MF-7 Seventh Microfluidics Consortium - CfBI · microfluidic technology platforms for genomics and...
Transcript of MF-7 Seventh Microfluidics Consortium - CfBI · microfluidic technology platforms for genomics and...
MF-7 Seventh Microfluidics Consortium
MF-7.4
(Closed Meeting – Members Only)
June 23th Boston, MA USA
(Open Meeting – Day Delegates + Members),
June 24th Boston, MA USA
Final Version
Agenda
Delegate List
Speaker Profiles
Table-top Demonstrations
Hotel and Travel Recommendations
Seventh Microfluidics Consortium
The Seventh Microfluidics Consortium brings together current and future stakeholders from across a wide range of backgrounds with a shared interest in facilitating the growth of the industry through better understanding of the challenges, opportunities and choices which it faces.
Our current membership includes: CEA (F) ; CorSolutions (US) ;EV Group (A) Philips (NL); Micronit (NL); Danaher (USA); Dolomite (UK) ; Fluigent (F); CEBAS [Fraunhofer (D) and University College Dublin (EI)], Lonza (CH) ; Philips (NL); IMT (CH), Magnomics (PT), and University of Cambridge (UK).
We organize closed meetings for our members on both sides of the Atlantic where we seek to promote our mission “to grow the market for microfluidics enabled products and services” by
- Finding shared interest across the landscape of applications - Championing modularity and standards where appropriate - Engaging with key industry influencers
While helping our members to do deals along the way.
With the support of Northeastern University on this occasion as well as our closed session on June 23rd we are also reaching out to selected guests in North America and beyond our membership in an Open Meeting on June 24th seeking to engage them in our vision, projects and thinking.
Location: room 406 (4th floor) Egan Research Center : Northeastern University
June 23rd (closed day, members only!)
10:00 Registration
10:30 Welcome
James Bean Provost and Senior Vice President for Academic Affairs – Northeastern University
The Provost guides the university in implementing the academic plan, with a special responsibility for integrating academic planning across the colleges and fostering cross-college interdisciplinary initiatives within the goals of the plan. The Provost collaborates with the President in setting overall academic priorities for the university and allocates funds to support those priorities; and works with the Deans, the Colleges, and the Faculty Senate to ensure that recruitment, mentoring, and tenure and promotion processes attract and retain excellent faculty.
10: 45 Scene Setting / Introductions
Peter Hewkin, CEO of Centre for Business Innovation who facilitates the MF7 consortium will introduce
delegates and set the scene for today’s meeting.
11:15 Session 1: Microfluidics – Opportunities and Challenges Expert Witness
Ali Tinazli – Global Head of Healthcare and Life Sciences Strategy CTO Office - Strategy & Incubation
Ali has recently joined HP with a strategic remit in life sciences.
After receiving his Ph.D. in Germany and being published in high impact journals such as
EMBO, Nature Cell Biology, Nature Nanotechnology, Ali Tinazli was in corporate development
at Applied Biosystems (now: Thermo Fisher) and covered the European landscape in biotech
and in-vitro diagnostics innovation. In 2008, Dr. Tinazli, joined Sony DADC (part of SONY
Corporation) and started the Americas business of their new biomedical business unit Sony
DADC BioSciences. As a member of the management team at Sony DADC BioSciences, until
recently he has headed the Americas business based out of Cambridge, MA.
Followed by Q & A
12:00 Lunch / Networking
13:00 Microfluidics Hotseat
Pitches from microfluidics start ups seeking to engage with the MF7 Consortium
Platelet Biogenesis - Lea Beaulieu
We mimic human bone marrow to trigger platelet production
from megakaryocytes (parent cells).
We scale platelet production to meet human clinical need. We
improve platelet purity to generate bacterial/viral-free,
immune-compatible human platelets that are safer for human
infusion.
We distribute bioreactor platelets to hospitals and blood banks to give to patients
Each Pitch to be followed by Q & A + feedback Chatham House Rule Applies!
