
![Page 8: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/8.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Fluidic PCB-Technology
cross section of channel
![Page 9: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/9.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Cross section of channel wall
epoxy
copper (2)
copper (1)channel
![Page 10: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/10.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9µC controlled programmable micro pump
Electrical connector- Power 4 –7 V DC- I2C - Bus - programming
500µl/min Flow 150 mBar max Backpressure
over USB-I2C IF fully programmable
![Page 11: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/11.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Flow-Injection-Analysis
quantitative measurement of components automated procedure short response times / high sample
throughput usage in quality control / automated
assays developed by J. Růžička and E.H. Hansen
in the year 1975
![Page 12: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/12.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Flow-Injection-Analysis
Sample
Reaction coil
Injection valve Detector
Reagent
Pump
![Page 13: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/13.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Reaction
Detection of Fe3+
Thiocyanate as reagent forms red colored Iron-Thiocyanate detection by absorption at 480 nm
SCNFe 33
3)(SCNFe
![Page 14: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/14.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Why a FIA?
All basic fluidic handling necessary- transportation of fluids- dosing of fluids- mixing- detecting- adoption to detection needed- electronics needed
![Page 15: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/15.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
FIA in PCB-Technologie Principle
reagentpump
sample pump
reaction coil
injection detector
• 2 separate controllable pumps • no injection valve• optical detection
photometrical 480 nm
![Page 16: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/16.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
MIXINGMIXINGFlow pattern in 180° curves
![Page 17: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/17.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Simulation results of the used reaction channel Simulation results of the used reaction channel
Parameters: 2 pumps with constant flow of 0.2ml/min
Fluidsimulation:FLOWORKS789388 cells
![Page 18: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/18.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
… and the reality
![Page 19: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/19.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Simulation results of the used reaction channel Simulation results of the used reaction channel
parameters:thermopneumatically actuated pumps
with pulsing flow of 0.2ml/min,
789388 cells
![Page 20: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/20.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Simulation results of the reaction channelSimulation results of the reaction channel
vector plot of the fluid velocity at the cross section of the channel after the second curve
parameters: thermopneumatically actuated pumps with pulsing flow of 0.2ml/min,
789388 cells
![Page 21: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/21.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
OPTICAL SENSOROPTICAL SENSOR in FIA
Pho to d io d e
O p tic a l p a th
1m m
Sim ula tio n Flo w 5 m l/m in!
LED
![Page 22: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/22.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Optical Cell with air bubble (vector of the force)Optical Cell with air bubble (vector of the force)
Sim ula tio n Flo w 5 m l/m in!
F
![Page 23: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/23.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Realization
5 cm
5 cm
• stack of four PCBs • one movable layer of polyimid• electronics on the back of the fourth PCB
![Page 24: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/24.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
FIA Realization
![Page 25: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/25.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
FIA in PCB with integrated electronics
![Page 26: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/26.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Signals in the photo detector in dependence on the concentration of Fe(III)ions
![Page 27: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/27.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
PCB FIA facts
Detection Fe3+ Ions0,16 mMol – 10 mMolreproducibility peak height 5%, peak area 10%
Monolithic system consisting fluidics and electronics in one stack of PCBs.
![Page 28: Micro fluidics in PCB technology](https://reader036.fdocuments.in/reader036/viewer/2022062421/56812b0d550346895d8ef8ba/html5/thumbnails/28.jpg)
Lienhard Pagel4.6.2007
UN
IV
E
RS I T Ä T R
O
ST
OC
K
g
eg r ü n d e t 1 4
1
9
Thank you for your attention!Thank you for your attention!