MHC general information
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Transcript of MHC general information
![Page 1: MHC general information](https://reader033.fdocuments.in/reader033/viewer/2022051323/54b3e9db4a7959bf068b4793/html5/thumbnails/1.jpg)
Major Histocompatibility Complex
MHC introduction
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What are MHCs? Normal cell surface proteins produced by most
cells. They are like ID tags for cells. They are involved in allowing T cells to
recognize self vs. nonself.
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What do MHCs do? MHCs bind to peptide fragments (parts of
chopped up proteins) and display/present them on the surface of the cell.
The T cells monitor the MHCs for evidence of an invasion of a cell or for foreign cells
*B cells do not interact with MHCs.
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What types of MHCs exist? Class I MHC molecules
Found on almost all nucleated cells (not RBCs) Bonds to portions of antigens (peptide fragments) Presents them on the cell surface. Cytotoxic T cells can recognize and begin specific
defense
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What types of MHCs exist? Class II MHC molecules
Found on dendritic cells, macrophages, & B cells (aka Antigen-presenting cells)
Bonds to portions of antigens (peptide fragments) that have been ingested and broken down.
Presents them on the cell surface. Helper T cells can recognize and begin specific
defense
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Dendritic Cell
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Macrophage
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Macrophages
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Are my MHCs similar to others? There are many different alleles for MHCs. Most of us are heterozygous for all of our
MHCs and therefore unique (except identical twins).
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Class I MHC
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