13:45 Recent Research
“New Approach to Pathogen Detection” Tania Konry : Assistant Professor
Department of Pharmaceuticals Sciences – Northeastern University.
Assistant professor of pharmaceutical sciences Tania Konry has developed
a system that efficiently tests for a wide range of biological specimens.
Whether you’re looking for complex cancer cell biomarkers in a sample or
simple bacteria in drinking water, the system costs significantly less than
standard approaches and spits out results in a fraction of the time.
“A Nanofluidic Device for Biologics Quality assurance” Dr. Sung Hee Ko – MIT Dr. Ko is a postdoc at Prof. Jongyoon Han group at MIT. He received the B.S. degree in the department of Mechanical Engineering of Busan National University, Busan, Korea. He received a M.S. and PhD degree in the department of Mechanical Engineering of Pohang University of Science and Technology (POSTECH), Pohang, Korea. Before joining MIT, he was a postdoctoral associate at POSTECH.
14:45 Discussion and Networking
- Member priorities
- Upcoming actions
- Next meeting (Dublin / uTAS Oct 7/8)
15:15 Transfer to: MIT
16:00 Laboratory Tour of Department of Biological Engineering – Prof. Linda Griffith Lab)
Our research encompasses molecular-to-systems level analysis, design and synthesis of biomaterials, scaffolds, devices and micro-organs for a range of applications in regenerative medicine, tissue engineering, and in vitro drug development. A central theme is connecting the experimental systems to systems biology measurements. Most projects are highly interdisciplinary and translational, involving basic scientists, clinicians, and engineers, often with industry partners, to solve important problems in medicine and biology. The lab is affiliated with the Center for Gynepathology Research (CGR), the Center for Environmental Health Sciences (CEHS), the Center for Emergent Behaviors of Integrated Cellular Systems
(EBICS), and the Koch Institute for Integrative Cancer Research.
Linda G. Griffith, PhD, is the School of Engineering Teaching Innovation Professor of Biological and Mechanical Engineering and MacVicar Fellow at MIT, where she directs the Center for Gynepathology Research and the “Human Physiome on a Chip” project supported by the DARPA/NIH-funded Microphysiological Systems Program.
17:00 Close / Transfer to..
June 23rd Evening
…Joint Reception with FluidicMEMS
Note this event is also open to Day Delegates who have registered for the Open Day on June 24th. Open
Day delegates will be automatically registered and receive their entry tickets by email.
Location: 700 Main Street (See Logistics Section below for Map)
Jointly Sponsored by:
FluidicMEMS
This is an opportunity for Members of the MF7 consortium to network with our colleagues and good friends
from FluidicMEMs over drinks/buffet.
6:00 pm Doors Open
Networking, Drinks and Buffet
7:00 pm Address from (tbc) David A Weitz
The Weitz group studies the physics of soft condensed matter, materials which are easily
deformable by external stresses, electric or magnetic fields, or even by thermal fluctuations.
These materials typically possess structures which are much larger than atomic or molecular
scales; the structure and dynamics at mesoscopic scales determine the physical properties of
these materials. The goal of our research is to probe and understand this relationship. We
study both synthetic and biological materials; our interests extend from fundamental physics
to technological applications, from basic materials questions to specific biological problems.
The techniques we use include light scattering, optical microscopy, rheology, and microfluidics.
9pm Close
June 24th (Open day, for non-member day-delegates - with member demos
and talks)
Location: Raytheon Amphi Egan Research Center : Northeastern University
Open Day Delegates register and pay here. http://www.cfbi.com/mf74paymentpage.htm Table-top demos will be on show in the networking area from the following MF7 member organisations:
9:00 Registration, Networking, Table-Top Demos
9:30 Welcome and Introduction to the MF7 Consortium - Peter Hewkin
(Centre for Business Innovation)
Peter Hewkin has led the MF7 consortium for 7 years and is responsible for the
delivery of its mission to grow the market for Microfluidics enabled products and
services. He will describe the processes which the consortium uses, the successes
which it has achieved and the ideas it has for the future.
