I

29 OCTOBER 1965

AAAS

Symposium Volume

SYSTEMS OF UNITS-NATIONAL ANDINTERNATIONAL ASPECTS

Edited by Carl F. Kayan

"This book is a compilation of papers on thesubject of measurement standardization andshould contribute much to helping each of usreach a position regarding this problem."Journal of Engineering Education, Oct. 1962

308 pages, 1959 ....................$6.75AAAS members discount price .......$5.75

Order from

AMERICAN ASSOCIATION FOR THEADVANCEMENT OF SCIENCE1515 Massachusetts Ave., NWWashington, D.C. 20005

THE CORRESPONDENCE OF HENRY OLDENBURGedited and translated by A. Rnpert Hall and Alarie Boas Hall

The corresponclence of the first secretary of the Royal Society of Londlon pre-sents an unparalleled picture of the intellectual life of later seventeenth cen-tury Europe. The e(lition will consist of about ten volumes.

Vol. I (1641-1664), 544 pages, 5 illus. $12.50Vol. II (1663-1665), 704 pages, 5 illus. $12.50Vol. III (1666-1667), 680 pages, 7 illus. $12.50Intro(luctory price throuigh 1965, 3 volumes $30.00

University of Wisconsin Publications in Medieval Science, Nos. 7, 8,10. Text (or facsimile) and translation of three important works inearly Arabic science:

No. 7. THE MEDICAL FORMULARY OR AQRABADHIN OF AL-KINDI,edited and translated by Martin Levey380 pages $8.50No. 8. KUSHYAR IBN LABBAN, PRINCIPLES OF HINDU RECKONING,edited and translated by Martin Levey and Marvin Petruck128 pages $6.00No. 10. THE ALGEBRA OF ABU KAMIL,in a commentary by Mordecai Finzi, edited and translated by Martin Levey272 pages $10.00

CEREBRAL LOCALIZATION AND ORGANIZATIONedited by Georges Schalten brand and Clinton N. Woolsey

Proceedings of a symposium on the function of the bi-ain held in Lisbon, Por-tugal, October 1960.176 pages, 19 illus. $7.50

i J |THE UNIVERSITY OF WISCONSIN PRESSP.O. Box 1379 - Madison, Wisconsin 53701

1RF ess

11TH INTERNATIONAL TRADE SHOWOF THE NUCLEAR INDUSTRY

Nov. 16-18 Sheraton-Pork Hotel, Wash., D.C.

in conjunction with annual meetins OTATOMIC INDUSTRIAL FORUM / AMERICAN'.1NUCLEAR SOCIETY * see newest nuclearindustry har'dware, applications, demonstra-tions, techniques ' For information:

ATOMIC INDUSTRIAL FORULM.8501THIRD AVE., NEW YORK, N.Y. 10022

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The J. T. Baker BATCH Directory--An ninormational tool tarlocating comPounds o1 carbonwith structural atomic emi-ments selected by the user.Now you can find the carbon compound youneed from J. T. Baker's laboratory line asquickly as you can jot down the BATCH Number. J. T. Baker's unique BATCH Direc-tory uses a five-digit code that classifies a chemical according to structural andatomic elements.

The code is easy to use. The B-digit (B=Basis or Benzene Ring Number) denotesthe nature (and number) of rings present. The A-digit (A=Atomic class) is assigned onthe nature (and number) of atoms present other than carbon, hydrogen and oxygen.The T-digit (T=Total heteratom count) relates to the number of atoms present otherthan carbon and hydrogen. The C-digit (C=Carbon) is the unit's value in the numberof carbon atoms in the empirical formula. The H-digit (H=Hydrogen) is derived fromthe number of hydrogen atoms in the empirical formula.

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J. T. Baker Chemical Co., Phillipsbur, N. J.BAKER ANALYZED' REAGENTS * LABORATORY ORGANICS * SPECIALTY GASES

Whenlittlethingsmeanalot

many different free radicals. On warm-ing to room temperature, the observedpattern goes through a series of'changes until it gradually resolves into

SCIENCE, VOL. 150

scientificDroductsMm - - -

GENERAL OFFICES:1210 LEON PLACE

EVANSTON, ILLINOIS

in the radical concentration, not sec-ond order as would be expected f&radical recombination. He suggestedthat the radicals might combine eitherwith hydrogen atoms moving throughthe lattice or with electrons. In the en-suing discussion, no really satisfactoyi'alternative to this hypothesis was pre-sented.

