MF-7 Seventh Microfluidics Consortium - CfBI · MF-7 Seventh Microfluidics Consortium MF-7.5...
Transcript of MF-7 Seventh Microfluidics Consortium - CfBI · MF-7 Seventh Microfluidics Consortium MF-7.5...
MF-7 Seventh Microfluidics Consortium
MF-7.5
(Closed Meeting – Members Only)
October 7th Dublin, Ireland
(Open Meeting – Day Delegates + Members),
October 8th Dublin, Ireland
Agenda
Delegate List
Speaker Profiles
Table-top Demonstrations
Hotel and Travel Recommendations
Seventh Microfluidics Consortium
The Seventh Microfluidics Consortium brings together current and future stakeholders from across a wide range of backgrounds with a shared interest in facilitating the growth of the industry through better understanding of the challenges, opportunities and choices which it faces.
Our current membership includes: CEA (F) ;EV Group (A) Philips (NL); Micronit (NL); Danaher (USA); Dolomite (UK) ; Fluigent (F); HP (USA); Dublin City University (IRL) and Fraunhofer (D), Lonza (CH) ; Philips (NL); IMT (CH), Magnomics (PT), and University of Cambridge (UK).
We organize closed meetings for our members on both sides of the Atlantic where we seek to promote our mission “to grow the market for microfluidics enabled products and services” by
- Finding shared interest across the landscape of applications - Championing modularity and standards where appropriate - Engaging with key industry influencers
While helping our members to do deals along the way.
With the support of DCU Dublin on this occasion as well as our closed session on Oct 7th we are also reaching out to selected guests in Europe and beyond our membership in an Open Meeting on Oct 8th seeking to engage them in our vision, projects and thinking.
Location: The Helix Centre
Oct 7th (closed day, members only!)
10:00 Registration
10:30 Welcome
Dr. Jens Ducrée is a principal investigator for Microfluidic Platforms at the Biomedical Diagnostics Institute (BDI) and holds a Full Professorship of Microsystems in the School of Physical Sciences at Dublin City University (DCU). Dr. Ducrée is also academic member of the National Centre for Sensor Research (NCSR) and the 3U Joint Institute of Global Health (JIGH).
The main part of his research is directed towards novel microfluidic platforms and associated actuation, detection, fabrication and instrumentation technologies for the integration, automation, miniaturization and parallelization of sample preparation and detection of bioanalytical assays (e.g. immunoassays, nucleic acid testing, general chemistry and cell counting). Typical applications are sample-to-answer systems for biomedical point-of-care and global diagnostics, liquid handling automation for the life sciences (e.g. concentration / purification and
amplification of DNA / RNA from a range of biosamples), environmental monitoring and food safety.
10: 45 Scene Setting / Introductions
Peter Hewkin, CEO of Centre for Business Innovation who facilitates the MF7 consortium will introduce
delegates and set the scene for today’s meeting.
New Member Presentation – Andy Racher – Associate Director, Future Technologies Group Lonza
I am an internationally recognised CMC biopharmaceutical development
expert and process development leader, with extensive experience in
advancing innovator and biosimilar protein therapeutics from development to
commercialisation. I have proven ability to add value to CMC programmes
through introducing market leading technologies. I have participated in the
development activities for 5 licensed and numerous candidate therapeutics.
11:30 Session 1: Regenerative Medicine – Landscape, Opportunities, Challenges
“Vision and Opportunities for Organ on a Chip” Expert Witness Presentation Chris Hinoj osa – Emulate Bio
Emulate Inc. is a privately held company that creates living products for understanding how diseases, medicines, chemicals, and foods affect human health. Our Human Emulation System sets a new standard for recreating true-to-life human biology and is being used to advance product innovation, design, and safety across a range of applications including drug development, agriculture, cosmetics, food, and chemical-based consumer products.
Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard
University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems.
Emulate continues to develop a wide range of Organ-Chips and disease models through collaborations with industry partners and internal R&D programs. Emulate is also working with clinical partners to produce Organ-Chips personalized with an individual patient’s stem cells, for applications in precision medicine and personalized health.