10:00 Session 1 – Manufacturing Options
In this session we will compare and contrast manufacturing options for Microfluidic
Devices highlighting performance, batch size, regulatory and economic implications.
Members of the MF7 consortium will be available at their table-tops with samples to
talk about their options and possibilities
CEBAS: Injection Moulding
Andre Sharon: The Fraunhofer Center for Manufacturing Innovation (CMI)
conducts advanced research and development and engineers solutions for a
broad range of industries, including biotechnology, photonics, manufacturing,
and renewable energy. Engineers, scientists, faculty, and students at our Center
transform emerging research into viable technology solutions that meet the
needs of both domestic and global clients. Our services include product and
device development, high precision automation systems, and laboratory assays
& instruments.
EVGroup: Industrial Implementation of Nanoimprint Lithography
Bernd Dielacher: EV Group is a recognized technology and market leader for
wafer processing equipment. The company offers system configurations for R&D
and volume production as well as implementation, process and materials know-
how according to the customer’s needs. Key products include wafer bonding,
lithography and metrology equipment in addition to photoresist coaters, cleaners
and inspection systems. Furthermore, EVG is among the leading companies in
the world providing micro- and nanoimprint equipment capable of hot
embossing, UV-NIL and micro-contact printing. EVG’s technology can thus
provide customers with a total solution for microfluidic device fabrication.
Fluidic Factory: Additive Manufacture
Richard Gray is co-founder and commercial director of Dolomite Microfluidics.
He is based in Boston. With an engineering degree from the University of
Cambridge, his early career has included posts at Mettler Toledo, TTP Group
and PA Consulting.
Richard will describe how prototype microfluidics chips can be created using
additive manufacturing techniques in your own laboratory.
MF Manufacturing Project : Béatrice Icard, Lab. Manager, CEA-LETI-HEALTH (Fr)
Beatrice Icard, lab manager at CEA-LETI-HEALH, after a short presentation of her institution, will give an overview of the status of the MFManufacturing project and the next perspectives. CEA-LETI-HEALTH is one of the division of the CEA-LETI, a French research-and-technology organization motivated on creating value and innovation through technology transfer to its industrial partners. CEA- LETI- Health Division focuses on the development of micro-nanotechnologies for applications in the fields of medical imaging, security, in vitro diagnostic, nanomedicine, medical devices and environment monitoring. These activities cover the design, integration and qualification of systems comprising sensors, actuators, analog front end electronics, and acquisition system, signal processing algorithms, data management
and control software.
Discussion: What option is right for me??
11:30 Break, coffee, networking, table top demos
12:00 Session 2 Latest Research and Applications for Microfluidics
Murat Cirit, Research Scientist, Massachusetts Institute of Technology (MIT) – Organ on a Chip
Murat Cirit, PhD, is a Research Scientist at MIT & director of the Translational Systems Pharmacology Team and System Integration Task in the DARPA-PhysioMimetics program (“Human Physiome on a Chip”) led by Linda Griffith. MIT and various institutions collaborate in creating a platform that supports ten interacting micro-physiological systems (MPS) and associated sensors for drug testing. Murat completed his PhD at NCSU focusing on systems biology of growth factor-mediated signal transduction pathways. After completion of his PhD, he worked in the pharmaceutical industry focusing on preclinical drug discovery for oncology. He brings an interdisciplinary and systematic approach through his extensive experimental
knowledge and computational modeling with an understanding of biological, physiological, and physical processes. His main research experience is systems pharmacology, systems biology, applied tissue engineering, cell biology and signal transduction networks. His current focus as the scientific lead is integrating various scientific fields to build interacting MPSs by interfacing platform engineering & tissue
engineering for pharmacology studies.