Mueller also discussed the difficul-ties in measuring absolute radical yieldsby electron-spin-resonance. In 1961 anumber of laboratories interchangetistandards and found that there weredifferences of a factor of two in theabsolute numbers measured by variouslaboratories. The source of this dis-crepancy is under active investigatioiat Karlsruhe and Utrecht, two labora-tories which were far apart on the in-itial exchange.

Robert Schulman (Bell TelephoneLaboratories) talked about the workwhich is being done at the Bell Tele,phone Laboratories on identifying theradicals produced in DNA by ultra-violet light. Irradiation of dry DNAwith ultraviolet light at 77°K gives astrong singlet, and a much smaller com-ponent showing a number of line3which can be unequivocally linked tothymine. If the sample is irradiated inthe presence of moisture, the thymninesignal can be made to dominate the ob-served signal. The Bell Telephone Lab-oratories group postulates that thisradical is

, C CH,93N 0I I HC C-"-'N C "

H

They have also identified a phos-phorescent emission from thymidinewhich is quenched when the thymidineXis in DNA in the native state. Thelevel giving rise to the phosphorescencewas unequivocally identified as a trip-let state. There were speculations onthe possible connection between thesSXresults and the formation of the thy-mine dimer in ultraviolet-irradiatedDNA.Thormod Henriksen (Oslo) reviewed

the introduction of ESR signals intodry protein by ionizing radiations. At.very low temperatures a broad, fea-tureless signal is produced which isbest interpreted as the superposition of

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1 2 /,,.j 3--l

4

'I',I1--11

11

two relatively distinct signals-a broadsignal having a g-factor somewhatmore than 2, associated with sulfuratoms, and a doublet having a g-factorequal to that of the free electron. Inseveral special cases, including crys-tals of various amino acids and in silkSbers, this doublet has been identifiedas a radical on the alpha carbon atomlocated in the polypeptide backboneand bonded to a single hydrogen atom.This might suggest that the glycineswere being preferentially attacked.^ The connection between radiation-induced ESR signals and biological ac-tivity, as shown in studies on trypsinirradiated in the dry state, was discussedby Peter Alexander (London). Hejuggested that a major inactivatingevent in the case of proteins could bethe removal of an amino acid residuefrom the polypeptide chain. This con-cept is certainly in good agreementwith the doublet signals described byI4enriksen. It was, however, pointedout that the postulated breakage ofthe bond between the alpha and betacarbons is unexpected.

Tolbert (Colorado) summarized in-formation on the radiation chemistryand radiation biochemistry of proteinsirradiated in the dry state. From thechemical data, Tolbert concluded thatthere is only a difference of a factorof 2 or 3 in radiosensitivity for de-.struction of various amino acids in ir-radiated proteins, and that there wasno selective breakage of sulfur-sulfurbonds. There also does not seem tobe any real evidence for breakage ofthe main polypeptide chain in mostproteins. Warren Garrison (Berkeley)briefly reviewed his mechanism forchain breakage following the produc-tion of a free radical on the alpha car-bon in the polypeptide backbone and

,gave evidence for this process in ir-radiated gelatin. No suggestion was ad-vanced as to why this breakage appar-ently does not occur in other proteins,except that the free ends may some-times recombine with each other.

Comprehensive studies on irradiateddry spores of Bacillus megaterium werepresented by E. L. Powers (Argonne).These studies show excellent correla-tions between spore viability and afree-radical mechanism within thespore, as deduced from the effects ofsuch reagents as oxygen, nitric oxide,or hydrogen sulfide, all of which havewell known reactions with free radi-cals. Powers preferred to define freeradicals on the basis of their chemi-cal reactivity with such reagents. Oth-

er participants thought that definitionof a free radical in terms of an un-paired electron was more satisfactory.The variations in spore survival couldalso be correlated with ESR measure-ments, although Powers was careful topoint out that a large number of freeradicals are created in a spore before itloses its ability to multiply, and thatthe free radicals responsible for sporeinactivation probably consitute only avery minute fraction of those whichcan be measured by the ESR tech-nique.