Q & A leading to discussion:
- Role of Microfluidics?
- Need for standards / design guidelines?
- How can MF7 help this industry to succeed?
-
12:30 Lunch / Networking
13:30 Microfluidics Hotseat
Pitches from microfluidics start ups seeking to engage
with the MF7 Consortium
Scotland: Ufraction8 – Brian Miller
Fast, Flow-Through Liquid-Particle Processing
An exciting new technology that broadens the scope of microfluidics' application to industrial scale problems. The platform is scalable to achieve any target throughput level and can be configured to remove particles from 500 μm down to 2 μm.
UK: Abingdon Health Diagnostics – Barry Lillis
We are building an innovative technology-led company focused on providing rapid and near-patient medical diagnostic testing solutions.
We are developing, manufacturing and selling products and systems that support the migration of testing from the laboratory closer to the patient with the intention of improving both clinical and economic healthcare outcomes. Our initial clinical focus is on developing a range of rapid testing products in the areas of hematology oncology,
specifically B-cell dyscrasias.
We will use our expertise in immunodiagnostics, plastic electronics, hardware and software, to develop the next generation of testing systems that meet the needs of our customers. Our current platform development is looking to provide customers with a multiplexed, portable, cost-effective and connected rapid testing solution.
Each Pitch to be followed by Q & A + feedback Chatham House Rule Applies!
14:15 Applications / Standards
Invited Expert Witness: Darwin Reyes-Hermandez NIST
Dr. Reyes-Hernandez is a research chemist in the Nanoscale Metrology Group in the
Engineering Physics Division of the Physical Measurement Laboratory (PML) at the
National Institute of Standards and Technology (NIST). He received his Ph.D. and B.S.
in chemistry from the University of Puerto Rico. He also received an M.S. in Applied
Biomedical Engineering from The Johns Hopkins University. In his doctoral work, he
combined the fields of environmental analytical chemistry and toxicology. In it, he
chemically characterized airborne particulate matter from an area in Puerto Rico of high
incidence of cancer, asthma, and other respiratory diseases, using cell-based
toxicological assays. After completing his Ph.D. he was awarded with a National
Science Foundation Postdoctoral Fellowship to work with Professor Andreas Manz at
Imperial College, London, U.K., where he worked for two years. During this postdoctoral
experience, he worked with microfluidic devices in developing two-dimensional
separation systems and analog computing using glow discharge in microfluidic chips.
14:45 Discussion
- Member priorities
- Review of Standards work
- Upcoming actions
- Next meeting (London December)
15:15 Break / Networking
15:45 Transfer to: DCU Biomedical Diagnostics Institute / NanoBiological
Research Facility
16:00 Visit hosted by Dr Kieran Flynn Associate Director BDI ; Barry Byrne and Robbie Sinnott
The Biomedical Diagnostics Institute (BDI) is a Science Foundation Ireland CSET (Centre for Science, Engineering and Technology). Established in October 2005, the BDI is an Academic-Business-Clinical partnership that carries out cutting-edge research programmes focused on the development of next-generation biomedical diagnostic devices. The BDI vision is to transform healthcare by pioneering advances in the science and technology of diagnostics and by translating these advances into clinical use.
BDI research addresses major clinical challenges informed by the partnership of clinicians, scientists and industry. Building on key scientific insights, the BDI will now apply its established capabilities to create integrated Point-of-Care solutions, which will have major impacts on diagnosing disease and sustaining human health.
17:00 Close / Transfer to..
Oct 7th Evening
…Joint Reception with Young Microfluidics Researchers
Note this event is also open to Day Delegates who have registered for the Open Day on Oct 8th. Open Day
delegates will be automatically registered and receive their entry tickets by email.
Location: Top floor of BDI. Sponsorship to be confirmed.
This is an opportunity for Members of the MF7 consortium to network with the next generation of
researchers / employees over an informal buffet.
