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MF-5 Fifth Microfluidics Consortium

MF-5.5

(Closed Meeting – Members Only) September 22nd Cambridge, MA USA

(Open Meeting – Day Delegates + Members) September 23rd Cambridge, MA USA

Final Version

Contents:

Agenda

Delegate List

Speaker Profiles

Table-top Demonstrations

Hotel and Travel Recommendations

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Fifth Microfluidics Consortium Agenda for 5th Meeting MF-5.5

The fifth Microfluidics Consortium brings together current and future stakeholders from across a wide range of backgrounds with a shared interest in facilitating the growth of the industry through better understanding of the challenges, opportunities and choices which it faces.

Our current membership includes: Becton Dickinson (USA); CEA (F); DTU (Dk); Danaher (USA); Delta (Dk); EV Group (A); Philips (NL); SonyDADC (A); Micronit (NL); Dolomite (UK); Fluigent (F); Invenios (NL / USA) ; IX-Factory (D); Janssen (B / USA); JSR Micro (J / B); IMT (CH), Little Things Factory / Plan Optik (D); NILT (DK); DIBA (USA/UK) and University of Cambridge (UK).

We organize closed meetings for our members on both sides of the Atlantic where we seek to promote our mission “to grow the market for microfluidics enabled products and services” by

- Finding shared interest across the landscape of applications - Championing modularity and standards where appropriate - Engaging with key industry influencers

While doing a few deals along the way.

On this occasion as well as our closed session on Sept 22 we are also reaching out to selected guests in the USA beyond our membership in an Open Meeting on Sept 23 seeking to engage them in our vision, projects and thinking.

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Sept 22nd (Members Only Closed Day)

Location: 7th Floor 1 Broadway (See logistics section below for Map) Note: Photo ID will need to be shown to security on the ground floor.

10:00 am Arrivals and Networking 10:30 am Welcome – Anne Avidon, British Consulate General Boston

Anne Avidon is Vice Consul, Trade and Investment Officer and USA Sector Lead for Healthcare at UK Trade & Investment. Based at the British Consulate-General in Boston, Anne consults with UK companies on their international business strategy and helps them commercialize their medical devices and technologies in the US market. She also works with US firms to help them understand the strengths of Britain's Healthcare and Life Sciences sector in order to promote cross-border collaboration and inward investment into the UK. She has hosted many successful

trade missions, ministerial visits and think tanks for industry executives and policy leaders. Anne has a Masters Degree (with Distinction) from the University of Westminster, and is an active member of the Massachusetts Medical Device Industry Association (MassMEDIC), the Medical Development Group (MDG), the New England Health Information Management Systems Society (NEHIMSS) and the Massachusetts Technology Leadership Council (MTLC).

10:45 am Houserules and Introductions Peter Hewkin CfBI

British Consulate General Boston

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11:15 am Keynote Presentation – George M. Whitesides

“Changing the Business Model for Biomedical Analysis”

George M. Whitesides was born August 3, 1939 in Louisville, KY. He received an A.B. degree from Harvard University in 1960 and a Ph.D. from the California Institute of Technology (with J.D. Roberts) in 1964. He was a member of the faculty of the Massachusetts Institute of Technology from 1963 to 1982. He joined the Department of Chemistry of Harvard University in 1982, and was Department Chairman 1986-89, and Mallinckrodt Professor of Chemistry from 1982-2004. He is now the Woodford L. and Ann A. Flowers University Professor.

Q & A and Discussion Arising 12:15 “Bacterial Analysis - Need for Sub-microfluidics & role of standards”

- Ed Goluch Edgar Goluch is DiPietro Assistant Professor Department of Chemical Engineering at Northeastern University.

Edgar D. Goluch received his B.S. in Chemical Engineering from the University of Illinois at Urbana-Champaign. He remained at Illinois for graduate school, receiving a M.S. in Mechanical Engineering and Ph.D. in Bioengineering. From 2008 to 2010, Ed was a NSF Postdoctoral Fellow at Delft University of Technology in the Netherlands. Since 2010, Ed is the DiPietro Assistant Professor of Chemical Engineering at Northeastern University. He received a NSF BRIGE Award in 2011. Ed has published over 40 peer-reviewed journal articles and conference proceedings in the areas of microfluidics, sensors, and biophysics, which collectively have been cited over 800 times. Research in the Goluch Group is currently focused on

developing micro/nano-fluidic devices and sensor technology for detecting and studying

bacterial cells and biofilms. Q & A Discussion 13:00 Lunch/Networking

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14:00 “A unique point of view on Sample Prep and Genomics Applications” Paul Blainey – Broad Institute

Assistant Professor of Biological Engineering, Core Member, Broad Institute of Harvard and MIT. The Blainey laboratory employs a multi-disciplinary approach to develop research tools enabling new measurement capability in biological science, with emphasis on implementing these capabilities in automated lab-on-a-chip formats for high-throughput, multi-parametric, low-cost, or portable application. We use these tools and chemical, physical, and statistical modes of thinking to address research problems in the biological sciences.

