media. · Web viewsynaptic transmission 3.77E-07 90 13 Basal cell carcinoma 0.036661464 17...

Supplementary Table S1. All miRNAs detected in the lipid fractions of tMBM and pMBM

microRNA ID Total reads

P-value (pMBM v. tMBM)

FDR step up (pMBM v. tMBM)

Ratio (pMBM v. tMBM)

Fold change (pMBM v. tMBM)

LSMean (pMBM v. tMBM)

hsa-miR-4470 3.24E+02 1.50E-08 4.31E-06 6.75E+01 6.75E+01 1.67E+03hsa-miR-4687-3p 1.52E+04 1.85E-08 4.31E-06 2.82E-01 -3.54E+00 3.03E+03hsa-miR-1260a 7.92E+04 5.96E-08 9.25E-06 4.75E-01 -2.10E+00 2.49E+04hsa-miR-1260b 8.54E+04 1.82E-07 1.70E-05 4.98E-01 -2.01E+00 2.81E+04hsa-miR-378a-3p 7.05E+04 1.53E-07 1.70E-05 5.09E-01 -1.97E+00 2.20E+04hsa-miR-378g 5.73E+04 4.32E-07 3.35E-05 4.76E-01 -2.10E+00 1.67E+04hsa-miR-378c 6.13E+04 8.06E-07 5.36E-05 5.31E-01 -1.88E+00 2.00E+04hsa-miR-4474-5p 2.46E+02 1.15E-06 5.94E-05 3.33E+01 3.33E+01 1.25E+03hsa-miR-6763-3p 2.56E+02 1.03E-06 5.94E-05 4.56E-01 -2.19E+00 9.33E+01hsa-miR-5585-5p 1.93E+02 1.54E-06 7.16E-05 5.89E-01 -1.70E+00 1.11E+02hsa-miR-1200 1.31E+02 8.01E-06 3.39E-04 6.10E-01 -1.64E+00 8.64E+01hsa-miR-4783-5p 1.55E+02 8.88E-06 3.44E-04 5.02E-01 -1.99E+00 9.13E+01hsa-miR-6772-3p 8.70E+02 1.23E-05 4.39E-04 4.97E+00 4.97E+00 2.28E+03hsa-miR-187-5p 2.45E+02 1.81E-05 5.25E-04 5.63E-01 -1.78E+00 1.61E+02hsa-miR-6510-5p 2.08E+02 1.78E-05 5.25E-04 5.02E-01 -1.99E+00 1.13E+02hsa-miR-7852-3p 3.43E+02 1.71E-05 5.25E-04 2.26E+01 2.26E+01 1.73E+03hsa-miR-4302 2.67E+02 2.13E-05 5.71E-04 4.74E-01 -2.11E+00 1.02E+02hsa-miR-92a-3p 5.15E+03 2.21E-05 5.71E-04 3.02E+00 3.02E+00 1.05E+04hsa-miR-296-3p 4.06E+02 2.67E-05 6.53E-04 3.91E-01 -2.56E+00 9.60E+01hsa-miR-5688 1.30E+02 2.90E-05 6.73E-04 1.13E+00 1.13E+00 1.56E+02hsa-miR-500a-5p 6.38E+02 3.52E-05 7.80E-04 3.24E-01 -3.09E+00 1.94E+02hsa-miR-183-5p 3.02E+03 4.26E-05 9.00E-04 3.48E+00 3.48E+00 6.76E+03hsa-miR-2276-3p 2.01E+03 4.54E-05 9.17E-04 4.26E+00 4.26E+00 4.45E+03hsa-miR-6748-3p 1.94E+02 9.30E-05 1.80E-03 4.59E-01 -2.18E+00 1.08E+02hsa-miR-4684-3p 2.20E+02 9.90E-05 1.84E-03 5.43E-01 -1.84E+00 1.40E+02hsa-miR-20b-3p 1.76E+02 1.30E-04 2.32E-03 1.79E+01 1.79E+01 6.74E+02hsa-miR-134-3p 1.70E+03 1.71E-04 2.94E-03 5.42E+01 5.42E+01 7.33E+03hsa-miR-3928-5p 1.69E+02 1.98E-04 3.18E-03 6.39E-01 -1.57E+00 1.28E+02hsa-miR-6757-5p 2.04E+03 1.98E-04 3.18E-03 2.05E+00 2.05E+00 2.69E+03hsa-miR-127-3p 2.32E+02 2.15E-04 3.33E-03 5.04E-01 -1.98E+00 1.21E+02hsa-miR-542-3p 5.04E+02 2.62E-04 3.93E-03 6.31E-01 -1.59E+00 3.24E+02hsa-miR-369-3p 1.74E+03 2.81E-04 3.97E-03 2.54E-01 -3.94E+00 4.45E+02hsa-miR-7975 2.01E+04 2.77E-04 3.97E-03 5.94E-01 -1.68E+00 7.27E+03hsa-miR-3615 1.71E+02 3.12E-04 4.27E-03 7.80E-01 -1.28E+00 1.45E+02hsa-miR-4418 2.04E+02 4.33E-04 5.75E-03 5.02E-01 -1.99E+00 1.35E+02hsa-miR-4712-5p 1.52E+02 5.53E-04 6.96E-03 9.70E-01 -1.03E+00 1.80E+02hsa-miR-6729-3p 1.39E+02 5.54E-04 6.96E-03 1.30E+00 1.30E+00 1.58E+02hsa-miR-452-5p 1.55E+02 6.38E-04 7.81E-03 8.21E-01 -1.22E+00 1.23E+02hsa-miR-1909-3p 1.84E+02 6.82E-04 8.13E-03 7.95E-01 -1.26E+00 1.40E+02hsa-miR-6750-3p 4.74E+02 7.40E-04 8.61E-03 4.09E-01 -2.44E+00 1.77E+02hsa-miR-6727-5p 1.49E+02 9.46E-04 1.07E-02 1.01E+00 1.01E+00 1.53E+02microRNA ID Total P-value FDR step Ratio (pMBM Fold change LSMean (pMBM

reads (pMBM v. tMBM)

up (pMBM v. tMBM) v. tMBM) (pMBM v.

tMBM) v. tMBM)