In the final session, Peter Alexandersuggested that electron-spin-resonancewas rather unlikely to give much of aclue as to what events were signifi-cant in causing the loss of biologicalactivity of irradiated cells. On the oth-er hand, he felt that the ESR tech-nique had great potential for theunderstanding of details of events tak-ing place once the key materials in-volved in the biological inactivationprocess had been identified. Alan Con-ger (Temple) echoed a rather similaridea when he said that he did notreally care about the detailed interpre-tation of ESR signals. What concern-ed him was the location in which theESR signals were found.

In summing up, E. C. Pollard (Penn-sylvania State), chairman of the Sub-committee on Radiobiology, felt that itwas clear that evidence of physical dam-age by radiation was plentiful, but thatrelating it to biological effects stillseemed difficult.The conference was sponsored by the

subcommittee on radiobiology of theNational Research Council. The com-plete proceedings, including the exten-sive discussion after each paper, willappear soon as an NRC publication.

FRANKLIN HUTCHINSONYale University,New Haven, Connecticut

Forthcoming Events

November

7. American College of Dentists, LasVegas, Nev. (0. W. Brandhorst, 4236Lindell Blvd., St. Louis, Mo.)

7-9. American Science Film Assoc., an-nual, Washington, D.C. (ASFA, 1319 FSt., NW, Washington 20004)

7-11. American Soc. of Mechanical En-gineers, winter annual mtg., Chicago, III.(ASME, 345 East 47 St., New York)

7-12. Anatomical Pathology, 5th LatinAmerican congr., Lima, Peru. (J. J. An-dujar, P.O. Box 118, Fort Worth, Tex.)

7-13. Paediatrics, 11th intern. congr.,

29 OCTOBER 1965

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Transfer, serological and meas-uring models in 1, 2, 5 and 10 mlcapacities. May be assorted withother Nalgene Labware for maxi-mum discount. Ask your lab sup-ply dealer, or write Dept.-21222,The Nalge Co., Inc., 75 PanoramaCreek Drive, Rochester, NewYork 14625.

AXNALGENEq LABVWARELeader in quality plastic labware since 1949

647

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EVANSTON, ILLINOIS

The story of howa 20th-century astronomer -and 60 seconds of computer

time - solved one of thegreat puzzles of the

ancient world

STONEHENGE DECODEDby GERALD S. HAWKINS

it/itl Jo1ll B. Wlhite

A comlplete accoUnt of the dra-matic evidence that ancient Eng-land's Drutidl temple' is actalUlx1a sophisticated, brilliantly-con-ceived astrononmical observatory.Dr. Hawkins, professor of astron-omy at Boston U., is an associateof the Smithsonian AstrophysicalObservaitory, Cambridge, Mass. 11-lUstriated xwith photographs anddrawings, $5.95 at all booksellers.

DOUBLEDAYNowA

Because they mean a lot to you, they mean a lot to us. That'swhy S/P maintains 16 distribution centers, offers more than30,000 items. For example -disposable, color-coded diSPoPipets for micro sampling-calibrated to contain to + 10%. Weguarantee you'll enjoy using them. They can mean a lot in yourlaboratory.No. P4518X-diSPo8 Micro PipetsCapacity, mi. Package 6 pkgs.,of 288 pkg.0.02 (20X)0.025 (25 A) $14.40 $12.300.05 (50X) (5¢ each) (4.3¢ each)0.1 (10Ox)Send for your free copy of the S/P 1965 Glassware Catalog.

BIOCHEMISTPh.D.II

TO HEADRESEARCH &DEVELOPMENT

TEAM

with leading manufacturer of en-zymes, fermentation products, andchemical specialties.Development of new enzyme systemsfor use in pharmaceutical and indus-trial applications. Requires thoroughbackground in enzyme and proteinchemistry. Up to 5 years experience.

Distinct opportunities for professionalgrowth. Salary open. Excellent benefitprograms including profit sharing.

For further details,write in confidence to:

PERSONNEL DIRECTOR

WALLERSTEIN CO.