Discussion Q& A … Leading into 14:45 Roundtable debate on:

Sample Preparation Standards Perspectives, Promises and Pitfalls

Led by Peter Hewkin CfBI. 15:15 Way forward for the Microfluidics Consortium – opportunity to facilitate Member consensus on ..

- What they want the consortium to do - Where they want it to go - Who they want to meet

During the upcoming MF6 programme

15:45 Close and Networking The CfBI team will be on hand to assist with introductions and logistics needs

http://web.mit.edu/Blainey-lab/images/blainey.jpg

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September 22nd Evening Joint Reception with FluidicMEMS Note this event is also open to Day Delegates who have registered for the Open Day on Sept 23rd. Such delegates will be automatically registered.

Location: 700 Main Street (See Logistics Section below for Map) Jointly Sponsored by:

This is an opportunity for Members of the MF5 consortium to network with our colleagues and good friends from FluidicMEMs over drinks/buffet.

6:00 pm Doors Open

Networking, Drinks and Buffet

7:00 pm Address from Vincent Linder, CTO, OPKO Diagnostics

Dr. Linder serves as Chief Technology Officer at OPKO Diagnostics, a company focusing on the commercialization of clinical diagnostics products, including a high-performance Point-of-Care test system (Claros1TM) and a high-specificity laboratory test for prostate cancer (4KscoreTM). He is also a co-founder of Claros Diagnostics Inc. (now part of OPKO) and co-invented the Claros technology, while being a post-doctorate fellow in George Whitesides’ laboratory at Harvard University. Dr. Linder also worked as Group Leader in microfluidics at the University of Neuchatel (Switzerland), and has served as Research Scientist at

CSEM (Switzerland), a leading company in micro/nanotechnology and microelectronics. He holds a M.Sc. in Chemistry and a Ph.D. in Science from the University of Neuchatel, where he performed research in the area of microfluidic technology for immunoassays with Prof. Nico de Rooij, one of the pioneers in the field of microfluidics.

9pm Close

http://www.dolomite-microfluidics.com/

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September 23rd Open Day (Non-member Day Delegates please register here ) Location: 4th floor Microsoft Technology Center, 225 Main St (See Logistics Section for Map) Note: Government Issued Photo ID will be required for entry

Table-top demos will be on show in the networking area from these MF5 member organisations:

Agenda: 8:30 Registration / Networking / Table-top demos 9:00 Welcome, Introduction to the Microfluidics Consortium and Context for the day

- Peter Hewkin, CfBI

http://www.cfbi.com/mf55landingpage.htmhttp://www.dolomite-microfluidics.com/

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9:30 Microfluidics Based Solutions to Real Problems – update with case studies from: Advanced Flow Control for Microfluidics – Anne Le-Nel: Fluigent (F / US)

Anne graduated from Ecole Normale Supérieure de Cachan and Ecole Nationale Supérieure de Chimie Paris. She defended PhD in 2008 in miniaturized system for protein analysis directed by Jean-Louis Viovy (MMBM, UMR168 Institut Curie) and Myriam Taverna (LPNSS, University Paris-Sud). She has a 7 years experience in microfluidics and project management.

New Applications of Microfluidics Richard Gray, Dolomite . (US / UK)

Richard Gray is co-founder and commercial director of Dolomite Microfluidics. He is based in Boston

With an engineering degree from the University of Cambridge, his early career has included posts at Mettler Toledo, TTP Group and PA Consulting.

