METAL IONS IN BIOLOGY AND MEDICINE

LES IONS METALLIQUES EN BIOLOGIE ET EN MEDECINE

Volume 4

UB/TIB Hannover 89116 462 71X

CONTENTS/SOMMAIRE

V ForewordVII Avant-proposIX CommitteesX List and addresses of editors

CHEMISTRY, STRUCTURAL ANALYSIS

3 Manganese and cobalt cytosine (Cyt) and 1 -methylcytosine(1 -Mecyt) complexesDE MUNNO G., GEDAY M.A., MEDAGUA M., ANASTASSOPOULOU J.,THEOPHANIDES T.

6 Light-controlled selective regulators of transmembrane trans-port of metal ions. Crown ether dyes : structural role ofdimers's formation in the ion-binding functionFEOFANOV A., IANOUL A., KRYUKOV E., OUINIKOV V., ZAITSEV S.,GROMOV S., FEDOROVA O., ALFIMOV M., NABIEV I.

9 In vitro bioavailability of copper, zinc, and iron in infant formulassupplemented with copper saltsALEGRIA A., BARBERA R., FARRE R., LAGARDA M.J., MANDIN A.

12 Tin-based antitumor drugsGlELEN M.

15 From metal antidotes to antibiotics: designing new chelatingagents for therapeutic usesJONES M.M.

18 Selenium-specific biological indexes for selenium-demand byHPLC/ICPMS with enriched stable isotopeSUZUKI K.T., ITOH M., OHMICHI M.

21 X-ray absorption spectroscopy: a structural probe of biologi-cal metal sitesMARONEY M.J., Gu Z., CHOUDHURY S.B., ALLAN C.B.

2 4 Ion beam analysis of metalloproteinsSZOKEFALVI-NAGY Z.

27 Towards an ultra high magnetic field biological electron spinresonance large scale facilityVAN DAM PJ., REUERSE EJ., KIAASEN A.A.K., BOONMAM M.E.J.,VAN BENTUM P.J.M., PERENBOOM J.A.A.J., HAGEN W.R.

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3 0 Acenapthenequinone thiosemicarbazone and its transitionmetal complexes. Synthesis, structure and biological activityRODRIGUEZ-ARGUELLES M.C., FERRARI BEUCCH M., FAVA GASPARRI G.,

PEUZZI C , PELOSI G., ALBERTINI R., LUNGHI P., PINELJJ S.

3 3 Determination of healthy serum iron content by MRI.YlLMAZ A., YURT A., LONGO R., TuGRUL P., DALLA PAIMA L

BIOMOLECULAR INTERACTIONS

1 . Nucleic acids

3 9 FT-IR spectra of oligonucleotide-Mg++ complexesMlSSAIUDIS S. , ANASTASSOPOULOU ) . , THEOPHANIDES I

4 2 Interaction of 1.3-dimethyluracil in solid state with metal ionsNa+, Mg2+ and Cu2+ in aqueous solution by FT-IR and ramanspectroscopyIZA N., GIL M.

4 5 Zinc ions and nucleotide interactionsANASTASSOPOULOU J . , SARROS G . , FOTOPOULOS N . , MlSSAIUDIS S.,

NASTOU H., SARROU V., NASTOS A.

4 8 Rotational and conformational effects on Pt-DNA bindingand anti-tumor activity: Part 1. Influence of amine ligandstructure on Pt-purine bond rotation in c/s-bis(purine) Pt(ll)complexes containing substituted pyridines and 1,2-phenyie-nediaminesCLEMENT O., BUNCEL E.

5 1 Rotation and conformational effects on Pt-DNA binding andanti-tumor activity: Part 2. Influence of amine ligand struc-ture on Pt-purine bond rotation in c/s-bis(purine) Pt(ll)complexes containing aromatic alpha-diiminesBUNCEL E., CLEMENT O.

5 4 Vibrarional study of the complex of Cd(ll) with cytidine-3'-monophosphateDE LA FUENTE M., NAVARRO R., HERNANZ A., CAMPOS M., DlAZ C ,PADILLA L, DIAZ G.

5 7 Interactions of Cr(lll) with 5'-CMP and 5'-GMP. Spectrosco-pic studyDE LA FUENTE M., NAVARRO R., HERNANZ A.

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6 0 Mechanistic studies on the inhibition by Nl(ll) of 8-oxo-2'-deoxyguanosine-5'-triphosphatase (MutT), a nucleotidepool-sanitizing enzymePORTER D.W., NELSON V.C., FIVASH Jr M.J., KASPRZAK K.S.

6 3 Effects of zinc on metallothionein gene expression andcadmium accumulation in the testes ana liver or ratsMCKENNA I.M., WAALKES M.P.

6 7 Molecular approaches to elucidate genetically-programmedresponses to aliminum, arsenic and selenium in prokaryotesand eukaryotesDIORIO C , DuBow M.S.

7 0 Elevated DNA single-strand breakage frequencies in lym-phocytes of chromium/nickel-exposea weldersPOPP W., VAHRENHOLZ C , BRAUKSIEPE A., LANGEN V., NORPOTH K.

7 3 Chromatin condensation and DNA methylation during nickelcarcinogenesisCOSTA M.