Prof. Paul Blainey, Massachusetts Institute of Technology (MIT) – New
microfluidic technology platforms for genomics and drug discovery
The Blainey lab integrates molecular, optical, and microfluidic technologies to
address emerging challenges in the life sciences. Dr. Blainey will review
new technology platforms for host- and pathogen-directed genomic analysis,
as well as high-throughput compound screening systems.
Next-generation sequencing: microfluidic technology to
overcome the high sample count challenge in genomics and
epigenomics research
Drug discovery: scalable micro-droplet platform for rapid, flexible, low-cost
compound screening
13:00 Lunch, networking, table top demos
14:00 Session 3 Operational Techniques for Microfluidics
“Advanced Flow Control for Microfluidics”
-Robert Pelletier: Fluigent, Inc. (US)
Robert is a graduate of the University of Massachusetts with a degree in Biological Sciences, as
well as a Master’s in Business from Suffolk University. Prior to establishing Fluigent in the US,
he was responsible for the Fluidics Business at Harvard Apparatus. His previous experience
includes global, senior management roles in the scientific instrumentation industry, as well as
having started US subsidiaries for other European based companies.
“Scalable wafer level production of consumables made of non-CMOS compatible
materials on glass” - Alexios Tzannis : IMT
IMT is among the leading European suppliers of micro-lithographic products.
With more than 50 years of experience in the fields of optics and metrology IMT is well
positioned in the intersection of microfluidic and photonics to act as a development
partner as well as a large scale manufacturer of glass consumables for microfluidic
and biophotonic applications.
15:00 Session 4 Outlook for Point of Care Diagnostics
Discussion led by expert witness Gyorgy Abel, M.D., Ph.D., Director, Molecular Diagnostics,
Immunology & Clinical Chemistry, Laboratory Medicine, Lahey Hospital & Medical Center.
Way forward for point of care diagnostics, key issues which need to be address and how the
MF7 consortium might contribute to this.
Circa 15:45 Wrap-up and Details of next meeting (Dublin Oct 7,8)
16:00 Close
Name Surname Organisation Title Country
Gyorgy Abel Harvard Medical School Don Arnold AB Sciex
VP R&D Principal Scientist US
Christoph Baum Fraunhofer IPT (CEBAS) Dept Head Production Metrology D
Lea Beaulieu Platelet Biogenesis Paul Blainey MIT
Sergei Broude Resonetics Darryl Brousmiche Waters Corp Malcolm Burwell CfBI (Boston) Michael Deck Web Industries Murat Cirit MIT
Bradley Collier Northeastern Salil Desai Phenomyx Bernd Dielacher EVGroup
Business Development Manager A
Mark Dupal Perkin Elmer Hubert Geisler Fluigent
Product Specialist F
Alla Gimbel Draper Labs Richard Gray Dolomite
Commercial Director UK
France Hamber Fluigent
CEO F
Peter Hewkin CfBI
CEO UK
Gang Hu Broad Institute Beatrice Icard CEA
Laboratory Head F
Sasan Jalili Wyss / Harvard Medical School Sunghee Ko MIT
Tania Konry Northeastern Don Kuehl Redshift Systems Darin Latimer Danaher
Director Strategic Innovation US
Vincent Lindner Opko Diagnostics Brent Lunceford MEMStronics MST Timo Lunceford Swiss Productions Inc Frank Marszalkowski Waters Corp Jeff Motschman Dolomite
Applications Specialist US
Shashi Murthy Northeastern Associate Professor US
Roger Nassar RAN Biotechnologies Rich Parker Repco Development Technologies
Robert Pelletier Fluigent
President US
Ralph Peterson Northeastern Andy Racher Lonza
R&T Alliances UK
Ali Sahari Northeastern Eva Schmidt Johannes Heidenhain Head Business Development CH
Andre Sharon Fraunhofer IPT (CEBAS) Laboratory Head US
Ali Tinazli HP
Global Head Healthcare & Lifesciences US
Alexios Tzannis IMT
Business Development Manager CH
Thomas Umundum SonyDADC
A
Nicolas Verplanck CEA
Senior Scientist F
Table-Top Exhibits (in the Networking Area)
MFManufacturing project is the European initiative for the standardization and manufacturability of complex micro-fluidic (MF) devices. The project has been accepted by the ENIAC Joint Undertaking (JU), a public-private partnership focusing on nanoelectronics that brings together ENIAC Member/Dutch, German, French and United Kingdom States, the European Commission, and AENEAS (an association representing European R&D actors in this field). The objective is to bring the manufacturing of microfluidic devices to the same level of maturity and
industrialization of electronic devices, enabling them to address more widely in the healthcare needs. Electronic devices, which have been on the market for many years, have benefited from the long going standardization of electronic components, and were therefore easily integrated in the production process of the major foundries.