Recent developments & Technology Transfer to Industry – Guillaume Delapierre CEA (F) Guillaume is the Head of Biology and Microfluidics Architecture Laboratory at CEA/LETI (France’s nuclear research agency) Guillaume has worked for Bayer Healthcare and also IMTSSA (Institute for Tropical Medicine) He has a PhD in Chemistry from the University of Marseille

11:00 Networking break / Table-top demos

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11:30 Keynote address – Microfluidics and Regenerative Medicine

Geraldine Hamilton Lead Senior Staff Scientist Wyss Institute

Geraldine A. Hamilton serves as the Lead Senior Staff Scientist at the Wyss Institute at Harvard, focusing on technology innovation, development and translation of the automated Organs-on-Chips technology platform. Prior to her tenure at the Wyss Institute, Hamilton spent more than 11 years in the pharmaceutical industry, where her research achievements helped advance the development and application of human relevant in vitro models for drug discovery applications. She was a founding scientist and VP of Scientific

Operations for CellzDirect, a start-up biotech company that specialized in providing cell products to the pharmaceutical industry for safety testing. Hamilton was responsible for the successful translation of CellzDirect’s technology from academia to broad use and acceptance across the industry. Hamilton received her Ph.D. in cell biology/toxicology from the University of Hertfordshire (England) in conjunction with GlaxoSmithkline, followed by a post-doctoral research fellowship at the University of North Carolina. She has authored more than 40 publications and numerous patents.

Discussion 12:30 Lunch / Networking / Tabletop demonstrations 13:30 Enabling Technologies for Microfluidics Scalable production of sub-μm functional structures made of non-CMOS compatible materials on glass – Alexios Tzannis IMT (Switzerland)

Biophotonic and Life Science applications often require non-CMOS compatible materials to be patterned with sub μm resolution. Whilst the mass production of sub μm patterns is well established in the semiconductor industry, semiconductor fabs are limited to using CMOS compatible materials. IMT of Switzerland has implemented a fully automated manufacturing line that allows cost effective mass manufacturing of consumables for biophotonics in substrate materials like D263 glass or fused silica and layer/coating materials like Cr, SiO2, Cr2O5, Nb2O5, Ta2O5 and with some restrictions even gold with sub-μm patterns. The applied processes (lift-off and RIE) offer a high degree of

freedom in the design of consumables for Life Science applications.

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“New Applications New Possibilities” Robert-Jan Zwiers: Sales Exec Micronit (NL)

Robert-Jan has been with Micronit over nine years during which time he has built up extensive experience of microfluidics applications and requirements across a wide range of industries

“Digital Biology and its Commercialization” -Ali Tinazli (SonyDADC)

Dr. Ali Tinazli studied Biochemistry and graduated “excellent with highest university honors” at J.W. Goethe University (Frankfurt). In 2002, he contributed to Functional Proteomics research at Sanofi-Aventis (Frankfurt). From 2002 to 2006, he prepared his PhD Thesis "summa cum laude" - Molecular Organization and Manipulation of Proteins and Protein Complexes in Nanodimensions. Dr. Tinazli's academic work resulted in publications in various high impact journals in the field of nanotechnology, cell biology, and biochemistry. After his PhD he joined the Corporate Business Development dept of Applied

Biosystems (Frankfurt/San Francisco) in 2006. In 2008, he moved to Sony DADC and from the Cambridge MA office is setting up the smart consumables business in the life sciences and in-vitro diagnostics markets.

15:30 Opportunities for Collaborative Action to improve the uptake of Microfluidics

- Peter Hewkin (CfBI) Followed by Discussion 16:00 Close

Open Day Delegates will receive an email invitation to join the Open Day “Drop Box” folder, this contains the latest information about the event and e-copies of most of the presentations. If you experience difficulty with this please contact operations@cfbi.com

mailto:operations@cfbi.com

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Delegate List for MF5.5 Open Day

Abhinav Bhushan

Mass Gen Hospital US

Alex Lastovich

Becton Dickinson US

Alexios Tzannis

IMT CH

Ali Tinazli

SonyDADC US/A

Anne Le-Nel

Fluigent F

Benjamin Miller

Raindance Technologies US

Brian Bilenberg NILT Dk

Christine Peponnet CEA F

Christopher Coyne

Fabrico Medical US

Christopher Delametter Beckman Coulter US

Christopher Demers

University of Maine US

Christopher Hinojosa

Wyss Institute US

David Sebba

Becton Dickinson US

Darin Latimer

Danaher Corp US

Don Arnold

Eksigent US

Eli Zhang

Broad Institute US

Gary Helstern

Diba US/UK

Geraldine Hamilton

Wyss Institute US

Guillaume Delapierre CEA F

Hans Bouwes

iX-factory D

Hao-Yu Greg Lin

Harvard University US

Harald Kraushaar Volpi CH

Harry An

MIT US

James Biggins

Fikst US

Julia Skov

Delta DK

Julie Moore

Beckman Coulter US

Karsten Brandt Andersen DTU Nanotech DK

Kurt van Hout

Volpi US

Laurence Hayward

10X Technology LLC US

Lina Williamson Wyss Institute US

Mark Stephens

MIT US

Matthew Hancock

Veryst Engineering US

Michael Deck

Web Industries US

Nadia Sargaeva

Perkin Elmer US

Nigel Chou

MIT US

Peter Hewkin

CfBI UK

Qihua Xu

Becton Dickinson US

Qun Zhong

Raindance Technologies US

Richard Gray

Dolomite Microfluidics US/UK

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Robert Pelletier

Fluigent US

Robert Trottini

IMT CH/US

Roger Nassar

RAN Biotechnologies US

Roger Kautz

Northeastern University US

Robert Jan-Zwiers Micronit NL

Stefan Thalhammer Heidenhain D

Teodor Veres

National Research Council of Canada CAN

Todd Burt

Diba US/UK (See insert for last minute delegates)

