MEDICAL TELECONFERENCE: Hypertension

89
MEDICAL TELECONFERENCE: Hypertension 1 st year Post-Graduate Family Medicine Dr Munirah Mohd Basar

description

MEDICAL TELECONFERENCE: Hypertension. 1 st year Post-Graduate Family Medicine Dr Munirah Mohd Basar. GENERAL OBJECTIVE. The aim of the session is to enable the family practitioner to have sufficient knowledge and skills to diagnose and manage hypertensive patients . INTRODUCTION. - PowerPoint PPT Presentation

Transcript of MEDICAL TELECONFERENCE: Hypertension

Page 1: MEDICAL TELECONFERENCE: Hypertension

MEDICAL TELECONFERENCE:

Hypertension1st year Post-Graduate Family Medicine

Dr Munirah Mohd Basar

Page 2: MEDICAL TELECONFERENCE: Hypertension

The aim of the session is to enable the family practitioner to have sufficient knowledge and skills to diagnose and manage hypertensive patients.

GENERAL OBJECTIVE

Page 3: MEDICAL TELECONFERENCE: Hypertension

Major risk factor for Cardiovascular, cerebrovascular and renal disease

Prevalance of HPT was 43% in 2006 (age ≥ 30 years old) : 30% increase in 10 years

64% remain undiagnosed (silent disease) Only 26% achieved blood pressure control

INTRODUCTION

Page 4: MEDICAL TELECONFERENCE: Hypertension

HYPERTENSION◦persistent elevation of SBP ≥ 140mmHg and/or DBP ≥ 90mmHg

Prehypertension◦SBP 120-139mmHg and/or DBP 80 to 89mmHg

DEFINITION

Page 5: MEDICAL TELECONFERENCE: Hypertension
Page 6: MEDICAL TELECONFERENCE: Hypertension

A 30 year old Indian man come to your clinic for a medical examination for insurance. He

is found to have high blood pressure of 160/120mmHg (one reading). He is

otherwise well, with no other alarming symptoms.

Page 7: MEDICAL TELECONFERENCE: Hypertension

If blood pressure measured in the clinic is 140/90 mm Hg or higher:◦ Take a second measurement during the

consultation◦ If the second measurement is substantially

different from the first, take a third measurement◦ Record the lower of the last two measurements as

the clinic blood pressure.

Diagnosing hypertension

Page 8: MEDICAL TELECONFERENCE: Hypertension

If the clinic blood pressure is 140/90 mm Hg or higher, use ambulatory blood pressure monitoring to confirm the diagnosis of hypertension. ◦ This strategy will improve the accuracy of the

diagnosis compared with current practice and was also shown to be cost effective—indeed, cost saving—for the NHS. (Updated recommendation) [Based on a systematic review of randomised controlled trials ranging in quality from poor to good and on cost effectiveness evidence]

Page 9: MEDICAL TELECONFERENCE: Hypertension

When using ambulatory blood pressure monitoring to confirm a diagnosis of hypertension, ◦ ensure that at least two measurements an hour

are taken during the person’s usual waking hours (for example, between 0800 and 2200).

◦ Use the average value of at least 14 measurements taken during the person’s usual waking hours to confirm a diagnosis of hypertension. (New recommendation) [Based on prognostic and reliability or reproducibility studies determined to be at low risk of bias]

Page 10: MEDICAL TELECONFERENCE: Hypertension

If a person cannot tolerate ambulatory blood pressure monitoring, home blood pressure monitoring is a suitable alternative to confirm the diagnosis. (New recommendation) [Based on a systematic review of randomised controlled trials ranging in quality from poor to good and on cost effectiveness evidence]

Page 11: MEDICAL TELECONFERENCE: Hypertension

When using home blood pressure monitoring to confirm a diagnosis of hypertension:◦ For each blood pressure recording, take two

consecutive measurements, at least one minute apart and with the person seated, and

◦ Record blood pressure twice daily, ideally in the morning and evening, and

◦ Continue recording blood pressure for at least four days, ideally for seven days, and

◦ Discard the measurements taken on the first day and use the average value of all the remaining measurements to confirm a diagnosis of hypertension.

