35

MEPCO SCHLENK ENGINEERING COLLEGE, SIVAKASI

(AUTONOMOUS)

AFFILIATED TO ANNA UNIVERSITY, CHENNAI 600 025

REGULATIONS: MEPCO - R2013 (FULL TIME)

M.TECH NANO SCIENCE AND TECHNOLOGY (FULL TIME)

Department Vision Department Mission

Rendering services to the global

needs of engineering industries

by educating students to become

professional mechanical

engineers of excellent calibre

To produce mechanical engineering

technocrats with a perfect

knowledge of intellectual and hands

on experiences and to inculcate the

spirit of moral values and ethics to

serve the society

Programme Educational Objectives (PEOs)

Basic

Understanding

To provide the basic scientific, engineering

knowledge and practical knowledge to become a

skilled practicing nano technologist.

Breadth

To become full-fledged technocrats, applying

technical skills in the synthesis, analysis and

developing nano products for the real life concerns.

Adaptive

Learning

To engage in sustained learning for career research

opportunities in academics, entrepreneurial

endeavours and industries for ever-changing

technological requirements.

Competency

To have competency in research excellence to

pursue higher studies and to become eminent

technocrats.

36

Programme Outcomes (POs)

1. Emphasising the fundamentals in the general principles of physics,

chemistry, materials, electronics and biology.

2. Insight into the materials, fabrication and other experimental

techniques used in the nano scale.

3. Understanding the formation of complex nano systems to design

new functional products.

4. In-depth knowledge in the field of nano science and technology.

5. Expertise in latest nano engineering tools with advanced software

knowledge.

6. Implementing latest nano technological advancements for the

benefit of society.

7. Nanotech solutions to green and sustainable development.

8. Realizing professional ethics in technical field.

9. Perform individual activity/leadership ability in a multifaceted

research group.

10. Communication competency in presenting/publishing research

reports.

11. Capability in completing a task within financial constraint.

12. Updating the current nano technological developments.

I SEMESTER

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

THEORY

1. 13MA176 Mathematical modeling and simulation

3 1 0 4

2. 13NT101 Quantum mechanics 3 0 0 3

37

3. 13NT102 Fundamentals of nanomaterials

3 0 0 3

4. 13NT103 Carbon nano-structures and its

functionalisations

3 0 0 3

5. 13NT104 Fabrication of nanomaterials

3 0 0 3

6. 13NT105 Basic biological sciences 3 0 0 3

PRACTICAL

7. 13NT151 Material synthesis 0 0 4 2

8. 13NT152 Computation and simulation 0 0 4 2

TOTAL 18 1 8 23

II SEMESTER

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

THEORY

1. 13NT201 Photonics for nano technology 3 0 0 3

2. 13NT202 Processing and properties of

nanostructured materials 3 0 0 3

3. 13NT203 Characterization of nano materials 3 0 0 3

4. 13NT204 Advanced imaging techniques 3 0 0 3

5. 13NT205 Nanotechnology in health care 3 0 0 3

6. 13NT206 Nano electronic devices and nano

sensors

3 0 0 3

PRACTICAL

7. 13NT251 Nano metrology & microscopy 0 0 4 2

38

8. 13NT252 Mini Project * 0 0 4 2

TOTAL 18 0 8 22

* Internal Assessment only

III SEMESTER

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

THEORY

1. 13NT301 Lithography and Nanofabrication 3 0 0 3

2. Elective-I 3 0 0 3

3. Elective-II 3 0 0 3

PRACTICAL

4. 13NT351 Project Work (Phase I) 0 0 12 6

TOTAL 9 0 12 15

IV SEMESTER

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

PRACTICAL

5. 13NT451 Project Work (Phase II) 0 0 24 12

TOTAL 0 0 24 12

Total No. of Credits : 72

39

LIST OF ELECTIVES

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

1. 13NT401 Top down Manufacturing Methods 3 0 0 3

2. 13NT402 Bottom up Synthesis of Nanostructures 3 0 0 3

3. 13NT403 Semiconductor Nanostructures &

Nano-particles

3 0 0 3

4. 13NT404 Nanotechnology for Energy Systems 3 0 0 3

5. 13NT405 Molecular Electronics 3 0 0 3

6. 13NT406 Product Design, Management

Techniques and Entrepreneurship

3 0 0 3

7. 13NT407 MEMS and Bio MEMS 3 0 0 3

8. 13NT408 Nanocomposites 3 0 0 3

9. 13NT409 Chemical nanotechnology 3 0 0 3

10. 13NT410 Nanoparticles and microorganisms, Bio

nano composites 3 0 0 3

11. 13NT411 Optical properties of nanomaterials,

Nano photonics and plasmonics

3 0 0 3

12. 13NT412 Advanced nano drug delivery systems 3 0 0 3

13. 13NT413 Bio molecular machines 3 0 0 3

14. 13NT414 Bio sensors 3 0 0 3

15. 13NT415 Bio photonics 3 0 0 3

16. 13NT416 Nano toxicology 3 0 0 3

17. 13NT417 Advanced nano biotechnology 3 0 0 3

40

M.TECH NANO SCIENCE AND TECHNOLOGY (PART TIME)

I SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

THEORY

1. 13MA176 Mathematical Modeling and Simulation 3 1 0 4

2. 13NT101 Quantum mechanics 3 0 0 3

3. 13NT102 Fundamentals of nanomaterials 3 0 0 3

PRACTICAL

4. 13NT151 Material synthesis 0 0 4 2

Total 9 1 4 12

II SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

THEORY

1. 13NT201 Photonics for Nano Technology 3 0 0 3

2. 13NT202 Processing and properties of

Nanostructured Materials 3 0 0 3

3. 13NT206 Nanoelectronic devices and

Nanosensors 3 0 0 3

PRACTICAL

4. 13NT251 Nanometrology & Microscopy 0 0 4 2

Total 9 0 4 11

41

III SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

THEORY

1. 13NT103 Carbon nano-structures and its

Functionalisations

3 0 0 3

2. 13NT104 Fabrication of nanomaterials 3 0 0 3

3. 13NT105 Basic Biological Sciences 3 0 0 3

PRACTICAL

4. 13NT152 Computation and simulation 0 0 4 2

Total 9 0 4 11

IV SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

THEORY

1. 13NT203 Characterization of Nanomaterials 3 0 0 3

2. 13NT204 Advanced imaging techniques 3 0 0 3

3. 13NT205 Nanotechnology in health care 3 0 0 3

PRACTICAL

4. 13NT252 Mini project * 0 0 4 2

Total 9 0 4 11

* Internal Assessment only

42

V SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

THEORY

1. 13NT301 Lithography and Nanofabrication 3 0 0 3

2. Elective-I 3 0 0 3

3. Elective-II 3 0 0 3

PRACTICAL

4. 13NT351 Project Work (Phase I) 0 0 12 6

Total 9 0 12 15

VI SEMESTER

SL.

NO.

COURSE

CODE

COURSE TITLE L T P C

PRACTICAL

1. 13NT451 Project Work (Phase II) 0 0 24 12

Total 0 0 24 12

Total No. of Credits : 72

43

LIST OF ELECTIVES

SL.

NO.

COURSE

CODE COURSE TITLE L T P C

1. 13NT401 Top down Manufacturing Methods 3 0 0 3

2. 13NT402 Bottom up Synthesis of Nanostructures 3 0 0 3

3. 13NT403 Semiconductor Nanostructures &

Nano-particles

3 0 0 3

4. 13NT404 Nanotechnology for Energy Systems 3 0 0 3

5. 13NT405 Molecular Electronics 3 0 0 3

6. 13NT406 Product Design, Management

Techniques and Entrepreneurship

3 0 0 3

7. 13NT407 MEMS and Bio MEMS 3 0 0 3

8. 13NT408 Nanocomposites 3 0 0 3

9. 13NT409 Chemical Nanotechnology 3 0 0 3

10. 13NT410 Nanoparticles and Microorganisms, Bio

Nano Composites 3 0 0 3

11. 13NT411 Optical properties of Nanomaterials,

Nano photonics and Plasmonics

3 0 0 3

12. 13NT412 Advanced Nano Drug Delivery Systems 3 0 0 3

13. 13NT413 Bio Molecular Machines 3 0 0 3

14. 13NT414 Bio Sensors 3 0 0 3

15. 13NT415 Bio Photonics 3 0 0 3

16. 13NT416 Nano Toxicology 3 0 0 3

17. 13NT417 Advanced Nano Biotechnology 3 0 0 3

44

I SEMESTER

13MA176 : MATHEMATICAL MODELING AND

SIMULATION

L T P C

3 1 0 4

COURSE OBJECTIVES:

To introduce the fundamental principles of numerical methods.

To provide various methods of solving system of simultaneous

equations.

To know about mathematical modeling.

To have thorough knowledge about differential equations.

To familiarize in simulation and monte-carlo methods.

COURSE OUTCOMES:

Upon completion of the course the students will be able

To solve problems using numerical methods.

To obtain the solution of system of equations using matrix theory.

To model the real life problems into mathematical problems.

To identify the various types of differential equations and methods

for finding solutions.

To apply the simulation techniques in their field.

UNIT I FUNDAMENTAL PRINCIPLES OF NUMERICAL METHODS

12

Numerical data and numerical operations - Numerical algorithms -

Numerical programs - numerical software - Numerical analysis and

Numerical methods - assumptions and limitations in numerical solutions.

Numerical differentiation: Using Newton’s forward, backward and divided

differences. Numerical integration: Using Trapezoidal, simpson’s and

Gaussian quadrature rules in one and two dimensions.

45

UNIT II MATRICES AND LINEAR SYSTEMS OF EQUATIONS 12

Solution of linear systems: Cramer’s rule, matrix Inversion method,

Gauss - jordan method, Gauss-seidel iteration methods. Eigen value

problems: Power method with deflation for both symmetric and

unsymmetric matrices and jacobi method for symmetric matrices.

UNIT III MATHEMATICAL MODELING 12

Scientific modeling - mathematical modeling - stages of mathematical

modeling and life cycle - advantages of modeling and limitations -

developing model equations - approximations in mathematical model

building - first order ODE modeling equations and examples – concept of

physical domain and computational domain - process control -

Transport phenomena. variational methods: Rayleigh’s method, ritz

method.

UNIT IV DIFFERENTIAL EQUATIONS & APPLICATIONS 12

Solution of differential equations – initial value problems - single step

methods euler method, Runge-kutta method. multi step method: milne’s

method - boundary value problems – Finite difference approximations to

derivatives - finite difference method of solving second order ODEs -

partial differential equations - classification of second order PDEs - Finite

difference approximations to partial derivatives. Elliptic equations:

solution of laplace and poisson equations - one dimensional parabolic

equation - bender schmidt method. Hyperbolic equation: one

dimensional wave equation.

UNIT V SIMULATION & MONTE CARLO METHODS 12

Basic concepts of simulation - data manipulation, data exchange of the

structure, physical simulation - advantages and limitations - properties

and processing of materials - basics of the monte carlo method –

algorithms for monte carlo simulation - molecular dynamics simulation -

applications to systems of classical particles - modified Monte Carlo

46

techniques - percolation system – variation Monte Carlo method.

TOTAL: 60 PERIODS

REFERENCE BOOKS:

1. S.C. Chapra & R.P.Canale, “Numerical methods for Engineers”,

Tata McGraw Hill, New Delhi, 2002.

2. Erwin Kreyzig, “Advanced Engineering Mathematics”, John Wiley

& Sons, 2004.

3. R.J. Schilling & S.L. Harris, “Applied Numerical Methods for

Engineers using MATLAB and C”, Thomson publishers, New

Delhi, 2004.

4. F R Giordano, W P Fox, S B Horton & M D Weir, “Mathematical

Modeling Principles and Applications”, CENGAGE Learning, New

Delhi, 2009.

5. D. Frenkel & B. Smith, “Understanding molecular simulation from

algorithm to applications”, Kluwar Academic Press, 1999.

6. K. Ohno, K. Esfarjani & Y. Kawazoe, “Introduction to

Computational Materials Science from ab initio to Monte Carlo

Methods”, Springer-Verlag, 1999.

13NT101 : QUANTUM MECHANICS L T P C

3 0 0 3

COURSE OBJECTIVES:

To impart basic knowledge about the quantum concepts.

To become aware of the necessity for quantum methods in the

analysis of physical systems of atomic and solid state physics.

To understand the various parameters like linear and Hermitian

operator.

To improve mathematical skills necessary to solve differential

equations and eigen value problems.

47

To explain scientifically the new applications of quantum physics in

computation.

COURSE OUTCOMES:

Conceptual understanding of the basic principles of quantum

mechanics.

Ability to apply basic principles of the wave quantum mechanics

towards solutions of various problems.