STATE.,Ntc,, IS)oLoAND i,N.Y I3c.STATEN ISLAND, N.Y. I10303

A,, c( ta((l op1)issrfmatit!/ 1cmploYer

648

Assignments. conf.. Gatlinburg. Tenn. (F.K. McGoxwan. Oak Ridge NatIt. Labora-tor'. P.0. Box X. Oak Ridge. Tenn. 3783 1)

12-13. Clinical Pathology of Infancy.Assoc. of Clinical Scientists, Washington,

SCIENCE, VOL. 15(0

Tokyo, Japan. (K. NakamlUra. Dept. ofPediatrics, Univ. of Tok)o, P.O. Box 18,Hongo. Tokyo) 0

7- 14. Vienna Univ. of Teclhnology,50th lanniversary celebration. Vienna.

AuLstria. (Technische Hochschule, GLsIS-hbauWsstr-. 23. Vienna 4)

-S9. Engineering in the Practice ofMledicine. Philadelphia. PaI. (S. Rosen.Dept. of Medicine, Hahnemann M\edicalCollege. 230 N. Bi oad St., Philadelphia191(02)

S-1/. American Dental Assoc., l as\Vcgts. Nev. (H. Hillenbrand, 222 E.Siupeierior St.. Chicago, Ill. 60611)

8 11. Insecticide and Fungicide, 3.-dBi3itish conf., Brighton, England. (Secr--tarv. 140 Benshlam Lane, Thornlton He.ath.SiLH-i-ev. England)

s-11. Nutrition, Western Hemiispfihei ccong-i.. Chicago. Ill. (Dept. of Foods andNuLtritioni. American Medical Assoc., 535Nor-th Dearborn. Chicago 6061 (0)

(S-11. Quality Control. internl. congyi.*Tokx o, Japan. (Union of Japanese Scien-tists and Engineers. clo Sakata Bldg.. 3NIJUromachi 4-chonie, Nihombashi. ChLio-kuL. Tokxvo)

8-13. Austrian MIedical Congr., 19th an-IItual. Nielnal. ( NI. Schnarcdt. Oste-rreich-ische Arztekanmmer, Referat fuir Arztlichc*Fortbildlng WA/eihutrggasse 10-12, Vien-

9-12. Seismiiic Mlodels. sy;mp.. Prague.Czechoslovakia. (V. Karnik and J. Vanek.Inst. of Geophysics, Czechoslovak Acad.of Sciences. Bocni II, Prague 13-Sporilov)

9-/ Asocilcion M6edica de PuLertoRlico. SantuHrce. (J. A. Ramiriez, 13-5 Fer-nandez Juncos Ave., SaIntuLrce )

I)- 11. Power- Applications of Control-lable Semiconduictor Devices. conf., I -on-don, England. (Secretary. Inst. of Elec-ti-ical Engincers, Saxov Pl., 1.ondon.W.C.2)

10-12. Amc ican Soc. for Cell Biology.5th. Philadelphia. Pa. (NI. J. MNoses, Box2982. DuLke Univ. M\edical Center, DuLr-ham. N.C. 27706)

/0- /2. Engineering in M1edicine and lHi-ology. 8th annlal conf.. Philadelphia. Pa.(H. P. Schwxan. MN1oore School of Electri-c.il In-inee inn. Unix. of Pennsx Ivania.lPhiladelphia 191(4)

/0- 12. Isotope 1 echniquies in the HIy-drologic Cycle. synvp.. Univ. of Illinois.Urbana. (G. F. Stouit, MIeteorology Sec-tion. Illinois State Water Survexe. Unix. ofIllinois. UrbaIna)

101)3. Respiratory Therapy. 2nd NewEngland conf.. Boston, NMass. (D. Crocker.Chilld-en's Hospital Medical Center, 300I ongwxood Axe., Boston 15)

10 -20. Developmiient of Petroleumil Re-soturces of Asia and the Far East, 3rdsx mp.. Tokyo. Japan. (S. Santitham. Raja-damnemn Ave.. Bangkok. Thailand)

11-12. Kentucky Acad. of Scienc, Unix.of Kentuclkx. L-exington. (D. NI. lindsay.Georgetowx n College. Georgetown. Ky.)