2. Proteins, Metallothionein

7 9 Effect of zinc administration on metallothionein in CCL4-trea-ted ratsCABRE M., FOLCH J., PATERNAIN J.L, PADROL C , ROVIRA J.,

JOVEN J., CAMPS J.

8 2 Relative zinc-binding capacity of metallothionein in hepaticcytosols of zinc-injected ratsSAITO S., KOJIMA Y.

8 5 Limitations of zinc and metallothionein accumulation in ratlivers following zinc administrationSAITO S.

8 8 Metal toxicity and induction of metallothionein in culturedhuman proximal tubular cellsRODILLA V., MILES A.T., HAWKSWORTH G.M.

9 1 The effects of inorganic anions Cl, Br, I and NO3 on thesolution structure of proteins of photosystem IIBOGRAH A., CARPENTER R., TAJMIR-RIAHI H.A.

9 4 Coordination properties of L-cysteine and its derivativestowards diethyltin(IV) in aqueous solution: molecular basis ofthe biological activity of diorganotin(IV) compoundsBUZAS N ., GAJDA T., KUZMANN E., NAGY L., VERTES A., BURGER K.

9 7 The reaction of arsenite with glutathione in physiologicalbufferGAILER J.

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100 Characterization of a mercury and selenium-binding proteinspecific for the detoxification of both metals in serumYONEDA S., OHMICHI M . , SUZUKI K.T.

3 . Enzymes

105 The inhibition of xanthine oxidase (XO) in copper deficiencyFIELDS M., LEWIS C.G.

107 Induction of the MAP kinase cascade by organometal com-poundsZAUCKE F., KRUG H.F.

110 Inhibition of constitutive nitric oxide synthase of rat cerebellumby quinoid compoundsKUMAGAI Y., NAKAJIMA H., SHINYASHIKI M., HOMMA-TAKEDA S.,SHIMOJO N.

113 Inhibition of dehvdrogenase activity as a mechanism behindcisplatin-inducea toxicitiesAGGARWAL S.K., MEARA D.J.

116 Interaction of cisplatin with ribonuclease A and humansenjm albumin studied by FTIR spectroscopyNEAULT J.F., TAJMIR-RIAHI H.A.

119 Inhibition of isocitrate dehydrogenase from pig liver by alu-minumCHAYA S.S., JOSHI J.G.

122 Al3* ion does not substitute Cu2* ion at the active site of thesuperoxide dismutase of human erythrocytesFERNANDES M.A.S., OUVEIRA C.R.

126 Effect of vanadium on aerobic and anaerobic respiratoryenzymesMENDZ G. L.

4 . Carbohydra tes

131 Equilibrium studies, co-ordination isomers and local structureof organotin(IV) complexes formed with carbohydratesNAGY L, BUZAS N., GYURCSIK B., YAMAGUCHI T., BURGER K.,VERTES A.

134 Cobalt, the metallic component of "glucose tolerance factor"(GTF)Siu6 F., CEDENILLA O., LA SERNA B., RUBIO J.M.

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5. Oxidation, peroxidase

1 3 9 Iron catalyses the autoxidation of cysteine by formation of anoxygen-adductHERLINGER E., JAMESON R.F., LJNERTW.

142 Standardization of an in vitro model of oxidative stress in ratheart mitochondria based on the Fenton reogents : effect ofdifferent buffersASI'N J., MARSAI C , ANDREU A.L., ARB6S M.A., L6PCZ N.,

SCHWARTZ S.

1 4 6 Protective role of tetrathiomolybdate against oxidotive stressinduced by metalsOGRA Y., SUZUKI K.T.

1 4 9 The effect of desferrioxamine on chromium mediated oxida-tion and peroxidation reactionsALPOIM M.C., FERREIRA C.A.M., OUVEIRA C.R., LMA M.C.P.,GERAIDES C.F.G.C, SANTOS M.E.R.

1 5 2 Influence of histidine on hydroxyl radical production by thecoppen|ll)/ascorbate systemRANDALL-SIMPSON J., LAMBS L, BERTHON G.

1 5 6 Iron loading from ferrocene facilitates lipid peroxidation andhepatocellular injury in rats ingesting ethanolVALERIO L.G. JR, HARTLEY D.P., PETERSEN D.R.

ECOTOXICOLOCY

1 6 3 Determination of platinum levels in wines samplesCABRERA C , TEISSEDRE P.L., CABANIS M.T., CABANIS J.C.

1 6 6 Trace metal concentrations in soil and water from Petrolina,BrazilSCHUHMACHER M., JARDI M., DOMINGO J.L.

1 6 9 Concentrations of chosen microelements in fur of various nutriagenotypes during ontogenesisSUVEGOVA K., MERTIN D., HANUSOVA E., STEPANOK V.

1 7 2 Wine contribution to chromium and nickel dietary intakeand their biodisponibilitiesTEISSEDRE PL., CABRERA C , CABANIS M.T., CABANIS J.C.

175 Concentration levels of mercury in algae of the CanaryIslands LittoralLOZANO G., HARDISSON A., HERNANDEZ-VELAZQUEZ A.

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178 Analysis of some toxic metals and boron in workplace at-mospheres of ceramic factoriesROIG-NAVARRO A.F., L6PEZ F.J., HERNANDEZ F.