Capability to apply basic operator methods towards solutions of

various problems.

Conceptual and practical understanding of the following subjects of

1) quantum particle trapped in various potential wells 2) Quantum

simple harmonic oscillator 3) Simple quantum model of the

hydrogen atom.

Experience in computer simulation and modeling.

UNIT I INTRODUCTION 9

Inadequate of classical mechanics–Blackbody radiation - Compton

Effect - Photoelectric effect – Planck’s quantum concepts –

Correspondence principle - Wave-particle duality - Schrödinger equation

and expectation values - Uncertainty principle.

UNIT II BASICS OF QUANTUM MECHANICS 9

Solutions of one-dimensional Schrödinger equation for free particle -

particle in a box - particle in infinitely deep well potential, linear harmonic

oscillator - reflection and transmission by a potential step – particle

tunnelling – reflection and transmission coefficient – single particle

tunnelling.

48

UNIT III OPERATORS AND COMPUTATIONAL LAWS 9

Linear operator - Hermitian operator - postulates of quantum mechanics

- simultaneous measurability of observable - equations in motion - Linear

harmonic oscillator - Operator method. The angular momentum problem

- The spin half problem and properties of Pauli spin matrices - Eigen

values and eigen functions of Lz and L2 - Eigen values Jz and J2 - spin

angular momentum – addition of angular momenta.

UNIT IV APPROXIMATE METHODS 9

Time independent and time dependent perturbation theory for non-

degenerate and degenerate energy levels - Variation method - WKB

approximation - adiabatic approximation - sudden approximation.

UNIT V QUANTUM COMPUTATION 9

Physical proprieties and logic – Physical processes and algorithms –

Qubits and quantum circuits – examples of a quantum algorithm – Shor–

Grover – Simple programs using quantum concepts – Factorial

applications.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Beiser, “Modern physics”, 6th edition, Tata McGraw Hill Education

Private Ltd., 2009.

2. I.L. Schiff, “Quantum mechanics”, McGraw Hill,1968.

3. Bransden & Joachen, “Quantum mechanics”, 2nd edition, Prentice

Hall, 2000.

4. Eisberg Robert & Resnick Robert, “Quantum Physics of Atoms,

Molecules, Solids, Nuclei, and Particles”, 2nd edition, John Wiley &

Sons, 1985.

5. Ajoy Ghatak, “Quantum Physics – Theory and application”,

Springer, 2004.

49

6. R. Shankar, “Principles of Quantum Mechanics”, 2nd edition,

Cambridge University Press, 2000.

7. Cohen-Tannoudji, “Quantum Mechanics”, Vol. 1&2, Wiley, 1997.

8. S. Abramsky & B. Coecke, “Categorical quantum mechanics,

Handbook of Quantum Logic and Quantum Structures—Quantum

logic”, Elsevier, 2009.

13NT102 : FUNDAMENTALS OF

NANOMATERIALS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the evolution of nano science and basic concepts of

nano materials.

To acquire knowledge about theories behind the interaction of

nanoparticles.

To understand the chemistry of nano materials for various

applications.

To understand the exotic properties of nanostructured materials at

nano scale lengths.

To acquire knowledge about the bottom-up synthesis of various

nanoparticles.

COURSE OUTCOMES:

Gain knowledge on basic science behind nanotechnology.

Capable of interpreting the nano scale phenomena of particles.

Ability to diagnose and use the exact nanomaterial for needed

applications.

Acquire knowledge about the various properties of nano materials.

Able to synthesis and manipulate nanoparticles by bottom-up

approach.

50

UNIT I INTRODUCTION, CLASSIFICATION AND

NOMENCLATURE OF NANO MATERIALS 9

Background to nano technology - Scientific revolutions - Basic principles

of nano scale materials- Nano sized metals and alloys, semiconductors,

ceramics. Comparison with respective bulk materials; Organic

semiconductors, carbon nanotubes; Zero, one, two, and three

dimensional nanostructures – quantum dots, quantum wells, quantum

rods, quantum wires, Nano composites consisting of organic, inorganic

and biomaterials; Self-assembly.

UNIT II THEORIES OF NANO SIZED MATERIALS 9

Transition metal sols, origin of plasmon band, Mie theory, influence of

various factors on the plasmon absorption; Surface energy – chemical

potential as a function of surface curvature - electrostatic stabilization -

surface charge density - electric potential at the proximity of solid surface

- Zeta potential - Interaction between two particles: DLVO theory.

UNIT III CHEMISTRY ASPECTS OF NANOMATERIALS 9

Photochemistry - Electrochemistry of Nanomaterials - Nanoscale heat

transfer - Catalysis by gold nanoparticles - Transport in semiconductor

nanostructures - Transition metal atoms on nano carbon surfaces - Nano

deposition of soft materials.

UNIT IV NOVEL PROPERTIES OF NANOMATERIALS 9

surface area and aspect ratio - Size and shape dependent optical,

emission, electronic, transport, photonic, refractive index, dielectric,

mechanical, magnetic, non-linear optical properties; Catalytic and photo

catalytic properties.

UNIT V NANOSYSTEMS 9

Nanoparticles through homogeneous and heterogeneous nucleation -

Growth controlled by surface and diffusion process - Oswald ripening

process - influences of reduction reagents - solid state phase

51

segregation.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. K.W. Kolasinski, “Surface Science: Foundations of catalysis and

nanoscience”, Wiley, 2002.

2. Guozhong Cao, “Nanosrtuctures and nanomaterials: Synthesis,

properties and applications”, Imperial College Press, 2004.

3. Joel. I. Gersten, “The Physics and Chemistry of Materials”, Wiley,

2001.

4. S. Edelstein & R. C. Cammarata, “Nanomaterials: Synthesis,

properties and applications”, Institute of Physics Pub., 1998.

5. S.Yang & P.Shen, “Physics and chemistry of nanostructured

materials”, Taylor & Francis, 2000.

6. G.A. Ozin & A.C. Arsenault, “Nanochemistry: A chemical approach

to nano materials”, Royal Society of Chemistry, 2005.

7. H. Hahn, A. Sidorenko & I. Tiginyanu, “Nanoscale phenomena:

Fundamentals and applications”, Springer, 2009.

8. Zikang Tang & Ping Sheng , “Nanoscience and technology: Novel

structures and phenomena”,Taylor & Francis, 2003.

9. Klabunde K.J. (Ed.), “Nanoscale materials in chemistry”, John

Wiley & Sons Inc, 2001.

WEB REFERENCE:

1. “Encyclopedia of nano science and nanotechnology”,

Vol.1,2,6,7,10.

52

13NT103 : CARBON NANO-STRUCTURES AND

ITS FUNCTIONALISATIONS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To kindle the knowledge about a unique nano material like carbon

nano tube, occurrence, invention etc.

To gain idea about the synthesis of CNT by various methods.

To provide knowledge about the functionalization of CNT.

To apply CNT for different applications.

To provide information about graphene, diamond like thin films.

COURSE OUTCOMES:

Emphasizes the significance of carbon nano materials and its

applications.

Gives idea about the entire properties of CNT and its preparation

techniques.

To suit for advanced applications, functionalization of CNT.

Imparts about the applications of CNT in almost all fields.

Knowledge about Graphene, Graphene oxide, Diamond like films.

UNIT I CARBON NANOTUBES: STRUCTURE AND PROPERTIES

9

The element carbon: Allotropes of carbon – Fullerenes - Structure -

Single wall - Multi wall nano tubes - Filled tubes: Physical properties -

Thermal properties - Optical, Mechanical, Vibrational properties.

53

UNIT II PREPARATION OF CARBON NANOTUBES 9

Different methods of synthesis of CNTs: laser evaporation - carbon arc

method - Chemical vapor deposition – PECVD - Solid state formation of

CNT - Flame synthesis – Hipco method: Mechanism of growth.

UNIT III FUNCTIONALIZATION OF CARBON NANOTUBES 9

Carbon Nanotubes - Functionalization of Carbon Nanotubes - Covalent,

Non-covalent - Reactivity of Carbon Nanotubes – Purification methods:

Oxidation, Acid treatment – Annealing – Ultrasonication - Micro filtration -

Ferromagnetic separation – Cutting - Chromatography techniques.

UNIT IV APPLICATIONS OF CARBON NANOTUBES 9

Field emission - Fuel cells - Display devices - CNT based chemical &

biological sensors – automobile - composite materials - space elevators -

Electron and probe microscopy – Nano tweezers – nano gears etc.

UNIT V OTHER IMPORTANT CARBON BASED MATERIALS 9

Preparation and characterization fullerene and other associated carbon

clusters/molecules – Graphene - preparation - characterization and

properties - DLC and nano diamonds.

TOTAL: 45 PERIODS REFERENCE BOOKS:

1. Yury Gogotsi, “Carbon nanomaterials”, CRC, Taylor & Francis,

2006.

2. Ado Jorio, Gene Dresselhaus & Mildred S. Dresselhaus, “Carbon

Nanotubes”, Springer-Verlag Berlin Heidelberg, 2008.

3. S. Reich, C. Thornsen & J. Maultzsch, “Carbon nanotubes, basic

concepts and physical properties”, Wiley-VCH Verlag GmbH &

Co., 2004.

4. R. Saito, G. Dresselhaus & M.S. Dresselhaus, “Physical

properties of carbon nanotube”, Imperial College Press, 1998.

54

5. Rotkin, Slava V., Subramoney & Shekhar, “Applied physics of

carbon nanotubes: Fundamentals of theory, optics and transport

devices”, Springer Berlin Heidelberg, 2005.

6. Michael J. O'Connell, “Carbon Nanotubes: Properties and

applications”, CRC, Taylor and Francis, 2006.

7. Liming Dai, “Carbon nanotechnology”, Elsevier, 2006.

8. CNR Rao & A. Govindaraj, “Nanotubes and nanowires”, RSC

Publisher, 2011.

13NT104 : FABRICATION OF NANOMATERIALS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the vacuum technique for the purpose of

fabricating/imaging of nano materials.

To educate the chemical, physical approaches for the fabrication of

nano materials.

To envisage the bulk synthesis methods for nano materials.

To learn the concept and classification of lithography.

To study and analyse the nano porous materials and its

applications.

COURSE OUTCOMES:

Understand the concept of vacuum system.

Prominence the methods used for the fabrication of nano

materials.

Gain knowledge on bulk synthesis of nano materials.

Recognize the importance of nano porous materials.

Cultivate the concept of lithography.

UNIT I VACUUM TECHNIQUE 9

Inert gas condensation technique – vacuum production - ion pumps –

55

rotary pump – diffusion pump – molecular pump – sublimation pumps –

measurement of vacuum – material selection – sealing - degassing -

types of gauges - bayard alpert gauge – vacuum ranges of gauges -

vacuum systems.

UNIT II BULK SYNTHESIS 9

High energy ball mill – types of balls – ball ratio – medium for grinding –

limitations – severe plastic deformation – Mechano chemical process –

Arc plasma - Bulk and nano composite materials.

UNIT III CHEMICAL APPROACHES 9

Sol gel processing - Solvo thermal, hydrothermal, precipitation, Spray

pyrolysis - Electro spraying and spin coating - Self-assembly, self-

assembled monolayers (SAMs) - Langmuir-Blodgett (LB) films - micro

emulsion polymerization - templated synthesis, pulsed electrochemical

deposition.

UNIT IV PHYSICAL APPROACHES 9

Vapour deposition and different types of epitaxial growth techniques

(CVD, MOCVD, MBE) - Pulsed laser deposition, Magnetron sputtering -

Lithography: Photo/UV/EB/FIB techniques, Dip pen nanolithography -

Etching process: Dry and wet etching - micro contact printing.

UNIT V NANOPOROUS MATERIALS 9

Nanoporous materials – Silica - Zeolites, mesoporous materials – nano

membranes - AgX photography, smart sunglasses and transparent

conducting oxides – molecular sieves – nano sponges.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. C. Suryanarayana, “Mechanical alloying and milling”, Marcel

Dekker, Inc., New York, 2005.

56

2. A. Roth, “Vacuum technology”, North – Holand Pub., II Edition,

1982.

3. W.Gaddand, D.Brenner, S.Lysherski & G.J.Infrate(Eds.),

“Handbook of nano science, engg. and technology”, CRC Press,

2002.

4. K. Barriham & D.D. Vedensky, “Low dimensional semiconductor

structures: fundamental and device applications”, Cambridge

University press, 2001.

5. G. Cao, “Nanostructures & Nano materials: Synthesis, properties &

applications”, Imperial college press, 2004.

6. J.George, “Preparation of thin films”, Marcel Dekker, Inc., New

York, 2005.

13NT105 : BASIC BIOLOGICAL SCIENCES L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the various organelles of the cell and their function.

