Medicinal chemistry 101 -...
Transcript of Medicinal chemistry 101 -...
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Medicinal Chemistry
Dr H. ReddyWMH
Opioids
LA
NDMR
Barb’s
BZD’s
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S tructure A ctivity R elationship
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Common viva Qns…
• What is organic chemistry?
• Explain the meaning / relevance of SAR?
• Compare various drug groups and explain how their SAR affect their physicochemical properties?
• How would you design a drug?
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Symbol
Name
A No.
A Mass
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Symbol
Name
A No.
A Mass
Number of PROTONS
Number of PROTONS & NEUTRONS
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IONIC bonds
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COVALENT bonds
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METALLIC bonds
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VAN DER WAALS forces
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DIPOLE-DIPOLE bond
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HYDROGEN bonds
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Basic building blocks
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ESSENTIAL
Phenylalanine Valine
Threonine Tryptophan Methionine
Leucine Isoleucine
Lysine Histidine
CONDITIONAL
Arginine Cysteine Glycine
Glutamine Proline
Tyrosine
DISPENSABLE
Alanine Aspartic acid Asparagine
Glutamic acid Serine
9 6 5
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CATECHOL-Ethylamine
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CATECHOL-Ethylamine
αβ
A lpha binds A mine group
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Barbiturates
R Imino group
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BENZO-DIAZEPINEs
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BENZO-DIAZEPINEs
Benzene
Diazepine
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NDMR (Bis-Benzyl-isoquinolinium)
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NDMR (Bis-Benzyl-ISOQUINOLINIUM)
ESTER
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ESTER
Mivacurium
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NDMR (amino-steroids)
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NDMR (amino-STEROIDs)
3
17
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Suggammadex
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DMR
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Opi-ates / -oids
PHENOL
3
6
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Inhalation agents
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Local anaesthetics
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Questions???