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Open Day Table-Top Exhibits (in the Networking Area)

The LETI-HEALTH department (200 people), has been set up for micro/nano technology applications in the field of health care, life science and environment. At the frontier between micro/nano technologies and biology, the department’s knowledge lies in micromachining, microfluidics, surface chemistry, integrated optical

detection, electrochemistry and electrochemical grafting, electronics, information processing, with a strong emphasis on integration in a complete system comprising instrument, biochip and biological protocol. The exhibit is a good opportunity to present our microfluidic toolbox and our FlowPad platform based on the credit card standard.”

Diba is perfecting fluidics. We provide innovative solutions to the most demanding fluid path applications for clinical and scientific companies worldwide. At Diba our dedicated engineering professionals work side by side with you to design and create the highest quality fluid path assemblies and products for each unique application. Our core offerings are:

Diba Custom: Providing custom designed fluid path solutions optimized by application Dibafit: Providing standard components and products for fluid handling applications Omnifit Labware: Providing solutions for laboratory fluid handing.

Since 2006, Fluigent develops, manufactures and commercializes innovative microfluidic flow control and fluid handling solutions for laboratories, research units and industrials around the world

Enabling full control of your microfluidic systems through pressure, flow and electrical monitoring, Fluigent technologies provide innovating solutions for all your microfluidic and lab-on-a-chip applications (droplet-based drug testing, chromatography, cell perfusion, flow chemistry, cells and parasites separation, dielectophoresis, highly viscous fluids and liquid air manipulations, gene expression analysis in microdroplet, etc).

Indeed, Fluigent has created the market of pressure-driven flow controllers for microfluidic applications and low volume fluid handling. The products are based on the patented FASTAB technology optimizing stability and responsiveness of the flow inside your microfluidic systems (chip, microarray, etc).

In addition to the FASTAB technology, Fluigent owns or licences a portfolio of patents worldwide covering its core technologies in microfluidic flow control, Lab-on-a-chip devices, diagnosis and life science analysis (cell capture, etc).

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IMT has been synomynous with customized microstructures both in Glass and high precision thin-films for over 50 years. We are among the leading international providers of complete solutions in field of microlithography and thin films. Highly qualified employees, innovative technologies and the latest infrastructure form the basis of our high quality products and comprehensive services.

iX-factory provides customised chips in glass in silicon and is specialised in MEMS and microfluidic solutions. Industries: Medical, Biotechnology, Chemistry, Pharmaceutics, Automotive, Environment, Tele- und Data Communication, Life Sciences, Aerospace,

Optics. For more information please visit www.ix-factory.com.

Established in 2005 as the world’s first microfluidic application centre, Dolomite focused on working with customers to turn their concepts for microfluidic applications into reality. Today, Dolomite is the world leader in solving microfluidic problems. With offices in the UK, US and Japan, and distributors throughout the rest of the

world, our clients range from universities developing leading-edge analytical equipment, to manufacturers of chemical, life sciences and clinical diagnostics systems. Dolomite’s key strength lies in offering a complete service to customers from problem conceptualisation and feasibility testing through to full instrument design and development. By Productizing Science™, we have enabled customers around the world to develop more compact, cost-effective and powerful instruments. Dolomite also offers a Microfluidic Consultancy to develop a variety of versatile, complex and cutting edge custom devices, available in exceptionally short lead times. Whatever your microfluidic requirements and application, Dolomite is the right partner with the right expertise!