To learn the basic cellular processes like replication, transcription

and translation.

To understand the importance of amino acids and proteins.

To understand the structure and significance of carbohydrates and

lipids.

To develop a knowledge about the cells energy production

pathways.

COURSE OUTCOMES:

Able to differentiate cellular components.

57

Understand how the central dogma of life works out.

Describe the structure and function of various biomolecules.

Able to understand the importance of biomolecules and their role

in various cellular metabolic activities.

Able to understand the energetics of the cell.

UNIT I CELL BIOLOGY 9

Introduction to Eukaryotic and Prokaryotic cells, Organelles: Structure,

functions, Principle of membrane organization: composition, models,

cytoskeletal proteins: Microfilaments, Microtubules, Intermediate

filaments, Cell division: Mitosis, Meiosis, Cell cycle checkpoints and

control.

UNIT II NUCLEIC ACIDS 12

Introduction to DNA structure: Composition - nucleotide structures,

double helix, genome structure and organization of Prokaryotes and

Eukaryotes, Central dogma of life, DNA is the genetic material: Griffith,

avery and hershey experiments, DNA replication: Semi-conservative

mode of replication, experiment, enzymology, inhibitors, Transcription:

Enzymology, Transcription factors, inhibitors, Translation: genetic code,

enzymology, translational factors and inhibitors.

UNIT III AMINO ACIDS AND PROTEINS 9

Amino acids: Introduction, structure, classification, physical, chemical

and optical properties, peptide bond, Proteins: Structure - Primary,

secondary, super secondary, Tertiary and quaternary structures,

Covalent and non-covalent interactions in protein structure,

Classification, Enzymes- Introduction to structure, properties.

UNIT IV CARBOHYDRATES AND LIPIDS 9

Structure, Nomenclature, Function and classification of carbohydrates,

mono, di and polysaccharides and Lipids- saturated and unsaturated

fatty acids.

58

UNIT V METABOLISM AND ENERGY PRODUCTION 6

Energetics of Glycolysis, Kreb cycle, Electron transport chain, Pentose

phosphate pathway, β-oxidation of fatty acids.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. R. Cantor & P.R.Samuel, “Biophysical Chemistry”, W.H., Freeman

& Co., 1985.

2. Watson, James, T.Baker, S.Bell, A.Gann, M.Levine, & R.Losick.

“Molecular Biology of the Gene”, 5th Edition. San Francisco:

Addison-Wesley, 2000.

3. Alberts, Bruce, Alexander Johnson, Julian Lewis, Martin Raff,

Keith Roberts & Peter Walter, “Molecular Biology of the Cell”, 4th

Edition. New York: Garland Science, 2002.

4. Branden, Carl-Ivar & John Tooze “Introduction to Protein

Structure” 2nd Edition, New York, Garland Pub., 1991.

5. Creighton & E, Thomas, “Proteins: Structures and Molecular

Properties”, 2nd Edition. New York: W.H. Freeman, 1992.

6. B.Lewin, “Genes IX”, International Edition. Sudbury: Jones &

Bartlett, 2007.

13NT151 : MATERIAL SYNTHESIS L T P C

0 0 4 2

COURSE OBJECTIVES:

To give hands on training about the synthesis of nano particles.

To provide various methods for obtaining different categories of

nano particles.

To provide knowledge about the characterization of materials.

59

To evaluate the band gap of semi conducting nano particles.

To familiarize about various equipment and its operating

procedures.

COURSE OUTCOMES:

Able to follow different synthetic strategies adopted for isolating

nano particles.

Have acquired knowledge in background principles about the

formation of nano materials.

Understand the particle size evaluation, crystallite size

determination etc.

Knows about the characteristics of band gap of semi conducting

particles.

Getting trained in isolation of any kind of nano materials.

LIST OF EXPERIMENTS:

1. Aqueous to organic phase transfer of Ag and Cds nanoparticles;

Confirmation by UV- Visible absorption.

2. Sol gel synthesis of metal oxide (ZnO, TiO, CdO) nanoparticles.

3. Mechanical ball milling technique to oxide ceramics preparation:

Crystallite size measurement by XRD.

4. Bio leaf extraction route to Ag/Cu/Fe nanoparticles.

5. Electro spinning of polymer nano fibers: Surface morphology by

SEM.

6. Hydrothermal synthesis of ZnS Nano rods formation.

7. Synthesis of aqueous ferro fluid by chemical method.

8. Nano crystalline copper metallic powder by polyol method.

9. Metallic Ni particle by chemical reduction method.

10. Multi ferrites bimetallic nanoparticles synthesis.

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13NT152 : COMPUTATION AND SIMULATION L T P C

0 0 4 2

COURSE OBJECTIVES:

To provide an introduction to Molecular modeling & simulation.

To understand the principles and techniques involved in offline

image processing and image enhancements.

To study the Single-Electron Transistor (SET) device and process

simulation.

Provide hands-on experience in simulation software packages like

MATLAB, SIMULINK, MATERIALS STUDIO, XEI, TCAD, SEQUEL

and MOSES 1.2 simulator.

COURSE OUTCOMES:

After studying this course students would be able to:

Understand the concept of Molecular modeling & simulation.

Recognize the significance of computational modeling and

simulation.

Solve I-V characteristics for a single junction circuit using Circuit

simulator.

Emphasis on materials digital image processing and image

enhancement.

Incorporate Modeling and simulation knowledge for solving a real

scientific problem using software packages.

LIST OF EXPERIMENTS:

1. MATLAB programme to plot the first four Eigen functions of a one -

dimensional rectangular potential well with infinite potential barrier.

2. Numerical solution of the Schrodinger wave equation for a

rectangular potential well with infinite potential barrier using

61

MATLAB programme.

3. To model in molecular electronics: I-V characteristics of a single

level molecule.

4. To determine the lattice constant and lattice angles for atomically

resolved STM image of HOPG (Highly Oriented Pyrolytic Graphite

using offline Scanning Probe Imaging Processor (SPIP) Software.

5. To determine the surface roughness of raw and processed AFM

images of glass, silicon and films made by different methods using

offline SPIP software.

6. Simulation of I-V Characteristics for a single junction circuit with a

single quantum dot using MOSES 1.2 Simulator.

7. Study of Single Electron Transistor using MOSES1.2 Simulator.

8. Molecular Modelling and Simulation for Benzamide, Styrene, CNT

using Material studio.

9. Digital image processing using Matlab.

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II SEMESTER

13NT201 : PHOTONICS FOR

NANOTECHNOLOGY

L T P C

3 0 0 3

COURSE OBJECTIVES:

The course should enable the students to

Learn about quantum confinement of materials.

Learn about near field optics.

Know plasmonics.

Understand photonics in the field of biology.

Know concepts of photonics.

COURSE OUTCOMES:

The students will be able to

Describe the effects of quantization on the optical properties of

semiconductors and metals.

Know principles of surface plasmon resonance and meta

materials.

Understand fundamentals of near field optics and its applications.

Learn interactions of light with biological systems.

Know important features of photonic crystals and applications.

UNIT I QUANTUM CONFINED MATERIALS 9

Quantum dots – optical transitions – absorption-inter-band transitions -

quantum confinement intra band transitions - fluorescence/luminescence

– photoluminescence/fluorescence optically excited emission –

electroluminescence emission.

UNIT II PLASMONICS 9

Internal reflection and evanescent waves - plasmons and surface

63

plasmon resonance (SPR) - Attenuated total reflection - Grating SPR

coupling - Optical waveguide SPR coupling - SPR dependencies and

materials - plasmonics and nanoparticles.

UNIT III NEW APPROACHES IN NANO PHOTONICS 9

Near-Field Optics - Aperture near-field optics - Aperture less near - field

optics - Near-field scanning optical microscopy (NSOM or SNOM) -

SNOM based detection of plasmonic energy transport - SNOM based

visualization of waveguide structures - SNOM in nanolithography -

SNOM based optical data storage and recovery.

UNIT IV BIOPHOTONICS 9

Interaction of light with cells – tissues - nonlinear optical processes with

intense laser beams - photo induced effects in biological systems -

generation of optical forces - optical trapping and manipulation of single

molecules and cells in optical confinement - laser trapping and

dissection for biological systems - single molecule biophysics - DNA

protein interactions.

UNIT V PHOTONIC CRYSTALS 9

Important features of photonic crystals - Presence of photonic band gap

- Anomalous group velocity dispersion - Micro cavity - Effects in photonic

crystals - Fabrication of photonic crystals - Dielectric mirrors and

interference filters - Photonic crystal laser - PC based LEDs - Photonic

crystal fibers (PCFs) - Photonic crystal sensing.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. H.Masuhara, S.Kawata & F.Tokunaga, “Nano Biophotonics”,

Elsevier Science, 2007

2. V.M. Shalaev & S.Kawata, “Nano photonics with Surface

Plasmons (Advances in Nano-Optics and Nano-Photonics)”,

Elsevier B.V, 2007.

64

3. B.E.A. Saleh & A.C.Teich, “Fundamentals of Photonics”, John-

Wiley & Sons, New York, 1993.

4. M.Ohtsu, K.Kobayashi, T.Kawazoe, & T.Yatsui, “Principles of

Nano photonics (Optics and Optoelectronics)”, University of Tokyo,

Japan, 2003.

5. P.N. Prasad, “Introduction to Biophotonics”, John Wiley & Sons,

2003.

6. J.D.Joannopoulos, R.D.Meade & J.N.Winn, “Photonic Crystals”,

Princeton University Press, Princeton, 1995.

13NT202 : PROCESSING AND PROPERTIES OF

NANOSTRUCTURED MATERIALS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the metal forming methods and its deformation

mechanisms.

To gain knowledge about the microstructural properties of

materials.

To understand the processing methods of polymers.

To understand the processing methods of metals and ceramics.

To acquire knowledge about functional nano materials and its

processing techniques.

COURSE OUTCOMES:

Able to differentiate various metal forming methods.

Acquire knowledge on the microstructural properties of materials.

Ability to process the polymeric materials.

Capable of processing metals and ceramics.

Understand the mechanism to retain nanostructure during

synthesis.

65

UNIT I DEFORMATION PROCESSING AND METAL

FORMING

10

Classification of engineering materials - Tensile testing – Stress strain

curve – Flow stress - Mechanical properties – Formability - Deformation

processes - Mechanics of metal working – Metal forming - forging,

rolling, extrusion, wire drawing – Superplastic forming – Bulk

nanostructured materials by Severe Plastic Deformation (SPD) -

Comparison of processes.

UNIT II MICROSTRUCTURE AND PROPERTIES 9

Defects in solids – classifications of defects – Microstructure – grain

size, grain boundary, effects of processing and defects – Processing,

microstructure, properties correlations – Mechanical Properties and

processing - grain size evolution and grain size control; Hall - Petch

relation - strengthening mechanisms; work hardening - grain boundary

strengthening - solid solution strengthening – precipitation hardening -

effects of diffusion on strength and flow of materials.

UNIT III PROCESSING OF POLYMERS 7

Engineering plastics – Pellets and sheets – Glass transition temperature

of polymers – Melt flow index – Polymer processing tools and process

conditions - injection moulding, thermoforming, vacuum and pressure

assisted forming.

UNIT IV PROCESSING OF POWDERS OF METALS

AND CERAMICS

9

Metal/Ceramic Powder synthesis - Selection and characterization of

powders - compacting and sintering - Production of porous and dense

composite components: Advanced composite materials – Metal -

polymer and ceramic based composites and their properties –

Fabrication of composite materials.

66

UNIT V PROCESSING OF STRUCTURAL AND

FUNCTIONAL NANOMATERIALS

10

Properties required of nano crystalline materials used for structural,

energy, environmental, textile and catalytic applications - processing

techniques - techniques for retaining nano crystalline structure in

service.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. A. H. Cottrell “The mechanical properties of matter”, John Wiley,

New York- London, 1964.

2. R. Asthana, A. Kumar & N. Dahotre “Materials science in

manufacturing” Butterworth-Heinemann, Elsevier 2006.

3. G. E. Dieter & D Bacon, “Mechanical metallurgy”, SI Metric edition,

McGraw-Hill, Singapore, 1988.

4. C. C. Koch, “Nanostructured materials: Processing, properties and

applications”, 2nd Edition, William Andrew Pub, 2007.

5. Serope Kalpakjian & Steven R. Schmid, “Manufacturing

engineering and technology”, 4th Edition, Pearson, 2001.

WEB REFERENCE:

1. H. Gleiter, “Nanocrystalline Materials”, Progress in material

science Vol. 33, pp. 223-315, 1989.

13NT203 : CHARACTERIZATION OF

NANOMATERIALS

L T P C

3 0 0 3

COURSE OBJECTIVES:

As a nano technologist, the student should have the knowledge in

characterization of nano material in various aspects

67

To understand the fundamentals regarding the analysis and

interpretation of XRD data.