11-13 . Gerontological Soc., l8 th ain-nlLal, Los Angeles. Calif. (\W/. D. Ob)rist.Dept. of Psychiatrx, DuLke Unix. MedicalCenter. DuLrhaim. N.C. 27706)

I1 1-I. Balses lor Nuclealr Spin-Parity

I

D.C. (F. W. Sunderman, 1833 DeLanceyP1., Philadelphia, Pa. 19103),P 12-13. Society for Industrial and Ap.plied Mathematics, western regional, Seat-tle, Wash. (B. H. Colvin, Boeing Scien-tific Research Laboratories, P.O. Box 3981,Seattle)

12-14. Association of Clinical Scientists,Washington, D.C. (R. MacFate, 300 N.State St., No. 5322, Chicago, Ill. 60610)

12-15. Neutrality of Medicine, 2ndintern. congr., Paris, France. (R. Ellen-boger, Ministere des Anciens Combattantset Victimes de Guerre, 37, rue de Belle-chasse, Paris 7e)

14-15. National Medical Foundation fortEye Care, Chicago, Ill. (L. A. Zupan,Room 6, 1100 17th St., NW, Washing-ton, D.C.)

14-16. Hedrologicum Conlegium, In-tern. Soc. for the Study of Diseases of theColon and Rectum, 2nd congr., Tokyo,Japan. (J. F. Montague, 104 E. 40 St.,New York 10016)

14-17. Southern Medical Assoc., Wash-ington, D.C. (R. F. Butts, 2601 HighlandAve., Birmingham 5, Ala.)

14-18. Mexican Dental Assoc., 1st in-tern. congr., Mexico City. (R. EspinosawIe la Sierra, Asociacion Dental Mexicana,Sinaloa no. 9, Mexico 7, D.F.)

14-18. Dental, Pacific intern. conf.,Honolulu, Hawaii. (W. A. Wakai, 291Alexander Young Bldg., Honolulu 96813)

14-18. Society of Exploration Geo-physicists, 35th annual intern., Dallas, Tex.v(Dallas Geophysical Soc., Dallas)

14-19. American Acad. of Ophthalmol-ogy and Otolaryngology, Chicago, Ill. (W.L. Benedict, 15 Second St., SW, Roches-ter, Minn.)

14-21. Air Pollution, 1st world congr.,Buenos Aires, Argentina. (D. D. Torti,

4Asociaci6n Argentina Contra la Contami-naci6n del Aire, Sarmiento 680, BuenosAires)

15-16. Hypervelocity Techniques, 4thsymp., Tullahoma, Tenn. (J. Lukasiewicz,vonKarman Gas Dynamics Facility, ARO,Inc., Arnold Air Force Station, Tenn.'37706)

15-16. Science conf., 4th annual, BelferGraduate School of Science, YeshivaUniv., New York, N.Y. (A. Gelbart, Bel-fer Graduate School of Science, Amster-dam Ave. and 186th St., New York 10033)

15-17. Association of Military Surgeonsof the U.S., Washington, D.C. (F. E. Wil-son, 1500 Massachusetts Ave., NW, Wash-ington, D.C.)

15-18. Aircraft Design and Technology,Los Angeles, Calif. (American Inst. ofAeronautics and Astronautics, 1290 Sixth

WAve., New York 10019)15-18. Information Problems in the

Drug Industry, conf., Philadelphia, Pa.(C. P. Butcher, Graduate School of Li-brary Science, Drexel Inst. of Technology,32nd and Chestnut Sts., Philadelphia19104)

* 15-18. American Nuclear Soc./AtomicIndustrial Forum, winter meeting, Wash-ington, D.C. (O. J. DuTemple, AmericanNuclear Soc., 244 E. Ogden Ave., Hins-dale, Ill. 60521)

15-19. Animal Care Panel, 16th annual,Philadelphia, Pa. (H. P. Schneider, Hahne-

A mann Medical College, 230 N. Broad St.,Philadelphia 19102)29 OCTOBER 1965

PersonnelPlacement

Replies to blind ads should be addressedas follows:

Box (give number)SCIENCE1515 Massachusetts Ave., NWWashington, D.C. 20005

|||11111111111'POSITIONS WANTED 1l||l|l|l||ll|llll||11111111Bacteriologist-Clinical Chemist, advanced degree,seeks responsible position in research, industry,hospital, or commercial laboratory. Age 38.Fifteen years' experience including 10 years aslaboratory director. Varied interests include writ-ing and product development. Box 269, SCI-ENCE. XIBiochemist, Pharmacologist, enzyme experience,desires position in federal or state research pro-gram. Midwest. Box 273, SCIENCE. X

(a) Biochemistry Ph.D.; bacteriology minor; ex-perienced supervising hospital radioisotope-chemis-try laboratory, university teaching, metabolismand nutritional research; seeks research appoint-ment. (b) Zoology Ph.D.; entomology M.S.; avail-able for research or teaching opportunity. Forinformation write Woodward Medical PersonnelBureau, 185 North Wabash, Chicago 60601. X

Biologist (physiology, biochemistry). Ten years ofundergraduate teaching, eastern college; 6 years'full-time research, U.S. and abroad. Desires re-turn to undergraduate teaching in departmentaffording research opportunity. Box 262,SCIENCE. X

B.S. Chemist seeks position in Athens, Greece.Experienced in biochemical research. Single,speaks Greek. will pay travel expenses. L. F.Lyons, 5231 Grangehall Rd., Gurnee, Illinois. X

Copy Editor with 15 years' experience seeks posi-tion in medical or biological publishing, prefer-ably in the East. Box 271, SCIENCE. X

Microbiologist, B.V.M.Sc., 12 years of experiencein veterinary and medical microbiology, 6 yearsof research in bacteriology, biochemistry andgenetics, desires academic, government, or in-dustrial position. Write Voya Raykovic, 1391Edgewood Rd., Redwood City, California. X

Psycholgist, Ph.D.; radiation effects; hunger. Re-search position after June 1966. Box 272,SCIENCE. X

Ph.D. Biologist; plankton authority; publications;experienced in, and prefers, teaching, research;Ph.D. Anatomist (endocrinology, histochemistryminors); seeks Midwestern appointment in re-search, some teaching. Please write ScienceService, The Medical Bureau, Inc., 900 NorthMichigan Avenue, Chicago, Illinois 60611. X

Scientffic Editor, now with international researchcenter in Europe, seeks permanent position inU.S. Box 270, SCIENCE. X

||||||||||||||||||||||||||||||| POSITIONSOPEN||||||||||||||||

BOTANIST-PLANT ECOLOGISTOPERATIONS ANALYST

Immediate opening in the O.R. Department ofan applied research organization for an individualtrained as a botanist, plant ecologist, or plantgeographer. A strong math background and aworking knowledge of probability and statisticsis desirable. Objective will be to describe theenvironments in which man-machine systems in-teract in terms which permit mathematical analysisand prediction of the system performance. Vege-tation and plant life have strong jnteractions withthe systems presently being studied.

Mrs. R. H. MaletzProfesslsaal Staffing Services

422 Washington BuildingWashington, D.C. 20005

BIOCHEMICAL ENGINEERProminent midwestern pharmaceutical manu-facturer is seeking a Biomedical Engineer for itsnewly organized Research Computer Center.Candidates must possess a B.S. in engineering,mathematics or physics with M.S., Ph.D., or ex-perience in biophysical science and computertechnology. Position involves providing technicalassistance in the acquisition, development, anduse of computer and related instrumentation forthe automation and analysis of biomedical,clinical. and laboratory data. Please send com-plete resume to:

Technical EmploymentThe Upjohn Company301 Henrietta Street

Kalamazoo, Michigan 49001An equal opportunity employer

EDUCATORS

RESEARCHERS

Career opportunities in medical research, inradioisotope training and in science-educationand exhibits program.

Ph.D.MATHEMATICIAN

BIOPHYSICISTPHYSICIST

CHEMIST

M.S./B.S.RADIOISOTOPE LAB INSTRUCTOR

PHYSICS INSTRUCTORSCIENCE EDUCATOR

BIOCHEMISTLIBRARIAN

Competitive salary and extensive employee benefits.Send resume, including salary requirements, to:

OAK RIDGE INSTITUTE OFNUCLEAR STUDIES

P.O. Box 117

Oak Ridge, Tennessee

An equal opportunity employer

SECTION SUPERVISOR for clinical biochemistrylaboratory. M.S. or B.S. degree with equivalentexperience clinical chemistry. 579-bed univer-sity affiliated hospital. Duties include super-vision of staff in expanding laboratory andparticipation with Ph.D. biochemist in develop-mental activities. Write to: Personnel Director,St. Joseph Mercy Hospital, Ann Arbor, Mich.