◦ (New recommendation) [Based on prognostic and reproducibility studies determined to be at low risk of bias]

Page 12: MEDICAL TELECONFERENCE: Hypertension

While waiting for a confirmed diagnosis of hypertension, investigate target organ damage (such as left ventricular hypertrophy, chronic kidney disease, and hypertensive retinopathy) and formally assess cardiovascular risk. (New recommendation) [Based on the experience and opinion of the GDG]

Use risk equations to assess cardiovascular risk—for example, the Framingham risk calculator7 (as used in the Joint British Societies’ risk charts available in the British National Formulary and QRISK2 [Based on the NICE guideline on lipid modification9 ]

Page 13: MEDICAL TELECONFERENCE: Hypertension

Evaluation◦ To exclude secondary cause of hypertension◦ To ascertain the presence or absence of target

organ damage◦ To assess lifestyle and identify other

cardiovascular risk factors or concomitant disorders that affect risk factors, prognosis and guide treatment

History, physical examination and investigation

DIAGNOSIS AND ASSESSMENT

Page 14: MEDICAL TELECONFERENCE: Hypertension

duration and level of elevated BP if known symptoms of secondary causes of hypertension symptoms of target organ damage, e.g. coronary heart

disease (CHD) and cerebrovascular disease symptoms of concomitant disease that will affect prognosis

or treatment, e.g. diabetes mellitus, renal disease and gout family history of hypertension, CHD, stroke, diabetes, renal

disease or dyslipidaemia dietary history including salt, fat, caffeine and alcohol intake drug history of either prescribed or over-the-counter

medication (NSAIDS, nasal decongestants) and herbal treatment

lifestyle and environmental factors that will affect treatment and outcome, e.g. smoking, physical activity, work stress and

excessive weight gain since childhood

HISTORY

Page 15: MEDICAL TELECONFERENCE: Hypertension

General examination including height, weight and waist circumference

Two or more BP measurements separated by two minutes with the patient either supine or seated; and after standing for at least one minute

Measure BP on both arms Fundoscopy Cardiovascular examination : examination for carotid

bruit, abdominal bruit, presence of peripheral pulses and radio-femoral delay, evidence of cardiac failure

Abdominal examination for renal masses, aortic aneurysm and abdominal obesity

Neurological examination to look for evidence of stroke Signs of endocrine disorders, e.g. Cushing syndrome,

acromegaly and thyroid disease

Physical examination

Page 16: MEDICAL TELECONFERENCE: Hypertension

Full blood count Urinalysis Measurement of urine albumin excretion or

albumin/creatinine ratio Renal function tests (urea, creatinine, serum

electrolytes and uric acid) Fasting blood sugar Lipid profile (total cholesterol, HDL cholesterol,

LDL cholesterol and triglycerides) Electrocardiogram (ECG) Chest X-ray

Investigations

Page 17: MEDICAL TELECONFERENCE: Hypertension
Page 18: MEDICAL TELECONFERENCE: Hypertension

CARDIOVASCULAR RISK FACTORS

Page 19: MEDICAL TELECONFERENCE: Hypertension
Page 20: MEDICAL TELECONFERENCE: Hypertension
Page 21: MEDICAL TELECONFERENCE: Hypertension
Page 22: MEDICAL TELECONFERENCE: Hypertension
Page 23: MEDICAL TELECONFERENCE: Hypertension

37% of Malaysian population has prehypertension (NHMS 1996)

For inviduals aged 40-70 y.o, risks of CVD rises progressively beginning 117/75mmHg

It is been estimated that almost a third of BP-related deaths from CHD occurs in individuals with SBO between 110-139mmHg

PREHYPERTENSION

Page 24: MEDICAL TELECONFERENCE: Hypertension

All patients should be managed with non-pharmacologic interventions/therapeutic lifestyle modifications to lower BP

Yearly follow-up -> to detect and treat hypertension as early as possible

Pharmacological treatment? ◦ Individual patient’s global CVD risk◦ Eg: DM/CKD – treat if BP > 130/80

Page 25: MEDICAL TELECONFERENCE: Hypertension

If the person has severe hypertension (clinic blood pressure ≥180/110 mm Hg), consider starting antihypertensive drug treatment immediately, without waiting for the results of ambulatory or home blood pressure monitoring. (New recommendation) [Based on the experience and opinion of the GDG]