To understand about thermal properties like thermal stability,

thermal degradation etc.,

Elucidation of structural features, molecular properties etc., will be

gained by understanding knowledge based on spectroscopic

techniques.

To know about the applications of spectroscopy.

To inculcate the mechanical properties of nano films by

understanding nano indentation.

COURSE OUTCOMES:

Able to analyse, interpret X-ray diffraction data of nano materials.

It provide information about the thermal behaviours of nano

materials.

Understanding the concepts of spectroscopy towards elucidating

structural aspects of nano materials.

Capable to understand the molecular properties of nano material

by spectroscopy.

Able to comprehend the principles of nano indentation towards

evaluating mechanical properties.

UNIT I SPECTROSCOPIC TECHNIQUES 9

Introduction to molecular spectroscopy and differences with atomic

spectroscopy - UV-Vis. spectroscopy and applications to nano system

(silver and gold ) – Infrared (IR) Spectroscopy and applications to metal

oxide and chalcogenides – Raman Spectroscopy, applications to CNT

and graphene – NMR Spectroscopy – Theory, principles, applications to

simple molecules - Nuclear magnetic double resonance; Dynamic light

scattering (DLS), ESR spectroscopy.

68

UNIT II X-RAY DIFFRACTION 9

X-ray powder diffraction – Debye Scherer camera - Determination of

accurate lattice parameters - line profile analysis - particle size analysis

using Scherer formula - Impedance measurement, Electrical transport

measurement (AC and DC conductivity, Magnetic transport properties

characterization, Vibrating sample magnetometer (Hysteresis loop for

soft and hard magnetic materials).

UNIT III THERMAL ANALYSIS METHODS 9

Principle and Instrumentation of thermo gravimetry; Differential thermal

analysis and Differential scanning calorimetry - Importance of thermal

analysis for nanostructures - Atomic absorption spectroscopy,

Inductively coupled plasma spectrometry.

UNIT IV QUALITATIVE AND QUANTITATIVE

ANALYSIS

9

Electron Energy Loss Spectroscopy; Atom probe field ion microscopy -

X-Ray Photoelectron spectroscopy - EDAX and WDA analysis – ZAF

corrections, Auger electron spectroscopy.

UNIT V NANOINDENTATION 9

Nano indentation principles - elastic and plastic deformation -

mechanical properties of materials in small dimensions - models for

interpretation of nano indentation load - displacement curves – Nano

indentation data analysis methods - Hardness testing of thin films and

coatings.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. B. D.Cullity, “Elements of X-ray diffraction”, 4th Edition, Addison

Wiley, 1978.

2. M. H.Loretto, “Electron beam analysis of materials”, Chapman and

69

Hall, 1984.

3. R.M.Rose, L.A.Shepard and J.Wulff, “The structure and properties

of materials”, Wiley Eastern Ltd, 1996.

4. B.W.Mott, “Micro-Indentation hardness testing”, Butterworths,

London, 1956.

5. A. D. Helfrick & W. D. Cooper, “Modern electronic instrumentation

and measurement techniques”, PHI, 1996.

6. J. Michael Hollas, “Modern spectroscopy”, Willey, 2004.

7. Willard, Merritt, Dean & Settle, “Instrumental methods of

analysis”, 7th edition,J. Chem. Educ., 1989.

13NT204 : ADVANCED IMAGING TECHNIQUES L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the concept of imaging techniques used for the

purpose of characterizing the materials.

To educate the different specimen preparation techniques for the

imaging of materials.

To envisage the imaging techniques for bulk and nano materials.

To study and analyse the electron microscopy and its applications.

To learn the advanced imaging techniques using atomic forces.

COURSE OUTCOMES:

Understand the concept and classification of imaging system.

Study of electron microscopy and its applications.

Gain knowledge on imaging of nano materials.

Differentiate morphology and topography of nano materials.

Cultivate the imaging using atomic forces.

70

UNIT I OPTICAL MICROSCOPY 9

Optical microscopy - Polarized light microscopy – Phase contrast

microscopy – Interference microscopy – morphology – Confocal

microscopy.

UNIT II SCANNING ELECTRON MICROSCOPY 12

Basic design of the scanning electron microscopy – Modes of operation

– Backscattered electrons – Secondary electrons - X-rays – typical forms

of contrast – Resolution and contrast enhancement – Specimen

preparation - replicas – various applications.

UNIT III TRANSMISSION ELECTRON MICROSCOPY 9

Basic principle - modes of operation – specimen preparation – diffraction

in imperfect crystals – dislocations – precipitates – structure of grain

boundaries and interfaces - HRTEM in nanostructures.

UNIT IV ATOMIC FORCE MICROSCOPY (SCANNING

PROBE MICROSCOPY)

9

Basic concepts - interaction force - AFM and the optical lever - scale

drawing - AFM tip on nano meter scale structures - force curves,

measurements and manipulations - different modes of operation –

contact and non-contact mode - imaging and manipulation of samples in

air/liquid environments - imaging of soft samples - shear force

microscopy - lateral force microscopy - magnetic force microscopy.

UNIT V SCANNING TUNNELING MICROSCOPY 6

Principle - instrumentation - importance of STM for nanostructures –

Scanning tunneling spectroscopy – FMM - surface and molecular

manipulation using STM - 3D map of electronic structure - limitations.

TOTAL: 45 PERIODS

71

REFERENCE BOOKS:

1. R.Haynes, D.P.Woodruff & T.A.Talchar, “Optical Microscopy of

Materials”, Cambridge University press, 1986.

2. J.Goldstein, D. E. Newbury, D.C. Joy & C.E. Lym, “Scanning

electron microscopy and X-ray microanalysis”, Kluwer Academic,

New York, 2003.

3. S.L. Flegler, J.W. Heckman & K.L. Klomparens, “Scanning and

transmission electron microscopy: A Introduction”, WH Freeman &

Co, 1993.

4. P.J.Goodhew, J.Humphreys & R.Beanland, “Electron microscopy

and analysis”, Taylor & Francis, 2001.

13NT205 : NANOTECHNOLOGY IN HEALTH

CARE

L T P C

3 0 0 3

COURSE OBJECTIVES:

To gain basic knowledge about biological molecules and various

methods in nano scale reactions.

To understand the recent trends in biotechnology.

To be aware of nano scale experiments in immuno technology.

To design various disease diagnosis methods based on

nanotechnology.

To device treatments and nano drug delivery methodologies.

COURSE OUTCOMES:

Understand biological systems and design nano devices using

biomimicry.

Design nano devices to solve biological problems.

Understand techniques in biotechnology which helps in designing

nano probes and nano scaffolds.

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Detect tumors and other diseases using in-vivo imaging and

sensors.

Recognize the cancer treating methods using nano medicines.

UNIT I NANO BIOLOGY AND BIOCONJUGATION OF

NANO MATERIALS

10

Properties of DNA and motor proteins - Reactive groups on

biomolecules (DNA & Proteins) - Surface modification and conjugation to

nano materials - Lessons from nature on making nano devices -

Fabrication and application of DNA nanowires - Nano fluidics to solve

biological problems.

UNIT II TRENDS IN BIOTECHNOLOGY 9

Nanotechnology in gene therapy - PCR, ELISA, DNA profiling and

blotting techniques - nanoprobes, nano scaffolds - stem cell technology.

UNIT III IMMUNO TECHNIQUES IN NANO SCIENCES 8

Immunoassay and immuno sensors - bio-barcode assay - use of

magnets, gold, DNA and antibodies - magnetic nanoparticles.

UNIT IV NANO TECHNOLOGY BASED MEDICAL

DIAGNOSTICS

9

Improved diagnosis by in vivo imaging - detection of tumors and central

nervous system disorders, plaque and genetic defects, nano bot medical

devices - cantilever sensors.

UNIT V NANO DRUG DELIVERY AND NANO

MEDICINE

9

Properties of nano carriers - drug delivery systems used in nano

medicine - enhanced permeability and retention effect - blood-brain

barrier - active and passive targeting of diseased cells - health and

environmental impacts of nanotechnology.

73

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. R Eggins, “Chemical sensors and biosensors”, Wiley, New York,

Chichester; 2002.

2. Wilson & Wilson’s, “Biosensors and modern bio specific

analytical techniques, comprehensive analytical chemistry”, Ed.

L Gorton; Elsevier, Amsterdam, London; 2005.

3. Allen J Bard & Larry R Faulkner, “Electro chemical methods:

fundamentals and applications”, Wiley, New York, Chichester:

2nd Edition, 2001.

4. Ed. Vladimir & M. Mirsky, “Ultrathin electrochemical chemo- and

biosensors: Technology and performance on chemical sensors

and biosensors”, Volume 2, Springer, Berlin, 2004.

5. Ed. David Wild, “The immunoassay handbook”, 3rd Edition

Amsterdam: Elsevier, 2005.

13NT206 : NANOELECTRONIC DEVICES AND

NANOSENSORS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To make students to learn the basic concepts of nanoelectronics.

To enable the students to understand the quantum devices.

To enable the students to know the tunneling devices and its uses.

To make the students to analyze the superconducting devices and

photonics.

To make students to learn the basic concepts of nano sensors and

its applications.

COURSE OUTCOMES:

To understand basic and advanced concepts of nano electronic

devices, sensors and transducers and their applications in

74

nanotechnology.

To design advanced electronic systems integrated on a

miniaturized Silicon chip.

To have detailed knowledge of the operation of micro- and nano-

scale devices, their applications and the technologies used to

fabricate them.

To analyse & design a range of devices using relevant

mechanical/electrical engineering principles.

Apply the basic nano sensor concepts for their applications.

UNIT I BASICS OF NANO ELECTRONICS 9

Physical fundamentals – quantization of action, charge and flux –

electrons in potential well – photons interacting with electrons in solids –

diffusion processes – basic information theory – data & bits – data

processing - size effects on structure and morphology of free or

supported nanoparticles – size and confinement effects – fraction of

surface atoms – specific surface energy and surface stress.

UNIT II QUANTUM DEVICES 9

Quantum electronic devices – electrons in mesocopic structures – short

channel, MOS transistor – split gate transistor – electron wave transistor

– electron spin transistor – quantum dot array – quantum computer - bit

and qubit - carbon nanotube based logic gates, optical devices:

connection with quantum dots, quantum wires and quantum wells.

UNIT III TUNNELING DEVICES 9

Tunneling element – tunnel effect - tunneling diode – resonant tunneling

diode – three terminal resonate tunneling devices - technology of RTD -

digital circuits design based on RTDs - basics of logic circuits – single

electron transistor (SET) – principle – coulomb blockade – performance

– technology - circuit design - logic and memory circuits – SET adder as

an example of a distributed circuit.

75

UNIT IV SUPERCONDUCTING DEVICES AND

PHOTONICS

9

Basics - macroscopic model - super conducting switching devices –

cryotron - Josephson tunneling devices - elementary circuits –

associative or content – addressable memory - SQUID – flux quantum

device – LC – Gate – magnetic flux quantum – quantum cellular

automata - quantum computer with single flux devices – SFQD - RSFQD

– application of superconducting devices.

UNIT V NANO SENSORS 9

Micro and nano sensors - fundamentals of sensors – biosensor - micro

fluids - packaging and characterization of sensors - method of packaging

at zero level - dye level and first level. Sensors for aerospace and

defence: accelerometer - pressure sensor - night vision system - nano

tweezers - nano-cutting tools - integration of sensor with actuators and

electronic circuitry.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Keith Barnham & Dimitri Vvedensky, “Low-dimensional

semiconductor structures: Fundamentals and device applications”,

Cambridge University Press, 2001.

2. K. Goser, P. Glosekotter & J. Dienstuhl, “Nanoelectronics and

nano systems: From transistors to molecular quantum devices”,

Springer, 2004.

3. Herve Rigneault, Jean-Michel Lourtioz, Claude Delalande & Ariel

Levenson,“Nano photonics”, Wiley-ISTE, 2006.

4. W.R.Fahrner, “Nano technology and nano electronics: Materials,

devices and measurement techniques” Springer, 2005.

5. Tai–Ran Hsu, “MEMS & Microsystems design and manufacture”,

Tata McGraw-Hill, 2001.

6. P. Rai-Choudhury, “MEMS and MOEMS technology and

applications”, SPIE Press, 2000.

76

13NT251 : NANOMETROLOGY AND

MICROSCOPY

L T P C

0 0 4 2

COURSE OBJECTIVES:

To make students to learn the basic experimental analysis of

optical microscopy.

To enable the students to understand the imaging using SEM.

To facilitate the students to know the topography of nano materials

using AFM.

To test the nano materials property by nano indentation & F/D

curve.

