BCM208 Metabolic Biochemistry Topic 7: Gene metabolism and Expression.
METABOLIC BIOCHEMISTRY Summer 2005 Lecture 6 August 12, 2005.
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METABOLIC BIOCHEMISTRY Summer 2005 Lecture 6 August 12, 2005
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Transcript of METABOLIC BIOCHEMISTRY Summer 2005 Lecture 6 August 12, 2005.
Pyruvate dehydrogenase as seen by electronmicroscopy
E. coli enzyme:
Mass > 4.5x106
24 copies of transacetylase (E2)
24 copies of pyruvate dehydrogenase (E1)
12 copies of dihydro-lipoyl dehydrogenase
Pyruvate + CoASH + NAD+ acetyl-CoA + CO2 + NADH
LNC 16.8
Citrate Synthase
open form without substrates
closed from with substrates bound
oxaloacetate: yellowacetyl-coA: red
LNC Fig.16.18
regulatory molecules:
NADHATP, ADPCa+2
key allosteric enzymes:
the dehydrogenasescitrate synthase
LNC Fig.16-20 Note that the figure 16-16 in the 3rd edition has an error(there is an O instead of an H)
C6
C6
C4
C4
C4C2C2
C2
from oxidation of fatty acids