menopause and hormone replacement therapy hrt (1)
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Menopause-symptom relief and treatment options
Irene Stronczak R.Ph.B.Pharm Hons.National Certified Menopause Practitioner
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•Discuss Symptoms of menopause
• Discuss the place in therapy of hormone replacement and bio-identical hormones in menopause
• Discuss dosage, formulations, route of administration, side effects, and contraindications
• Discuss the controversies and appropriate use of hormone replacement therapy
•Discuss patient case studies
OBJECTIVES
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HT formulation,route,and timing of initiation produce different effects
• Absolute risks for HT use in healthy women ages 50-59 are low
• HT initiation in older women carries greater risks
• Breast cancer risk increases with EPT beyond 3-5years
• ET can be considered for longer duration of use because it carries a lower risk for breast cancer
NAMS 2012 Position Statement
Hormone therapy—what we know today
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• HT may reduce total mortality when initiated soon after menopause
• Both ET and EPT may reduce total mortality by 30%
when initiated in women younger than age 60
NAMS position statement. Menopause 2012.
HT & Total Mortality
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estrogen/progesterone treatment started soon after menopause appears to be safe; relieves many of the symptoms of menopause; and improves mood, bone density, and several markers of cardiovascular risk.
KEEPS Results Give New Insight Into Hormone Therapy-2012
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HT & Coronary Heart Disease / Stroke ET may reduce CHD and coronary artery risk when initiated in younger and more recently postmenopausalwomen without a uterus
• HT is currently not recommended for coronary protection in women of any age
• Both ET and EPT appear to increase ischemic stroke risk and have no effect on hemorrhagic stroke risk
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Hulley S, et al. JAMA. 1998;280:605-13; Grady D, et al. JAMA. 2002;288:49-57; Blumenthal RS, et al. Am J Cardiol. 2000;85:1015-7.
The women in HERS were on average 18 years post menopause, suggesting that years since menopause may have an important influence on the cardiovascular effects associated with initiation of CEE/MPA
Cardiovascular risks of CEE/MPA in this population were observed early and did not occur in individuals taking concomitant statin therapy
HERS: Lessons Learned
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Therapeutic goal is lowest effective estrogen dose,plus appropriate progestogen dose for women with a uterus
•Lower doses have fewer side effects and may have more favorable benefit-risk ratio than standard doses
•All routes of administration of ET can effectively treat menopausal symptoms
•Transdermal ET may be associated with lower risk of DVT, stroke, and MI
•Multiple progestogen options for endometrial protection
NAMS position statement. Menopause 2012.
Dose & Route of Administration
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Lower daily doses typically used with systemic ET: 0.3 mg oral CE 0.5 mg oral micronized 17ß-estradiol 0.014-0.025 mg transdermal 17ß-estradiol patch
Typical lowest doses of progestogen: 1.5 mg oral medroxyprogesterone acetate 0.1 mg oral norethindrone acetate 0.5 mg oral drospirenone 50 mg oral micronized progesterone
HT Starting Dosages
10NAMS position statement. Menopause 2010.
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No First-pass Effect
Less of an effect on:
- Clotting factors
- Triglycerides
- C-reactive protein
- Sex hormone-binding globulin
Transdermal v oral route
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First line therapy for VMS and for patients with conditions:
- High risk of DVT or PTE - High triglyceride levels - Gall bladder disease- Hypertension
2. Need for “steady state” drug release - Daily mood swings
- Migraine headaches - Shift workers
3. Inability to use oral tablets
- Stomach upset- Problems with taking a daily pill
Consider using transdermal estrogen
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Transdermal/Topical Transdermal mimics the way the ovaries release
hormones. No first pass metabolism & metabolites formed. Greater chance that hormone gets to target tissue prior to
metabolism Steroids are well absorbed through the skin Transdermal Estradiol when given with or without oral
progesterone, has no detrimental effects on coagulation and no observed increased risk for venous thromboembolism
Health Canada approved Estradiol for women Testosterone for men
Delivery System-creams and gels
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“It remains possible that transdermal estradiol with progesterone which more closely mimics the normal physiology and metabolism of endogenous sex hormones may provide a different risk-benefit profile”
writing group for WHI July 2002
Conclusions of WHI
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ET alone 1.29 (1.02-1.65)
ET+ other progestin 1.69 (1.50-1.9)
ET+ progesterone 1.00 (0.83-1.22)
ET+ dydrogesterone 1.16 (0.94-1.43)Estrogen in combination with micronized progesterone = no increased risk Ref: Fournier 2008
Breast cancer risk and progestogen selection
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No clear indication that longer HT duration improves or worsens the benefit-risk ratio
HT effects on long-term risks have not been studied in perimenopausal women
Thus, findings from RCTs of postmenopausal women should be extrapolated with caution for younger women
Duration of HT Use
16NAMS position statement. Menopause 2010.