To make students to learn the roughness concepts of nano

particles using AFM.

COURSE OUTCOMES:

Understand the practice of various imaging systems.

Morphology of nano particles using SEM.

Topography and roughness studies using AFM.

Practicing various AFM modes.

Electro deposition of nano materials.

LIST OF EXPERIMENTS:

1. Determination of size and lateral dimensions of various samples

(pollen grains, strands of hair) using optical microscope.

2. Synthesis of SiO2 polysphere film and morphology characterization

using an optical microscope.

3. Surface topography of SiO2 film using AFM.

4. Surface topography of a polymer film on glass using AFM in the

non-contact mode; phase imaging

5. Nano indentation on a polycarbonate substrate using AFM; F-D

curves and hardness determination.

6. Surface topography of a freshly cleaved mica.

77

7. Sol-gel spin coating route to SnO2 nano thin films: surface

roughness measurement by AFM.

8. Electro deposition of Cu nano structures and its morphology.

9. Surface topography of a metal film prepared by sputtering using

AFM.

13NT252 : MINI PROJECT* L T P C

0 0 4 2

COURSE OBJECTIVES:

To well verse about the knowledge in nano particle synthesis.

To facilitate idea in isolating nano particles.

Effective training in characterization of nano particles.

To give a strong foundation towards proceeding main project.

To familiarize about various nano based materials used in different

applications.

COURSE OUTCOMES:

Able to follow different synthetic strategies adopted for isolating

nano particles.

Familiarized in the characterization of nano materials.

Able to elucidate the structural behavior, purity and other important

features of nano materials.

Knows about uniqueness of nano particles.

Getting trained in isolation, tuning towards specific applications.

Based on the literatures, knowledge gained in the theory subjects

and facilities available at the lab, every student has to individually

synthesis / develop a nano material with minimum of four related

characterizations in detail with proper justification.

*Internal Assessment only

78

III SEMESTER

13NT301 : LITHOGRAPHY AND

NANOFABRICATION

L T P C

3 0 0 3

COURSE OBJECTIVES:

Lithography is a study of printing micron to nano scale features on silicon

wafer. Complete understanding of the course makes the student

technically strong in nano fabrication.

To impart sound knowledge about the fundamentals of clean room

and nano fabrication by optical projection lithography.

To emphasize about the importance of mask and maskless

lithography.

To motivate the pattern transfer technique with high energetic

electron beam concepts.

This course provides information about printing the pattern with ion

beam sources.

To enable the knowledge about printing with soft lithographic

concepts and etching the unwanted portions.

COURSE OUTCOMES:

It emphasize about the fabrication of integrated circuits on

microchip using optical principles.

Understand about the extreme UV light and zone plates as

maskless techniques.

Applying scanning electron beam techniques in nano fabrication.

Imparts knowledge about the use of Ion beam/focussed ion beam

as tools for developing nano objects.

Provides impression about soft lithography techniques and various

modes of etching.

79

UNIT I INTRODUCTION TO LITHOGRAPHY 10

Introduction to lithography – lithography processes; mask making, wafer

pre-treatment, resist spinning – pre-bake, exposure, development and

rinsing, post-bake, resist stripping, positive and negative photoresists –

lift off profile - introduction to semiconductor processing - necessity for a

clean room - different types of clean rooms - maintenance of a clean

room – micro fabrication process flow diagram – chip cleaning, coating

of photoresists, patterning, etching, inspection – process integration -

etching techniques - reactive Ion etching - magnetically enhanced RIE-

Ion beam etching - other etching techniques.

UNIT II PHOTOLITHOGRAPHY AND PATTERNING

OF THIN FILMS

9

Lithography - optical lithography - different modes - optical projection

lithography - multistage scanners – resolution and limits of

photolithography – resolution enhancement techniques - photo mask-

binary mask - phase shifting mask - attenuated phase shift masks -

alternating phase shift masks - off axis illumination - optical proximity

correction - sub resolution assist feature enhancement - optical

immersion lithography.

UNIT III DIRECT WRITING METHODS - MASKLESS

OPTICAL LITHOGRAPHY

7

Maskless optical projection lithography – types, advantages and

limitations – required components - zone plate array lithography -

extreme ultraviolet lithography – light sources - optics and materials

issues.

UNIT IV ELECTRON BEAM LITHOGRAPHY, ION

BEAM & X-RAY LITHOGRAPHY

10

Scanning electron - beam lithography - electron sources and electron

optics system – maskless EBL- electron beam projection lithography -

80

scattering with angular limitation projection e-beam lithography -

projection reduction exposure with variable axis immersion lenses - Ion

beam lithography - focusing ion beam lithography - ion projection

lithography – X-ray lithography – X-ray masks, resists, merits and

demerits - atom lithography.

UNIT V NANOIMPRINT LITHOGRAPHY AND SOFT

LITHOGRAPHY

9

Nano imprint lithography - hot embossing - soft Lithography-

moulding/replica moulding: PDMS stamps - printing with soft stamps -

edge lithography - dip-pen lithography - set up and working principle –

self-assembly – LB films.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Chris Mack, “Fundamental principles of optical lithography: The

science of micro fabrication”, Wiley, 2008.

2. M. Madou, “Fundamentals of micro fabrication”, 2nd Edition,

CRC Press, 2002.

3. Stepanova, Maria, “Nano fabrication techniques and principles”,

Dew, Steven (Eds.) Springer, 2012.

4. John A. Rogers & Hong H. Lee, “Unconventional nano

patterning techniques and applications”, A John Wiley & Sons,

Inc., 2009.

5. Sergey Edward Lyshevski, “MEMS and NEMS: Systems,

devices and structures”, CRC Press LLC, 2002.

6. Zheng Cui, “Nano fabrication – Principles, capabilities and

limits”, Springer Science, 2008.

7. Mark J. Jackson, “Micro fabrication and nano manufacturing”,

CRC Press Taylor & Francis Group, 2006.

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13NT351 : PROJECT WORK (PHASE –I) L T P C

0 0 12 6

COURSE OBJECTIVES:

Gain knowledge in the synthesis of nanoparticles.

Obtain idea about the process control parameters in the synthesis.

Familiarise on the various characterisation techniques.

Interpret on the structural and functional behaviour of

nanoparticles.

Know about the fundamental behaviour of nanoparticles for

functional applications.

COURSE OUTCOMES:

Able to synthesis wide variety of nanoparticles.

Capable of formulating nanoparticles for desired applications.

Gain knowledge in the characterisation techniques.

Able to predict the structural and functional behaviour of

nanoparticle.

Expertise in synthesis and analyse the fundamental behaviour of

nanostructures.

Based on the literatures, knowledge gained in the theory subjects

every student has to individually prepare a proposal to develop a

nano material for certain applications.

Synthesis by chemical route/ PVD/ mechanical milling method etc.,

The broad areas will be synthesis and characterization of nano

material with proper justification.

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IV SEMESTER

13NT451 : PROJECT WORK (PHASE –II) L T P C

0 0 24 12

COURSE OBJECTIVES:

To optimize the synthesis method for specific product.

To completely evaluate the developed material for applications.

Gain knowledge in advanced characterisation techniques.

To get hands-on experience in handling the characterisation tools.

To make a product for social welfare.

COURSE OUTCOMES:

Able to synthesis particles with unique functionalities.

Ability to handle the various characterisation equipments.

Manipulate the nanoparticles for desired applications.

Capable of converting the nanomaterial into products.

Able to publish the work in research articles.

It is the continuation of Phase I project.

Optimization of synthesis method for a specific product.

Complete evaluation of the developed material by various

characterization tools with Justification.

Synthesized and characterized material has to be converted in to a

product.

The final product has to be demonstrated at the end of the phase.

83

ELECTIVES

13NT401 : TOP DOWN MANUFACTURING

METHODS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide basic knowledge in lithographic techniques.

To obtain the knowledge about advanced lithographic techniques.

To know about etching process followed after lithography.

To have an idea about the development of nano crystalline

ceramics using ball mill.

To know about different micro milling processes.

COURSE OUTCOMES:

Upon completion of the course the students will be able

To develop various lithographic techniques with etching

techniques.

To advance knowledge on E-beam and ion beam lithography.

To develop ball milling processes to fabricate nano crystalline

materials.

To gain knowledge on micro milling/machining techniques.

To differentiate the types of micro milling processes.

UNIT I INTRODUCTION 12

Introduction to micro fabrication and Moore’s law – importance of

lithographic techniques - different types of lithographic techniques -

optical projection lithography – photo mask - binary mask - phase shift

mask - optical immersion lithography - maskless optical projection

lithography - zone plate array lithography - extreme ultraviolet

lithography.

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UNIT II E-BEAM AND ION BEAM LITHOGRAPHY 15

Principle and instrumentation - scanning electron-beam lithography -

mask less (ML2) EBL - parallel direct-write e-beam systems - E-beam

projection lithography - PREVAIL X-ray lithography - focused ion beam

lithography - ion projection lithography - masked ion beam direct

structuring – nano imprint lithography - soft lithography - dip-pen

lithography.

UNIT III ETCHING TECHNIQUES 5

Reactive ion etching - RIE reactive ion etching - magnetically enhanced

RIE - ion beam etching - wet etching of silicon - isotropic etching -

anisotropic etching - electrochemical etching - vapor phase etching - dry

etching - other etching techniques.

UNIT IV BALL MILLING TECHNIQUE 5

Nano powders produced using micro reactors – nano crystalline

ceramics by mechanical activation - formation of nanostructured

polymers.

UNIT V MACHINING PROCESSES 8

Micro milling/micro drilling/micro grinding processes and the procedure

for selecting proper machining parameters with given specifications -

EDM micro machining, laser micro/nano machining - models to simulate

micro/nano machining processes using molecular dynamics techniques -

wet chemical etching - dry etching - thin film and sacrificial processes.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. M. J. Jackson, “Micro fabrication and nano manufacturing”,

CRC Press, 2005.

2. P.Rai-Choudhury, “Handbook of micro lithography, micro

machining, and micro fabrication”, Vol. 2, SPIE Press, 1997.

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3. M. Madou, “Fundamentals of micro fabrication,” CRC Press,

1997.

4. G.Timp, “Nano technology”, AIP press, Springer-Verlag, New

York, 1999.

13NT402 : BOTTOM UP SYNTHESIS OF

NANOSTRUCTURES

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide synthetic approach about thin films.

Knowledge about physical vapour deposition on sputtering.

To know about epitaxial growth of semi-conductor films.

To have an idea about the development of thin film by chemical

methods.

To know about different printing technologies.

COURSE OUTCOMES:

Upon completion of the course the students will be able

To develop thin films using CVD and other methods.

To obtain thin films using sputtering methods.

To develop epitaxial growth of thin films.

To grow thin films using various chemical methods.

To differentiate different types of printing techniques.

UNIT I THIN FILM TECHNOLOGIES – I 9

CVD chemical vapor deposition – atmospheric pressure CVD (APCVD)

– low pressure CVD (LPCVD) - plasma enhanced chemical vapor

deposition (PECVD) - HiPCO method – photo-enhanced chemical vapor

deposition (PHCVD) - LCVD Laser – induced CVD.

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UNIT II THIN FILM TECHNOLOGIES – II 9

Physical vapor deposition - sputter technologies - diode sputtering -

magnetron sputtering - ion beam (sputter) deposition, ion implantation

and ion assisted deposition - cathodic arc deposition - pulsed laser

deposition.

UNIT III EPITAXIAL FILM DEPOSITION METHODS 9

Epitaxy, different kinds of epitaxy - influence of substrate and substrate

orientation, mismatch, MOCVD metal organic chemical vapor deposition

- CCVD combustion chemical vapor deposition - ALD atomic layer

deposition - LPE Liquid phase epitaxy - MBE molecular beam epitaxy.

UNIT IV CHEMICAL METHODS 9

Sol-gel synthesis – different types of coatings - spin coating - self-

assembly - (periodic) starting points for self-assembly - directed self-

assembly using conventional lithography - template self-assembly -

vapor liquid solid growth - langmuir-blodgett films – DNA self-assembly.

UNIT V PRINTING TECHNOLOGIES 9

Screen printing - inkjet printing - gravure printing and flexographic

printing - flex graphic printing - gravure printing – roll to roll techniques.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. G. Cao, “Nanostructures & nano materials: Synthesis, properties

& applications” , Imperial college press, 2004.

2. W.T.S. Huck, “Nanoscale assembly: chemical techniques

(nanostructure science and technology)”, Springer, 2005.

3. E. Gdoutos and I. M. Daniel, “Handbook of nano science

engineering and technology”, Kluwer publishers, 2002.

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13NT403 : SEMICONDUCTOR

NANOSTRUCTURES AND NANO-PARTICLES

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide fundamentals about semi-conducting materials.