hsa-miR-1193 2.34E+03 1.14E-03 1.20E-02 2.01E+00 2.01E+00 3.22E+03hsa-miR-5196-3p 7.66E+04 1.09E-03 1.20E-02 6.67E-01 -1.50E+00 2.98E+04hsa-miR-6751-3p 1.89E+02 1.14E-03 1.20E-02 9.30E-01 -1.08E+00 2.39E+02hsa-miR-3074-5p 8.97E+03 1.29E-03 1.31E-02 3.25E+00 3.25E+00 1.59E+04hsa-miR-7107-5p 2.47E+02 1.29E-03 1.31E-02 7.80E-01 -1.28E+00 1.76E+02hsa-miR-1208 3.24E+02 1.43E-03 1.41E-02 4.88E-01 -2.05E+00 1.90E+02hsa-miR-6722-3p 3.27E+02 1.47E-03 1.43E-02 5.63E-01 -1.78E+00 1.97E+02hsa-miR-101-3p 3.41E+02 1.54E-03 1.47E-02 7.59E-01 -1.32E+00 2.34E+02hsa-miR-19b-3p 3.30E+02 1.59E-03 1.48E-02 9.62E-01 -1.04E+00 2.89E+02hsa-let-7a-5p 6.20E+03 1.68E-03 1.53E-02 2.43E+00 2.43E+00 8.91E+03hsa-miR-4688 3.00E+02 1.74E-03 1.55E-02 8.05E-01 -1.24E+00 2.09E+02hsa-miR-3656 4.30E+02 1.87E-03 1.61E-02 7.64E-01 -1.31E+00 3.07E+02hsa-miR-4283 2.55E+02 1.87E-03 1.61E-02 7.08E-01 -1.41E+00 1.46E+02hsa-miR-1237-3p 1.47E+02 1.97E-03 1.64E-02 8.55E-01 -1.17E+00 1.15E+02hsa-miR-6815-5p 4.41E+02 1.94E-03 1.64E-02 8.64E-01 -1.16E+00 3.28E+02hsa-miR-1249-3p 1.87E+02 2.03E-03 1.66E-02 1.04E+00 1.04E+00 1.76E+02hsa-miR-10a-5p 2.76E+03 2.37E-03 1.81E-02 1.75E+00 1.75E+00 3.20E+03hsa-miR-203a-3p 9.53E+02 2.34E-03 1.81E-02 3.48E+00 3.48E+00 2.50E+03hsa-miR-203b-5p 9.53E+02 2.34E-03 1.81E-02 3.48E+00 3.48E+00 2.50E+03hsa-miR-887-3p 3.19E+02 2.37E-03 1.81E-02 6.62E-01 -1.51E+00 1.86E+02hsa-miR-4651 3.03E+02 2.44E-03 1.83E-02 3.54E-01 -2.83E+00 1.02E+02hsa-miR-1273f 3.24E+02 2.55E-03 1.88E-02 7.79E-01 -1.28E+00 2.44E+02hsa-miR-150-5p 5.20E+02 2.68E-03 1.88E-02 4.23E-01 -2.36E+00 2.63E+02hsa-miR-6865-5p 1.44E+04 2.65E-03 1.88E-02 6.20E-01 -1.61E+00 5.29E+03hsa-miR-7157-5p 1.25E+02 2.71E-03 1.88E-02 1.18E+00 1.18E+00 1.62E+02hsa-miR-8080 9.41E+02 2.69E-03 1.88E-02 1.09E+00 1.09E+00 6.13E+02hsa-miR-491-3p 1.19E+03 3.12E-03 2.10E-02 1.69E+01 1.69E+01 5.04E+03hsa-miR-6815-3p 2.49E+02 3.07E-03 2.10E-02 1.10E+00 1.10E+00 1.87E+02hsa-miR-6741-5p 1.27E+02 3.22E-03 2.14E-02 1.06E+00 1.06E+00 9.94E+01hsa-miR-4664-3p 1.73E+02 3.43E-03 2.22E-02 8.30E-01 -1.21E+00 1.47E+02hsa-miR-4723-5p 2.54E+02 3.41E-03 2.22E-02 1.13E+00 1.13E+00 2.21E+02hsa-miR-6738-5p 1.45E+02 3.67E-03 2.34E-02 1.24E+00 1.24E+00 1.47E+02hsa-miR-6863 1.72E+02 3.77E-03 2.37E-02 7.31E-01 -1.37E+00 1.17E+02hsa-miR-510-3p 1.94E+02 3.89E-03 2.41E-02 9.32E-01 -1.07E+00 1.68E+02hsa-miR-3972 9.60E+01 4.21E-03 2.51E-02 1.27E+00 1.27E+00 1.11E+02hsa-miR-4508 4.74E+02 4.18E-03 2.51E-02 6.72E-01 -1.49E+00 3.24E+02hsa-miR-6862-3p 9.70E+01 4.14E-03 2.51E-02 1.59E+00 1.59E+00 1.60E+02hsa-miR-193a-5p 3.16E+02 4.45E-03 2.56E-02 1.00E+00 1.00E+00 2.29E+02hsa-miR-345-3p 2.58E+02 4.53E-03 2.56E-02 6.24E-01 -1.60E+00 1.30E+02hsa-miR-378i 1.58E+04 4.56E-03 2.56E-02 6.26E-01 -1.60E+00 5.64E+03hsa-miR-3934-5p 8.11E+02 4.47E-03 2.56E-02 8.92E+00 8.92E+00 2.50E+03hsa-miR-5684 1.14E+02 4.37E-03 2.56E-02 1.39E+00 1.39E+00 1.41E+02hsa-miR-221-3p 1.82E+02 5.23E-03 2.87E-02 9.83E-01 -1.02E+00 1.44E+02microRNA ID Total

readsP-value (pMBM v.

FDR step up (pMBM


Fold change (pMBM v.


tMBM) v. tMBM) tMBM)hsa-miR-6777-5p 2.73E+02 5.25E-03 2.87E-02 1.02E+00 1.02E+00 2.09E+02hsa-miR-6743-5p 2.78E+02 5.47E-03 2.96E-02 8.99E-01 -1.11E+00 2.04E+02hsa-miR-1231 1.17E+02 5.69E-03 3.04E-02 9.62E-01 -1.04E+00 1.09E+02hsa-miR-4784 6.56E+03 5.78E-03 3.06E-02 2.07E+00 2.07E+00 6.31E+03hsa-miR-1273g-3p 1.96E+02 6.03E-03 3.14E-02 1.07E+00 1.07E+00 1.99E+02hsa-miR-6812-3p 3.60E+02 6.13E-03 3.14E-02 9.94E-01 -1.01E+00 2.41E+02hsa-miR-6893-3p 1.67E+02 6.15E-03 3.14E-02 9.83E-01 -1.02E+00 1.50E+02hsa-miR-6874-5p 1.38E+02 6.22E-03 3.14E-02 1.03E+00 1.03E+00 1.06E+02hsa-let-7b-5p 4.29E+03 6.39E-03 3.16E-02 2.42E+00 2.42E+00 6.64E+03hsa-miR-378f 3.97E+02 6.34E-03 3.16E-02 7.09E-01 -1.41E+00 1.46E+02hsa-miR-4700-3p 1.26E+02 6.92E-03 3.32E-02 1.32E+00 1.32E+00 1.02E+02hsa-miR-4726-3p 1.49E+02 6.87E-03 3.32E-02 8.92E-01 -1.12E+00 1.12E+02hsa-miR-7158-5p 3.12E+02 7.01E-03 3.32E-02 6.95E-01 -1.44E+00 1.98E+02hsa-miR-8079 1.75E+02 6.97E-03 3.32E-02 5.53E-01 -1.81E+00 1.48E+02hsa-miR-5787 1.16E+03 7.14E-03 3.35E-02 2.11E+00 2.11E+00 1.72E+03hsa-miR-378h 8.75E+04 7.29E-03 3.36E-02 8.03E-01 -1.25E+00 3.44E+04hsa-miR-4668-5p 3.16E+03 7.29E-03 3.36E-02 3.02E-01 -3.31E+00 1.35E+03hsa-miR-4529-3p 3.88E+02 7.96E-03 3.63E-02 7.26E-01 -1.38E+00 2.35E+02hsa-miR-6892-3p 1.63E+02 8.32E-03 3.75E-02 1.16E+00 1.16E+00 1.30E+02hsa-miR-639 2.67E+03 8.62E-03 3.85E-02 2.21E-01 -4.53E+00 6.99E+02hsa-miR-484 1.95E+02 1.03E-02 4.56E-02 1.07E+00 1.07E+00 1.74E+02hsa-miR-29c-3p 2.04E+02 1.04E-02 4.57E-02 9.73E-01 -1.03E+00 2.01E+02hsa-miR-4745-3p 1.53E+02 1.06E-02 4.60E-02 1.25E+00 1.25E+00 1.43E+02hsa-miR-3655 2.54E+03 1.07E-02 4.63E-02 2.97E-01 -3.37E+00 8.69E+02hsa-miR-615-5p 3.20E+02 1.13E-02 4.83E-02 1.28E+00 1.28E+00 2.80E+02hsa-miR-5100 7.58E+03 1.16E-02 4.90E-02 1.53E+00 1.53E+00 1.12E+04hsa-miR-671-3p 2.16E+02 1.17E-02 4.90E-02 9.30E-01 -1.08E+00 1.59E+02hsa-miR-4787-3p 1.85E+02 1.20E-02 4.95E-02 1.63E+00 1.63E+00 2.14E+02hsa-miR-6513-5p 5.27E+02 1.20E-02 4.95E-02 6.19E-01 -1.62E+00 3.35E+02hsa-miR-4304 1.88E+02 1.24E-02 5.05E-02 8.43E-01 -1.19E+00 1.80E+02hsa-miR-4680-3p 4.79E+02 1.27E-02 5.10E-02 4.97E-01 -2.01E+00 3.83E+02hsa-miR-6126 6.41E+02 1.27E-02 5.10E-02 1.80E+00 1.80E+00 9.20E+02hsa-miR-6730-3p 1.34E+02 1.31E-02 5.19E-02 1.00E+00 1.00E+00 1.39E+02hsa-let-7d-3p 6.39E+02 1.36E-02 5.37E-02 7.62E-01 -1.31E+00 4.71E+02hsa-miR-5703 1.67E+02 1.44E-02 5.64E-02 9.65E-01 -1.04E+00 1.15E+02hsa-miR-650 5.84E+03 1.51E-02 5.84E-02 3.70E-01 -2.70E+00 1.37E+03hsa-miR-147a 5.49E+03 1.53E-02 5.87E-02 2.07E+00 2.07E+00 4.96E+03hsa-miR-654-5p 3.20E+02 1.54E-02 5.87E-02 9.41E-01 -1.06E+00 2.33E+02hsa-let-7f-5p 4.50E+03 1.61E-02 6.04E-02 2.55E+00 2.55E+00 7.25E+03hsa-miR-15a-5p 6.35E+03 1.61E-02 6.04E-02 3.60E-01 -2.77E+00 3.29E+03hsa-miR-151a-5p 2.84E+02 1.66E-02 6.12E-02 8.67E-01 -1.15E+00 2.12E+02hsa-miR-6772-5p 1.97E+02 1.65E-02 6.12E-02 1.17E+00 1.17E+00 1.82E+02hsa-miR-27a-3p 3.14E+02 1.75E-02 6.39E-02 1.12E+00 1.12E+00 3.22E+02