(cont’d)
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Extending HT use is acceptable: For women well aware of potential
risks and benefits With lowest effective dose For prevention of further osteoporosis-related
fracture and bone loss when alternate therapies are inappropriate or benefit-risk ratio is unknown
With clinical supervision
HT Duration of Use (cont’d)
17NAMS position statement. Menopause 2010.
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Moderate to severe vasomotor symptoms have been documented in 42% of women aged 60 to 65 years. Thus, many women will continue to have vasomotor symptoms after age 65, and these symptoms can disrupt sleep and adversely affect health and quality of life.Provided that the woman has been advised of the increase in risks associated with continuing HT beyond age 60 and has clinical supervision, extending HT use with the lowest effective dose is acceptable under some circumstances, such as for the woman who has persistent bothersome menopausal symptoms and for whom her clinician has determined that the benefits of menopause symptom relief outweigh the risks
The North American Menopause Society Statement on Continuing Use of Systemic Hormone Therapy After Age 65-2015
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Use of HT should be individualized and not discontinued solely based on a woman’s age.
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• Progestogens alone or low-dose oral contraceptives can be offered as alternatives for the relief of menopausal symptoms during the menopausal transition
•E.g.,Oral progesterone 200mg nightly day14-28 of cycle SOGC Clincal Practice Guideline, January 2009, JOGC
Progestogens in the Menopause Transition
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Mood changes Insomnia-60% Headaches Hot flashes-80% Memory problems Aches and pains Fatigue Decreased libido Bloating Night sweats Skin changes Vaginal dryness Heart palpitations Bone changes Abnormal uterine bleeding
Signs and symptoms of hormone imbalance in patients
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Regulates body temp Improves insulin sensitivity Increases basal metabolic rate Increases blood flow Improves sleep Maintains skin collagen Decreases risk of cataracts Increases bone density Decreases LDL,increases HDL Increases mood and energy Decreases wrinkles Decreases homocysteine Increases serotonin formation Decreases depression,anxiety,pain sensitivity
Functions of estrogen
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Progesterone Helps the body use estrogen Prevents and treat symptoms of estrogen excess
or deficiency (i.e. vasomotor symptoms) Natural antidepressant Prevents endometrial overgrowth Has receptors in almost every cell of the body Progesterone is needed not only for its balancing
effect on uterine tissue, but also its effect on the breast tissue, heart, brain, bones and its balancing effect on other hormones.
Functions of progesterone
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Relief of symptomsGrowth and repairPrevention of memory lossHeart health-improved lipid profilePrevention of osteoporosisQuality of lifeMaintenance of skin healthNeurotransmitter balancePrevention of urogenital atrophy
WHY REPLACE?
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Response to widely publicized results from 2002 WHI52% stopped HRT-25% restarted for symptom relief
Suspicion of traditional medicine Dislike of big Pharmaceutical companies Perception it’s a safer alternative “Natural” is equated with safer Wider and more aggressive advertising, via internet and other
media-Oprah phenomenon Patient preference for alternative medicine. Patients still symptomatic on commercial HR products
Why the Surge in Prescriptions for Bioidenticals from Patient P.O.V.?
