Medicamente de Sinteza

8/10/2019 Medicamente de Sinteza

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Inversia chirala la R-ibuprofen


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Chloramine-T ,Clorami na T

Tosylchloramide is an antiseptic /disinfectant ,often used as the sodium salt tosylchloramidesodium . It is available under the brand nameDisifin .
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Hidantoine dactin, dibromantin, BCDMH

Some N-Halogenated derivatives of hydantoin are usedas chlorinating or brominating agents in

disinfectant /sanitizer or biocide products. The threemajor N-halogenated derivatives aredichlorodimethylhydantoin ( DCDMH ),bromochlorodimethylhydantoin ( BCDMH ), anddibromodimethylhydantoin ( DBDMH )
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Iodoform


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Formaldehyde, Glutaraldehyde


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Acid salicilic


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Faringosept


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Quaternary Ammonium Compounds

Also known as Quats or QAC's , include the chemicalsbenzalkonium chloride (BAC), benzethonium chloride

(BZT) and Benzalkonium chloride is used in some pre-operative

skin disinfectants (conc. 0.05 0.5%) and antiseptictowels.
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Derivati de acridina

Ethacridine lactate (ethacridine monolactatemonohydrate, acrinol , trade name Rivanol ) is an

aromatic organic compound based on acridine . Its formalname is 2-ethoxy-6,9-diaminoacridine monolactatemonohydrate. It forms orange-yellow crystals with amelting point of 226 C and it has a stinging smell.
http://en.wikipedia.org/wiki/Aromatichttp://en.wikipedia.org/wiki/Organic_compoundhttp://en.wikipedia.org/wiki/Acridinehttp://en.wikipedia.org/wiki/Acridinehttp://en.wikipedia.org/wiki/Organic_compoundhttp://en.wikipedia.org/wiki/Aromatic


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Quinoline oxichinol, cliochinol,saprosan,decalina


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Prima Sulfamida Prontozilul rosuprodrug

Sulfonamide drugs were the first antimicrobial drugs, and paved the way forthe antibiotic revolution in medicine. The first sulfonamide was trade namedProntosil , which is a prodrug

Sulfonamidochrysoidine (KI-730), first synthesized by Bayer chemists JosefKlarer and Fritz Mietzsch, was tested and found effective against someimportant bacterial infections in mice by Gerhard Domagk , whosubsequently received the 1939 Nobel Prize in Medicine . Prontosil was theresult of five years of research and testing involving thousands ofcompounds related to azo dyes .
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Sulfanilamida

Jacques and Thrse Trefouel and their team at the French PasteurInstitute found in 1936 that prontosil is metabolized to sulfanilamide (para-aminophenylsulfonamide), a much simpler, colorless

molecule, redefining Prontosil as a prodrug . Prontylin became thefirst oral version of sulfanilamide by Bayer. Its synthesis had been first reported by Paul Gelmo, a chemistry

student working at the University of Vienna in his 1909 thesis, but hehad not realized its medical potential.
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Short acting sulfonamide Sulfisomidine (INN), also known as

sulphasomidine (BAN until 2003), [1] sulfamethin and sulfaisodimidine , isa sulfonamide antibacterial . It isclosely related to sulfadimidine .

(A British Approved Name (BAN ) isthe official non-proprietary or genericname given to a pharmaceutical substance , as defined in the BritishPharmacopoeia (BP) . The BAN is alsothe official name used in manycountries across the world, especiallythose of the Commonwealth of Nations

Sulfanilamida Sulfaisodimidine Sulfamethizole

Sulfadimidine Sulfapyridine Sulfafurazole Sulfanilamide (Prontosil ) Sulfathiazole Sulfathiourea
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Intermediate-acting sulfonamide Sulfadiazina - Silver sulfadiazine is

a sulfa derivative [1] topical antibacterial historically used as atopical burn cream on second- andthird-degree burns

Sulfamethoxazole (abbreviatedSMX [1][2] and less reliably [3] SMZ [4][5][6]) is a sulfonamide bacteriostatic anti biotic . It is most oftenused as part of a synergisticcombination with trimethoprim in a 5:1ratio in co-trimoxazole (abbreviatedSX T, SMX-TMP and SMZ-TMP, [7] orTMP-SMX and TMP-SMZ), also knownunder trade names such as Bactrim ,Septrin , or Septra .

Sulfamethoxazole Sulfadiazine # Sulfamoxole
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Biseptol (400-50)


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Sulfatiazol


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Sulfametoxazol

Sulfamethoxazole (abbreviated SMX [1][2] and less reliably [3] SMZ [4][5][6]) is asulfonamide bacteriostatic antibiotic . It is most often used as part of a synergisticcombination with trimethoprim in a 5:1 ratio in co-trimoxazole (abbreviated SXT,SMX-TMP and SMZ-TMP, [7] or TMP-SMX and TMP-SMZ), also known under trade

names such as Bactrim , Septrin , or Septra . Its primary activity is against susceptibleforms of Streptococcus , Staphylococcus aureus (including MRSA ), Escherichia coli ,Haemophilus influenzae , and oral anaerobes . It is commonly used to treat urinarytract infections. In addition can be used as an alternative to amoxicillin -basedantibiotics to treat sinusitis .
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Antibiotice beta-lactamice

Penicillin , the first naturalantibiotic discovered by

Alexander Fleming in1928.