hsa-miR-208b-3p 3.16E+03 1.76E-02 6.41E-02 3.31E-01 -3.02E+00 1.49E+03hsa-miR-1272 9.10E+01 1.79E-02 6.47E-02 1.02E+00 1.02E+00 1.16E+02hsa-miR-1913 4.64E+03 1.84E-02 6.58E-02 3.23E-01 -3.10E+00 9.08E+02hsa-miR-7106-5p 1.44E+02 1.85E-02 6.58E-02 1.95E+00 1.95E+00 3.06E+02hsa-miR-4695-3p 1.76E+04 1.89E-02 6.66E-02 7.61E-01 -1.31E+00 7.91E+03hsa-miR-582-5p 4.41E+02 2.05E-02 7.15E-02 6.03E-01 -1.66E+00 2.32E+02hsa-miR-4800-3p 3.50E+02 2.09E-02 7.24E-02 1.13E+00 1.13E+00 3.68E+02hsa-miR-1343-5p 3.09E+02 2.10E-02 7.25E-02 9.01E-01 -1.11E+00 2.49E+02hsa-miR-1233-5p 1.12E+02 2.19E-02 7.33E-02 2.26E+00 2.26E+00 1.70E+02hsa-miR-1307-3p 4.41E+02 2.16E-02 7.33E-02 9.65E-01 -1.04E+00 3.98E+02hsa-miR-4502 4.08E+02 2.16E-02 7.33E-02 5.69E-01 -1.76E+00 1.95E+02hsa-miR-7704 2.68E+03 2.19E-02 7.33E-02 1.25E+00 1.25E+00 3.72E+03hsa-miR-7161-3p 1.42E+02 2.24E-02 7.43E-02 1.27E+00 1.27E+00 1.22E+02hsa-miR-320a 8.80E+03 2.28E-02 7.51E-02 2.75E+00 2.75E+00 1.20E+04hsa-miR-1228-3p 1.23E+02 2.44E-02 7.89E-02 1.31E+00 1.31E+00 1.24E+02hsa-miR-3141 8.53E+02 2.41E-02 7.89E-02 1.76E+00 1.76E+00 1.15E+03hsa-miR-4684-5p 1.08E+02 2.44E-02 7.89E-02 1.49E+00 1.49E+00 1.42E+02hsa-miR-6836-5p 1.89E+02 2.55E-02 8.18E-02 1.76E+00 1.76E+00 2.20E+02hsa-miR-149-3p 1.12E+02 2.62E-02 8.30E-02 1.11E+00 1.11E+00 1.14E+02hsa-miR-888-3p 1.12E+02 2.62E-02 8.30E-02 1.19E+00 1.19E+00 1.22E+02hsa-miR-1181 4.83E+02 2.70E-02 8.44E-02 2.23E+00 2.23E+00 6.84E+02hsa-miR-4261 2.48E+02 2.69E-02 8.44E-02 8.70E-01 -1.15E+00 1.71E+02hsa-miR-30d-5p 6.62E+03 2.75E-02 8.53E-02 6.33E-01 -1.58E+00 4.09E+03hsa-miR-6780b-5p 1.64E+02 2.82E-02 8.67E-02 1.36E+00 1.36E+00 2.47E+02hsa-miR-4664-5p 2.83E+03 2.88E-02 8.82E-02 3.69E-01 -2.71E+00 6.59E+02hsa-miR-3180-5p 1.71E+02 2.93E-02 8.90E-02 1.22E+00 1.22E+00 2.15E+02hsa-miR-4739 3.85E+02 2.95E-02 8.90E-02 2.12E+00 2.12E+00 5.53E+02hsa-miR-6786-5p 2.02E+02 2.97E-02 8.92E-02 1.43E+00 1.43E+00 2.47E+02hsa-miR-3944-5p 7.25E+02 3.04E-02 9.06E-02 4.88E-01 -2.05E+00 3.57E+02hsa-miR-6850-5p 1.37E+02 3.10E-02 9.19E-02 1.67E+00 1.67E+00 1.74E+02hsa-let-7g-3p 6.17E+03 3.16E-02 9.20E-02 5.96E-01 -1.68E+00 2.72E+03hsa-miR-1180-3p 2.23E+02 3.16E-02 9.20E-02 1.15E+00 1.15E+00 2.11E+02hsa-miR-4321 1.93E+02 3.14E-02 9.20E-02 1.07E+00 1.07E+00 1.81E+02hsa-miR-4513 1.07E+02 3.22E-02 9.29E-02 1.53E+00 1.53E+00 1.33E+02hsa-miR-3178 1.94E+02 3.24E-02 9.30E-02 2.58E+00 2.58E+00 2.68E+02hsa-miR-23a-5p 1.10E+02 3.26E-02 9.30E-02 1.68E+00 1.68E+00 1.62E+02hsa-miR-3692-5p 8.33E+02 3.31E-02 9.39E-02 1.85E+00 1.85E+00 1.42E+03hsa-miR-4660 2.19E+02 3.49E-02 9.82E-02 1.21E+00 1.21E+00 2.03E+02hsa-miR-6071 9.40E+01 3.57E-02 1.00E-01 1.94E+00 1.94E+00 1.41E+02hsa-miR-361-3p 2.77E+02 3.60E-02 1.00E-01 1.38E+00 1.38E+00 2.92E+02hsa-miR-425-5p 2.76E+02 3.71E-02 1.03E-01 2.16E+00 2.16E+00 4.41E+02hsa-miR-4299 2.38E+02 3.93E-02 1.08E-01 1.32E+00 1.32E+00 2.15E+02hsa-miR-1303 8.14E+02 4.10E-02 1.09E-01 5.69E-01 -1.76E+00 5.06E+02