0-

Personnel Assistant 1The Sterling Winthrop Research Institute, a division of Sterling DrugInc., located in Rensselaer, N.Y., near Albany, has created a unique andchallenging position for a Personnel Assistant. A minimum of 2 yearsgeneral personnel experience in a biological or scientific research functionis required. A degree is mandatory and a major in personnel administra-tion is preferred.Responsibilities will include college recruiting, wage and salary, andgeneral personnel administration. Some travel required to meet personnelrecruiting needs.

Interested candidates submit a detailed resume including salary requirementsin complete confidence to C. E. Alford, Director of PersonnelSTERLING-WINTHROP RESEARCH INSTITUTE

Rensselaer New York~An equal opportunity employer

649

Am

14

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I Mililljlllllllll POSITIONS OPEN

jSfPOSiTIONS OPEN **POSITIONS OPENon FEOWSHIPS If,~.WMl POIIN OPE MIL JMwM FELWSH wwwiasS- CHEMICAL ABSTRACTS SERVICE

KEY TO THE WORLD S CHEMICAL LITERATURE

Our continued growth has created full-time permanentpositions for chemists in Columbus, Ohio

ALL LEVELS OF TRAINING

ALL FIELDS OF INTEREST

Foreign Language ability desirable

Write:

PERSONNEL DEPARTMENT

CHEMICAL ABSTRACTS SERVICE

THE OHIO STATE UNIVERSITY pCOLUMBUS, OHIO 43210

ANALYTICAL CHEMIST Ph.D. With compre-hensive knowledge of modern instrumentation.Salary range $9,860 to $12,900. Reply to

B. DearingtonConnecticut State Health Department

79 Elm StreetHartford, Connecticut

An equal opportunity employer

BIOCHEMIST, Ph.D.

To pursue basic research in protein chemistryand metabolism. UCLA appointment, work atV.A. hospital. Starting salary $7,848. Contact

Dr. Harry WalterV. A. Hospital

Long Beach, CaliforniaAn equal opportunity employer

Clinical Chemist, Ph.D.For position in methodology research with majorreference clinical laboratory. Salary open. Reply to

R. J. Henry, M.D.Bio-Science Laboratories12330 Santa Monica Blvd.

Los Angeles, California 90025

MICROBIOLOGISTS

The Department of Biology, University ofWaterloo, Ontario, Canada, invites applicationsfor faculty appointments in microbiology. Ap-pointments will date from 1 July 1966. Salaryaccording to qualifications. Submit applications,with the names of two referees, to Dr. H. B.Noel Hynes, Chairman, Department of Biology.

Research Position available for qualified personwith B.S. or M.S. degree, major in chemistry orbiological science with college courses in mathe-matics and physics. Problems being studied arein the field of hemostasis with the major interestin the adenosine nucleotides and blood coagula-tion. Opportunty for continuing graduate train-ing. Applicants should submit curriculum vitaeand state salary desired. This position is withthe Department of Physiology, Marquette Univer-sity School of Medicine, at the Veterans Adminis-tration Hospital, Milwaukee, Wisconsin.

Dr. Shirley A. JohnsonResearch Service

Woods Veterans Administration HospitalMilwaukee, Wisconsin, 53193

650

Postdoctoral position in Blood Program Re-search Laboratory for work with Dr. RichardMoore in experimental and theoretical re-search on cell membrane permeability. Salarycompetitive. Reply: Norman A. Durfee, Na-tional Director, Personnel Services, AmericanNational Red Cross, Washington, D.C. 20006.

An equal opportunity employer.

SENIOR LECTURESHIP IN BIOCHEMISTRYTHE UNIVERSITY OF SINGAPORE invites appli-

cations for appointment to a Senior Lectureship in Bio-chemistrv. Candidates should have a Ph.D. or M.Sc. inBiochemistry, or a registrable medical qualification withrelevant teaching and research experience.