6:30pm Close
October 8th (Open day, for non-member day-delegates - with member demos
and talks)
Location: The Helix Centre
Open Day Delegates register and pay here. http://www.cfbi.com/mf74paymentpage.htm Table-top demos will be on show in the networking area from the following MF7 member organisations:
9:00 Registration, Networking, Table-Top Demos
9:30 Welcome and Introduction to the MF7 Consortium - Peter Hewkin
(Centre for Business Innovation)
Peter Hewkin has led the MF7 consortium for 7 years and is responsible for the
delivery of its mission to grow the market for Microfluidics enabled products and
services. He will describe the processes which the consortium uses, the successes
which it has achieved and the ideas it has for the future.
10:00 Session 1 – Manufacturing Options
In this session we will compare and contrast manufacturing options for Microfluidic
Devices highlighting performance, batch size, regulatory and economic implications.
Members of the MF7 consortium will be available at their table-tops with samples to
talk about their options and possibilities
CEBAS: (D, IRL, US) Injection Moulding
Christoph Baum: The Fraunhofer Center for Manufacturing Innovation (CMI)
conducts advanced research and development and engineers solutions for a
broad range of industries, including biotechnology, photonics, manufacturing, and
renewable energy. Engineers, scientists, faculty, and students at our Center
transform emerging research into viable technology solutions that meet the
needs of both domestic and global clients. Our services include product and
device development, high precision automation systems, and laboratory assays
& instruments.
EVGroup: (A) Industrial Implementation of Nanoimprint Lithography
Bernd Dielacher: EV Group is a recognized technology and market leader for
wafer processing equipment. The company offers system configurations for R&D
and volume production as well as implementation, process and materials know-
how according to the customer’s needs. Key products include wafer bonding,
lithography and metrology equipment in addition to photoresist coaters, cleaners
and inspection systems. Furthermore, EVG is among the leading companies in
the world providing micro- and nanoimprint equipment capable of hot
embossing, UV-NIL and micro-contact printing. EVG’s technology can thus
provide customers with a total solution for microfluidic device fabrication.
“Scalable wafer level production of consumables made of non-CMOS compatible materials on
glass” - Alexios Tzannis : IMT (CH)
IMT is among the leading European suppliers of micro-lithographic products.
With more than 50 years of experience in the fields of optics and metrology IMT is well
positioned in the intersection of microfluidic and photonics to act as a development
partner as well as a large scale manufacturer of glass consumables for microfluidic
and biophotonic applications.
“Hermetically Sealed Liquid Lens Technology” Richard Bijlard : Invenios (US / NL)
Invenios designs, develops, and manufactures microfluidics, MEMS, and 3D microstructures.
The company also engineers exclusive processes and custom production equipment that is
required to manufacture this range of products. Invenios has a fully capable
microfluidics/MEMS foundry that offers high performance, cost effective solutions for both
established and emerging companies. Unlike traditional microsystems foundries, Invenios
delivers a complete production cycle, which includes design review, process development,
manufacturing, and testing within an ISO 9001:2008 environment to support a broad range of
micron and sub-micron level products.
Discussion: What option is right for me? How do I plan / choose?
11:30 Break, coffee, networking, table top demos
12:00 Session 2 Latest Research and Applications for Microfluidics
Sammy Datwani : Labcyte (US) - Droplets
Design, develop and launch new products to expand the market capability of acoustic liquid dispensing. I direct, manage and lead internal and external research programs for R&D, systems, scientific and advanced developments to create new instruments and new products (plastic consumables and reagents) and other novel capabilities for the company. My unique skill set combines understanding fluid dynamics on the micro- and nanoscale, the knowledge of interactions of system components, interfacial transport, microscale reactors, electrostatics, solution and polymer chemistry, genomics, proteomics, single-cell analysis, advanced applications, instrument engineering, laboratory automation, modeling, microarraying, analytical methods and biological instrumentation.
