Medical Countermeasures Research

www.emkatech.comemka TECHNOLOGIES

Solutions for MCMOur nation must have the nimble, flexible capability to produce medical countermeasures rapidly in the face of any attack or threat, whether known or unknown, novel or reemerging, natural or intentional.

emka TECHNOLOGIES products and services provide the medical countermeasure researchers and developers the tools to achieve this demanding, unique and critical goal.

emka TECHNOLOGIES

Medical Countermeasures Research

Plethysmography

emkaPACK

easyMATRIX

iox2

ecgAUTOecgAUTO studyDESIGNER

studyDESIGNER

studyDESIGNER

studyDESIGNER

iox2studyDESIGNER

rodentPACK

iox2studyDESIGNER

usbACQ

iox2studyDESIGNER

usbAMPCustomizedreports

NHP equipped with external emkaPACK telemetry.

rodentPACK head-mounted transmitter.

emka TECHNOLOGIES’ products and tools provide solutions to the MCM community’s unique requirements.

and analysis. These unique require-ments are due to the biosafety 2, 3, and 4 laboratories containment structure, as well as unknown changes in physiologi-cal waveform morphologies and infec-tions disease responses caused by novel infections and treatments.

emka TECHNOLOGIES under-stands that medical counter-measures research and devel-opment is unique and requires specific solutions throughout the process of data capture

Plethysmography » Complete software and hardware solutions for pulmonary

studies from mice to NHP. » Pulmonary data integrated with telemetry data allowing

for easy cross model assessments of responses.

www.emkatech.com

Plethysmography

emkaPACK

easyMATRIX

iox2

ecgAUTOecgAUTO studyDESIGNER

studyDESIGNER

studyDESIGNER

studyDESIGNER

iox2studyDESIGNER

rodentPACK

iox2studyDESIGNER

usbACQ

iox2studyDESIGNER

usbAMPCustomizedreports Respiration Impedence Plethysmography calibration

and volume analysis.

emkaPACK

» Noninvasive telemetry system that acquires and monitors physiologic signals from ambulatory animals (i.e., NHPs, swine, ...)

» One simple Ethernet cable used to transmit information for up to 16 subjects/receiver from the containment rooms.

» No surgery requirements, reduces costs and saves time. » Available with calibrated tidal volume measurements

and/or noninvasive blood pressure monitoring.

rodentPACK

» Simple and robust solution for wireless monitoring of neurological parameters from rodents to NHP.

easyMATRIX and analog interface to DSI & ITS/KI implants » Regardless of the implanted telemetry setup used, we provide

a seamless interface for direct integration into our software suite.

iox » Versatile data acquisition platform for collection of required

ambulatory physiologic signals. » One elegant and simple interface for many physiologic

signal sources. » Flexible and easy setup for acute as well as chronic studies. » Monitoring and alarms of key clinical parameters.

Analysis of signals from one subject with different morphologies and arrhythmias using pattern recognition.

ecgAUTO

» Analyze, mine, and report all of your required physiologic data in house.

» The user defined analysis templates and reports solve the challenges of working with agents that produce unknown physiologic waveform morphologies and pathological affects.

studyDESIGNER

» Reliable and automated study setup and daily experimental recordings within the biosafety laboratory environment.

» Automatically organize the study and user workflow. » Manage all acquisition and analysis sessions from several

sources and/or containment rooms. » Produce on-demand and custom reports.

Validation Support Services2 levels of efficient and cost-effective validation assistance are available:

» A-la-carte Validation - customized to best leverage client’s in-house resources.

» Full Validation - complete IQ, OQ, PQ, and final report assistance.

emka TECHNOLOGIES

Medical Countermeasures Research

ecgAUTO » For researchers collecting ECG and other physiologic signals from

in-vivo (acute or chronic) or ex-vivo (i.e. isolated hearts, ...) » Powerful shape-recognition technique. » Optional modules are available for analysis of other signal-types (i.e.

CV, RIP, NIBP, EEG/EMG, Epilepsy, sleep scoring, ...) » 21 CFR Part 11 compliant.

studyDESIGNER » A single platform to design, acquire, analyze, manage, report,

and archive all your studies. » Run multiple concurrent studies. » All actions done through one interface, with user-specific

access levels. » Secure link to your LIMS (Provantis, ...) » 21 CFR Part 11 compliant.

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CONTACT US!For simple to very demanding projects, please call on us.

North America emka TECHNOLOGIES Inc.307 Annandale Road, suite 203 - Falls Church, VA 22042 - USA T: +1 (703)237-9001 - F: +1 (703)237-9006emkatech@emkatech.com

Europe emka TECHNOLOGIES SA59, Bld. Général Martial Valin - 75015 Paris - France T: +33 (0)1 40 60 76 00 - F: +33 (0)1 40 60 65 55emka@emka.fr

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012Features and Technical

Specifications.Plethysmography

» Various chambers available ranging from mice to NHP (i.e. head-out, whole-body, ...)

» Real-time, breath-by-breath analysis of respiratory parameters (breathing rate, tidal volume, minute volume, accumulated volume).

» Drive aerosol devices via the software (shut off aerosol delivery device after defined amount of time or volume has been accumulated).

emkaPACK

» Noninvasive, jacketed telemetry for ambulatory large animals. » Record respiration, ecg, temperature, activity, blood pressure, and

integrated video for complete assessment of physiologic and behavioral data.

» Excellent screening tool prior to implantation, or as a stand-alone alternative to implantable telemetry.

rodentPACK » Head mounted, wireless biopotential telemetry device. » Acquire 2 eeg, 2 emg/ecg, 3 directional activity signals,

and 1 summation activity signal from each subject. » Completely wireless and digitally coded to avoid crosstalk. » Up to 70 hours continuous data transmission. » 2 easily replaceable batteries.

easyMATRIX » Bridges signals from your existing receivers with iox for seamless

integration with emka TECHNOLOGIES software suite. » Directly record calibrated data with iox software. » Connects to your existing receivers (rodents and large animals). » Contains its own ambient pressure transducer. » Connects to computer through USB port (no need for an add-on

A/D acquisition card). » Up to 4 receivers connect to a single easyMATRIX. » 1 easyMATRIX manages 1 to 4 receivers per implant. » Up to 4 easyMATRIX connect to a single computer.

iox » Up to 64 Channels per collection station. » Multiple iox workstations have seamless interface with

studyDESIGNER and ecgAUTO. » Clinical monitoring and alarms. » Real time trends and signal graphs. » 21 CFR Part 11 compliant. » Interfaces with wide range of front end sources:

› emkaPACK

› DSI and KI implants › Plethysmography › rodentPACK › Analog devices.

» Video recording.

ReferencesBattelleCenter for Disease ControlLovelace Respiratory Research InstituteSouthern Research InstituteUSARDECOM ECBCUSAMRICDUSAMRIIDUtah State UniversityUTMB-Galveston National Laboratory