Salary scale: $1250x50-1500 p.m.; $1520 p.m. (meidicallyqualified)In addition, there is an expatriation allowsance of $220a month, and a variable allowance at the rate of 35%of basic salary subject to a maximum, depending onmarital stattss (Rate of exchange: £1 sterling = approx.$8.50). P'assages for appointee, wife and children under12 years. PIrovident Fund Scheme.

Further particulars may be obtained from the Regis-trar, University of Singapore, Singapore 10, with whomapplications must be lodged not later than 15 November1965.

p|||||||||||||||||||||l||| FELLOWSHIPS

Fellowships in Infectious Disease Pathol-ogy. Research methodology in autopsy,surgical pathology; immunology; micro-biology; clinical, tropical medicine. SpokenSpanish desirable. $5,500 plus dependents'stipends. One to four years. Send biog-raphy to Professor R. Baker, L.S.U. Med-cal School, 1542 Tulane Avenue, NewOrleans 70112.

FELLOWSHIP IN ORTHOPEDIC RESEARCHThe Research Institute for Skeletomuscular Dis-eases of the Hospital for Joint Diseases offers abroad, basic, flexible program. The programconsists of didactic instruction, participation incurrent laboratory research, and opportunities forclinical research. Applicants should have com-pleted the clinical portion or all of an approvedresidence training program and be citizens of theUnited States or have permanent residence status.Appointments are for a minimum of 2 years.Appropriate stipends will be determined indi-vidually. Application should be made to Dr.Vincent Hollander, Director, Research Inst. forSkeletomuscular Diseases, Hospital for Joint Dis-eases, 1919 Madison Ave., New York 10035.

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Postdoctoral ResearchAssociateships

CYTOPATHOLOGY: Micro and fine structurechanges in cultured cells caused by infection offoot and mouth disease virus; ENTOMOLOGY:Insect Pathology and Insect Physiology; MIN-ERAL NUTRITION OF PLANTS: Plant bio-.chemistry in nutrient uptake and utilization; HU-MAN NUTRITION: Functions and metabolismof nutrients; PLANT PHYSIOLOGY: Light ac-tion in controlling plant growth and development;plant hormone growth regulators; fruit and vege-table ripening and senescence; PLANT VIROL-OGY: Physical, chemical, and biological studiesof plant viruses; BIOCHEMISTRY: Allergens ofagricultural products; protein metabolism in seeds;*plant enzyme studies; IMMUNOLOGY-physical,chemical, and biological characterization of anti-bodies of viruses; MOLECULAR VIROLOGY:The structure and chemical composition of footand mouth disease virus; CELLULOSE CHEM-ISTRY: Crosslink structures of cotton cellulose;radiochemistry of cellulose; ORGANIC CHEM-ISTRY: of cereal carbohydrates; structural andreaction studies in organic phytochemical re-#search; MICROBIOLOGICAL CHEMISTRY:Biosynthetic pathways in microbiological syn-thesis; investigation of attenuated strains of virus;PHYSICAL CHEMISTRY: Physical, chemical,and molecular properties of proteins; physicalchemistry of cereal carbohydrates; fine fiber struc-ture; microcalorimetry; OIL SEED PROTEINCHEMISTRY: Physical chemical properties ofoilseed proteins; protein analysis; organic chem--istry of lipids; physical chemical investigations oflipids; TURPENE CHEMISTRY: Citrus com-ponents; pine gum investigations; PLANT HIS-TOCHEMISTRY: Histology and histochemistryof sweet potatoes; BIOPHYSICS: Microscopy ofseed proteins; microscopy investigations of cot-ton; spectroscopy investigations; measuring fruitand vegetable quality. Tenable with AgriculturalResearch Service, US Dept. Agri. Locations: ^Calif., Fla., La., Md., N.Y., Pa., and Wash., D.C.$10,250 plus moving costs. Nondiscrimination inselection. Write: Office of Scientific Personnel,NATIONAL ACADEMY OF SCIENCES-NA-TIONAL RESEARCH COUNCIL, 2101 Consti-tution Avenue, N.W., Washington, D.C. 20418

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