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Bio-identical hormones have a chemical structure identical to human hormones but are chemically synthesized from yams or soy and are identical in composition to human hormones, such as progesterone, estriol,testosterone and estradiol.
Natural – neither artificial nor pathologic They look and behave just as our own natural hormones do. They
will act at our cell receptors and break down in our cells (metabolize) exactly the same way as the estrogen and progesterone naturally made inside our body have always done.
Non-bioidentical hormones are not structurally identical to human hormones and may either be chemically synthesized, such as MPA, or derived from a nonhuman source, such as CEE.
Bioidentical Hormones=Bioequivalent
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Chemical substitution with a pharmaceutical drug, only mimics some hormonal functions
Ingredients-50%E1,0.5% E2, 40% Horse equilins While some estrogens are from a natural
source, such as equine urine, they are not considered bioidentical because many of their components are foreign to the human body.
Synthetics- Premarin
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Progesterone is the same hormone that is produced and circulates in your body Vital to pregnancy
Progestins are synthetically produced molecules that produce the same effects on the endometrium as progesterone Do not have the same structure May not function the same as progesterone in other
tissues Harmful in pregnancy
Progesterone vs. Progestins
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Evidence Oral medroxyprogesterone (MPA) and estrogen
Increased incidence of breast cancer versus estrogen alone Increased heart disease
Counteracts the vasodilatation of estradiol Increase in blood clots, C-reactive protein MPA speeds the growth of arterial smooth muscle cells,
whereas progesterone slows this growth Norethindrone did not have the same effect Oral micronized progesterone (Prometrium®)
Produces sedating byproducts Stabilizes and protects the endometrium from estrogen Had less breakthrough bleeding than with MPA Same incidence of uterine cancer between MPA and
progesterone Premarin® alone increased stroke and clots
Progesterone vs. Progestins
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Side effects- Increased weight Fluid retention Depression Breast tenderness Acne Insomnia Vasospastic Increases LDL
Provera is not progesterone
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Prometrium Crinone, Estrace, Divigel, Estradot,Climara
Pro,Oescilim,Estalis Estrogel, Androgel, Testim,Androderm Estring, Vagifem,Estragyn Ovestin-Estriol (OTC, Europe)
Cortef Cytomel (T3) Synthroid (T4)
Patented/Conventional Bio-identical Hormones
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Compounded Estrone Estradiol Estriol Progesterone Testosterone DHEA Cortisol T3 T4
Methods of delivery Oral Topical
Creams Gels
Sublingual drops, troches Vaginal/mucous membrane
Cream Suppository
Pellets SQ injection
Bio-identical Hormones
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Estrone (E1): Second strongest estrogen Converted from estradiol & released from adrenal glands Main estrogen in menopause-converted from androstenedione in
adipose tissue,liver and skinEstradiol (E2): Strongest estrogen Mainly made from the ovary Formed by testosterone aromatization Primary estrogen in menstrual cycleEstriol (E3): Weakest estrogen, end metabolite of estrogen pathway Dominant in pregnancy Considered possibly protective from more potent proliferative
effects of E1 and E2
Bio-identical Estrogens
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Pharmacy compounding – defined by both Ontario College of Pharmacy and Pharmacy industry; its core is the “triad” relationship between the patient, her physician, and the pharmacy which prepares a prescription for that patient only upon receipt of a valid prescription
All pharmacies licensed and inspected-OCP Specialized training All drugs used have certificate of analysis- USP Leave out colourants,additives Provide technical help and expertise on dosing guidelines
Pharmacy compounding
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History and symptoms may not be enough Every patient is biochemically unique Get baseline for follow up and optimal balance and treatment Low normal may not be optimal for health Many labs do not have ‘age specific ranges’ FSH-does not measure estrogen Blood: Estradiol,FSH,free and total testosterone
Thyroid Panel -free T4,TSH, free T3, Saliva: estradiol , progesterone, testosterone,
DHEAS, and Cortisol 24 hour Urine
Testing-why test?