180 Transfer of heavy metals from soils to crops irrigated withuntreated sewage effluents from Mexico-citySIEBE CH., GARO-SANTOS E., SCHUHMACHER M., CIFUENTES E.,DOMINGO J.L.

183 Contribution of wine in vanadium dietary intake : geographi-cal origin has a significant impact on wine vanadium levelsTEISSEDRE PL, CROS G., KROSNIAK M., PORTET K., SERRANO J.J.,CABANIS J.C.

CELL BIOLOGY

1 . Ionic t r anspo r t

189 Subcellular imaging of metal ions and the application ofstable isotopes for measuring the influx of calcium ions andlabeled molecules in single cells by secondary ion massspectrometryCHANDRA C , MORRISON G.H

192 7Li NMR study of lithium ion transport in perfused humanneuroblastoma cellsCASTRO M.M.C A , NKOLAKOPOULOS J., ZACHARIAH C , FREITAS D.M.,STUBBS JR E.B., GERALDES C.F.G.C, RAMASAMY R.

195 Iron transport and localization in mammalian cell nucleusGURGUEIRA S.A., SASSAKI R.M., GALEMBECK F., CAIRO DA SUVA I.,MILDER R., MENEGHINI R.

198 Monitoring intracellular free magnesium in human cells bymicrospectrofluorimetrySEBILLE S., MIUOT J.M., JACOUOT J., ARNAUD M., DELABROISE A.M.,MANFAIT M.

201 In situ ion transport: nutritional and toxic metal SIMS studiesLAZOF D.B., GOLDSMITH J.G., LJNTON R.W., GILLEN G.

2 0 4 Mercury compounds reduce voltage-activated ion channelcurrentsLEONHARDT R., PEKEL M., PLATT B., HAAS H I . , BUSSELBERG D.

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2. Cell distribution, microanalysis

2 0 9 SEM-mapping X-ray microanalysis of embedded material.An alternative technique to bulk (SEM) and stem microanalysisFlGUERAS M.J., MONCUSJ M. , MAYAYO E.

2 1 2 Metal mobilization and subcellular distribution of cadmiumand copper in rainbow trout (O. mykiss) exposed to repea-ted IP injections of cadmium chlorideCARBONELL G., BOLEAS S., FERNANDEZ C , SANTIAGO D.,TARAZONA J.V.

2 1 5 Luminescent biosensors for the detection of metal bioavaila-bilityVIRTA M., TAURIAINEN S., LAMPINEN J., KARP M.

2 1 8 Zinc-uptake by human erythrocytes. I. Effect of Na* and K*in the medium at different temperaturesGALVEZ M., MORENO J.A., EL6SEGUI L.M., ESCANERO J.F.

2 2 2 Zinc-uptake by human erythocytes. II. Effect of the tempera-ture on Zn-uptake sensitive to the stilbenesGALVEZ M., MORENO J.A., ELOSEGUI L.M., ESCANERO J.F.

3. Cell membrane

2 2 9 Electrophysical analysis of metal ions-induced toxic shock inphototrophic microorganismsKHASSANOVA L., IVANOV A., KHASSANOVA Z., PAVLOVA E.,

COLLERY P., CHOISY C , ETIENNE J.C.

2 3 4 Control by electrical parameters of Escherichia coli K-12membrane damages resulting from metal ionsIVANOV I., KHASSANOVA L, KHASSANOVA Z., COLLERY P., CHOISY C ,ETIENNE J.C.

2 3 8 Effect of cadmium on citrate uptake by isolated rat renalbrush border membrane vesiclesSATO K., KUSAKA Y, ZHANG Q.W., OKADA K., NAKAKUKI K.,

MURAOKA R.

2 4 1 Actions of lead on neuronal membrane currents and synap-tic plasticityBUSSELBERG D.

2 4 4 Transport of iron, aluminium and gallium at the blood-brainbarrierRADUNOVIC A., DELVES H.T., DAY J.P., BRADBURY M.W.B.

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4. Mitochondrial function

2 4 9 The effect of gallium on the calcium retention capacity of ratliver mitochondriaGOGVADZE V , ZHUKOVA A . , IVANOV A . ; KHASSANOVA L,

KHASSANOVA Z., COLLERY PH.

2 5 3 Liver mitochondrial dysfunction induced by free iron duringiron overload in ratsGALLESI D., GOVANNNI F., CECCARELLI D., KOZLOV A.V., TOMASI A.,

TRENTI T., MASINI A.

2 5 7 Mitochondrial alterations observed in rats after intravenousadministration of plutonium citrateTHANNOO D., GALLE P., PAOUET F., BERRY J.P.

5. Cell immunology

2 6 3 Implications of the zinc and mercury salts on the structureand function of lysozymeQ M O R., MARTIN J.A., ca SOCORRO J.M., GARCIA O., TEIJON J.M.

2 6 7 Induction of aneuploidy in human lymphocytes by vanadiumsaltsMlGUORE L , SCARPATO R.

2 7 0 Mitogenic effect of zinc on splenic lymphocytes proliferationin certain developmental stages of miceLASTRA M.D., PASTEUN R., CAMACHO A., SALDIVAR L, AGUILAR A.E.