To provide various methods for synthesizing semi-conducting nano

particles.

To have a knowledge of physical properties of semi-conducting

materials.

To provide idea about the applications of semi-conducting

materials.

To give idea about the properties and preparation of nano wires.

COURSE OUTCOMES:

Sound knowledge in semi-conductors.

This will give idea about the synthetic strategies about the semi-

conductor particles.

It will provide all types of physical properties about the semi-

conducting materials.

Applications of semi-conducting materials will be gathered.

Idea about nano wire properties, synthetic strategies will be

gained.

UNIT I SEMICONDUCTOR FUNDAMENTALS 9

Introduction to semiconductor physics – fabrication techniques –

semiconductor nanostructures – electronic structure and physical

process – principles of semiconductor nanostructures based electronic

and electro-optical devices – semiconductor quantum dots – quantum

lasers – quantum cascade lasers – quantum dot optical memory.

88

UNIT II SEMICONDUCTOR NANOPARTICLE

SYNTHESIS

9

Cluster compounds - quantum-dots from MBE and CVD - wet chemical

methods - reverse micelles - electro-deposition - pyrolytic synthesis -

self-assembly strategies.

UNIT III PHYSICAL PROPERTIES 9

Melting point - solid-state phase transformations – excitons - band-gap

variations - quantum confinement - effect of strain on band-gap in

epitaxial quantum dots - single particle conductance.

UNIT IV SEMICONDUCTOR NANOPARTICLES –

APPLICATIONS

10

Optical luminescence and fluorescence from direct band gap

semiconductor nanoparticles - surface-trap passivation in core-shell

nanoparticles - carrier injection - polymer-nanoparticle - LED and solar

cells – electroluminescence - barriers to nanoparticle lasers - doping

nanoparticles - Mn-Zn-Se phosphors - light emission from indirect

semiconductors - light emission form Si nano dots.

UNIT V SEMICONDUCTOR NANOWIRES 8

Fabrication strategies - quantum conductance effects in semiconductor

nanowires - porous silicon – nano belts – nano ribbons – nano springs.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Bharat Bhusan, “Handbook of nanotechnology”, Springer, 2004.

2. Balandin, K. L. Wang, “Handbook of semiconductor nano structures

and nano devices” Vol. 1-5- A. A., American Scientific Publishers,

2006.

3. Cao, Guozhong, “Nano structures and nano materials – synthesis,

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properties and applications”, World Scientific Publisher Co., 2011.

WEB REFERENCES:

1. Hari Singh Nalwa, “Encyclopedia of nano science and

nanotechnology”, American Scientific Publishers, 2004.

13NT404 : NANOTECHNOLOGY FOR ENERGY

SYSTEMS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To provide fundamentals about different types of energy sources.

Idea about renewable energy sources will be provided.

Familiarization about fuel cell, micro fuel cell technology is

proposed.

To gather idea about micro-fluidic devices, MEMS etc.,

To provide knowledge about hydrogen storage with nano

technology concepts.

COURSE OUTCOMES:

Completion of this course gives sound knowledge about the

fundamentals and types of energy sources.

Renewable energy sources and its importance.

Understanding the knowledge about fuel cell, micro fuel cell

technology is provided.

Idea about micro fluidic devices like piezo electric membrane.

Knowledge about hydrogen storage for automotive applications.

UNIT I INTRODUCTION 9

Nanotechnology for sustainable energy - materials for light emitting

diodes – batteries - advanced turbines - catalytic reactors – capacitors -

90

fuel cells.

UNIT II RENEWABLE ENERGY TECHNOLOGY 9

Energy challenges - development and implementation of renewable

energy technologies - nanotechnology enabled renewable energy

technologies - energy transport - conversion and storage - nano, micro

and meso scale phenomena and devices.

UNIT III MICRO FUEL CELL TECHNOLOGY 9

Micro-fuel cell technologies - integration and performance for micro-fuel

cell systems - thin film and micro fabrication methods - design

methodologies - micro-fuel cell power sources.

UNIT IV MICROFLUIDIC SYSTEMS 9

Nano-electromechanical systems and novel microfluidic devices - nano

engines - driving mechanisms - power generation – micro channel

battery - micro heat engine (MHE) fabrication – thermo capillary forces –

thermo capillary pumping (TCP) - piezoelectric membrane.

UNIT V HYDROGEN STORAGE METHODS 9

Hydrogen storage methods - metal hydrides - size effects - hydrogen

storage capacity - hydrogen reaction kinetics - carbon-free cycle-

gravimetric and volumetric storage capacities - hydriding/dehydriding

kinetics - high enthalpy of formation - and thermal management during

the hydriding reaction - distinctive chemical and physical properties -

multiple catalytic effects - degradation of the sorption properties - hydride

storage materials for automotive applications.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. J. Twidell & T. Weir, “Renewable energy resources”, E & F N

Spon Ltd, London, 1986.

2. D. Infield, “Hydrogen from renewable energy sources”,

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Springer, 2004.

3. R. A. Shatwell, “Fuel storage on board hydrogen storage in

carbon nano structures”, CRC Press, 1996.

4. Hoogers, “Fuel cell technology handbook”, CRC Press, 2003.

5. Vielstich, “Handbook of fuel cells: Fuel cell technology and

applications”, Wiley, CRC Press, 2003.

13NT405 : MOLECULAR ELECTRONICS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basic concepts of organic molecules for

molecular electronics applications.

To acquire knowledge about unimolecular devices.

To gain knowledge about the computer architecture of molecular

electronic devices.

To understand the fabrication technologies of molecular electronic

devices.

To gain knowledge about hybrid nano materials for biomolecular

optoelectronic device.

COURSE OUTCOMES:

Gain knowledge about material properties used in molecular

electronics.

Able to design advanced unimolecular electronic devices.

Capable of interpreting the computing architectures of molecular

electronic devices.

Able to fabricate optoelectronic and thin film transistors.

Able to process hybrid structures for biomolecular optoelectronic

devices.

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UNIT I INTRODUCTION 9

Controlling surfaces and interfaces of semi-conductor sensing organic

molecules - types of molecule - manipulation experiments -

measurements in molecular electronics - soft and hard electronics -

electronic structure of absorbed organic molecule.

UNIT II UNIMOLECULAR ELECTRONICS 9

Organic semiconductor for new electronic device - photo voltaic cells -

Schotkey diodes FET digital processing and communication with

molecular switches.

UNIT III MOLECULAR ELECTRONIC COMPUTING

ARCHITECTURES

9

Molecular electronics overview – rectifiers - molecular wires – molecular

switches – data storage - photo switches - molecular magnets.

UNIT IV MOLECULAR ELECTRONIC DEVICES 9

Molecular engineering of doped polymer for optoelectronics - fabrication

for molecular electronics organic FETs – organic thin film transistors.

UNIT V BIO MOLECULAR ELECTRONICS AND

PROCESSING

9

Bio electronics – molecular and biocomputing – prototypes for molecular

functional limits and actuators – molecular assembly – characterization

of hybrid nano materials - biomolecular optoelectronic device.

TOTAL: 45 PERIODS

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REFERENCE BOOKS:

1. G. Cumbertl & G. Fagas, “Introducing molecular electronics”,

Springer, 2005.

2. S.C. Levshevski, “Nano and molecular electronics handbook”,

CRC Press, 2007.

3. Karl Goser & Jan Dienstuhl, “Nano electronics & nano systems:

From transistor to molecular & quantum devices”, Springer,

2004.

13NT406 : PRODUCT DESIGN, MANAGEMENT

TECHNIQUES AND ENTREPRENEURSHIP

L T P C

3 0 0 3

COURSE OBJECTIVES:

To teach the concept of product design, entrepreneurship and

management principles to the students.

The method of preparing the feasibility report will be explained to

the students.

Knowledge on various related concepts like supply chain

management, product launching and so on.

COURSE OUTCOMES:

Gain knowledge on the product design methodology.

Acquire knowledge on various management principles.

Gain information on entrepreneurship.

The knowledge on project profile preparation will be gained.

The knowledge on supply chain management, global management

will be gained.

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UNIT I PRODUCT DESIGN 9

Concept generation - product architecture - industrial design process -

management of industrial design process and assessing the quality of

industrial design - establishing the product specification.

UNIT II PRODUCT DEVELOPMENT 9

Criteria for selection of product - product development process - design for

manufacture - estimate the manufacturing cost - reduce the support cost -

prototyping – economics of product development projects - elements of

economic analysis - financial models - sensitive analysis and influence of

the quantitative factors.

UNIT III MANAGEMENT TECHNIQUES 9

Technology management - scientific management - development of

management thought - principles of management - functions of management

– planning – organization - directing, staffing and controlling - management

by objective – SWOT analysis - enterprise resource planning and supply

chain management.

UNIT IV ENTREPRENEURIAL COMPETENCE &

ENVIRONMENT

9

Concept of entrepreneurship - entrepreneurship as a career - personality

characteristic successful entrepreneur - knowledge and skill required for

an entrepreneur - business environment - entrepreneurship development

training - centre and state government policies and regulations - international

business.

UNIT V MANAGEMENT OF SMALL BUSINESS 9

Pre-feasibility study - ownership – budgeting – project profile

preparation - feasibility report preparation - evaluation criteria - market

and channel selection - product launching - monitoring and evaluation of

business - effective management of small business.

TOTAL: 45 PERIODS

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REFERENCE BOOKS:

1. Karal, T.Ulrich Steven & D.Eppinger, “Product design and

development”, McGraw- Hill International, editions, 2003.

2. S.Rosenthal, “Effective product design and development”, Irwin,

1992.

3. H.Koontz & H.Weihrich, “Essentials of management”, McGraw Hill,

Singapore international edition, 1980.

4. J.J.Massie, “Essentials of management” Prentice Hall of India Pvt.

Ltd., 1985.

5. Hisrich, “Entrepreneurship” Tata Mc Grew Hill, New Delhi, 2000.

13NT407 : MEMS AND BIO MEMS L T P C

3 0 0 3

COURSE OBJECTIVES:

This course will provide basic platform about MEMS and its

fabrication methods.

Offer knowledge about thermal actuator, thermal sensor and its

scaling methods.

Provide basic idea about micro system design, micro

accelerometer etc.

Provides fundamentals about material to be used for fabricating

MEMS.

Idea about commercialization of miniaturized products.

COURSE OUTCOMES:

On completion of this course, the student will have an idea

about MEMS, its fabrication methods.

96

The designing of thermal sensors, thermal actuators and its

mechanics will be familiarized.

Idea about the materials to be used for designing MEMS will

be offered.

Students get knowledge about micro accelerometer, thin film

techniques etc.

Give platform about commercialization of high density chip,

lab-in-chip for DNA etc.

UNIT I MEMS MICRO FABRICATION 10

Historical development of microelectronics, evolution of micro sensors -

evolution of MEMS - emergence of micro machines - modeling - finite

element analysis - CAD for MEMS – fabrication - ALD - lithography micro

machining - LIGA and micro moulding - Saw-IDT micro sensor

fabrication - packaging – challenges, types, materials and processes.

UNIT II SCALING OF MEMS 9

Introduction to scaling Issues - scaling effects on a cantilever beam -

scaling of electrostatic actuators - scaling of thermal actuator - scaling of

thermal sensors - mechanics and electro statistics - influence of scaling

on material properties.

UNIT III MICROSYSTEMS 10

Micro sensors – micro accelerometer – micro fluidics - mechanics for

micro systems design – thermo mechanics - fracture mechanics - thin

film mechanics – micro fluid mechanics.

UNIT IV MATERIALS FOR MEMS 8

Materials for MEMS and pro MEMS - silicon-metals and polymers -

substrate materials for MEMS - silicon-quartz – ceramics - bulk metallic

glasses - sharp memory alloys, carbon based MEMS.

97

UNIT V COMMERCIAL AND TECHNOLOGICAL

TRENDS

8

Commercial trends in miniaturization – high density chip analysis - micro

accelerometers - micro resonators - lab-in-chip for DNA and protein

analysis – nano HPLC system - nano patches.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Marc Madou, “Fundamentals of micro fabrication”, CRC Press

1997.

2. Tai-Ran Hsu, “MEMS and Micro systems design and

manufacture”, Tata Mc Graw Hill, 2011.

3. Sergey Edward & Lyshevski, “Nano and micro

electromechanical systems”, CRC Press 2000.

4. Vijay Varadan, Xiaoning Jiang & Vasundara Varadan, “Micro

stereolithography and other fabrication techniques for 3D

MEMS”, Wiley 2001.

5. Tai-Ran Hsu, “MEMS and micro systems: Design and

manufacture”, McGraw-Hill, 2001.

6. Ken Gilleo, “MEMS/MOEMS packaging: Concepts, designs,

materials and processes”, McGraw-Hill, 2005.