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Estradiol Can be used alone Compounded into SR capsules,
transdermal, topical & vaginal creams-topical 50-500mcg daily
Start low go slow Priming may be necessary higher dose for
1/12 then decrease
Bio-Identical + Compounded Hormone Replacement
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Estriol Blocks the more potent effect of
Estradiol at the receptor Can be given orally-many studies Given alone can help improve urinary
incontinence & vaginal dryness0.05-0.5% vaginal cream 0.5-1g daily x1/12 then prn
Bio-Identical Compounded Hormone Replacement
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Bi-Est Estriol/estradiol combination Compounded cream or capsules Offers the benefit of estradiol and the
protective effect of estriol Strength in mg and ratio of the two
estrogens Example: Bi-Est 1.25mg 80:20 = 1.0mg estriol
+ 0.25mg estradiol
Bio-Identical Compounded Hormone Replacement
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Progesterone Topical and oral (Prometrium→) Usual topical dosage is 20-100mg OD-BID, daily Peri menopause cycle days 14- 28 ,or 2 steps day 1-14,day 15-28 Menopause continuous(stop for at least one day) or cycle Oral doses range from 100-400mg daily 1% cream=10mg/g 1g=1/4tsp Progesterone metabolites may cause a tranquilizing effect SOGC does not recommend progesterone cream to provide
endometrial protection Maintain endometrial stripe on U/S<4mm Expect 1-2 periods if starting cyclic progesterone within 6 months of
menopause May cause increase in testosterone
Bio-Identical Compounded Hormone Replacement
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Testosterone: ↑ sense of wellbeing and libido Helps maintain vaginal mucosa, skin
elasticity, muscle mass & heart health Compounded into creams or gels Range 0.05-1%=0.5-10mg Testosterone/ml
Bio-Identical Compounded Hormone Replacement
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Vaginal lubricants
•May be recommended for subjective symptoms
•Do not reverse vaginal atrophy
Are non-physiological
•Give temporary symptom relief, often followed by vaginal irritation
Vaginal Moisturizers and Lubricants
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• Polycarbophil gel is effective for symptoms of vaginal atrophy
• Improve lubrication
Do not reverse vaginal atrophy
• Are useful for women who cannot take hormones
vaginal moisturizers
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Restore urogenital physiology
- > Estrogen therapy lowers vaginal pH, thickens the epithelium, increases blood flow, improves vaginal
lubrication- Alleviate symptoms
• > Most women will obtain substantial relief from their symptoms after about 3 weeks of treatment
Some women may require 4–6 weeks before adequate improvement is observed
Principles of local estrogen therapy (supported by NAMS and SOGC)
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1. Start treatment early,before atrophic changes have occurred. 2. Continued treatment is needed to maintain the benefits. 3.All local estrogen preparations are effective. 4.Patient preference will usually determine the treatment that is used. 5.Additional progestin is not indicated when appropriate
low- dose, local estrogen is used. If estrogen is ineffective or undesired, vaginal lubricants and
moisturizers can relieve symptoms due to dryness.
7.Itisessentialthathealthcareprovidersroutinelyengagein open and sensitive discussions with postmenopausal women to ensure that symptomatic atrophy is detected early and managed appropriately.
IMS Key Treatment Recommendations
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Dehydroepiandrosterone (DHEA) is an androgen derivative that is available in Canada by prescription only[ It has been evaluated intravaginally for effectiveness in treating VVA and is thought to exert an effect through the androgen and estrogen receptors.The 12-week trials showed improvements in VMI and vaginal pH at 2 dosesV3.25 mg and 13 mg, once daily. It also significantly improved the most bothersome symptoms.
Intravaginal DHEA
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1 Several selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) decrease the frequency and severity of vasomotor symptoms in postmenopausal women.2 The SSRI paroxetine is the first nonhormonal medication to be government approved for the treatment of vasomotor symptoms. The approved dose (paroxetine 7.5 mg) is lower than the doses of paroxetine approved for the treatment of depression.3 Although randomized, controlled trials demonstrate efficacy greater than placebo for other SSRIs and SNRIs, including venlafaxine and escitalopram, and other doses of paroxetine, these formulations are not currently approved for the treatment of vasomotor symptoms.4 Some SSRIs and SNRIs inhibit the cytochrome P450 enzyme system and may render tamoxifen less effective.
SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND SEROTONIN NOREPINEPHRINE REUPTAKE INHIBITORS
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Applying Hormone CreamsGeneral Tips Absorption is better in moist skin than dry
Shower and pat dry, then apply Absorption is better in thin skin than thick
Apply to soft skin (inner forearm, inner thigh) Apply to a large area Rub in well Consider a 3-5 day break for progesterone every month to decrease
tolerance
Location Testosterone may cause hair growth on the inner thigh Progesterone on the breast may decrease the tissue density Estrogen on the breast can cause proliferation .: avoid Hormone creams applied to the abdomen will be absorbed to the
liver
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Compounded BHT may be just as effective as commercial HT
BHT may be safer and as effective as synthetics-although non human not as bad as we thought
Compounded BHT should be just as safe as commercial HT Research often puts all HRT together ,regardless of type or
dosage form used Research supports use of BHRT Topical estrogen over oral estrogen Avoid synthetic progestins More research needed to support optimum dosing and
testing of compounded creams
The Likely Bottom Line on BHRT
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All hormones are designed to work together Use same hormones as body produces Be informed and educated Develop a partnership with the pharmacist If one hormone is deficient it affects actions of all
other hormones-thyroid Cortisol Determine each patients needs and goals-stress
nutritional deficiencies Follow up and testing needed One size does not fit all
SUMMARY
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Valuable option – Not the Holy Grail Individual pharmacies should produce
consistent product Studies on compounded BHRT usually
terrible-more becoming available Studies by Big Pharma often skew data Too many people who are involved don’t
know enough (public & professionals)
My perspective on Compounded BHRT
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44 yo female Pmh-tah,b/o 2006 Rx-ogen3mg daily,oxycocet prn, c/o insomnia,low libido,low energy,25lb weight gain,night
sweats,hot flashes,mood swings,migraine headaches, Labs-free testosterone,<0.5,estradiol 49 Tx-Prometrium 100mg po hs,testosterone 5mg topically,Bi-est
1.5mg daily topically f/up estradiol 107,free T 5
sleep improved,weight decrease,mood better,d/c Ogen,night sweats rare,hot flashes one every 2-3 weeks,no headaches,’DID NOT THINK THIS WOULD WORK”
Patient case
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20 August 2006
Patient Case Study
KE 34 yo female 5’3” 140lbs Symptoms-
– Insomnia, weight gain, anxiety, hot flashes, painful intercourse, mood swings
– Goals & priorities-I want to feel as good as I possibly can without synthetic hormones
Medical hx-TAH BSO hypothyroid, interstitial cystitis, endometriosis, arthritis
Medications-Thyroxine, Premarin
Vitamins-Multivitamin Lifestyles-
– Exercise-Pilates, walking, outdoor sports
– Smoking-quit 1994(8yrs)– Alcohol-social– Caffeine-occasionally
Family hx- mother ovarian cancer, diabetes (uncles)
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20 August 2006
Lab Results & Treatment Recommendations
28/05/05-– TSH=6.00,E2=389,DHEA-S=2.4– Restart thyroxine
11/09/05-– Free T <1,Total T=4.7,P=1.09– Tx-testosterone 1.0% 1ml daily– Progesterone 200mg daily
9/01/06-– E2=107,TSH=3.35,free T=4.0
Pt reports a world of difference ,lost 12lbs,no naps ,less joint aches ,some breast tenderness
Decrease Premarin to 1 every other day
02/02/06-– E2=79,free T=4.9,P=41.4
07/04/06-– Pt c/o skin breakouts– Decrease T to every other day, add
saw palmetto 2 x a week
22/06/06– Pt c/o some decreased libido– TSH=2.17,E2=138,P=12.5,Free T=2.0– Replace Premarin with Biest (80/20)
1.0mg bid topically, Testosterone 1% 1.0ml daily/alternating with 0.5mls