The CfBI team will be on hand to help with introductions
13:00 Lunch, networking, table top demos
14:00
Professor Gregory Nordin (Brigham Young University, US)
In this talk we demonstrate that 3D printing with a digital light processor
stereolithographic (DLP-SLA) 3D printer can be used to create high density
microfluidic devices with active components such as valves and pumps.
Leveraging our previous work on optical formulation of inexpensive resins (RSC
Adv., 2015, 5, 106621), we demonstrate valves with only 10% of the volume of our
original 3D printed valves (Biomicrofluidics, 2015, 9, 016501), which were already
the smallest that have been reported. Moreover, we show that incorporation of a
thermal initiator in the resin formulation along with a post-print bake can
dramatically improve the durability of 3D printed valves up to 1 million actuations.
Using two valves and a valve-like displacement chamber (DC), we also create compact 3D printed pumps.
With 5-phase actuation and a 15 ms phase interval, we obtain pump flow rates as high as 40 μL min−1.
Followed by Q & A
14:45 Session 3 Operational Techniques for Microfluidics
“Advanced Flow Control for Microfluidics”
-Anne Le Nel: Fluigent, Inc. (F, US)
Anne Le Nel is graduated from Ecole Normale Supérieure de Cachan and Ecole Nationale Supérieure de Chimie Paris. She defended PhD in 2008 in miniaturized system for protein analysis directed by Jean-Louis Viovy (MMBM, UMR168 Institut Curie) and Myriam Taverna (LPNSS, University Paris-Sud). She has a 7 years experience in microfluidics and project management.
“Next Generation inVitro Diagnostics” Filipe Cardoso : Magnomics (PT)
Our device consists of a portable reader with inbuilt sample treatment (swab of fluid),
including bacteria separation and DNA purification. After DNA amplification, also
performed by the device, the DNA is identified via magnetic detection on the surface of
a small chip, which can detect up to thousands of different strands, including antibiotic
resistance genes. This chip is part of a disposable, one-off cartridge that is inserted
into the reader and that can be produced to meet the diagnosis needs of the client.
The readout consists of a simple yes/no marker for each type of bacteria and gene,
sent via email or text message to the user
Dolomite (UK) Droplets in Genomics
Mark Gilligan is group chairman and CEO of Blacktrace Holdings.
The group is now structured so that the underlying theme of all that we do is
"Productising Science". The Blacktrace Group includes two kinds of businesses.
Firstly Brands, which are the core drivers of product development, global
marketing, operations, manufacturing and support. One of these Brands is Syrris
itself, and another is Dolomite, with more to come.
CEA-LETI-HEALTH (Fr) “Cellenc Platform : First Steps towards Cell Encapsulation Standardization
for Cell Therapy and Tissue Engineering Applications Claire Authesserre, PhD student
The CellencTM platform has the ambition to standardize the cell containing
microcapsules by automating the multi-step process of cell encapsulation. This
microfluidic platform delivers biopolymer microcapsules ranging from 50 to 500µm in
which cells can be cultured. Microfabrication developments are performed to integrate
the whole process in a closed-loop credit card-footprint cartridge in order to insure
sterility. The next generation of µfluidic cartridge will follow the standards defined with
the ENIAC-MFManufacturing project where CEA-LETI is strongly involved. Main
applications of such a platform are the production of bio-inks, the enhancement of
grafting or the immune protection of cells for cell therapy and tissue engineering
applications.
Joost Driven : Micronit (NL)
Details tbc
Circa 15:45 Wrap-up and Details of next meeting (London December)
16:00 Close of Open Day
Free time!
18:00 MF7 Members Dinner
Location: The Tower Suite at Clontarf Castle Hotel
This is an opportunity for Members to dine and network in
private in exclusive surroundings. Over dinner we will be
addressed by John Carrano of Paratus to stimulate
discussion about the future of droplet based chemistry.