13NT408 : NANOCOMPOSITES L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the basic difference between composites and nano

composites.

To learn different preparation techniques for nano composites.

98

To design and study the super hard nano composite coatings for

different applications.

To enable the methods for fabrication of polymer based nano

composites.

To know the concept of core-shell structured nano composites.

COURSE OUTCOMES:

Understand the concept and classification of composites.

Designing of super hard coatings and its applications.

Gain knowledge on nano composite manufacturing methods.

Information on new kinds of nano materials.

Cultivate the industrial possibilities of polymer nano composites.

UNIT I NANOCERAMICS 9

Metal-oxide or metal-ceramic composites - different aspects of their

preparation techniques and their final properties and functionality.

UNIT II METAL BASED NANOCOMPOSITES 9

Metal-metal nanocomposites - some simple preparation techniques and

their new electrical and magnetic properties.

UNIT III DESIGN OF SUPER HARD MATERIALS 9

Super hard nanocomposites - its designing and improvements of

mechanical properties.

UNIT IV NEW KIND OF NANOCOMPOSITES 9

Fractal based glass - metal nanocomposites, its designing and fractal

dimension analysis - electrical property of fractal based nanocomposites

- core-shell structured nanocomposites.

UNIT V POLYMER BASED NANOCOMPOSITES 9

Preparation and characterization of di block copolymer based

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nanocomposites – polymer-carbon nanotubes based composites their

mechanical properties - industrial possibilities.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. P. M. Ajayan, L.S. Schadler, P. V.Braun, “Nanocomposites

science and technology”, Wiley-Vch Verlag GmbH Co. KGaA,

Weinheim, 2006.

2. R. Saito, “Physical properties of carbon nanotubes”, Imperial

College Press, 1998.

3. M. Endo, S. Iijima, “Carbon nanotubes (carbon , Vol. 33) ”, M.S.

Dresselhaus, 1997.

WEB REFERENCES:

1. Christian Brosseau,Jamal Ben, Youssef, Philippe Talbot &

Anne-Marie Konn, “Electromagnetic and magnetic properties of

multi component metal oxides, hetero nano meter versus micro

meter-sized particles”, (Review Article), J. Appl. Phys, Vol. 93,

2003.

2. Aviram, “Diblock copolymer, (Review Article), Nature, 2002.

3. Stan Vepriek, “The search for novel, super hard materials”,

(Review Article) JVST A, 1999.

13NT409 : CHEMICAL NANOTECHNOLOGY L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the concept of chemistry of nano particles,

molecular self-assembly etc.

To educate about different types of polymeric materials and its

100

applications.

To have knowledge about macromolecular system like dendrimer,

molecular switches etc.

To emphasize about the catalytic activities of nano particles, use of

nano particles in different chemical reactions etc.

To study about the background of electrochemical concepts

available in semi-conductors, metal oxides etc.

COURSE OUTCOMES:

Offered fundamentals of chemistry behind the organic molecular

templates, self-assembly of molecules etc.

Gathering of knowledge about polymeric molecules and its

applications in various fields.

Knowledge about molecular switches, dendrimer preparations, its

applications.

Emphasize about nano catalysis in different fields.

Utilization of electrochemical based principles in different fields.

UNIT I CHEMISTRY OF NANOPARTICLES 9

Synthesis by organic molecule templates – molecular self-assembly –

spatially constrained synthesis – biomimetic synthesis – oxide

nanoparticles – particle size – particle shape – particle density –

composite structure – pore structure – surface modification of inorganic

nanoparticles by organic functional groups.

UNIT II ADVANCED POLYMERIC MATERIALS 9

Polymer chain statistics – static light scattering – polymer blends – high

performance thermoplastics – polymer material for photovoltaic

applications – synthetic biomedical polymers – assembly of polymer –

nanoparticle composite material – fabrication of polymer – applications

of polymers in catalysis.

101

UNIT III SUPRA MOLECULAR CHEMISTRY 9

Catenanes and rotaxanes – synthesis and uses as molecular switches –

dendrimers – preparations – classifications – applications.

UNIT IV NANO CATALYSIS 9

Types of catalysis – homogeneous, heterogeneous and biocatalysis –

catalysis by nanoparticles – physical properties of free and supported

nanoparticles – reactivity of supported metal nanoparticles – gold

nanoparticles – preparative methods and properties – reactions – water

gas shift – vinyl acetate synthesis – hydrogenation – CO oxidation –

Heck reaction – commercial application.

UNIT V ELECTROCHEMISTRY OF NANOMATERIALS 9

Electrochemistry of semiconductor nanostructures, nanostructured metal

oxide films – electrochemistry with nanoparticles – preparation of

nanostructures, electrochemistry with metallic nanoparticles – monolayer

protected nano clusters – nano electrode ensembles - single electron

events - probing nanoparticles using electrochemistry coupled with

spectroscopy.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. M. Hosokawa, K. Nogi & M.Y. Naito Y,“Nanoparticle technology

handbook” Vol. I, Elsevier, 2007.

2. B. Pignataro, “Tomorrow’s chemistry today, concepts in

nanoscience, organic materials and environmental chemistry”,

Wiley-Vch Verlag GmbH, 2008.

3. C.E. Carraher & R.B. Seymour, “Polymer chemistry”, CRC /

Taylor and Francis, 2008.

4. C.N.R. Rao, A. Muller & A.K. Cheetham, “The Chemistry of

nanomaterials: Synthesis, properties and applications”, Wiley-

Vch Verlag GmbH, 2004.

5. G.A. Ozin & A.C. Aresenault, “Nanochemistry: A chemical

102

approach to nanomaterials”, RSC Publishing, 2005.

6. C. Brechignac, P. Houdy & M. Lahmani “Nano materials and

nano chemistry”, Springer-Verlag, 2007.

13NT410 : NANOPARTICLES AND MICRO

ORGANISMS BIO NANO COMPOSITES

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the biosynthesis of nano materials and its toxicity.

To learn about the biomimetic synthesis of nanocomposite

materials.

To learn the basic concepts of bioelectronic devices.

To cultivate the idea about novel drug delivery routes.

To know the concept of tissue engineering for biomedical

applications.

COURSE OUTCOMES:

Able to synthesis nanoparticles through microorganisms.

Ability to develop synthetic nanocomposites by biomimetic route.

Capable of designing nanoparticle-enzyme hybrids based

bioelectronic systems.

Able to target diseases using nano mediated drug delivery

systems.

Understand the fundamentals of tissue engineering.

UNIT I MICROORGANISMS FOR SYNTHESIS OF

NANO MATERIALS

8

Natural and artificial synthesis of nanoparticles in microorganisms - use

of microorganisms for nanostructure formation - testing of environmental

toxic effect of nanoparticles using microorganisms.

103

UNIT II NANOCOMPOSITE BIOMATERIALS 9

Natural nanocomposite systems as spider silk, bones, shells - organic-

inorganic nanocomposite formation through self-assembly - biomimetic

synthesis of nanocomposite material - use of synthetic nanocomposites

for bone, teeth replacement.

UNIT III NANO BIO SYSTEMS 10

Nanoparticle - biomaterial hybrid systems for bioelectronic devices -

bioelectronic systems based on nanoparticle-enzyme hybrids -

nanoparticle based bioelectronic biorecognition events - biomaterial

based metallic nanowires - networks and circuitry - DNA as functional

template for nano circuitry. Protein based nano circuitry; Neurons for

network formation - DNA nanostructures for mechanics and computing

and DNA based computation - DNA based nano mechanical devices -

biosensor and biochips.

UNIT IV NANOPARTICLES AND NANO DEVICES 9

Targeted, non-targeted delivery - controlled drug release - exploiting

novel delivery routes using nanoparticles - gene therapy using

nanoparticles - nanostructures for use as antibiotics - diseased tissue

destruction using nanoparticles.

UNIT V TISSUE ENGINEERING 9

Major physiologic systems of current interest to biomedical engineers –

cardiovascular – endocrine – nervous – visual – auditory -

gastrointestinal and respiratory - useful definitions - The status of tissue

engineering of specific organs - including bone marrow - skeletal muscle

and cartilage - cell biological fundamentals of tissue engineering.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. David S. Goodsell, “Bionanotechnology: Lessons from Nature,

Wiley, 2004.

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2. Robert A. Freitas, “Nano medicine, Vol. IIA: Biocompatibility”,

maimai_bn, 2003.

3. Hari Singh Nalwa, “Handbook of nanostructured biomaterials and

their applications in nanobiotechnology”, Book News, Inc., 2005.

4. C.M.Niemeyer & C.A. Mirkin, “Nanobiotechnology”, Wiley, 2006.

5. Ajayan, Schadler & Braun, “Nanocomposite science & technology”,

Wiley, 2003.

13NT411 : OPTICAL PROPERTIES OF

NANOMATERIALS, NANOPHOTONICS AND

PLASMONICS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To introduce the fundamental principles of nano metal particles.

To provide various semi conducting nano materials.

To know the physics of linear & nonlinear photonic crystals.

To have thorough knowledge about plasmonics.

To familiarize the applications of plasmonics.

COURSE OUTCOMES:

Upon completion of the course the students will be able

To know the properties and nature of nano metal powders.

To obtain the technical knowledge on semi conducting nano

materials.

To classify the linear & nonlinear photonic crystals.

To identify the various materials for linear & nonlinear photonic

crystals.

To apply the plasmonics for real time applications.

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UNIT I METAL NANOPARTICLES 8

Metal nanoparticles - alloy nanoparticles - stabilization in sol, glass and

other media - change of band gap – blue shift - colour change in sol,

glass, and composites - plasmon resonance.

UNIT II SEMICONDUCTOR NANOPARTICLES –

APPLICATIONS

10

Optical luminescence and fluorescence from direct – band gap

semiconductor nanoparticles - surface-trap passivation in core-shell

nanoparticles - carrier injection - polymer-nanoparticle LED’s and solar

cells – electroluminescence - barriers to nanoparticle lasers - doping

nanoparticles - Mn-ZnSe phosphors - light emission from indirect

semiconductors - light emission from Si nano dots.

UNIT III PHYSICS OF LINEAR PHOTONIC CRYSTALS 8

Maxwell’s equations - Bloch’s theorem - photonic band gap and localized

defect states - transmission spectra - nonlinear optics in linear photonic

crystals - guided modes in photonic crystals slab.

UNIT IV PHYSICS OF NONLINEAR PHOTONIC

CRYSTALS

9

1-D quasi phase matching - nonlinear photonic crystal analysis -

applications of nonlinear photonic crystals devices - materials: LiNbO3,

chalcogenide glasses etc. - wavelength converters etc.

UNIT V ELEMENTS OF PLASMONICS 10

Plasmonics, merging photonics and electronics at nano scale

dimensions, single photon transistor using surface plasmon, nanowire

surface plasmons - interaction with matter, single emitter as saturable

mirror, photon correlation, and integrated systems. All optical modulation

by plasmonic excitation of quantum dots, channel plasmon-polariton

guiding by subwavelength metal grooves, near-field photonics: surface

plasmon polaritons and localized surface plasmons, slow guided surface

plasmons at telecom frequencies.

TOTAL: 45 PERIODS

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REFERENCE BOOKS:

1. Bharat Bhushan, “Hand book of nanotechnology”, Springer, 2004.

2. Mool Chand Gupta & John Ballato, “The handbook of photonics”,

CRC Press, 2007.

3. J. M. Martinez-art, Raúl J. Martín-Palma & Fernando Agullo-

Rueda, “Nanotechnology for microelectronics and optoelectronics”,

Elsevier Science, 2006.

4. S. Kawata & H. Masuhara, “Nano plasmonics from fundamentals

to applications”, vol. 1 & 2, Elsevier, 2006.

WEB REFERENCES:

1. Hari Singh Nalwa, “Encyclopedia of nanotechnology”, American

Scientific Publishers, 2004.

13NT412 : ADVANCED NANO DRUG DELIVERY

SYSTEMS

L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand about fundamentals of nano drug carriers.

To gain knowledge about dendrimers and its poly valency

properties.

To learn about ligand based drug delivery.

To learn the basics of drug targeting and bacterial and virus

dependent delivery of vaccines.

To understand basic concepts of drug delivery systems.

COURSE OUTCOMES:

Learn the pharmacokinetics of different modes of drug delivery.

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Gain Knowledge about dendrimers and its uses for efficient drug

delivery.

Ability to design lipid based drug delivery systems.

Know about virus based nanoparticles for drug targeting and

biomedical imaging.

Understand MEMS technology for fabrication of implantable

microchips.