Thresholds for intervention

Page 26: MEDICAL TELECONFERENCE: Hypertension

Offer antihypertensive drug treatment to people aged under 80 years with stage 1 hypertension (that is, an average ambulatory or home blood pressure of ≥135/85 mm Hg and <150/95 mm Hg; a clinic blood pressure of ≥140/90 mm Hg and <160/100 mm Hg) and who have one or more of the following:◦ Target organ damage◦ Established cardiovascular disease◦ Renal disease◦ Diabetes◦ A 10 year cardiovascular risk equivalent to ≥20%.*(Updated recommendation) [Based on systematic reviews

and meta-analyses of low quality observational and low to high quality randomised controlled trials; prognostic studies determined to be at low risk of bias; and a blood pressure equivalence study of low quality]

Page 27: MEDICAL TELECONFERENCE: Hypertension

Offer antihypertensive drug treatment to people of any age with stage 2 hypertension (an average ambulatory or home blood pressure of ≥150/95 mm Hg; a clinic blood pressure ≥160/100 mm Hg) irrespective of the presence of target organ damage, cardiovascular disease, renal disease, or the 10 year risk of cardiovascular disease.*(Updated recommendation) [Based on systematic

reviews and meta-analyses of low quality observational and low to high quality randomised controlled trials; prognostic studies determined to be at low risk of bias; and a low quality observational study]

Page 28: MEDICAL TELECONFERENCE: Hypertension

For people aged under 40 years with stage 1 hypertension and no evidence of target organ damage, cardiovascular disease, renal disease or diabetes, consider seeking specialist evaluation for secondary causes of hypertension and a more detailed assessment of potential target organ damage. This is because 10 year cardiovascular risk assessments can underestimate the lifetime risk of cardiovascular events in these younger people. *(Updated recommendation) [Based on systematic

reviews and meta-analyses of low quality observational and low to high quality randomised controlled trials; prognostic studies determined to be at low risk of bias; and a blood pressure equivalence study of low quality]

Page 29: MEDICAL TELECONFERENCE: Hypertension

Non-pharmacological (Therapeutic lifestyle modification)

Pharmacological

Management

Page 30: MEDICAL TELECONFERENCE: Hypertension

1) Weight reduction- Most beneficial in patients > 10%

overweight- Aim for BMI 18.5 to 23.5kg/m2- Target 5% reduction of body weight- 4.5 kg weight reduction significantly

reduces BP

NON-PHARMACOLOGICAL MANAGEMENT

Page 31: MEDICAL TELECONFERENCE: Hypertension

2) Sodium intake- Elderly more sensitive to sodium intake- Intake of <100mmol of sodium or 6g of

NaCl a day is recommended (= <1¼ teaspoonfuls of salt or 3 teaspoonfuls of monosodium glutamate

3) Avoidance of alcohol intake- No more than 21 units (men) and 14 units

(women)*1 unit = ½ pint of beer OR 100mls of wine OR

20mls of proof whisky

Page 32: MEDICAL TELECONFERENCE: Hypertension

4) Regular physical exercise- Aerobic exercise more effective than

resistance training- Cardiovascular health : “milder” exercise

such as brisk walking for 30 – 60 minutes at least 3x/week

5) Healthy eating- Rich in fruits, vegetables and dairy products

with reduced saturated and total fat lower BP (11/6mmHg in HPT patients and 42mmHg in preHPT patients)

Page 33: MEDICAL TELECONFERENCE: Hypertension

6) Cessation of smoking- Important in overall management of CVD

risk

7) Others- Stress management- Micronutrient alterations- Dietary supplementations with fish oil,

potassium, calcium, magnesium, and fibre (limited or unproven efficacy)

Page 34: MEDICAL TELECONFERENCE: Hypertension

Stage I HPT – 3-6 months observational period (unless target organ involvement is already evident)

First line monotherapy – ACEIs, ARBs, CCBs, and diuretics

Beta blocker are no longer recommended for 1st line monotherapy in this group of patients

B-blocker may be considered in younger people:◦ Those with an intolerance or contraindication to ACEIs or

ARBs◦ Women of child bearing potential or◦ Patients with evidence of increase sympathetic drive

