Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown...
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Transcript of Metabolism of Glycogen - core.ac.uk · Metabolism of Glycogen Describe the synthesis and breakdown...
Dr. Mirhashemi
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Dr. Mirhashemi
Dr. Mirhashemi
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Citric acid
cycle
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Biosynthetic roles of The citric acid cycle
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Metabolism of Glycogen
Describe the synthesis and breakdown of glycogen and how
the processes are regulated in response to hormone action.
Describe the various types of glycogen storage diseases
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Glycogen structure
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Electron micrograph of a liver cell
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Glycogen Is Synthesized and Degraded
by Different Pathways
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UDP-glucose is an activated form of glucose
UDP-glucose is synthesized from glucose 1-phosphate and
uridine triphosphate (UTP) in a reaction catalyzed by
UDP-glucose pyrophosphorylase.
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Glycogen synthase catalyzes the transfer of glucose
from UDP-glucose to a growing chain.
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A branching enzyme forms a-1,6 linkages
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The biosynthesis of glycogen
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Cross section of a glycogen molecule
Glucose 6-phosphate +ATP + Glycogen +
H2O Glycogen + ADP + 2 Pi
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Steps in glycogenolysis
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Glycogen Breakdown and Synthesis Are
Reciprocally Regulated
The principal enzymes controlling glycogen metabolism: glycogen phosphorylase and glycogen synthase.
Phosphorylation of glycogen phosphorylase increases its activity.
phosphorylation of glycogen synthase reduces its activity.
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Some types of Glycogen-storage diseases
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