Point of Care Testing Solutions : John Carrano : CEO Paratus Diagnostics (US)
Our mission is to develop a small, low-cost, FDA cleared diagnostic solution suitable for easy use right in the doctor’s office or clinic that can rapidly and accurately diagnose patients for infectious diseases. We allow clinicians to make decisions during the patient visit – resolving the issues associated with lengthy delays waiting on lab results and improving patient outcomes.
Our products are driven by our Paratus SDS® consumable cartridge technology that allows for the total automation of even complex assay panel protocols in a safe, fast, and effective manner. Our cartridge requires no change to current clinical practice for
obtaining patient specimens and no special tools or equipment beyond a standard smartphone for readout.
Table-Top Exhibits (in the Networking Area)
Established in 2005 as the world’s first microfluidic application centre, Dolomite focused
on working with customers to turn their concepts for microfluidic applications into reality.
Today, Dolomite is the world leader in solving microfluidic problems. With offices in the
UK, US and Japan, and distributors throughout the rest of the world, our clients range from
universities developing leading-edge analytical equipment, to manufacturers of chemical,
life sciences and clinical diagnostics systems.
Dolomite’s key strength lies in offering a complete service to customers from problem conceptualisation
and feasibility testing through to full instrument design and development. By Productizing Science™, we
have enabled customers around the world to develop more compact, cost-effective and powerful
instruments.
Dolomite also offers a Microfluidic Consultancy to develop a variety of versatile, complex and cutting edge
custom devices, available in exceptionally short lead times.
Whatever your microfluidic requirements and application, Dolomite is the right partner with the right
expertise!
For more information please contact us on +44 (0)1763 242491, [email protected] or visit our website www.dolomite-microfluidics.com.
EV Group is a recognized technology and market leader for wafer
processing equipment. The company offers system configurations for R&D
and volume production as well as implementation, process and materials
know-how according to the customer’s needs. Key products include wafer
bonding, lithography and metrology equipment in addition to photoresist
coaters, cleaners and inspection systems. Furthermore, EVG is among the
leading companies in the world providing micro- and nanoimprint equipment capable of hot embossing, UV-
NIL and micro-contact printing. EVG’s technology can thus provide customers with a total solution for
microfluidic device fabrication.
Since 2006, Fluigent develops, manufactures and commercializes innovative
microfluidic flow control and fluid handling solutions for laboratories, research
units and industrials around the world
Enabling full control of your microfluidic systems through pressure, flow and electrical monitoring, Fluigent
technologies provide innovating solutions for all your microfluidic and lab-on-a-chip applications (droplet-
based drug testing, chromatography, cell perfusion, flow chemistry, cells and parasites separation,
dielectophoresis, highly viscous fluids and liquid air manipulations, gene expression analysis in
microdroplet, etc).
Indeed, Fluigent has created the market of pressure-driven flow controllers for microfluidic applications and
low volume fluid handling. The products are based on the patented FASTAB technology optimizing stability
and responsiveness of the flow inside your microfluidic systems (chip, microarray, etc).
In addition to the FASTAB technology, Fluigent owns or licences a portfolio of patents worldwide covering
its core technologies in microfluidic flow control, Lab-on-a-chip devices, diagnosis and life science analysis
(cell capture, etc).
IMT has been synonymous with customised microstructures both on and in
glass and high-precision thin-films for over 50 years. We are among the
leading international providers of complete solutions in the field of
microlithography and thin-films. Highly qualified employees, innovative
technologies and processes as well as the latest infrastructure form the basis
of our high-quality products and comprehensive services.
At the centre of our endeavours is the aim of achieving the maximum benefits possible for our customers.
We support our customers' individual projects with industry-specific expertise, extensive experience and
innovative thinking, creating added value through long-term partnerships focused on lasting success.
Leading biotech and semiconductor firms work with Invenios because we have prototyping and production capabilities incorporating technologies and processes not offered by other micro-fabrication foundries. We are MEMS experts in High-Aspect-Ratio-Processing (HARP) of various types of glass, silicon, ceramics and metals. Our manufacturing systems, capable of high volume production of 3D microstructures using Photo-Sensitive-Glass-Ceramic (PSGC), are second to none. Our newest innovation, Ambient-Temperature-Bonding (ATB), provides an unparalleled method to bond several materials such as glass-to-glass, glass-to-silicon, glass-to-metal, and more—at room temperature without use of adhesives or high temperature treatment.