6. Cytotoxicity

2 7 5 Calcium as a mediator and/or amplifier of organometaltoxicityKRUG H.F., ADE I , ZAUCKE F., ZOLTZER H.

2 7 8 Protective effects of magnesium on glutamate neurotoxicityZHU L, GAO J., W U J., ZHAO X.N., ZHANG Z.X.

281 Enhancing effects of Tb3+ on glutamate cytotoxicity in PCI 2cellsLIN L, ZHOU F.Q., TANG G.Z., ZHANG H.Y., ZHAO X.N., ZHANGZ.X.

2 8 4 Aluminium accumulation and toxicity in cultured neuronsand astrocytesSUAREZ FERNANDEZ M.B., TORREBLANCA PAOOS A., GOENAGAINFANTE H.; SOLDADO A.B., SANZ MEDEL A., VEGA J.A., NOVELU A.

2 8 7 Cytotoxicity of cadmium chloride in alveolar type II cellsRAMIS I., FARRES D., RosEao-CATAFAU J., GELPI' E., BULBENA O.

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2 9 1 Methyl mercury-induced acute neurotoxicity in peripheralnervous tissue. Implications for oxidative stressWEBER S., BOSCH-MORELL F., ROMERO F.J.

2 9 4 Vanadium compounds alter cell proliferation and differentia-tion on cultured osteoblast-like cellsCORTIZO A.M., BARRIO D.A., ETCHEVERRY S.B.

2 9 8 Mitogenicity, cytotoxicity and morphological changes byvanadium compounds on Swiss 3T3 cellsETCHEVERRY S.B., SAUCE V.C., VESQNA C M . , CORTIZO A.M.

7. Mutagenicity

3 0 3 Metallothionein blocks mutagenicity of anticancer drugsGONCHAROVA E., PEREZ R., ROSSMAN T.G.

3 0 6 Protective effect of vitamin C on cisplatin induced mutagenicityGIRI A., PRASAD S.B.

8. Cell function

3 1 1 Tissue culture and mineralizationBARCKHAUS R.H.

3 1 4 Enhancing effects of B-endorphin on glutamate-inducedelevation of calcium levelsG A O J., ZHU L, W U J., ZHAO X.N., ZHANG Z.X.

3 1 7 Effects of Lazaroids U74389F and U89843D on iron-induceddegeneration of nigrostriatal dopaminergic neuronsCRANDAU B.M., SENGSTOCK G.J., ARENDASH G.W.

3 2 0 Mechanism of attenuation of dopaminergic activity innucleus accumbens of rats exposed to low levels of leadJADHAV A.L., KALA S.V.

3 2 3 Antagonic effect of zinc on intracellular calcium during acuteinfusion of TRH, in vivo : a possible interaction with prolactinregulationCASTRO A.V.B., BRANDAO-NETO J., MENDONCA B.B., MENDESA.L., CAMPOS F.J.

3 2 5 In vivo or in vitro exposure to the anti-diabetic agent VOSO,has opposite effects on insulin release from isolatedpancreas preparationCADENE A., CROS G., MONGOLD J.J., POUCHERET P., GROSS R.,

MASIELLO P., RIBES G., SERRANO JJ.

3 2 8 Mechanism of insulin-like actions of vanadium compoundsSRIVASTAVA A. K., CHIASSON J.L, PANDEY S.K.

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V EXPERIMENTAL ANIMAL STUDIES

1. Biodistribution, bioavailability

3 3 3 Study on heavy metal pollution in the Western Mediterra-nean area (Spain). Distribution, bioavailability and relation-ships with fish catchesSERRANO R., HERNANDEZ F., LOPEZ F.J., ANSUATEGUI J.

3 3 6 Copper and zinc status in different rat tissues after theadministration of ginsengGALLARDO PEREZ L, SANCHEZ-MAYORAL A., MIGUEL R., INSERN F.,

ROMERA J.A., GRANADOS I., SANTOS A .

3 3 9 Comparison of ferrous and ferric iron bioavailability follo-wing rat cecal infusionKAMINO H., EBIHARA K.

3 4 2 Changes in bioavailability of iron caused by magnesiumdeficiency in ratsSANCHEZ-MORITO N., PLANELLS E.M., MORENO M.J., LERMA A.,

ARANDA P., LLOPIS J.

3 4 6 Effects of magnesium deficiency on the bioavailability ofmanganese in ratsMORENO M.J., PLANELLS E.M., SANCHEZ-MORITO N., LERMA A.,ARANDA P., LLOPIS J.

3 5 0 Potassium concentration in mouse tissues : effect of age,sex, strain and potassium deficiencyCREMADES A., TEJADA F, GALINDO J.D., PENAFIEL R.

3 5 4 Effect of chromium picolinate on the tissular distribution ofmanganese and its repercussion on glucose metabolismMATEOS CJ., JORGE A., MESEGUER I., LABORDA J.M., BERNAO A.,

GONZALEZ M.J., MARTINEZ PARA M.C, AGUILAR M.V.

3 5 7 Quantification of total chromium and Cr(VI) in rat liver byelectrothermal atomization atomic absorption spectrometryBASTOS M.L., SOARES M.E., FERREIRA M.A.