PHARMACOLOGICAL MANAGEMENT

Page 35: MEDICAL TELECONFERENCE: Hypertension
Page 36: MEDICAL TELECONFERENCE: Hypertension
Page 37: MEDICAL TELECONFERENCE: Hypertension
Page 38: MEDICAL TELECONFERENCE: Hypertension
Page 39: MEDICAL TELECONFERENCE: Hypertension

Target BP : o<140/80mmHg for patients <65 years oldo<130/80mmHg for diabetic/CKD patients

Resistant HypertensionoBP >140/90mmHg with 3 drugs including diuretics at

near maximal doseso Look for possible causeso Noncomplianceo Secondary hypertensiono White coat hypertensiono Excessive sodium intake, excessive liquorice intake and

drug interactionso Complications of long standing HPT such as

nephrosclerosis, loss of aortic distensibility and atherosclerotic renal artery stenosis

Page 40: MEDICAL TELECONFERENCE: Hypertension

Aim for a target clinic blood pressure below 140/90 mm Hg in people aged under 80 years with treated hypertension.*(Updated recommendation) [Based on systematic

reviews of very low to moderate quality randomised controlled

trials, and observational studies] Aim for a target clinic blood pressure below

150/90 mmHg in people aged 80 years and over with treated hypertension. *(Updated recommendation) [Based on a

systematic review and meta-analysis that included moderate and high quality randomised controlled trials]

Page 41: MEDICAL TELECONFERENCE: Hypertension

WHEN TO REFER

Page 42: MEDICAL TELECONFERENCE: Hypertension
Page 43: MEDICAL TELECONFERENCE: Hypertension

Definition : BP > 180/110mmHg Presentation:

◦ Asymptomatic i.e Incidental findings◦ Non-specific symptoms : headache, dizziness,

lethargy◦ Symptoms & signs of acute target organ damage

including acute coronary syndromes, acute renal failure, dissecting aneurysm, hypertensive encephalopathy

SEVERE HYPERTENSION

Page 44: MEDICAL TELECONFERENCE: Hypertension
Page 45: MEDICAL TELECONFERENCE: Hypertension

Asymptomatic severe hypertension Hypertensive urgencies Hypertensive emergencies

Page 46: MEDICAL TELECONFERENCE: Hypertension
Page 47: MEDICAL TELECONFERENCE: Hypertension
Page 48: MEDICAL TELECONFERENCE: Hypertension
Page 49: MEDICAL TELECONFERENCE: Hypertension
Page 50: MEDICAL TELECONFERENCE: Hypertension

Grade III or IV retinal changes (also known as accelerated and malignant hypertension respectively) but no overt organ failure

BP measurement repeated after 30minutes bed rest

Aim for 25% reduction of BP over 24hrs but not lower than 160/90mmHg

Hypertensive urgencies

Page 51: MEDICAL TELECONFERENCE: Hypertension
Page 52: MEDICAL TELECONFERENCE: Hypertension
Page 53: MEDICAL TELECONFERENCE: Hypertension

In patient presented with complications of severe hypertension :◦ acute heart failure, ◦ dissecting aneurysm, ◦ acute coronary syndromes, ◦ hypertensive encephalopathy, ◦ subarachnoid hemorrhage ,◦ acute renal failure

Hypertensive Emergencies

Page 54: MEDICAL TELECONFERENCE: Hypertension

Aim for BP reduction by 25% depending on clinical scenario over 3 to 12 hours but not lower than 160/90mmHg

Page 55: MEDICAL TELECONFERENCE: Hypertension
Page 56: MEDICAL TELECONFERENCE: Hypertension
Page 57: MEDICAL TELECONFERENCE: Hypertension

Should be detected and treated early to prevent CVD and delay progression of renal disease and diabetic retinopathy

Screen for proteinuria & microalbuminuria Pharmacological treatment to be initiated if

SBP persistently > 130mmHg and/or DBP >80mmHg

Treat microalbuminuria or proteinuria even BP not elevated (ACEI or ARB preferred)

Hypertension & DM

Page 58: MEDICAL TELECONFERENCE: Hypertension

Target SBP < 130mmHg and DBP < 80mmHg If presence of proteinuria >1g/24hrs :

<125/75mmHg AntiHPT and DM:

◦ Diuretics : - ↓ insulin responsiveness with higher dose of- dyslipidaemia

◦ Beta-blockers : - masks early symptoms of hypoglycaemia- slowing of recovery from hypoglycaemia (non-selective

beta-blockers)- Aggravation of peripheral vascular disease symptoms- Dyslipidaemia

◦ Alpha-blockers / central acting drugs : worsening orthostatic hypotension

Page 59: MEDICAL TELECONFERENCE: Hypertension

◦ ACEIs - Cardiovascular and renal protective effects- Do not have adverse effects on lipid and carbohydrate

metabolism◦ ARBs

- Slowing the progress of nephropathy at microalbuminuric stage as well as overt nephropathy stage in Type 2 diabetis

Diuretics can be used as initial therapy or added on when monotherapy is inadequate. Lowest possible dose to minimise adverse effects. Adverse metabolis effects with higher dose of diueritics have been reportedly reduced when used in combination with an ACEI or an ARB

Page 60: MEDICAL TELECONFERENCE: Hypertension

◦ CCB no significant adverse metabolic effects or compromise diabetic control- Non dihydropyridine CCBs may be superior to dihydropiridine

CCBs in reducing proteinuria in diabetic nephropathy Beta-blockers may be used when ACEIs, ARBs or

CCBs cannot be used or when there are concomitant compelling indications. However, they should be used with caution, especially in patients with type 1 diabetes.86

Peripheral alpha blockers do not have adverse effects on carbohydrate or lipid metabolism. Orthostatic hypotension due to autonomic neuropathy may be aggravated with their use.

Page 61: MEDICAL TELECONFERENCE: Hypertension
Page 62: MEDICAL TELECONFERENCE: Hypertension

HPT is one of the criteria for diagnosis of metabolic syndrome

Hypertension & Metabolic Syndrome

Page 63: MEDICAL TELECONFERENCE: Hypertension

Renal disease is the most important cause of secondary hypertension

Hypertension in renal disease is often associated with an elevated serum creatinine, proteinuria and/or haematuria.

50-75% of individuals with GFR<60 (CKD stages 3-5) have hypertension.

The target BP :◦ proteinuria of < 1g/24Hrs< 130/80 mmHg◦ proteinuria of > 1g/24Hrs: < 125/75

Hypertension & non-diabetic renal disease

Page 64: MEDICAL TELECONFERENCE: Hypertension

Treatment : to control BP & proteinuria ACEI :

◦ overall 30% reduction in incidence of ESRD◦ Antiproteinuric effects and reduction of ESRD

greater than BP lowering effect ARB similar with ACEI Combination ACEI + ARB reduce rate of

doubling of serum creatinine and ESRD

Page 65: MEDICAL TELECONFERENCE: Hypertension

Diuretics◦ Creatinine > 200 :

- thiazide may not be effective- Preferred loop diuretics

◦ Concurrent diuretic therapy may necessary in patients with renal insufficiency

CCBs◦ non-dihydropyridine (diltiazem/verapamil) are

preferred◦ combination of an ACEI and a non-dihydropyridine

CCB is more anti-proteinuric than either drug

Page 66: MEDICAL TELECONFERENCE: Hypertension
Page 67: MEDICAL TELECONFERENCE: Hypertension

Aetilogy of renovascular HPT◦ atherosclerotic renovascular disease◦ fibromuscular dysplasia◦ Takayasu arteritis◦ transplant renal artery stenosis

Atherosclerotic renal artery stenosis (ARAS)◦ it can lead to ESRD◦ associated with coronary heart disease, cerebrovascular

disease and peripheral vascular disease.◦ In patients older than 60 years, 5 year-survival rate 45%

in patients with bilateral ARAS and 18% in those requiring dialysis therapy.

Renovascular Hypertension

Page 68: MEDICAL TELECONFERENCE: Hypertension

Some clinical features associated with renovascular hypertension include:◦ onset of hypertension before 30 years, especially

without family history◦ recent onset of hypertension after 55 years◦ resistant hypertension◦ abdominal bruit; particularly if associated with a

unilateral small kidney◦ flash pulmonary oedema◦ hypokalemia in absence of diuretic◦ renal failure of uncertain cause in the presence of

normal urine sediment◦ renal failure induced by ACEIs or ARBs◦ coexisting diffuse atherosclerotic vascular disease

Page 69: MEDICAL TELECONFERENCE: Hypertension

Renal angiography including measurement of the pressure gradient remains the gold standard in the diagnosis of renovascular hypertension.