Invenios designs, develops, and manufactures microfluidics, MEMS, and 3D microstructures. The company also engineers exclusive processes and custom production equipment that is required to manufacture this range of products. Invenios has a fully capable microfluidics/MEMS foundry that offers high performance, cost
effective solutions for both established and emerging companies. Unlike traditional microsystems foundries, Invenios delivers a complete production cycle, which includes design review, process development, manufacturing, and testing within an ISO 9001:2008 environment to support a broad range of micron and sub-micron level products.
The Fraunhofer IPT combines knowledge and experience in all fields of
production technology. In the areas of process technology, production
machines, mechatronics, production metrology and quality as well as
technology management, we offer partners and customers tailor made solutions and immediately
actionable results for modern production.
Fraunhofer IPT recently teamed up with Jens Ducrées microfluidics research group at Dublin City
Universityin order to found the Fraunhofer Project Center for Embedded Bioanalytical Systems (CEBAS),
which will offer the DCU competencies in design, prototyping, assay and systems development combined
with the strong manufacturing capabilities of IPT and Fraunhofer CMI, Boston.
Magnomics is a start-up focused on delivering the next generation of fully portable, easy to use in-vitro molecular diagnostic devices.
Our novel proprietary technology is centred around on-chip DNA extraction, amplification and magnetic detection. It is a lab, on a chip.
Magnomics therefore provides a fast and portable solution for bacterial detection, identification and antibiotic resistance profiling, making use of a single, small fluid sample.
With broad applications in both human and animal health, as well as in food safety, Magnomics will initially address a key veterinary problem: the detection of bovine mastitis causing
pathogens in milk, an ailment affecting dairy cows all over the world.
Micronit Microfluidics mission is to design, develop and manufacture custom made microfluidic components based on micro- and nanotechnology.
Micronit provides added value to customers and end-users by offering a unique combination of micro technologies, materials, microfluidics knowledge and customer application know-how, which enables Micronit to provide innovative and sustainable solutions.
Earlybird Registrations from:
Avectas (EI)
Philips (NL)
DCU (EI)
Fraunhofer IPT (D)
Dolomite (UK)
Emulate Bio (US)
HLab (UK)
Magnomics (PT)
Labcyte (US)
CEA (F)
Fluigent (F)
IMT (CH)
Invenios (NL)
Lonza (UK/CH)
ESIEE Engineering School (F)
EV Group (A)
Uni Edinburgh (UK)
Micronit (NL)
Paratus Diagnostics (US)
UCD (EI)
EnablingNMT (NL)
CfBI (UK)
Logistics:
Delegates are responsible for making their own travel and
accommodation arrangements. Please tell us how you plan to travel and
where you will be staying so we can offer taxi/transfer shares. The
information below will facilitate this.
Overview:
Dublin Airport is easily reached by flag carrier and low cost airlines from across Europe. There are also
some intercontinental flights to USA and Asia. The airport is approximately 10Km north of the centre of
town and 6Km north of the MF7 venue which is on the DCU (Dublin City University) Campus.
Taxis are relatively cheap and plentiful. Public transport is available.
Orientation
MF7 Venue Airport uTAS Venue MF7 Members Dinner
Hotels
A Regency Hotel and Leisure Centre (closest) http://www.regencyhotels.com/
B Travelodge Dublin Airport South (cheapest) https://www.travelodge.co.uk/hotels/378/Dublin-Airport-
South-hotel
C Raddison Blu (downtown) https://www.radissonblu.com/en/royalhotel-dublin
B MF7 Venue A
C (downtown)
Dinner Venue
The Tower Suite, Clontarf Castle Hotel
Castle Ave, Dublin 3, Ireland
clontarfcastle.ie
+353 1 833 2321