3 6 0 In situ determination of mercury distribution and apoptoticcells in mercury-treated rat kidney by a combination or syn-chrotron radiation X-ray fluorescence (SR-XRF) imaging andTUNEL stainingHOMMA-TAKEDA S., ISHIDO M., KUMAGAI Y., TAKENEDA Y,SHIMOJO N.

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3 6 3 Sodium 2,3-dimercapto-l-propanesulfonate treatment doesnot redistribute mercury or lead to the brain of ratsAPOSHIAN M.M., MAIORINO R.M., Xu Z., APOSHIAN H.V.

3 6 6 Interaction of iron, sodium and calcium with intestinal alu-minium absorptionDE WOLFF F.A., VAN DER VOET G.B.

3 6 9 Bioavailability studies of tetradentate Schiff-base galliumcomplexes (Salens)Ho D.H., ABRAMS M., GIANDOMINICO C , BRADLEY F., FROST D.,

BEKERSKY I.

2. Carcinogenesis

3 7 5 Single cell gel electrophoresis assay in the evaluation ofmetal carcinogenicityROJAS E., VALVERDE M., SORDO M., ALTAMIRANO-LOZANO M.,OSTROSKY-WEGMAN P.

3. Antitumor effects

381 Determination of ruthenium by atomic absorption spectro-scopy after treatment with Na[frans-RuCl4(DMSO)lm]COCCHIETTO M., SALERNO G., MESTRONI G., ALESSIO E., SAVA G.

4. Immunology

3 8 7 Zn effects on phagocytic responses during certain stages ofontogeny in miceAGUILAR A.E., PASTELIN R., MONROY B., ARRONA P., LASTRA

M.D.

5. Toxicology

3 9 3 The effect of zinc on spina bifida produced by GABA ago-nists in the ratBRINER W.E., BALL J.D.

3 9 6 Strategies to improve urinary aluminium excretion in the ratLOTE C.J., WILLMOTT K.L., THEWLES A., W O O D J.A.

3 9 9 Arsenic toxicology: does methylation of arsenic specieshave an evolutionary significance ?APOSHIAN H.V.

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4 0 2 Modificative effects of dietary iron ingestion on the manifes-tation of anemia by oral cadmium administration in ratsOHTA H., SEKI Y., YOSHIKAWA H.

4 0 5 Contribution to the mechanism of chromate nephrotoxicityin developing ratsAPPENROTH D., ROST M., FRIEDRICH M.

4 0 8 Maternal stress and prenatal exposure to arsenite and me-thylmercury : evaluation of acquisition and retention effectsin a food search taskALBINA M.L., ESPARZA J.L., COLOMINA M.T., DOMINGO J.L.,CORBELLA J.

4 1 1 Biological monitoring of Hg exposure using DMPSClKRT M., NERUDOVA J., CABELKOVA Z., FRANTiK E.

4 1 4 Protective effects of 2,3-dimercaptopropanol and meso-2,3-dimercaptosuccinic acid against mercury-induced nephro-toxicityDE LA TORRE A., BELLES M., GRANERO S., G6MEZ M., LLOBETJ.M., MAYAYO E., DOMINGO J.L, CORBELLA J.

4 1 7 Effects of lead in murine placentaFUENTES M., TORREGROSA A., MORA R., GOTZENS V , CORBELLA J.,DOMINGO J.L.

4 2 0 Neuroendocrine mechanisms underlying the reproductivetoxicity of lead in a rat lifetime exposure modelRONS M.J.J., BELL L.M., PARKER J., SHAW M., GANDY J.,BADGER T.M., GREEN K.

4 2 3 Genotoxic and reprotoxic effects of vanadium and lithiumALTAMIRANO-LOZANO M.A., AIVAREZ-BARRERA L.

6 . Phys io logy

4 2 9 Influence of potassium homeostasis on testosterone levelsand renal androgenic effectsSANCHEZ-CAPELO A., TEJADA F., CASTELLS M.T., MONSERRAT R,CREMADES A., PENAFIEL R.

4 3 3 Sodium and calcium channel blockade effects of / - tetrahy-dropalmatine a myocardial electrophysiological observationW A N G Y, U D.X., ZHAO X.N., ZHANG Z.X.

4 3 6 Relative and combined effects of propylthiouracil (PTU),ethanol and protein deficiency on musclePEREZ-LABAJOS J., GONZALEZ-REIMERS E., SANTOLARIA F, BATISTAN., RODRIGUEZ-MORENO F., MARTJNEZ-RIERA A., RODRIGUEZ-RODRIGUEZ E., MOLINA-PEREZ M.

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4 3 9 Chromium content in target organs insulin in diabetic ratsMESEGUER I., MATEOS C.J., JORGE A., BERNAO A., LABORDA

J.M., MARTINEZ-PARA M.C, AGUILAR M.V., GONZALEZ M.J.

4 4 2 Lithium effect in Vizcacha [lagostomus maximus maximus).A comparative biochemical and histological study with ratGARCIA ASEFF S., ORELLANO G., PEREZ ROMERA E., RIBFS A.,GUINAZO F., MARIA A., MOHAMED F, MUNOZ E., VILIFGAS O.,

FUENTES L., DOMINGUEZ S., SCARDAPANE L., GUZMAN J.A.