Non-invasive investigations include spiral CT angiography (CTA), colour coded duplex sonography (CDS), captopril enhanced radionuclide renal scan (CR) and magnetic resonance angiography (MRA).

Page 70: MEDICAL TELECONFERENCE: Hypertension

Revascularisation has been shown to alleviate renovascular hypertension as well as to salvage renal function.

It should be considered under the following circumstances.◦ flash pulmonary oedema◦ rapidly deteriorating renal function especially if leading to

dialysis◦ stenosis >70%◦ refractory hypertension◦ transplant renal artery stenosis◦ fibromuscular dysplasia associated with hypertension◦ Takayasu arteritis

Page 71: MEDICAL TELECONFERENCE: Hypertension

The management of renal artery stenosis include conservative treatment, angioplasty with or without stenting and surgery.

Conservative treatment can be considered for patients with stenosis less than 70%. These lesions should be monitored for progression using colour duplex sonography.

Medical treatment of patients with ARAS will include statins, low dose aspirin and cessation of smoking.

ACEI and ARB can be used in patients with suspected ARAS if renal function is carefully monitored. A persistent rise in creatinine of >30% warrants cessation of drug therapy. This is best done under specialist's supervision.

Page 72: MEDICAL TELECONFERENCE: Hypertension

Ostial ARAS is best treated with angioplasty with stenting due to problem of recoil post angioplasty.

In patients with deteriorating renal function or global obstructive atherosclerotic renovascular disease, renal artery stenting improves or stabilizes renal function and preserves kidney size.

Patients with complex renovascular disease such as renal artery aneurysm or failed endovascular procedures may benefit from renal artery surgery.

Page 73: MEDICAL TELECONFERENCE: Hypertension

Doctors have to distinguish patients with a high likelihood of treatment benefit from those with incidental ARAS.

The presence of refractory hypertension, recent deterioration of renal function and evidence of progression of the stenotic lesion will help to determine the plan of management for these patients.

Page 74: MEDICAL TELECONFERENCE: Hypertension

Duplex Doppler examination is ideal for screening and follow-up monitoring of patients with renal transplant artery stenosis. These lesions should only be treated if there is a recent worsening of renal function as there is a possibility of spontaneous reversal of stenosis.

Percutaneous Renal Angioplasty (PTRA) is the treatment of choice where indicated. Further studies comparing intervention and conservative treatment are needed.

Patients with fibromuscular dysplasia rarely have excretory dysfunction, and hypertension in these patients generally responds to ACE inhibitors.

Revascularisation is indicated for patients with refractory hypertension.

Page 75: MEDICAL TELECONFERENCE: Hypertension

Hypertension is one of the major risk factors for atherosclerosis and cardiovascular disease.

Beta-blockers, ACEIs and long-acting CCBs are the preferred antihypertensives.

Short-acting CCBs, especially nifedipine in high doses should be avoided as they are associated with increased cardiac events. These agents should also be avoided in patients with unstable angina.

In post-infarction patients, ACEIs and betablockers especially in patients with LV dysfunction, help to reduce future cardiac events which include cardiac failure, cardiac mortality and morbidity

Hypertension & Cardiovascular disease

Page 76: MEDICAL TELECONFERENCE: Hypertension

In congestive heart failure, diuretics, aldosterone antagonists, betablockers, ACEIs and ARBs have been shown to be beneficial

Hypertension is a major risk factor for peripheral vascular disease (PVD).◦ Care should be taken with beta-blockers in

patients with intermittent claudication. Its presence suggests an increased likelihood of generalized atherosclerosis including coronary artery disease.