hsa-miR-24-2-5p 2.70E+02 4.08E-02 1.09E-01 6.46E+00 6.46E+00 8.37E+02hsa-miR-3939 1.99E+02 4.07E-02 1.09E-01 8.14E-01 -1.23E+00 1.80E+02hsa-miR-4492 7.46E+02 4.09E-02 1.09E-01 1.07E+00 1.07E+00 7.58E+02hsa-miR-7110-5p 2.53E+02 4.04E-02 1.09E-01 1.44E+00 1.44E+00 2.06E+02hsa-miR-8077 5.12E+02 4.06E-02 1.09E-01 3.13E+00 3.13E+00 9.06E+02hsa-miR-6826-5p 1.75E+02 4.30E-02 1.14E-01 1.27E+00 1.27E+00 2.49E+02hsa-miR-181a-5p 2.24E+03 4.36E-02 1.14E-01 1.83E+00 1.83E+00 2.96E+03hsa-miR-6511a-5p 1.66E+02 4.49E-02 1.17E-01 1.59E+00 1.59E+00 2.34E+02hsa-miR-125b-5p 5.04E+02 4.67E-02 1.21E-01 9.16E-01 -1.09E+00 3.43E+02hsa-miR-885-5p 2.31E+02 4.74E-02 1.22E-01 6.88E-01 -1.45E+00 1.25E+02hsa-miR-6796-3p 1.55E+02 4.83E-02 1.24E-01 1.64E+00 1.64E+00 1.87E+02hsa-miR-1180-5p 3.05E+02 4.98E-02 1.26E-01 1.34E+00 1.34E+00 3.13E+02hsa-miR-4270 1.33E+02 4.96E-02 1.26E-01 1.69E+00 1.69E+00 1.24E+02hsa-miR-6768-5p 1.94E+02 4.95E-02 1.26E-01 1.63E+00 1.63E+00 2.47E+02hsa-miR-3195 8.87E+02 5.06E-02 1.27E-01 8.92E-01 -1.12E+00 6.03E+02hsa-miR-596 1.53E+02 5.21E-02 1.30E-01 1.22E+00 1.22E+00 1.63E+02hsa-miR-4267 1.36E+02 5.24E-02 1.30E-01 1.08E+00 1.08E+00 1.88E+02hsa-miR-4652-3p 2.19E+02 5.37E-02 1.33E-01 7.57E+00 7.57E+00 6.74E+02hsa-miR-6822-5p 1.49E+02 5.44E-02 1.34E-01 1.41E+00 1.41E+00 1.60E+02hsa-miR-6088 1.82E+02 5.50E-02 1.35E-01 1.43E+00 1.43E+00 2.23E+02hsa-let-7g-5p 8.08E+03 5.71E-02 1.38E-01 1.86E+00 1.86E+00 1.12E+04hsa-miR-4674 2.09E+02 5.70E-02 1.38E-01 1.70E+00 1.70E+00 2.28E+02hsa-miR-183-3p 8.83E+02 5.74E-02 1.38E-01 1.93E+00 1.93E+00 1.36E+03hsa-miR-339-3p 2.15E+02 5.77E-02 1.38E-01 9.86E-01 -1.01E+00 2.37E+02hsa-miR-370-3p 1.41E+03 5.84E-02 1.39E-01 1.28E+00 1.28E+00 1.99E+03hsa-miR-6870-5p 1.88E+02 5.91E-02 1.40E-01 1.06E+00 1.06E+00 1.62E+02hsa-miR-4783-3p 2.48E+03 6.09E-02 1.44E-01 1.80E+00 1.80E+00 3.01E+03hsa-miR-29a-3p 9.81E+02 6.21E-02 1.45E-01 1.20E+00 1.20E+00 9.85E+02hsa-miR-4497 1.29E+03 6.18E-02 1.45E-01 1.48E+00 1.48E+00 1.67E+03hsa-miR-375 2.15E+04 6.30E-02 1.45E-01 1.61E+00 1.61E+00 2.68E+04hsa-miR-4763-3p 1.31E+02 6.29E-02 1.45E-01 1.83E+01 1.83E+01 6.13E+02hsa-miR-4781-5p 9.90E+01 6.30E-02 1.45E-01 1.76E+00 1.76E+00 1.33E+02hsa-miR-1237-5p 8.32E+02 6.49E-02 1.49E-01 1.51E+00 1.51E+00 7.68E+02hsa-miR-6769a-5p 3.04E+02 6.55E-02 1.49E-01 4.57E+00 4.57E+00 6.95E+02hsa-miR-4665-5p 1.12E+02 6.61E-02 1.50E-01 2.16E+00 2.16E+00 2.15E+02hsa-miR-148a-5p 1.28E+02 6.70E-02 1.51E-01 2.94E+00 2.94E+00 2.41E+02hsa-miR-4258 2.00E+02 6.78E-02 1.52E-01 2.33E+00 2.33E+00 2.22E+02hsa-miR-6805-3p 4.65E+02 6.81E-02 1.52E-01 1.18E+00 1.18E+00 4.58E+02hsa-miR-1276 1.67E+02 6.88E-02 1.53E-01 1.03E+00 1.03E+00 2.66E+02hsa-miR-200c-3p 4.49E+03 6.92E-02 1.53E-01 1.83E+00 1.83E+00 5.73E+03hsa-miR-584-3p 1.46E+02 7.15E-02 1.58E-01 1.41E+00 1.41E+00 2.09E+02hsa-miR-125a-3p 1.65E+02 7.19E-02 1.58E-01 1.99E+00 1.99E+00 2.30E+02hsa-miR-5010-3p 2.36E+03 7.22E-02 1.58E-01 1.87E+00 1.87E+00 2.97E+03