4 4 5 Influence of endothelium on manganese-induced relaxationin isolated phenylephrine-contracted aorta from DOCA-salthypertensive ratsGAILLARD E., LAURANT P., ROBIN S., BERTHELOT A.

4 4 8 Effect of VOSO4 on smooth muscle contractility and V tissuelevels after six -month treatmentCADENE A., MONGOLD J.J., SOULIE M l , MAGOUS R., BAH J.P.,

TEISSEDRE P.L., PORTET K., SERRANO J.J., CROS G.

4 5 1 Effects of aluminum intoxication on various aspects of lear-ning in the ratJUNG P. H., LEHR P.R., TONIOLO A.M., BERTELLE D., DESOR D.

4 5 4 Studies on the hepatic handling of aluminium in the isolatedperfused rat liverWILHELM M., JAEGER D.E., SCHULL-CABUTZ H.

4 5 9 Acute and chronic cadmium administration on pituitaryhormone secretion in adult male ratsLAFUENTE A., ESQUIFINO A.I.

4 6 2 Effects of a single dose of cadmium on the episodic secre-tion of prolactinLAFUENTE A., GONZALEZ E., MOUTEIRA R.C, ESQUIFINO A.I.

4 6 5 Pulmonary responses of Wistar rats and C57 and DBA miceto inhalea cadmium oxideMCKENNA I.M., GORDON T., CHEN L C , WAALKES M.P.

4 6 9 Effect of oral cadmium administration at daily intake levelon the age-dependent change of bone mineral density inratsOHTA H., NAKAKITA M., SEKI Y, YOSHIKAWA H.

4 7 2 Alterations of animal motor activity in early stages of expe-rimental manganese poisoningCANO G., SUAREZ-ROCA H., GOMEZ G., ARCAYA J.L,

AVERSANO C , LATAN J.C, BONILLA E.

4 7 5 Enhancement by ryanodine of the effects of HgCl, on theisolated rat diaphragmR0ED A.

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4 7 8 Effects of exposures to Cd, Pb, Mo, Hg, and Se on bioche-mical and physiological parameters in chickens and rabbitsSZILAGYI M., FEKETE S., ABAZA M., TOTH L., SANKARI S., ROZSAL, ZSOLNAINE-HARCZI I., EL-SEBAI A., RABIE M.H.

4 8 1 Plasma copper and zinc evolution in renal failurePEREZ C.C., DIEZ I., GARCIA M.B., SOMBORO G., Rios M.A.,GARCIA- PARTIDA P.

7. Radiometals

4 8 7 The action of chelating agents in experimental mobilizationof cesium in mice : variations with structureLLOBET J.M., DE LA TORRE A., BELLES M., DOMINGO J.L,CORBELLA J.

4 9 0 Chelation therapy in rat with intramuscularly deposited tho-rium-234RENCOVA J., VOLF V , BURGADA R.

4 9 3 Comparison of pulmonary toxicity of yttrium chloride (YCl3)between saline and YCl3 pretreated ratsMARUBASHI K., HIRANO S., SUZUKI K.T.

HUMAN STUDIES

1 . Medicolegal studies

4 9 9 Diagnosis of drowning by blood strontium determinationversus diatom testTRAQUI A., LUDES B., BOSQUE M.A., MANGIN P.

2 . Epidemiological studies

5 0 5 Selenium content of breast milk and infant formulae : anestimation of intakes in the United kingdomFOSTER L.H., KONDZA B., SUMAR S.

5 0 8 Selenium distribution in infant formulas and breast milkTAMARI Y., KIM E.S., TSUJI H.

5 1 1 Biological markers of oxidative stress. I. Relevance of Cu, Znand Se, protective enzymes and radical-trapping moleculesNOGUES M.R., GIRALT M., ARGANY N., CERVELLO I., MALIOL J.

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5 1 4 Biological markers of oxidative stress. II. Erythrocytic andplasmatic changes after a short-term treatment with a-toco-pherol, (3-carotene and taurineGIRALT M., NOGUES M.R., ARGANY N., CERVELLO I., MALIOL J.

5 1 7 Association of blood cadmium levels to cigarette smoking inan environmentally cadmium-exposed populationFEENSTRA O., PRIDNIG G., DRASCH G., ROIDER G.

5 1 9 Copper, zinc and superoxide dismutase reference values ofa Spanish population group residing in ValenciaALEGRIA A., BARBERA R.# FARRE R., GARCIA M.J., LAGARDA MJ .

5 2 2 The assessment of trace element and toxic metal levels inhuman placental tissuesCENTENO J.A., PESTANER J.P., NIEVES S., RAMOS M., MULUCK F.G.,

KALER S.G.

5 2 5 On the massbalance in crematoriaCHARBON G.A.

5 2 9 Trace elements and mineralogy of renal calculiDE PABLO P., LASTRA M.D., DE PABLO L

5 3 2 Daily dietary intake of calcium, magnesium, copper, man-ganese, chromium and selenium in Belgium, using duplicateportion samplingROBBERECHT H., VAN CAUWENBERGH R., HENDRIX P., DEELSTRA H.A.

5 3 5 Effect of diabetes mellitus non-insulin-dependent on chro-mium content in plasma and on its urinary excretionSAAVEDRA P., ARRIETA F.J., JORGE A., MATEOS C , MARTINEZ-

PARA M.C, AGULAR M.V., GONZALEZ M.J., MESEGUER I.