For more information please contact us on +44 (0)1763 242491, info@dolomite-microfluidics.com or visit our website www.dolomite-microfluidics.com.

http://www.ix-factory.com/mailto:info@dolomite-microfluidics.comhttp://www.dolomite-microfluidics.com/http://www.dolomite-microfluidics.com/

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As a leading supplier in the fields of fluidics and microreaction technology, the Little Things Factory develops and produces high-quality components and systems solutions in glass, quartz and glass-silicon composite materials for a variety of sectors. Typical applications in the fields of life science, chemistry and research and

development are lab-on-chip products as well as microreactors of the kind required in the fields of diagnostics, medicine distribution and implantology or the manufacture of special chemicals. The Little Things Factory has many years of expert knowledge in the design and application of optical, electronic and chemical functions within a wafer as the basis for microstructured processes. The company has thus become a sought-after partner for technology concerns, research institutions and universities alike

Micronit designs and manufactures customized lab-on-chip products and will show some examples together with a microfluidic connection kit. www.micronit.com

NILT has since 2006 supplied masters and molds for imprinting/hot-embossing/injection moulding to the market. We are using state-of-the-art tools like electron beam lithography, deep UV lithography and ICP etching in the production of masters as well as in-house Ni plating and laser cutting tools for

the production of advanced molds/inserts for injection moulding. Since we have the technology to supply molds/inserts to the production of microfluidic and lab-on-a-chip systems we have lately started to approach the microfluidic community to discover new customers who need high quality molds/inserts for their production and fast prototyping.

http://www.micronit.com/

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Logistics: Delegates are responsible for making their own travel and accommodation arrangements. Please tell us how you plan to travel and where you will be staying so we can offer taxi/transfer shares. The information below will facilitate this. The Open and Closed Meetings take place in Cambridge, MA just across the Charles River from Boston and circa 30mins from Logan International Airport which has very good connections to Europe and the USA as well as regular shuttle flights to New York.

Hotel Recommendation Cambridge Central Cambridge hotels located within walking distance of the meeting venues are not cheap! Here is a mix of price/convenience options Boston Marriott Cambridge (5 mins walk) Two Cambridge Center, 50 BroadwayCambridge, MA 02142, USA 1 617-494-6600View Hotel Website

View Photos Located across the Charles River from downtown Boston, our Cambridge hotel is located in the heart of the Cambridge business district. This Cambridge, the hotel is conveniently located in Kendall Square near MIT, Harvard and Boston University. Room prices start at $299

Holiday Inn Express (10 mins cab) 69 Boston Street MA 02125

https://www.marriott.co.uk/hotels/quickView.mi?marshaCode=BOSCB&pin=2&map=true&view=https://www.marriott.co.uk/hotels/quickView.mi?marshaCode=BOSCB&pin=2&map=true&view=https://www.marriott.co.uk/hotels/quickView.mi?marshaCode=BOSCB&pin=2&map=true&view=https://www.marriott.co.uk/hotels/quickView.mi?marshaCode=BOSCB&pin=2&map=true&view=https://www.marriott.co.uk/hotels/photo-tours/?marshaCode=boscb&pageID=HWHOM&imageID=0https://www.marriott.co.uk/hotels/photo-tours/?marshaCode=boscb&pageID=HWHOM&imageID=0https://www.marriott.co.uk/hotels/photo-tours/?marshaCode=boscb&pageID=HWHOM&imageID=0https://www.marriott.co.uk/hotels/photo-tours/?marshaCode=boscb&pageID=HWHOM&imageID=0https://www.marriott.co.uk/hotels/photo-tours/?marshaCode=boscb&pageID=HWHOM&imageID=0

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Prices start at $199 A Friendly Inn at Harvard (Guest House)

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Rooms start at $150

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Venue for Joint Reception with FluidicMEMS eve Sept 22

700 Main Street Cambridge, MA 02139

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Closed Meeting Venue Location (Cambridge, MA USA) Day Sept 22

British Consulate General Boston

7th Floor 1 Broadway Note: Photo ID will need to be shown to security on the ground floor.

Cambridge

MA 02142

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Open Meeting venue Location (Cambridge MA USA) Day Sept 23: 4th Floor One Cambridge Center (aka Microsoft Technology Center) Note Photo ID required for entry 225 Mainstreet Cambridge, MA 02142 Phone: (781) 487-6400 Fax: (425) 936-7329 mtcbos@microsoft.com

Convenient Parking: Parking is conveniently located at Cambridge Center West at Kendall Square, adjacent to One Cambridge Center and the Marriott Hotel. There are garage entrances off of both Broadway and Ames Street (see below). Please follow the Microsoft signs to our main entrance in the front of our building. The following parking rates currently apply: • Up to one hour $15.00 • Up to three hours $30.00 • Up to twenty four hours $40.00

Questions?:CfBI staff are available before or during MF-5.5 to help with delegate queries including transfer and ride share options. operations@cfbi.com

http://www.microsoft.com/en-us/mtc/locations/mtcbos@microsoft.commailto:operations@cfbi.com