Micro-encapsulation - DECHEMAdechema.de/efce_media/Downloads/Section+PDE/EFCE_Meiners.pdf · Micro...
Transcript of Micro-encapsulation - DECHEMAdechema.de/efce_media/Downloads/Section+PDE/EFCE_Meiners.pdf · Micro...
Frankfurt, September 24, 2010
Micro-encapsulation :
at Crossroads of Art, Science and Technology
Jean-Antoine Meiners
Laboratoire Meiners Sàrl, 2013 Colombier
Micro-encapsulation : Thinking out of the box
Thinking outside the box is to think differently, unconventionally or from a new perspective.
Micro capsule concepts are the result of the Art of thinking out of the box, the Science to turn imagination into concept and the understanding of Technology to transfer the concept into a product
micro encapsulation
Not all capsules are micro capsules !
micro encapsulation Presentation outline
• Definitions • Capsule types • Release mechanisms • Examples • Process • Physical methods • Chemical methods • Complexation • Discussion
micro encapsulation Definitions
As straightforward and precise as such a definition may sound, the scientific literature and commercial publications typically accept a much broader application field i.e. all sub-millimeter material embedded by a matrix material. Some authors even consider particles of more than one millimeter micro capsules.
Ref. : Jean-A. Meiners, Laboratoire Meiners sàrl
Micro encapsulation is defined as a technology for the packaging of particles of finely ground solids, droplets of liquids, or gaseous materials with the help of protective membranes, also called shell or coating.
Ref. : Prof. Bojana Boh, University of Lubljana
micro encapsulation Definitions
We will use the definition of micro capsules (1 -999 µ) for bodies destined to provide protection against influence from the environment, with a release mechanism destined to make the active substance available at time and place desired.
For the purpose of this presentation we will use the definition of micro spheres for granules that have not as a primary objective the controlled release of their active substance
We will use the definition of micro beads destined to contain the active substance, but being permeable to allow its action to persist.
micro encapsulation Purposes of micro encapsulation
• Protection • Heat, Oxygen,
• Controlled release • Medicine delivery
• Immobilisation • High cell density in bioreactors
• Capsular Perstraction • In Situ Product Removal
• Structuration • Liquid or gas to solid • Dispersability • Dust free
• Functionalisation • Visual aspect • Marketing
What are the desired properties?
• Size • Size distribution • Mechanical strength • Molecular weight cut- off • Liquid/ solid core • Stability (dissolve with time, long- term, etc.) • Surface properties (neutral, charged, hydrophobic) • …….etc.
micro encapsulation Capsule types
α : layered with central core β : layered with central void δ : Composite shell γ: Embedded particles
δ α
β γ
Wet and leaky versus dry and tight
Liquid core capsule Solid core capsule
micro encapsulation Capsule types
Solid core
Gas core
Liquid core
Multiwall membrane
micro encapsulation Release mechanisms
Release profiles Triggered release Sustained release
Release mechanisms
Diffusion Dissolution Trigger molecules Thermal Mechanic Osmotic Biochemical
Release effects Immediate Pulsed Delayed
micro encapsulation Entrapment mechanism
micro encapsulation Examples
Bio encapsulation Bio medical cell implants Pharmaceutical targetted delivery Protection micro organisms Seed protection
Flavor and Fragrances encapsulation Phase change liquid - powder Protection volatile molecules Delivery in the consumer item Sensation in the mouth or nose
micro encapsulation Examples
Textile cosmetotextile color change fire retardants
Paper scratch and sniff self copying carbonless paper
Cosmetics skin activated pH dependant delivery system
micro encapsulation Examples
Construction phase change materials
Adhesives multi component
Electrophoretic displays positioning
micro encapsulation Markets of micro encapsulation
Source : Frost & Sullivan 2002
micro encapsulation Examples
Use of micro encapsulation in food and feed manufacturing:
• Survival of micro organisms
• Enzymes and Probiotics
• Thermo sensitive
• Metabolism aW dependent
• Shelf life reduction at ambient conditions
• Difficulties with further processing conditions
micro encapsulation Process
Main principles
Physical
apply a coating on the surface of the substrate Chemical
different polymerisation techniques for entrapment
Complexation inclusion, adsorbtion
micro encapsulation Process
Main principles
Physical apply a coating on the surface of the substrate
• Fluidized bed coating
• Pan coating
• Atomization
• Hybridizing
• Extrusion
• Compacting
micro encapsulation Process
Physical apply a coating on the surface of the substrate
• Fluidized bed coating
micro encapsulation Process
Physical apply a coating on the surface of the substrate
• Fluidized bed coating
micro encapsulation Process
Physical apply a coating on the surface of the substrate
• Fluid Bed agglomeration
micro encapsulation Process
Physical apply a coating on the surface of the substrate
• Pan coating
micro encapsulation Process
Physical methods apply a coating on the surface of the substrate
• Hybridizing
micro encapsulation Process
Physical methods apply a coating on the surface of the substrate
• Extrusion • Double barrel extrusion • Planetary roller extruder • Centrifugal extrusion
micro encapsulation Process
Physical methods apply a coating on the surface of the substrate
• Double barrel extrusion
micro encapsulation Process
Physical methods apply a coating on the surface of the substrate
• Planetary roller extrusion
micro encapsulation Process
Physical methods apply a coating on the surface of the substrate
• Centrifugal extrusion
micro encapsulation Process
Chemical methods different techniques to induce entrapment
• Coacervation methods • Simple coacervation • Complex coacervation • Interfacial coacervation
• Polymerization methods • Interfacial polymerisation • Polymerisation in situ • Matrix polymerisation
micro encapsulation Process
Chemical methods different techniques to induce entrapment
• Coacervation methods
• Formation of macromolecular aggregates as a result of phase separatation – partial desolvation of a homogeneous colloid polymer solution.
• Hardening through
• crosslinking and formation of new covalent bonds • non covalent hardening, where hydrogen bonds are formed
between gelatin molecules
micro encapsulation Chemical Methods
micro encapsulation Coacervation
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Chemical Methods
micro encapsulation Complexation
• Cyclodextrin α-cyclodextrin β- cyclodextrin γ- cyclodextrin
• Liposomes
micro encapsulation about Laboratoire Meiners Sàrl
Independant laboratory for discovery and development of Micro encapsulation processes.
Founded :1982 Staff : 9
Laboratories : 250 m2 Affiliated to : University of applied sciences, CH Sion
Active participation in EEC scientific projects. such as Cost 865
Unmatched experience with probiotics and enzymes
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