Claudio F. R. Geyer II - UFRGS Inês de Castro Dutra COPPE - Sistemas - UFRJ
Metallurgical and Materials Engineering of COPPE/UFRJ ... · Metallurgical and Materials...
Transcript of Metallurgical and Materials Engineering of COPPE/UFRJ ... · Metallurgical and Materials...
‘Mecânica, Materiais Avançados e Nanotecnologia’
Metallurgical and Materials Engineeringof COPPE/UFRJ:
from 1967 to Biomaterials
Gloria de Almeida Soares
‘Mecânica, Materiais Avançados e Nanotecnologia’
• Teaching (undergraduate and graduate levels)
• M.Sc. and Ph.D. Projects
• Cooperative Research and Exchange
• Technological Projects, Evaluations and Consulting Services
Academic Staff: 31Technical & Administration Staff: 27
Metallurgical and Materials Department
2001-2003: ≈ US$ 4 million
‘Mecânica, Materiais Avançados e Nanotecnologia’
ACADEMIC RESULTS
Graduates degrees more than 600 (up to dec. 2003)
PERIOD M.Sc. Ph.D. TOTAL
1967-1997 363 52 415
1998-2000 79 30 109
2001-2003 73 40 113
TOTAL 515 122 637
Undergraduate: more than 600 (Metal. & Materials)
‘Mecânica, Materiais Avançados e Nanotecnologia’
Research Groups:
• Mineral Processing and Extractive metallurgy• Thermomechanical processing and microstructural eng.
• Physical metallurgy and mechanical properties• Welding and non-destructive testing
• Corrosion• Surfaces and thin films
• Advanced ceramics• Biomaterials
‘Mecânica, Materiais Avançados e Nanotecnologia’
BIOMATERIALS:
Start: 1995
Academic results: 24 M.Sc and 6 D.Sc.
Research Themes:• Materials for bone-substitution: Development of porous and granular hydroxyapatite -based materials. Hydroxyapatite-based composites.
• Materials for implants: surface treatments on titanium and titanium alloys. Bioactive coatings.• Correlation between properties and microstructure on dental ceramics.• Corrosion of metallic alloys.• Polymer and Composites for Restorative Function.• Failure analysis on dental restoration
‘Mecânica, Materiais Avançados e Nanotecnologia’
characterization of commercial CaP granules
Materials for bone-substitution:
Calcium Phosphate (CaP) Materials
Bone graft
Scaffold for cell therapy
Carriers for drug delivery
multiphase, micro ormacroporous granules or tablets
hydroxyapatite-collagen composites
Zn-containing hydroxyapatite
‘Mecânica, Materiais Avançados e Nanotecnologia’
2. CaP porous tablets
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PO
RE
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TR
IBU
TIO
N (
%)
(mea
sure
d by
imag
e an
alys
is)
RAN G E O F P O RE S IZE (µm)
20 wt.% naphthalene 40 wt.% naphthalene
SEM
Oliveira, J.F., 2003
‘Mecânica, Materiais Avançados e Nanotecnologia’
3. HA-collagen composites
Sena, L.A., 200418 20 22 24 26 28 30 32 34 36 38
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2θ
L002 = 17 nm
L300 = 7 nm
‘Mecânica, Materiais Avançados e Nanotecnologia’
4. Zn-apatites calcinated at 1150°C
20 30 40 50
Znhap 20%ZnTCPHap
Znhap 10%
Znhap 5%
Hap
2θ
1200 1000 800 600
945920
965977
1009102910651122
597555
923942
963
10291045
10201088
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631
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10451089
571600631961
10451089
número de onda (cm-1)
Hap calc. ZnHap 5% calc. ZnHap 10% calc. ZnHap 20% calc.
5%Zn - calc
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[Zn]
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Dias
Zn -ZnHap5c. Tris Zn -ZnHap5c. Hepes
Costa, A.M., 2004
‘Mecânica, Materiais Avançados e Nanotecnologia’
SAMPLE COMPOSITION
CDb 59.8 HA – 40.2 α-TCP
Eb 95.4 HA – 4.6 α-TCP
5. Cell culture on HA/α-TCP tablets
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Time in culture (days)
CDb Eb
‘Mecânica, Materiais Avançados e Nanotecnologia’
BONE FORMATION
Depends on:
Surface Energy Surface Composition
Topography
Materials for implants:
Titanium and Ti-alloys
Jones, J., 2001
‘Mecânica, Materiais Avançados e Nanotecnologia’
1. Surface Treatment on cp Titanium
-538 -537 -536 -535 -534 -533 -532 -531 -530 -529 -528 -527 -526
Ti-acid + oxide2
Ti-acid + oxide1
Ti-acid
Ti
BINDING ENERGY (eV)
INT
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Y
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721
CA
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BF
(mg/
L)
SOAKING TIME (days)
Ti-control
Ti-etched
Ti-etched + oxide 1
Ti-etched + oxide 2
Vanzillotta, P.S., 2003
‘Mecânica, Materiais Avançados e Nanotecnologia’
2.Anodic oxidation with H3PO4
50V 100V
150V 200V
Santos Jr., E., 2004
‘Mecânica, Materiais Avançados e Nanotecnologia’
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3 BEST THREADSALL THREADS
% C
ON
TA
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BO
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-IM
PLA
NT
c.p.Ti HA-coated Ti
3. Ti Implants coated with HA by
Electrophoresis
BSE image
Costa, C.A., 2002