In 1999, Time Magazine named Fleming one ofthe 100 Most ImportantPeople of the 20th

Century for his discoveryof penicillin

Testing the susceptibility of Staphylococcus aureus to antibiotics by the
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Testing the susceptibility of Staphylococcus aureus to antibiotics by theKirby-Bauer disk diffusion method . Antibiotics diffuse out from

antibiotic-containing disks and inhibit growth of S. aureus resulting in a

zone of inhibition
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Efitard


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Ampicilina


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Oxacilina


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Cefalosporine Cephalosporin compounds were first

isolated from cultures of Cep halospor iumacremonium from a sewer in Sardinia in1948 by Italian scientist Giuseppe Brotzu [2].He noticed that these cultures producedsubstances that were effective againstSalmonella typhi , the cause of typhoid fever ,which had beta-lactamase . Guy Newton andEdward Abraham at the Sir William Dunn

School of Pathology at the University ofOxford isolated cephalosporin C . Thecephalosporin nucleus, 7-aminocephalosporanic acid ( 7-ACA ), wasderived from cephalosporin C and proved tobe analogous to the penicillin nucleus 6-aminopenicillanic acid , but it was notsufficiently potent for clinical use.Modification of the 7-ACA side-chainsresulted in the development of usefulantibiotic age nts, and the first agentcephalothin ( cefalotin ) was launched by EliLilly in 1964
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Aspirin (USAN ), also knownas acetylsalicylicacid (abbrev

iated ASA ), is a salicylate drug ,often used as an analgesic to relieve minor

aches and pains, as an

antipyretic to reduce fever, andas

an antiinflammatory medication.

Aspirin was first isolatedby Felix Hoffmann , a chemistwith the Germancompany Bayer in 1897. [1][2]
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(RS )-2-(4-(2-methylpropyl)phenyl)-propanoic acid

Ibuprofen (INN) (from iso- bu tyl- pro panoic - phen olic acid) is a nonsteroidalanti-inflammatory drug (NSAID) used for pain relief, fever reduction, andagainst swelling.

Ibuprofen has an antiplatelet effect, though relatively mild and somewhat short-lived compared with aspirin or prescription antiplatelet drugs. In general,ibuprofen also acts as a vasoconstrictor. Ibuprofen is a 'core' medicine inthe World Health Organization's Model List of Essential Medicines necessary tomeet the minimum medical needs of a basic healthcare system.

Ibuprofen was derived from propanoic acid by the research arm of BootsGroup during the 1960s and patented in 1961. Originally marketed as Brufen ,ibuprofen is available under a variety of popular trademarks, includingMotrin, Nurofen, Advil, and Nuprin. Generic formulations are available as well.

In Europe, Australia, and New Zealand, ibuprofen lysine (the lysine salt ofibuprofen, sometimes called "ibuprofen lysinate" even though the lysine isin cationic form) is licensed for treatment of the same conditions as ibuprofen.The lysine salt increases water solubility


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2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1 H -indol-3-yl}aceticacid

Indometacin (INN) or indomethacin (USAN andformer BAN) is a non-steroidal anti-inflammatorydrug (NSAID) commonly used as a prescriptionmedication to reduce fever, pain, stiffness, and swelling. Itworks by inhibiting the production of prostaglandins,

molecules known to cause these symptoms. It is marketedunder more than seventy different trade names.

Indomethacin was discovered in 1963 and it was firstapproved for use in the U.S. by the Food and Drug

Administration in 1965. Its mechanism of action, along with

several other NSAIDs that inhibit COX, was described in1971.


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Diclofenac (INN ) is a nonsteroidalanti-inflammatory drug (NSAID) takento reduce inflammation and asan analgesic reducing pain in certainconditions.

The name is derived from itschemical name: 2-(2,6-dichlo ranilino) phen ylacetic ac id.

In the United Kingdom, India, Brazil,and the United States, it may besupplied as either the sodium orpotassium salt , in China most oftenas the sodium salt, while in someother countries only as the potassiumsalt. Diclofenac is available as ageneric drug in a number offormulations, including

diclofenac diethylamine appliedtopically . Over-the-counter (OTC) useis approved in some countries forminor aches and pains and feverassociated with common infections.

Pi i i id l i i fl d f


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Piroxicam is a non-steroidal anti-inflammatory drug ofthe oxicam class used to relieve the symptoms ofrheumatoid and osteoarthritis, primary dysmenorrhoea,postoperative pain ; and act as an analgesic , especially where there

is an inflammatory component. It is manufactured by Pfizer underthe tradename Feldene , and is available in the UK, Spain, Portugal,Belgium, Australia, Italy, Brazil and the United States. It is alsomanufactured by Bosnalijek under the tradename Roxam , and isavailable in Eastern Europe, Africa, and the Middle East. In India, itis available by the tradename Dolonex . In Thailand it is available bythe tradename Fasden . It is manufactured as a patch by SKChemicals Co., Ltd. in Korea (www.skchemicals.com.cn) for use inChina under the trade name "Trast"; the Chinese name (in Pinyin) isBiluoxikang Tiepian ".

It is also used in veterinary medicine to treatcertain neoplasias expressing cyclooxygenase (COX) receptors,such as bladder, colon, and prostate cancers.

Other brand names for Piroxicam include "Arantil", "Brexidol","Brexin", "Erazon", "Exipan", "Faxiden", "Felden", "Feldoral","Flamexin", "Hawksone", "Hotemin", "Lubor", "Mobilis", "Pirox vonct", "Proponol", "Reumador", "Remox", "Roxam", "Sinartrol","Toricam", "Tracam", "Ugesic", "Veral" and "Vurdon".

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