5 3 8 Behavior of ultrafiltrable serum magnesium after maximalexercise in sportsmenC6RDOVA A., NAVAS F., GOMEZ M.A., ALVAREZ-MON M.

5 4 1 Variations in the serum ionized magnesium levels in post-operative and traumatic patients entering the ICUESCUELA M.P., GUERRA M., VlDAL M.D., SORIA M.S., ZAPATEROM.D., CELAYA S., ESCANERO J.F.

5 4 4 Total and ionic plasmatic magnesium assessment after abicycle ergometric testGUERRA M., MONJE A., VlDAL M.D., ZAPATERO M.D., VlUANUEVAJ. , AUAGA C , DOMINGUEZ M., HERRERA A., ESCANERO J.F.

5 4 7 Ca, Zn and Mg levels in hair of children with some allergicdiseasesKROSNIAK M., JEDRYS U., SCHLEGEL-ZAWADZKA M., BADAWI M.,

MAZUREK H.

XXV

5 5 0 The effect of general anaesthesia in serum magnesium andcalcium levelsNASTOU H., SARROS G., PALTA M., NASTOS A., DRAKOPOUOU A.,

ANASTASSOPOULOU J .

5 5 3 Selenium status in a healthy mediterranean population: acontribution to the world selenium mapTORRA M., RODAMILANS M., MONTERO F., To- FlGUERAS J.,BRUNET M., CORBELLA J.

5 5 7 A comparative study of chemical elements of seminalpbsma in fertile and infertile menCHEN W., HAN X.D., ZHU Y.W., HUANG H.

5 6 0 Influence of a low-fat diet and an activity program on thetrace element status of patients with coronary heart diseaseKRACHLER M., HABERSACK-WALLNER S., EBER B., LJNDSCHNGER M.,

WATZJNGER N., IRGOUC KJ.

5 6 3 Mineral composition of foods and drinking water fromVilcabambaSiu6 F., LAGUNA A.H., GARCJA L.E., GUAMAN J.G., SALVADOR

M.S.

5 6 6 Zinc, human diseases and agingMOCCHEGIANI E., SANTARELU L, FABRIS N.

5 6 9 Pb, Cd, Zn and Cu concentrations in human neonatal bonesand livers measured by pulse differential polarographyBARANOWSKI J.

5 7 1 Trace elements and prostate diseasePlCURELu L, CXCINA P.V.

5 7 4 Trabecular bone mass (TBM) and diet-rebted bone traceelements in the prehispanic population of Gran CananaVELASCO J., ARNAY M., GONZALEZ-REIMERS E., BARROS-L6PEZ N.,

HDEZ-TORRES O.

5 7 7 Diet-rebted trace elements in the prehistoric population ofEl HierroVELASCO-VAZQUEZ J., ARNAY M., GONZALEZ-REIMERS E., LUGO-

RODRIGUEZ M.J., HERNANDEZ-TORRES O., GOMEZ L

5 8 0 Trace element study in nucleus pulposus of human herniatedlumbar discZHU Y.W., HAN X.D., CHEN W , W E N G W.J., CHEN L.

5 8 3 Analytical evaluation of local tissues surrounding titaniumimplantsJORGENSON D.S., CENTENO J.A., MAYER M.H., MUUICK F.G.,MANSON P.N.

XXVI

5 8 6 Multielement^ analysis of human fetal tissues using inducti-vely coupled plasma-mass spectromefryGEUNAS. Y, LAFOND J., SCHMIT J.P.

5 8 9 Relationship between chromium levels in plasma and urineand some metabolic alterations associated with diabetesmellitus related to cardiovascular accidentsSAAVEDRA P., ARRIETA F.J., JORGE A., MATEOS C.J., MARTI'NEZ-

PARA M.C., AGUILAR M.V., GONZALEZ M.J., MESEGUER I.

5 9 2 Antioxidant trace elements, glutathione and glutathione per-oxidase in cystic fibrosis patients: relation to lipid peroxida-tion statusDOMINGUEZ C , LLOVERA M., RUIZ E., ARAUJO V , LJNAN S.,

GARTNER S., COBOS N.

5 9 6 Cadmium in human hair. Is there a correlation with nicotinehair contents ?BOSQUE M.A., ClRIMELE V, KlNTZ P., CORBELLA J., MANGIN P.

5 9 9 Cadmium in urine: relations with dietary habits, tobaccoconsumption and semen parameters in a human malepopulationGOMEZ-CATALAN J., FUENTES-ALMENDRAS M., INGLES GONZALEZ C,MORA RIPOLL R., CLADERA BOHIGAS T., CORBELLA CORBELLA J.,SERRA MAJEM L.

6 0 2 Blood cadmium concentrations in professionally exposedadultsGEORGIOU Z., SANTAS R., FLESSURAS I., ZIMAUS E.

6 0 5 Changes of mortality among inhabitants in a cadmium pol-luted areaNAKAGAWA H., NISHIJO M., MORIKAWA Y, TABATA M., MIURA K.,

KAWANO S., NISHI M., KIDO T., NOGAWA K.