hsa-miR-3665 1.33E+02 7.34E-02 1.59E-01 2.16E+00 2.16E+00 1.83E+02hsa-miR-6735-3p 2.69E+02 7.35E-02 1.59E-01 1.38E+00 1.38E+00 2.08E+02hsa-miR-4690-3p 1.88E+02 7.39E-02 1.59E-01 1.31E+00 1.31E+00 2.44E+02hsa-miR-26b-5p 3.08E+02 7.44E-02 1.59E-01 2.13E+00 2.13E+00 4.40E+02hsa-miR-1539 3.76E+02 7.59E-02 1.62E-01 8.56E-01 -1.17E+00 3.77E+02hsa-miR-320b 4.13E+02 7.82E-02 1.64E-01 6.85E+00 6.85E+00 7.40E+02hsa-miR-378a-5p 2.16E+05 7.84E-02 1.64E-01 8.00E-01 -1.25E+00 8.71E+04hsa-miR-4281 2.31E+02 7.80E-02 1.64E-01 1.10E+00 1.10E+00 1.98E+02hsa-miR-629-5p 1.56E+02 7.85E-02 1.64E-01 2.34E+00 2.34E+00 2.29E+02hsa-miR-638 1.67E+02 8.01E-02 1.67E-01 2.35E+00 2.35E+00 2.15E+02hsa-miR-30e-5p 4.82E+02 8.06E-02 1.67E-01 8.53E-01 -1.17E+00 3.98E+02hsa-miR-1225-3p 1.46E+02 8.15E-02 1.68E-01 1.72E+00 1.72E+00 1.45E+02hsa-miR-92b-3p 2.65E+02 8.24E-02 1.69E-01 1.01E+00 1.01E+00 3.42E+02hsa-miR-4462 1.73E+02 8.74E-02 1.79E-01 1.09E+00 1.09E+00 1.53E+02hsa-miR-5001-5p 9.80E+01 8.86E-02 1.81E-01 1.54E+00 1.54E+00 1.33E+02hsa-miR-1301-5p 1.53E+02 9.03E-02 1.83E-01 2.77E+00 2.77E+00 3.08E+02hsa-miR-3127-5p 1.71E+02 9.03E-02 1.83E-01 1.56E+00 1.56E+00 2.77E+02hsa-miR-4802-5p 3.38E+02 9.37E-02 1.89E-01 6.87E-01 -1.46E+00 2.31E+02hsa-miR-4781-3p 1.74E+03 9.45E-02 1.89E-01 6.09E+00 6.09E+00 5.01E+03hsa-miR-6087 7.05E+02 9.70E-02 1.94E-01 1.74E+00 1.74E+00 9.30E+02hsa-miR-4767 1.88E+02 9.74E-02 1.94E-01 1.83E+00 1.83E+00 2.22E+02hsa-miR-7114-5p 2.83E+02 9.81E-02 1.94E-01 1.32E+00 1.32E+00 3.77E+02hsa-miR-663b 1.57E+03 9.95E-02 1.96E-01 1.51E+00 1.51E+00 1.76E+03hsa-miR-7107-3p 1.59E+02 9.98E-02 1.96E-01 1.18E+01 1.18E+01 7.39E+02hsa-miR-6803-5p 1.84E+02 1.01E-01 1.97E-01 1.98E+00 1.98E+00 3.36E+02hsa-miR-93-5p 3.82E+03 1.02E-01 1.99E-01 1.70E+00 1.70E+00 5.09E+03hsa-miR-5196-5p 1.04E+03 1.03E-01 1.99E-01 8.92E-01 -1.12E+00 5.36E+02hsa-miR-1289 9.10E+01 1.07E-01 2.05E-01 2.44E+00 2.44E+00 1.86E+02hsa-miR-27b-3p 4.41E+02 1.07E-01 2.05E-01 1.65E+00 1.65E+00 4.74E+02hsa-miR-3975 1.46E+02 1.07E-01 2.05E-01 5.14E+00 5.14E+00 3.25E+02hsa-miR-940 2.97E+02 1.07E-01 2.05E-01 1.35E+00 1.35E+00 3.53E+02hsa-miR-212-5p 3.48E+02 1.08E-01 2.05E-01 1.32E+00 1.32E+00 5.38E+02hsa-miR-432-3p 4.38E+02 1.08E-01 2.05E-01 1.42E+00 1.42E+00 3.69E+02hsa-miR-323a-5p 1.73E+02 1.13E-01 2.13E-01 1.25E+00 1.25E+00 1.49E+02hsa-miR-433-5p 1.26E+02 1.15E-01 2.15E-01 2.04E+00 2.04E+00 1.87E+02hsa-miR-1254 1.79E+02 1.16E-01 2.17E-01 1.39E+00 1.39E+00 1.76E+02hsa-miR-429 1.30E+03 1.19E-01 2.22E-01 1.45E+00 1.45E+00 1.52E+03hsa-miR-4787-5p 1.76E+04 1.21E-01 2.23E-01 7.91E-01 -1.26E+00 8.06E+03hsa-miR-6790-3p 2.87E+02 1.21E-01 2.23E-01 1.84E+00 1.84E+00 4.25E+02hsa-miR-4322 3.01E+02 1.23E-01 2.27E-01 1.71E+00 1.71E+00 3.24E+02hsa-miR-668-3p 8.51E+02 1.26E-01 2.31E-01 8.73E-01 -1.15E+00 7.22E+02hsa-miR-598-5p 2.88E+03 1.29E-01 2.35E-01 7.60E-01 -1.31E+00 1.22E+03hsa-miR-3185 1.39E+02 1.30E-01 2.36E-01 2.07E+00 2.07E+00 2.05E+02







hsa-miR-145-5p 9.60E+01 1.34E-01 2.42E-01 5.89E+00 5.89E+00 3.00E+02hsa-miR-3181 1.18E+03 1.36E-01 2.45E-01 8.82E-01 -1.13E+00 6.57E+02hsa-miR-762 6.05E+02 1.38E-01 2.47E-01 1.38E+00 1.38E+00 6.45E+02hsa-miR-4731-3p 3.78E+02 1.44E-01 2.58E-01 9.91E-01 -1.01E+00 3.34E+02hsa-miR-34b-3p 1.28E+02 1.48E-01 2.63E-01 1.74E+00 1.74E+00 1.87E+02hsa-miR-4449 2.59E+02 1.49E-01 2.64E-01 1.17E+00 1.17E+00 2.47E+02hsa-miR-6737-5p 2.26E+02 1.50E-01 2.66E-01 1.55E+00 1.55E+00 2.43E+02hsa-miR-1263 5.38E+02 1.55E-01 2.71E-01 1.25E+00 1.25E+00 4.74E+02hsa-miR-449b-3p 2.36E+02 1.54E-01 2.71E-01 1.16E+00 1.16E+00 2.70E+02hsa-miR-4792 6.08E+02 1.55E-01 2.71E-01 5.45E-01 -1.84E+00 3.17E+02hsa-miR-4488 1.42E+03 1.56E-01 2.72E-01 1.48E+00 1.48E+00 1.18E+03hsa-miR-1469 7.55E+02 1.60E-01 2.77E-01 1.22E+00 1.22E+00 7.61E+02hsa-miR-26a-5p 4.60E+03 1.61E-01 2.79E-01 1.65E+00 1.65E+00 5.70E+03hsa-miR-4730 1.48E+02 1.66E-01 2.87E-01 1.48E+00 1.48E+00 2.08E+02hsa-miR-125a-5p 4.63E+02 1.68E-01 2.88E-01 1.09E+00 1.09E+00 4.21E+02hsa-miR-132-3p 3.53E+02 1.68E-01 2.88E-01 1.36E+00 1.36E+00 3.15E+02hsa-miR-6856-5p 1.00E+02 1.71E-01 2.91E-01 1.74E+00 1.74E+00 1.17E+02hsa-miR-572 1.74E+02 1.75E-01 2.96E-01 2.17E+00 2.17E+00 2.43E+02hsa-miR-636 3.34E+02 1.75E-01 2.96E-01 1.10E+00 1.10E+00 3.83E+02hsa-miR-6723-5p 2.96E+02 1.78E-01 3.00E-01 1.05E+00 1.05E+00 4.61E+02hsa-miR-1268b 1.24E+02 1.82E-01 3.04E-01 2.09E+00 2.09E+00 1.44E+02hsa-miR-24-3p 2.08E+03 1.82E-01 3.04E-01 2.60E+00 2.60E+00 3.66E+03hsa-miR-6871-3p 8.13E+02 1.83E-01 3.05E-01 7.75E-01 -1.29E+00 5.38E+02hsa-miR-4785 8.55E+02 1.85E-01 3.07E-01 1.08E+00 1.08E+00 7.13E+02hsa-miR-3621 4.82E+02 1.91E-01 3.17E-01 3.38E+00 3.38E+00 1.18E+03hsa-miR-1281 1.59E+02 1.96E-01 3.22E-01 2.58E+00 2.58E+00 3.11E+02hsa-miR-578 4.95E+02 1.96E-01 3.22E-01 1.24E+00 1.24E+00 4.97E+02hsa-miR-2277-3p 1.62E+02 2.05E-01 3.35E-01 1.36E+00 1.36E+00 1.91E+02hsa-miR-5581-3p 3.06E+02 2.05E-01 3.35E-01 1.14E+00 1.14E+00 2.06E+02hsa-miR-3134 2.90E+03 2.07E-01 3.36E-01 1.52E+00 1.52E+00 2.57E+03hsa-miR-508-3p 1.44E+03 2.09E-01 3.39E-01 1.50E+00 1.50E+00 1.25E+03hsa-miR-103a-3p 6.97E+02 2.17E-01 3.40E-01 1.11E+00 1.11E+00 6.63E+02hsa-miR-103b 6.97E+02 2.17E-01 3.40E-01 1.11E+00 1.11E+00 6.63E+02hsa-miR-185-3p 1.53E+02 2.15E-01 3.40E-01 1.86E+00 1.86E+00 2.42E+02hsa-miR-1908-5p 2.36E+02 2.13E-01 3.40E-01 5.28E+00 5.28E+00 5.52E+02hsa-miR-4286 7.24E+02 2.12E-01 3.40E-01 1.01E+00 1.01E+00 4.90E+02hsa-miR-4459 2.34E+02 2.15E-01 3.40E-01 3.52E+00 3.52E+00 5.48E+02hsa-miR-4693-3p 7.08E+02 2.14E-01 3.40E-01 4.96E+00 4.96E+00 1.98E+03hsa-miR-4741 2.99E+02 2.12E-01 3.40E-01 3.16E+00 3.16E+00 5.07E+02hsa-miR-5696 8.50E+01 2.14E-01 3.40E-01 2.02E+00 2.02E+00 1.38E+02hsa-miR-30e-3p 2.08E+02 2.19E-01 3.43E-01 1.85E+00 1.85E+00 3.16E+02hsa-let-7c-5p 8.32E+02 2.28E-01 3.53E-01 3.35E+00 3.35E+00 1.48E+03hsa-miR-1295a 6.65E+01 2.28E-01 3.53E-01 1.29E+00 1.29E+00 7.80E+01