Page 77: MEDICAL TELECONFERENCE: Hypertension
Page 78: MEDICAL TELECONFERENCE: Hypertension

BP is the most consistent and powerful predictor of stroke

HPT – modifiable factor Both SBP and DBP associated with stroke

(SBP more predictive)

Hypertension and stroke

Page 79: MEDICAL TELECONFERENCE: Hypertension

Asia Pacific : 66% of strokes attributed to HPT

Worldwide – 15million suffer from stroke anually◦ 5.5 million people die◦ 5 million are left permanently disabled

Malaysia – 4th leading cause of death in government hospitals in 2005, accounting for 8.19% of all deaths

Page 80: MEDICAL TELECONFERENCE: Hypertension

Primary prevention of stroke◦ 10 mmHg reduction in SBP OR 5 mmHg reduction

in DBP can lead to a 34% reduction in the risk of stroke.- The benefits have been shown in both systolic-

diastolic hypertension and in isolated systolic hypertension.

◦ Beta-blockers, diuretics, CCBs, ACEIs and ARBs have been shown to reduce risk and mortality of stroke.

◦ CCB in particular, provided significantly better protection against stroke compared with diuretics and/or beta-blockers in Asian and Caucasian populations.

Page 81: MEDICAL TELECONFERENCE: Hypertension

Secondary prevention of stroke◦ BP lowering has been shown to reduce the risk of

subsequent strokes.◦ ACEI + diuretic = reduce stroke recurrence in

both normotensive and hypertensive patients when treatment was started at least two weeks after the stroke.

◦ The morbidity and mortality from further strokes were also shown to be significantly lower in patients receiving ARBs compared to CCBs for the same level of BP control.

Page 82: MEDICAL TELECONFERENCE: Hypertension

Treatment of hypertension in acute stroke◦ Treatment of elevated BP in acute stroke is still

controversial.◦ In general, it is best to avoid lowering BP in the

first few days after a stroke unless there is evidence of accelerated hypertension or patients presenting concurrently with hypertensive emergencies

Page 83: MEDICAL TELECONFERENCE: Hypertension
Page 84: MEDICAL TELECONFERENCE: Hypertension

Hypertension further magnifies the risk for cardiovascular disease in the elderly compared with younger populations.

The prevalence of hypertension in the elderly in Malaysia has been reported to be 62.4% (55% is isolated systolic hypertension)

Systolic BP, increases linearly with age leading to an increase of isolated systolic hypertension in elderly.

Systolic BP is a better predictor of cardiovascular events than DBP especially in the elderly.

Hypertension in the elderly

Page 85: MEDICAL TELECONFERENCE: Hypertension

Widened pulse pressure (SBP minus DBP) of >40 mm Hg, suggests increased stiffness in large arteries, may be an even better marker of increased cardiovascular risk than either SBP or DBP alone.

Treatment of hypertension in the elderly up to the age of 84 years reduces cardiovascular morbidity and mortality, particularly stroke.

Postural hypotension, i.e. a drop in systolic BP of >20 mmHg upon standing, is a common problem in the elderly.

Blood pressure should therefore be measured in both the seated/supine and standing positions.

Page 86: MEDICAL TELECONFERENCE: Hypertension

Patients with marked systolic hypertension and not tolerating treatment well, reducing SBP to below 160 mmHg initially is acceptable.

Non-pharmacological management◦ Weight loss and modest salt reduction may be

especially effective in the elderly because of their greater sensitivity to sodium intake.

Page 87: MEDICAL TELECONFERENCE: Hypertension

Pharmacological management◦ The five major classes of drugs (diuretics, b-blockers, CCBs,

ACEIs and ARBs) have been shown to reduce cardiovascular events in the elderly.

◦ In older patients with isolated systolic hypertension, diuretics are preferred

◦ Several trials using dihydropyridine CCBs have shown benefits particularly in stroke reduction.

◦ ACEIare the drugs of choice for those with concomitant left ventricular systolic dysfunction, post myocardial infarction or diabetes mellitus.

◦ ARB have also been shown to reduce fatal and non-fatal strokes in hypertensive patients aged 65 years or older.- The starting dose in older patients should be at the lowest

available.◦ Drugs that exaggerate postural changes in BP (peripheral

adrenegicblockers, alpha-blockers and high dose diuretics) or drugs that cause cognitive dysfunction (central alpha-2-agonists) should be used with caution.

Page 88: MEDICAL TELECONFERENCE: Hypertension

Elderly tends to be on many other concomitant medications.

They are also more vulnerable to side effects and treatment therefore should follow the adage “start low and go slow”. In order to maximise compliance, the drug regime should be as simple as possible.

Page 89: MEDICAL TELECONFERENCE: Hypertension