6 0 8 Clinical courses and prognosis of itai-itai disease patientsinduced by chronic cadmium exposureNISHUO M., NAKAGAWA H., MORIKAWA Y, TABATA M., MIURA K.,

KAWANO S., KASUYA M., TERANSHI H., KITAGAWA M.

6 1 1 Which is more immunotoxic to the respiratory system, ionicor metallic cobalt ?KUSAKA Y, ZHANG Q., SATOH K., KYONO H., KOHYAMA N.

6 1 4 Neocortical iron levels in Alzheimer's disease correlate withneocortical lipid peroxidation and amyloid angiopathyARENDASH G.W., CRANDAU B.M., KIENZL E., JELUNGER K.A.

6 1 7 Distribution of individual elements in Alzheimer diseasebran tissueKIENZJ. E., JELUNGER K., WRUSS W , HORHAGER S., PUCHINGER L.

XXVII

6 2 0 Proposed role of citric acid in the production of dietary ironoverloadCRAWFORD R.D.

6 2 3 Pathogenesis of iron-overloadLu J.P., HAYASHI K.

6 2 6 Illness in siblings of hereditary hemochromatosis homozy-gotesNELSON R.L, DAVIS F.G., PERSKY V , BECKER E.

6 2 9 A new concept of mercury-toxicity in manSPRUNG R., KIJEWSKI H., BLEICH S., KROPP S.

6 3 2 Correlation of mercury concentration in human kidney,blood, urine and hair or the scalpWANGHOFER E., DRASCH G., ROIDER G.

6 3 5 Sources and intensity of lead exposure in children in uteroand early childhood from tooth analysesGULSON B.L.

6 3 9 The role of lead in plasma on heme synthesis. Comparisonwith lead in whole bloodHlRATA M .

6 4 2 The lead content in blood and hair of children from theregion of exploitation and processing of sulfurZACHWIEJA Z., CHLOPIOXA J., KROSNAK M., FOLTA M.,ZAGRODZKI P.

6 4 5 Early capillaropathy and heavy metals: an examination ofthe interrelation through systemic stochastic analysisANDRZEJAK R., ANTONOWICZ J., KOCHEL B.

6 4 8 PRA, ACE, MAO, FEP levels and interactions in humansexposed chronically to heavy metalsANTONOWICZ J., ANDRZEJAK R., KOCHEL B., LUCINSKA A.,GALARY D.

6 5 1 Meconium analysis using AAS for screening the intrauterineexposure to heavy metals in an ecological disaster regionBARANOWSKI J., BARANOWSKA I.

6 5 4 Determination of lead and cadmium in placenta, umbilicalcord blood and maternal blood using pulse differentialpolarographyBARANOWSKI J., NORSKA-BOR6WKA I.

6 5 7 Mercury, lead and cadmium levels and children's psycho-metric performanceMARLOWE M.

KXVIII

3. Clinical studies

6 6 3 Kinetics of zinc status in patients with IDDMBRANDAO-NETO J., MAZETO G.M.F.S., CASTRO A.V.B.,SHUHAMA T., FIGUEREIDO N.B., FRANCO R.J.S., CURI PR.

6 6 7 Effects of training on serum Zn and in CD3* T and CD'9+ Blymphocytes in sportsmen along a seasonC6RDOVA A., SADA G., VlLLARUBIA V, AtVAREZ-MON M.

6 7 0 Aluminium and bismuth therapies of peptic duodenal ulcersPRASDNICOV E., GALIMOV O., GANTSHFV S., FYODOROV S.,NURTDINOV M .

6 7 1 Improvement of the bismuth treatment of reflux esophagitisreflux by anesthesia of the phrenic nerveGAUMOV O., GANTSHEV S., PRASDNICOV E., FYODOROV S.,NURTDINOV M.

6 7 2 Colloidal antiseptics on base of aluminium hydroxydeKHAVKIN M., ROJTMAN M.J., KHAVKIN Y., KHASSANOVA Z.,COLLERY P., KHASSANOVA L.

6 7 3 Vanadium as a potential therapeutic agent for the treatmentof diabetes mellitusKHANDELWAL R.L., PUGAZHFNTHI S.

6 7 6 Aluminium and silicon forms in human serum: techniquesand results relevant to aluminium detoxificationSANZ-MEDEL A., WROBEL K., SOLDADO CABEZUELO A.B.,BLANCO GONZALEZ E.

6 7 9 Demonstration of copper and zinc antagonism in free livingwell nourished adultsHALLFRISH J., ZHANG C , MULLER D.C.

6 8 2 Mammary cancer therapy with citratogallateSHUKLA S.K, FROSI A.M., LJMOURIS G.S., CIPRIANI C , ATZEI G.,ARGIR6 G., BOCCARDI F., BOEMI S., OSSICINI L

6 8 5 Advanced prosptate cancer therapy with Yttrium-90 citrateSHUKLA S.K., CIPRIANI C , ARGIRO G., ATZEI G., LJMOURIS G.S.,BOCCARDI F., BOEMI S., SINIBAIXH M., CRISTAUI M.

6 8 8 Combined radioisotopic treatment in breast and prostateosseous metastasesLJMOURIS G.S., SHUKLA KANT S.

Late paper

6 9 3 Triorganophosphinegold (I) thionucleobasesTIEKINK E.R.T.

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