hsa-miR-1295b-5p 6.65E+01 2.28E-01 3.53E-01 1.29E+00 1.29E+00 7.80E+01hsa-miR-197-3p 1.09E+02 2.34E-01 3.61E-01 1.86E+00 1.86E+00 1.43E+02hsa-miR-3190-5p 1.56E+02 2.37E-01 3.65E-01 1.44E+00 1.44E+00 1.61E+02hsa-miR-6820-3p 1.55E+02 2.38E-01 3.65E-01 1.85E+00 1.85E+00 1.47E+02hsa-miR-1292-5p 3.33E+02 2.42E-01 3.71E-01 1.95E+00 1.95E+00 5.53E+02hsa-miR-4540 9.58E+03 2.44E-01 3.72E-01 1.25E+00 1.25E+00 7.70E+03hsa-miR-4634 5.84E+02 2.51E-01 3.81E-01 1.25E+00 1.25E+00 5.97E+02hsa-miR-6769b-5p 9.80E+01 2.56E-01 3.87E-01 2.63E+00 2.63E+00 1.95E+02hsa-miR-1228-5p 1.62E+02 2.64E-01 3.99E-01 2.02E+00 2.02E+00 1.93E+02hsa-miR-3663-5p 2.21E+02 2.68E-01 4.03E-01 1.43E+00 1.43E+00 3.22E+02hsa-miR-3184-5p 2.27E+03 2.71E-01 4.06E-01 1.09E+00 1.09E+00 2.39E+03hsa-miR-4265 2.39E+02 2.75E-01 4.10E-01 2.05E+00 2.05E+00 2.67E+02hsa-miR-503-3p 2.18E+02 2.75E-01 4.10E-01 2.97E+00 2.97E+00 4.05E+02hsa-miR-181b-5p 1.45E+03 2.83E-01 4.20E-01 1.68E+00 1.68E+00 1.84E+03hsa-miR-4298 1.01E+03 2.97E-01 4.40E-01 1.68E+00 1.68E+00 1.37E+03hsa-miR-193b-3p 1.97E+03 3.01E-01 4.44E-01 1.50E+00 1.50E+00 2.87E+03hsa-miR-423-3p 8.69E+02 3.02E-01 4.44E-01 2.76E+00 2.76E+00 1.69E+03hsa-miR-6765-3p 4.08E+03 3.03E-01 4.44E-01 1.32E+00 1.32E+00 4.64E+03hsa-miR-6822-3p 1.27E+02 3.05E-01 4.44E-01 2.10E+00 2.10E+00 2.12E+02hsa-miR-7109-5p 1.95E+02 3.04E-01 4.44E-01 2.43E+00 2.43E+00 3.00E+02hsa-miR-4457 1.98E+02 3.08E-01 4.47E-01 1.56E+00 1.56E+00 2.56E+02hsa-miR-4771 9.60E+01 3.12E-01 4.50E-01 6.45E+00 6.45E+00 3.72E+02hsa-miR-501-5p 3.98E+02 3.12E-01 4.50E-01 1.40E+00 1.40E+00 4.79E+02hsa-miR-6821-5p 6.18E+02 3.11E-01 4.50E-01 9.63E-01 -1.04E+00 5.24E+02hsa-miR-1908-3p 8.00E+02 3.19E-01 4.56E-01 1.16E+00 1.16E+00 8.48E+02hsa-miR-4448 3.01E+02 3.20E-01 4.56E-01 2.20E+00 2.20E+00 4.42E+02hsa-miR-6765-5p 3.43E+03 3.19E-01 4.56E-01 8.25E-01 -1.21E+00 1.95E+03hsa-miR-874-3p 3.93E+02 3.21E-01 4.56E-01 1.50E+00 1.50E+00 4.83E+02hsa-miR-483-5p 1.17E+02 3.24E-01 4.59E-01 2.82E+00 2.82E+00 2.27E+02hsa-miR-1915-3p 3.36E+02 3.33E-01 4.71E-01 1.62E+00 1.62E+00 4.77E+02hsa-miR-3196 5.82E+02 3.34E-01 4.71E-01 1.40E+00 1.40E+00 6.29E+02hsa-miR-1251-3p 3.41E+02 3.40E-01 4.76E-01 7.95E-01 -1.26E+00 2.64E+02hsa-miR-210-3p 1.45E+02 3.39E-01 4.76E-01 1.97E+00 1.97E+00 1.57E+02hsa-miR-4433a-5p 5.65E+01 3.45E-01 4.80E-01 5.51E+00 5.51E+00 1.27E+02hsa-miR-4433b-3p 5.65E+01 3.45E-01 4.80E-01 5.51E+00 5.51E+00 1.27E+02hsa-miR-301b-5p 4.13E+02 3.50E-01 4.85E-01 2.48E+00 2.48E+00 7.66E+02hsa-miR-6724-5p 1.53E+03 3.50E-01 4.85E-01 1.14E+00 1.14E+00 1.26E+03hsa-miR-214-3p 2.54E+02 3.54E-01 4.89E-01 3.78E-01 -2.64E+00 1.04E+02hsa-miR-23a-3p 3.65E+02 3.65E-01 5.01E-01 2.31E+00 2.31E+00 5.27E+02hsa-miR-6789-3p 3.15E+02 3.65E-01 5.01E-01 2.08E+00 2.08E+00 3.64E+02hsa-miR-6782-5p 7.90E+01 3.71E-01 5.08E-01 3.10E+00 3.10E+00 1.48E+02hsa-miR-6804-5p 8.12E+04 3.80E-01 5.18E-01 8.89E-01 -1.13E+00 3.67E+04hsa-miR-4721 9.98E+02 3.98E-01 5.41E-01 1.64E+00 1.64E+00 1.19E+03