Established in 2005 as the world’s first microfluidic application centre, Dolomite focused
on working with customers to turn their concepts for microfluidic applications into reality.
Today, Dolomite is the world leader in solving microfluidic problems. With offices in the
UK, US and Japan, and distributors throughout the rest of the world, our clients range from
universities developing leading-edge analytical equipment, to manufacturers of chemical,
life sciences and clinical diagnostics systems.
Dolomite’s key strength lies in offering a complete service to customers from problem conceptualisation
and feasibility testing through to full instrument design and development. By Productizing Science™, we
have enabled customers around the world to develop more compact, cost-effective and powerful
instruments.
Dolomite also offers a Microfluidic Consultancy to develop a variety of versatile, complex and cutting edge
custom devices, available in exceptionally short lead times.
Whatever your microfluidic requirements and application, Dolomite is the right partner with the right
expertise!
For more information please contact us on +44 (0)1763 242491, [email protected] or visit our website www.dolomite-microfluidics.com.
EV Group is a recognized technology and market leader for wafer
processing equipment. The company offers system configurations for R&D
and volume production as well as implementation, process and materials
know-how according to the customer’s needs. Key products include wafer
bonding, lithography and metrology equipment in addition to photoresist
coaters, cleaners and inspection systems. Furthermore, EVG is among the
leading companies in the world providing micro- and nanoimprint equipment capable of hot embossing, UV-
NIL and micro-contact printing. EVG’s technology can thus provide customers with a total solution for
microfluidic device fabrication.
Since 2006, Fluigent develops, manufactures and commercializes innovative
microfluidic flow control and fluid handling solutions for laboratories, research
units and industrials around the world
Enabling full control of your microfluidic systems through pressure, flow and electrical monitoring, Fluigent
technologies provide innovating solutions for all your microfluidic and lab-on-a-chip applications (droplet-
based drug testing, chromatography, cell perfusion, flow chemistry, cells and parasites separation,
dielectophoresis, highly viscous fluids and liquid air manipulations, gene expression analysis in
microdroplet, etc).
Indeed, Fluigent has created the market of pressure-driven flow controllers for microfluidic applications and
low volume fluid handling. The products are based on the patented FASTAB technology optimizing stability
and responsiveness of the flow inside your microfluidic systems (chip, microarray, etc).
In addition to the FASTAB technology, Fluigent owns or licences a portfolio of patents worldwide covering
its core technologies in microfluidic flow control, Lab-on-a-chip devices, diagnosis and life science analysis
(cell capture, etc).
IMT has been synonymous with customised microstructures both on and in
glass and high-precision thin-films for over 50 years. We are among the
leading international providers of complete solutions in the field of
microlithography and thin-films. Highly qualified employees, innovative
technologies and processes as well as the latest infrastructure form the basis
of our high-quality products and comprehensive services.
At the centre of our endeavours is the aim of achieving the maximum benefits possible for our customers.
We support our customers' individual projects with industry-specific expertise, extensive experience and
innovative thinking, creating added value through long-term partnerships focused on lasting success.
The Fraunhofer IPT combines knowledge and experience in all fields of production technology. In the areas
of process technology, production machines, mechatronics, production metrology and quality as well as
technology management, we offer partners and customers tailor made solutions and immediately
actionable results for modern production.
