Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown...

19
Dr. Mirhashemi 1

Transcript of Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown...

Page 1: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Dr. Mirhashemi

1

Page 2: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Dr. Mirhashemi

Dr. Mirhashemi

2

Page 3: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Citric acid

cycle

Dr. Mirhashemi

3

Page 4: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Dr. Mirhashemi

4

Page 5: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Biosynthetic roles of The citric acid cycle

Dr. Mirhashemi

5

Page 6: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Metabolism of Glycogen

Describe the synthesis and breakdown of glycogen and how

the processes are regulated in response to hormone action.

Describe the various types of glycogen storage diseases

Dr. Mirhashemi

6

Page 7: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Glycogen structure

Dr. Mirhashemi

7

Page 8: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Electron micrograph of a liver cell

Dr. Mirhashemi

8

Page 9: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Glycogen Is Synthesized and Degraded

by Different Pathways

Dr. Mirhashemi

9

Page 10: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

UDP-glucose is an activated form of glucose

UDP-glucose is synthesized from glucose 1-phosphate and

uridine triphosphate (UTP) in a reaction catalyzed by

UDP-glucose pyrophosphorylase.

Dr. Mirhashemi

10

Page 11: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Glycogen synthase catalyzes the transfer of glucose

from UDP-glucose to a growing chain.

Dr. Mirhashemi

11

Page 12: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

A branching enzyme forms a-1,6 linkages

Dr. Mirhashemi

12

Page 13: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

The biosynthesis of glycogen

Dr. Mirhashemi

13

Page 14: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Cross section of a glycogen molecule

Glucose 6-phosphate +ATP + Glycogen +

H2O Glycogen + ADP + 2 Pi

Dr. Mirhashemi

14

Page 15: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Steps in glycogenolysis

Dr. Mirhashemi

15

Page 16: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Glycogen Breakdown and Synthesis Are

Reciprocally Regulated

The principal enzymes controlling glycogen metabolism: glycogen phosphorylase and glycogen synthase.

Phosphorylation of glycogen phosphorylase increases its activity.

phosphorylation of glycogen synthase reduces its activity.

Dr. Mirhashemi

16

Page 18: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Dr. Mirhashemi

18

Page 19: Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown of glycogen and how the processes are regulated in response to hormone action. Describe

Some types of Glycogen-storage diseases

Dr. Mirhashemi

19