hsa-miR-186-5p 5.03E+02 4.09E-01 5.52E-01 2.73E+00 2.73E+00 8.84E+02hsa-miR-30b-5p 2.98E+03 4.08E-01 5.52E-01 1.13E+00 1.13E+00 2.79E+03hsa-miR-106b-5p 8.86E+02 4.26E-01 5.72E-01 1.44E+00 1.44E+00 9.10E+02hsa-miR-7847-3p 5.70E+02 4.25E-01 5.72E-01 2.93E+00 2.93E+00 1.14E+03hsa-miR-133a-5p 1.66E+02 4.32E-01 5.77E-01 2.85E+00 2.85E+00 4.00E+02hsa-miR-4709-3p 1.72E+02 4.32E-01 5.77E-01 1.82E+00 1.82E+00 2.38E+02hsa-miR-4292 1.46E+02 4.35E-01 5.79E-01 2.30E+00 2.30E+00 2.33E+02hsa-miR-342-3p 1.60E+02 4.40E-01 5.85E-01 3.42E+00 3.42E+00 2.73E+02hsa-miR-4665-3p 3.98E+02 4.43E-01 5.86E-01 2.16E+00 2.16E+00 5.28E+02hsa-miR-611 1.07E+02 4.43E-01 5.86E-01 2.36E+00 2.36E+00 2.04E+02hsa-miR-140-3p 4.26E+02 4.51E-01 5.94E-01 4.32E+00 4.32E+00 1.10E+03hsa-miR-1299 7.31E+02 4.58E-01 6.02E-01 5.52E+00 5.52E+00 1.99E+03hsa-miR-4745-5p 1.26E+02 4.63E-01 6.06E-01 1.94E+00 1.94E+00 1.81E+02hsa-miR-223-3p 1.77E+02 4.66E-01 6.08E-01 2.67E+00 2.67E+00 3.63E+02hsa-miR-30c-5p 6.77E+02 4.67E-01 6.08E-01 1.25E+00 1.25E+00 6.89E+02hsa-miR-141-3p 2.19E+03 4.79E-01 6.15E-01 1.06E+00 1.06E+00 2.15E+03hsa-miR-374b-5p 1.22E+02 4.79E-01 6.15E-01 3.65E+00 3.65E+00 2.39E+02hsa-miR-374c-3p 1.22E+02 4.79E-01 6.15E-01 3.65E+00 3.65E+00 2.39E+02hsa-miR-4707-5p 4.47E+02 4.76E-01 6.15E-01 1.78E+00 1.78E+00 4.92E+02hsa-miR-4769-3p 9.80E+01 4.79E-01 6.15E-01 2.76E+00 2.76E+00 2.01E+02hsa-miR-200b-5p 9.31E+02 4.88E-01 6.25E-01 2.30E+00 2.30E+00 1.52E+03hsa-miR-148a-3p 1.22E+04 5.08E-01 6.47E-01 1.49E+00 1.49E+00 1.44E+04hsa-miR-499a-5p 1.65E+03 5.08E-01 6.47E-01 1.98E+00 1.98E+00 2.42E+03hsa-miR-4466 4.95E+02 5.11E-01 6.50E-01 2.04E+00 2.04E+00 6.07E+02hsa-miR-3922-5p 1.25E+03 5.17E-01 6.52E-01 1.41E+00 1.41E+00 1.50E+03hsa-miR-4433a-3p 5.70E+01 5.19E-01 6.52E-01 2.97E+00 2.97E+00 1.19E+02hsa-miR-4433b-5p 5.70E+01 5.19E-01 6.52E-01 2.97E+00 2.97E+00 1.19E+02hsa-miR-4516 1.79E+03 5.15E-01 6.52E-01 2.17E+00 2.17E+00 2.04E+03hsa-miR-6836-3p 2.35E+03 5.21E-01 6.53E-01 9.40E-01 -1.06E+00 1.78E+03hsa-miR-4469 1.91E+03 5.24E-01 6.55E-01 8.07E-01 -1.24E+00 2.16E+03hsa-miR-5088-3p 2.67E+02 5.28E-01 6.58E-01 2.30E+00 2.30E+00 4.54E+02hsa-miR-378d 4.39E+02 5.29E-01 6.58E-01 1.73E+00 1.73E+00 5.33E+02hsa-let-7i-5p 1.66E+03 5.32E-01 6.60E-01 2.72E+00 2.72E+00 2.84E+03hsa-miR-1245a 2.80E+03 5.34E-01 6.60E-01 1.41E+00 1.41E+00 2.34E+03hsa-miR-146b-5p 5.17E+03 5.37E-01 6.62E-01 1.08E+00 1.08E+00 5.15E+03hsa-miR-6787-5p 3.17E+02 5.43E-01 6.68E-01 3.11E+00 3.11E+00 5.55E+02hsa-miR-422a 5.32E+02 5.51E-01 6.74E-01 1.36E+00 1.36E+00 4.73E+02hsa-miR-6090 3.98E+02 5.50E-01 6.74E-01 3.76E+00 3.76E+00 8.91E+02hsa-miR-3183 1.31E+02 5.55E-01 6.77E-01 2.01E+00 2.01E+00 2.70E+02hsa-miR-6727-3p 2.66E+02 5.56E-01 6.77E-01 4.72E+00 4.72E+00 5.21E+02hsa-miR-8069 3.13E+02 5.58E-01 6.77E-01 1.84E+00 1.84E+00 4.27E+02hsa-miR-224-5p 1.54E+02 5.68E-01 6.85E-01 2.52E+00 2.52E+00 3.54E+02hsa-miR-564 8.05E+04 5.67E-01 6.85E-01 9.12E-01 -1.10E+00 3.68E+04







hsa-miR-718 7.87E+02 5.68E-01 6.85E-01 2.09E+00 2.09E+00 1.06E+03hsa-miR-21-5p 6.29E+03 5.70E-01 6.85E-01 1.76E+00 1.76E+00 9.06E+03hsa-miR-6734-5p 1.53E+02 5.76E-01 6.91E-01 5.33E+00 5.33E+00 4.93E+02hsa-miR-30a-5p 5.18E+03 5.84E-01 6.98E-01 1.37E+00 1.37E+00 5.94E+03hsa-miR-148b-3p 6.86E+02 5.98E-01 7.12E-01 1.07E+00 1.07E+00 6.82E+02hsa-miR-664a-5p 4.46E+02 5.99E-01 7.12E-01 2.68E+00 2.68E+00 7.51E+02hsa-miR-335-5p 3.38E+03 6.15E-01 7.30E-01 1.29E+00 1.29E+00 3.37E+03hsa-miR-589-5p 6.36E+02 6.17E-01 7.30E-01 4.52E+00 4.52E+00 1.84E+03hsa-miR-7641 4.27E+03 6.25E-01 7.37E-01 9.37E-01 -1.07E+00 3.78E+03hsa-miR-4294 3.81E+03 6.30E-01 7.42E-01 1.50E+00 1.50E+00 3.78E+03hsa-miR-99a-5p 1.04E+03 6.41E-01 7.53E-01 2.19E+00 2.19E+00 1.48E+03hsa-miR-499b-3p 2.92E+02 6.44E-01 7.54E-01 9.78E-01 -1.02E+00 2.47E+02hsa-miR-1183 7.25E+02 6.49E-01 7.58E-01 1.76E+00 1.76E+00 6.90E+02hsa-miR-1292-3p 2.51E+02 6.52E-01 7.60E-01 2.80E+00 2.80E+00 4.12E+02hsa-miR-493-5p 1.43E+03 6.57E-01 7.63E-01 1.55E+00 1.55E+00 1.31E+03hsa-miR-4776-3p 5.80E+01 6.63E-01 7.69E-01 1.48E+00 1.48E+00 7.53E+01hsa-miR-4530 5.43E+02 6.71E-01 7.74E-01 1.72E+00 1.72E+00 6.17E+02hsa-miR-6850-3p 1.25E+02 6.69E-01 7.74E-01 3.33E+00 3.33E+00 2.19E+02hsa-miR-4532 1.09E+03 6.80E-01 7.80E-01 1.81E+00 1.81E+00 1.19E+03hsa-miR-6799-3p 8.20E+01 6.78E-01 7.80E-01 5.95E+00 5.95E+00 2.31E+02hsa-miR-191-5p 2.49E+03 7.08E-01 8.09E-01 2.14E+00 2.14E+00 3.53E+03hsa-miR-28-3p 1.55E+02 7.08E-01 8.09E-01 2.86E+00 2.86E+00 3.01E+02hsa-miR-200a-3p 4.22E+03 7.11E-01 8.10E-01 1.41E+00 1.41E+00 4.84E+03hsa-miR-330-3p 1.71E+02 7.14E-01 8.11E-01 2.46E+00 2.46E+00 2.80E+02hsa-miR-1199-5p 4.40E+02 7.20E-01 8.13E-01 2.56E+00 2.56E+00 6.21E+02hsa-miR-224-3p 6.26E+02 7.18E-01 8.13E-01 2.55E+00 2.55E+00 1.08E+03hsa-miR-99b-5p 4.24E+02 7.20E-01 8.13E-01 2.34E+00 2.34E+00 6.91E+02hsa-miR-182-5p 1.36E+03 7.28E-01 8.18E-01 2.22E+00 2.22E+00 2.18E+03hsa-miR-5701 6.94E+02 7.28E-01 8.18E-01 6.58E-01 -1.52E+00 1.18E+03hsa-miR-7978 1.89E+03 7.31E-01 8.19E-01 9.93E-01 -1.01E+00 2.50E+03hsa-miR-1249-5p 1.14E+02 7.48E-01 8.34E-01 1.78E+00 1.78E+00 1.41E+02hsa-miR-3907 9.79E+02 7.50E-01 8.34E-01 1.28E+00 1.28E+00 9.28E+02hsa-miR-637 2.68E+02 7.50E-01 8.34E-01 2.18E+00 2.18E+00 3.68E+02hsa-miR-25-3p 6.66E+02 7.52E-01 8.35E-01 1.89E+00 1.89E+00 9.39E+02hsa-miR-6831-5p 3.74E+02 7.60E-01 8.42E-01 3.32E+00 3.32E+00 6.42E+02hsa-miR-3184-3p 2.86E+02 7.64E-01 8.42E-01 3.23E+00 3.23E+00 4.54E+02hsa-miR-423-5p 2.86E+02 7.64E-01 8.42E-01 3.23E+00 3.23E+00 4.54E+02hsa-let-7d-5p 7.23E+02 7.67E-01 8.44E-01 2.04E+00 2.04E+00 1.14E+03hsa-miR-6085 9.80E+01 7.70E-01 8.44E-01 2.35E+00 2.35E+00 1.43E+02hsa-miR-3176 1.46E+02 7.74E-01 8.47E-01 1.86E+00 1.86E+00 1.86E+02hsa-miR-1224-3p 9.50E+01 7.77E-01 8.48E-01 2.41E+00 2.41E+00 1.48E+02hsa-miR-23b-3p 2.24E+02 7.86E-01 8.56E-01 2.85E+00 2.85E+00 3.70E+02hsa-miR-3074-3p 1.08E+02 7.98E-01 8.64E-01 5.12E+00 5.12E+00 2.37E+02