Fraunhofer IPT recently teamed up with Jens Ducrées microfluidics research group at Dublin City
Universityin order to found the Fraunhofer Project Center for Embedded Bioanalytical Systems (CEBAS),
which will offer the DCU competencies in design, prototyping, assay and systems development combined
with the strong manufacturing capabilities of IPT and Fraunhofer CMI, Boston.
Logistics:
Delegates are responsible for making their own travel and
accommodation arrangements. Please tell us how you plan to travel and
where you will be staying so we can offer taxi/transfer shares. The
information below will facilitate this.
Overview:
Meeting Venue FluidicMEMs Reception MIT Lab Tour Airport
Venue for Joint Reception with FluidicMEMS
700 Main Street
Cambridge, MA 02139
Venue for the Griffiths Lab Visit
MF7 Meeting Location:
Egan Research Center
Closed Meeting June 23rd is in Room 406 Open Meeting June 24th is in the Raytheon Amphi 120 Forsyth Street Boston, Massachusetts 02115 United States http://www.northeastern.edu/egan/directions.html
(Harvard / Cambridge ^)
Egan Research Center
(Downtown
Boston/
Logan
Airport)
From the north
(via Route I-93 or Route 1)
Take the Storrow Drive exit, and proceed to the Fenway exit. Follow signs for Boylston Street inbound,
and bear right onto Westland Avenue. Turn right onto Massachusetts Avenue, proceed to the third
traffic light, and turn right onto Columbus Avenue. The Renaissance Parking Garage is at 835
Columbus Ave.
From the west
(via Route 90, Massachusetts Turnpike)
Take Exit 22 (Copley Square), and bear right. Proceed to the first traffic light, and turn right onto
Dartmouth Street. Take the next right onto Columbus Avenue. The Renaissance Parking Garage is at
835 Columbus Ave.
From the west
(via Route 9)
Proceed east on Route 9; it will become Huntington Avenue. Turn right onto Ruggles Street. At the
fourth traffic light, turn left onto Tremont Street. At the second set of lights, turn left onto Melnea Cass
Boulevard, and then turn left onto Columbus Avenue. The Renaissance Parking Garage is at 835
Columbus Ave.
From the south
(via Route 3, Southeast Expressway)
Take Exit 18 (Massachusetts Avenue), and proceed onto Melnea Cass Boulevard. Continue for
approximately two miles, and turn left onto Columbus Avenue. The Renaissance Parking Garage is at
835 Columbus Ave.
From Logan Airport
Take the Sumner Tunnel to Route 93 north. Proceed to the Storrow Drive exit. Follow the directions
indicated above for "From the north."
Via public transportation
Northeastern is accessible by subway via the Green Line of the MBTA. From downtown Boston, take an
"E" train outbound to the Northeastern stop, the first stop above ground. The campus can also be
reached from downtown via the Orange Line by taking any train going outbound to Forest Hills and
getting off at Ruggles Station. Commuter rail lines connect with the Orange Line at Back Bay Station
and North Station. Visit www.mbta.com for more information on subway, bus and commuter rail
schedules.
Parking
Visitors may park at the Northeastern University Renaissance Parking Garage at 835 Columbus Ave.
Campus Map
NU's campus map can help you locate the parking garage and academic and administrative building.
Recommended Hotels:
First Choice: Boston Park Plaza Hotel
http://www.bostonparkplaza.com/
The Boston Park Plaza Hotel & Towers is located in the heart of Boston's historic Back Bay and is just
steps from Boston's most popular attractions. See “A” on map below. This Boston Hotel is located just 2
blocks from Newbury Street, known for its Designer Boutiques and 5 blocks from the upscale Prudential
Center and Copley Place Mall, featuring more than 200 Shops and Boston Restaurants.
Also..
http://www.marriott.com/hotels/travel/bosco-boston-marriott-copley-place/
http://www.colonnadehotel.com/
More info:
++44 1223850173