UNIT I THEORY OF ADVANCED DRUG DELIVERY 10

Fundamentals of nano carriers - size, surface, magnetic and optical

properties - pharmacokinetics and pharmacodynamics of nano drug

carriers - critical factors in drug delivery - transport of nanoparticles - in

vitro and ex vivo models.

UNIT II POLYMERS 8

Dendrimers - synthesis – nano scale containers - dendritic nano scafold

systems - biocompatibility of dendrimers, gene transfection - pH based

targeted delivery - chitosan and alginate - copolymers in targeted drug

delivery - PCL - PLA - PLGA.

UNIT III LIPID BASED NANO CARRIERS 9

Liposomes - niosomes and solid lipid nanoparticles - ligand based

delivery by liposomes - cubosomes.

UNIT IV MICROBES AND ANTIBODY BASED NANO

CARRIERS

9

Bacterial dependent delivery of vaccines - drug delivery and subcellular

targeting by virus - drug packaging and drug loading - delivery of

therapeutics by antibodies and antibody - bioconjugates.

UNIT V SITE SPECIFIC DRUG DELIVERY 9

Concepts and mechanism of site specific drug delivery – micro needles

– micro pumps – micro valves - implantable microchips.

108

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. M.Salzman, “Drug delivery: Engineering principles for drug

therapy”, Oxford University Press, 2001.

2. A.M. Hillery, “Drug delivery and targeting”, CRC Press, 2002.

3. B. Wang, “Drug delivery: Principles and applications”, Wiley

Intersceince, 2005.

4. Ram B. Gupta & Uday B. Kompella, “Nanoparticle technology

for drug delivery”, Taylor & Francis, 2006.

13NT413 : BIO MOLECULAR MACHINES L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand about fundamentals of molecular scale machines.

To gain knowledge about bio molecular machines.

To learn about molecular nano reactors.

To learn the basics of logic gate memories.

To understand the basic concepts of nano scale devices.

COURSE OUTCOMES:

Learn the types of molecular machines & switches.

Gain knowledge about bio molecular machines.

Ability to design molecular nano reactors.

Know about logic gate memories.

Understand the fabrication of nano scale devices.

109

UNIT I MOLECULAR SCALE-MACHINE 9

Characterization of molecular machine - energy supply - chemical fuels-

molecular shuttle - electrochemical energy - molecular machines

powered by light energy: molecular switching - chemical switching and

electrochemical switching.

UNIT II BASIC PRINCIPLES OF MOTOR DESIGN 9

Biomolecular machines: transcription, translation and replication

processes at single molecule level – initiation and force control of

biological processes - force generation and real-time dynamics – active

transport by biological motors – mechanism, dynamics and energetic of

kinesin, myosin, dyneins and ATP synthesis.

UNIT III NANO REACTORS 9

Self-assembled nano reactors - molecular nano reactors - covalent

system - nano covalent system - macro molecular nanoreactions

micelles and polymers – biomacro molecular nanoreactions - protein

cages-viruses - rod shaped and cage structured.

UNIT IV MEMORIES, LOGIC GATES AND RELATED

SYSTEMS

9

Memories logic gates – multistate – multifunctional systems.

UNIT V NANO SCALE DEVICES 9

Fabrication and patterning of nano scale device.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. V. Balazani, “Molecular devices and machines: A Journey into

the nanoworld”, Wiley – VCH, 2003.

2. M. Schilva, “Molecular motors”, Wiley - VCH. 2005.

110

13NT414 : BIOSENSORS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand about protein based biosensors.

To gain knowledge about DNA based biosensor.

To learn about detection techniques of biosensors.

To learn the basics of micro fabrication of electrodes.

To understand the basic concepts of molecular design of

biosensors.

COURSE OUTCOMES:

Learn about the materials used in protein based biosensors.

Determine the complex metals in food samples by DNA based

biosensor.

Ability to differentiate detection techniques of biosensors.

Able to fabricate electrodes for biosensing.

Understand cellular biosensing techniques.

UNIT I PROTEIN BASED BIOSENSORS 9

Nano structure for enzyme stabilization – single enzyme

nano particles – nano tubes micro porous silica – protein based nano

crystalline - diamond thin film for processing.

UNIT II DNA BASED BIOSENSOR 9

Heavy metal complexing with DNA and its determination - water and

food samples – DNA zymo biosensors.

UNIT III BIOSENSOR BASED DETECTION

TECHNIQUES

9

Detection in biosensors - fluorescence - absorption – electrochemical.

111

Integration of various techniques – fiber optic biosensors.

UNIT IV FABRICATION 9

Techniques used for micro fabrication – micro fabrication of electrodes

on chip analysis.

UNIT V MOLECULAR DESIGN 9

Future direction in biosensor research - designed protein pores as

components of biosensors - molecular design - bionanotechnology for

cellular biosensing - biosensors for drug discovery – nano scale

biosensors.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. J. Cooper & C. Tass, “Biosensors: A practical approach”, Oxford

University Press, 2004.

2. C.S. Kumar, “Nano materials for biosensors”, Wiley – VCH, 2007.

3. G.K. Knoff, A.S. Bassi, “Smart biosensor technology”, CRC Press,

2006.

13NT415 : BIOPHOTONICS L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand the interaction of light with biological systems.

To learn the principles of various imaging techniques.

To gain knowledge about single molecule spectroscopy.

To learn the basics of optical trapping technologies.

To understand basic bio detection techniques.

COURSE OUTCOMES:

Learn the effects of light with body organelles.

112

Capable of operating imaging tools.

Ability to differentiate various spectroscopy techniques.

Understand the optical confinement phenomena for trapping

applications.

Able to detect cellular and molecular tags.

UNIT I INTRODUCTION 9

Interaction of light with cells, tissues - non-linear optical processes with

intense laser beams - photo-induced effects in biological systems.

UNIT II IMAGING TECHNIQUES 9

Light microscopy – wide field - laser scanning – confocal – multi photon -

fluorescence lifetime imaging - FRET imaging – frequency domain

lifetime imaging - cellular imaging - imaging of soft and hard tissues and

other biological structures.

UNIT III SINGLE MOLECULE SPECTROSCOPY 9

UV-Vis. spectroscopy of biological systems - single molecule spectra

and characteristics – IR and raman spectroscopy and surface enhanced

raman spectroscopy for single molecule applications.

UNIT IV ANALYTICAL BIOTECHNOLOGY 9

Optical force spectroscopy: generation optical forces – optical trapping

and manipulation of single molecules and cells in optical confinement -

laser trapping and dissection for biological systems - single molecule

biophysics.

UNIT V DETECTION TECHNIQUES 9

Biosensors - fluorescence immunoassay - flow cytometry - fluorescence

correlation spectroscopy - fluorophores as cellular and molecular tags.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Michael P. Sheetz (Ed.), “Laser tweezers in cell biology and

113

methods in cell biology”, Vol.55, Academic Press, 1997.

2. P.N. Prasad, “Introduction to biophotonics”, John-Wiley, 2003.

3. G. Marriot & I. Parker, “Methods in enzymology”, Vol.360,361,

Academic Press, 2003.

13NT416 : NANOTOXICOLOGY L T P C

3 0 0 3

COURSE OBJECTIVES:

To understand about fundamentals of toxicology.

To learn about risk on nano toxicology.

To gain knowledge about protocols in toxicology studies.

To learn the animal studies on toxicology.

To understand concepts on risk assessment and execution.

COURSE OUTCOMES:

Learn the toxicological terminology.

Gain knowledge about nano toxicity.

Ability to assess toxicity of nano materials.

Know about dosing profile for animal models.

Exposure on the regulations of toxicity.

UNIT I INTRODUCTION TO TOXICOLOGY 9

Concept of toxicology - types of toxicity based on route of entry - nature

of the toxin – toxicodynamics – dose Vs. toxicity relationships -

toxicokinetics – ADME - LADMET hypothesis - genotoxicity and

carcinogenicity – mechanisms and tests - organ toxicity – respiratory -

dermal hepato - neuro and nephro.

UNIT II NANO TOXICOLOGY 9

Characteristics of nanoparticles that determine potential toxicity - bio-

114

distribution of nanoparticles - interation of nanoparticles with

biomembrane and genes - evaluation of nanoparticle transfer using

placental models - nanomaterial toxicity – pulmonary – dermal – hepato

– neuro - ocular and nephron - estimation of nanoparticle dose in

humans - in vitro toxicity studies of ultrafine diesel exhaust particles;

toxicity studies of carbon nanotubes.

UNIT III PROTOCOLS IN TOXICOLOGY STUDIES 10

Methods for toxicity assessment – cyto, geno, hepato, neuro,

nephrotoxicity - assessment of toxicokinetics - assessment of oxidative

stress and antioxidant status.

UNIT IV ANIMAL MODELS 9

Types, species and strains of animals used in toxicity studies - dosing

profile for animal models - studies on toxicology - pathology and

metabolism in mouse and rat - laws and regulations - governing animal

care and use in research.

UNIT V RISK ASSESSMENT AND EXECUTION 8

Risk assessment of nanoparticle exposure - prevention and control of

nano particles exposure - regulation and recommendations.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. John H. Duffus & Howard G. J. Worth, “Fundamental toxicology”,

The Royal Society of Chemistry, 2006.

2. Nancy A. Monteiro-Riviere & C. Lang Tran., “Nano toxicology:

characterization, dosing and health effect”, Informa healthcare

publishers, 2007.

3. Lucio G. Costa, Ernest Hodgson, David A. Lawrence, Donald J.

Reed & William F. Greenlee, “Current protocols in toxicology”,

John Wiley & Sons, Inc. 2005.

4. Shayne C. Gad, “Animal models in toxicology”, Taylor & Francis

Group, LLC 2007.

115

5. P. Houdy, M. Lahmani & F. Marano, “Nanoethics and

Nanotoxicology”, Springer-Verlag Berlin Heidelberg, 2011.

6. M.ZafarNyamadzi, “A Reference handbook of nanotoxicology”,

2008.

7. Andreas Luch, “Molecular, clinical and environmental toxicology

Volume 2: Clinical toxicology”, Birkhauser Verlag AG, 2010.

13NT417 : ADVANCED NANO BIOTECHNOLOGY L T P C

3 0 0 3

COURSE OBJECTIVES:

To gain knowledge about natural nanocomposites for agricultural

applications.

To learn the principles of bio delivery systems.

To gain knowledge about design strategies of protein and DNA

nanostructures.

To learn the basics of nano bioelectronics.

To understand applications of nanoparticles in therapeutic and

diagnostic applications.

COURSE OUTCOMES:

Able to differentiate synthetic and natural nanocomposites and its

applications.

Capable of synthesizing thermo responsive delivery systems.

Ability to fabricate biomimetic nanostructures.

Understand the bio recognition techniques of nanoparticles.

Able to understand the role of nanoparticles in cancer therapy.

UNIT I NATURAL NANOCOMPOSITES 9

Natural nano composite materials – biomineralisation – biologically

synthesized nano structures – metals, ceramic and silica deposition

vesicles –nanotechnology in agriculture - fertilizers and pesticides.

116

UNIT II SMART NANO PARTICULATE SYSTEMS 9

Thermo responsive delivery systems - pH responsive delivery systems -

external stimuli based delivery systems (magnetic, photosensitive and

ultra sound sensitive delivery systems) – stealth nanoparticles - multi

targeting systems.

UNIT III PROTEIN AND DNA BASED

NANOSTRUCTURES

9

S-Layer proteins, biotemplating – engineered nano pores – protein

based nanostructure formation – nanoparticle, biomaterial hybrid

systems – De novo designed Structures – biomolecular motors – DNA-

protein nanostructures - biomimetic fabrication of DNA based metallic

nanowires - conjugates and networks.

UNIT IV NANO BIOELECTRONICS 9

DNA based nano mechanical devices – biology inspired concepts – DNA

as a biomolecular template - DNA branching for network formation –

bioelectronics – nanoparticle enzyme hybrids – biorecognition events of

nanoparticles – DNA analyzer as biochip – biomimetic ferritins.

UNIT V THERAPEUTIC AND DIAGNOSTIC

APPLICATIONS OF NANOPARTICLES

9

Gene therapy using nanoparticles – nanofluids (aqueous dispersed

applications of nanoparticles) – nanoparticles in bioanalytical techniques

(quantum dots, SPR based and peptide based sensors) – advances in

cancer therapy.

TOTAL: 45 PERIODS

REFERENCE BOOKS:

1. Niemeyer C.M, & Mirkin C.A, “Nano biotechnology: Concepts,

applications, and perspectives”, Wiley-VCH Verlag GmbH ,2004.

2. Robert A. F. Jr., “Nano medicine: Basic capabilities” Vol.1, Landes

Biosciences, 2003.

3. Shoseyov, O. & Levy, I, “Nano biotechnology: bioinspired devices

and materials of the future”, Humana Press Inc., 2008.