LSMean (Premie) (pMBM v. tMBM)

hsa-miR-3666 3.53E+04 7.98E-01 8.64E-01 9.39E-01 -1.06E+00 2.37E+04hsa-miR-16-5p 1.51E+03 8.02E-01 8.67E-01 1.77E+00 1.77E+00 2.05E+03hsa-miR-4443 2.23E+03 8.08E-01 8.70E-01 2.14E+00 2.14E+00 2.78E+03hsa-miR-506-5p 8.80E+01 8.08E-01 8.70E-01 4.03E+00 4.03E+00 2.11E+02hsa-miR-6089 1.30E+03 8.15E-01 8.73E-01 1.30E+00 1.30E+00 1.41E+03hsa-miR-921 1.81E+02 8.15E-01 8.73E-01 5.68E+00 5.68E+00 5.00E+02hsa-miR-522-3p 3.95E+02 8.23E-01 8.80E-01 1.11E+00 1.11E+00 3.34E+02hsa-miR-4707-3p 1.41E+02 8.25E-01 8.80E-01 2.78E+00 2.78E+00 2.32E+02hsa-miR-6746-3p 3.10E+02 8.34E-01 8.83E-01 3.64E+00 3.64E+00 4.98E+02hsa-miR-6789-5p 1.89E+03 8.33E-01 8.83E-01 1.68E+00 1.68E+00 2.46E+03hsa-miR-7977 3.74E+03 8.32E-01 8.83E-01 8.52E-01 -1.17E+00 2.37E+03hsa-miR-6762-5p 1.18E+02 8.38E-01 8.86E-01 2.71E+00 2.71E+00 1.67E+02hsa-miR-146a-5p 6.91E+02 8.45E-01 8.86E-01 5.17E+00 5.17E+00 1.54E+03hsa-miR-663a 8.33E+02 8.43E-01 8.86E-01 1.36E+00 1.36E+00 9.39E+02hsa-miR-6748-5p 1.18E+02 8.41E-01 8.86E-01 2.49E+00 2.49E+00 1.99E+02hsa-miR-8072 4.62E+02 8.46E-01 8.86E-01 3.43E+00 3.43E+00 7.43E+02hsa-miR-200b-3p 2.99E+03 8.50E-01 8.88E-01 2.59E+00 2.59E+00 4.63E+03hsa-miR-30a-3p 1.32E+03 8.52E-01 8.88E-01 3.70E+00 3.70E+00 2.36E+03hsa-miR-3960 2.54E+03 8.58E-01 8.92E-01 1.64E+00 1.64E+00 2.77E+03hsa-miR-4454 3.65E+04 8.62E-01 8.92E-01 9.92E-01 -1.01E+00 2.53E+04hsa-miR-6869-5p 8.47E+02 8.61E-01 8.92E-01 3.92E+00 3.92E+00 1.38E+03hsa-miR-4655-3p 2.63E+02 8.72E-01 9.01E-01 4.29E+00 4.29E+00 4.54E+02hsa-miR-192-5p 1.68E+02 8.75E-01 9.02E-01 4.07E+00 4.07E+00 3.28E+02hsa-miR-125b-2-3p 9.03E+02 8.85E-01 9.11E-01 3.23E+00 3.23E+00 1.60E+03hsa-miR-3614-3p 5.84E+02 8.95E-01 9.18E-01 1.22E+00 1.22E+00 5.86E+02hsa-miR-146b-3p 6.90E+02 9.00E-01 9.22E-01 1.34E+00 1.34E+00 8.49E+02hsa-miR-22-3p 4.34E+03 9.09E-01 9.28E-01 1.26E+00 1.26E+00 4.88E+03hsa-miR-574-3p 1.84E+02 9.13E-01 9.31E-01 2.22E+00 2.22E+00 2.63E+02hsa-miR-324-3p 1.46E+02 9.28E-01 9.45E-01 2.21E+00 2.21E+00 2.64E+02hsa-miR-6880-5p 9.83E+02 9.31E-01 9.45E-01 1.62E+00 1.62E+00 1.07E+03hsa-miR-1470 9.70E+01 9.37E-01 9.48E-01 1.67E+00 1.67E+00 1.43E+02hsa-miR-4632-3p 2.21E+02 9.38E-01 9.48E-01 1.60E+00 1.60E+00 4.01E+02hsa-miR-195-5p 1.57E+02 9.44E-01 9.52E-01 3.03E+00 3.03E+00 3.39E+02hsa-miR-769-3p 1.74E+02 9.54E-01 9.60E-01 3.85E+00 3.85E+00 3.77E+02hsa-miR-7114-3p 2.65E+02 9.85E-01 9.89E-01 2.06E+00 2.06E+00 3.63E+02hsa-miR-5694 2.74E+02 9.88E-01 9.90E-01 5.19E+00 5.19E+00 6.85E+02hsa-miR-200a-5p 2.15E+02 9.93E-01 9.93E-01 2.47E+00 2.47E+00 3.61E+02

Abbreviations: FDR = Benjamini Hochberg False Detection Rate, LSMean = least-squares mean, pMBM = premature maternal breast milk, tMBM = term maternal breast milk.

Supplementary Table S2. The miRNAs “altered” in lipid pMBM target mRNAs enriched in 90 gene ontology (GO) processes (A) and 24 KEGG Pathways (B), many of which are related to metabolic regulation and biosynthesis.

A BGO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)organelle 1.35E-96 1877 14 Arrhythmogenic right ventricular

cardiomyopathy (ARVC)0.0007 22

ion binding 3.49E-68 1216 14 Lysine degradation 0.0007 14cellular nitrogen compound metabolic process

1.36E-61 960 14 FoxO signaling pathway 0.0007 37

biosynthetic process 3.57E-35 777 14 Ubiquitin mediated proteolysis 0.0012 38cellular protein modification process

1.99E-28 479 14 Thyroid hormone signaling pathway

0.0014 32

gene expression 2.47E-24 142 13 Pathways in cancer 0.0017 94Molecular function 4.28E-19 2986 14 Wnt signaling pathway 0.0041 37nucleic acid binding transcription factor activity

1.03E-16 219 14 Valine, leucine and isoleucine biosynthesis

0.0129 2

catabolic process 8.96E-15 369 14 Insulin secretion 0.0129 26protein complex 7.75E-14 694 14 TGF-beta signaling pathway 0.0187 20neurotrophin TRK receptor signaling pathway

6.52E-13 62 13 Signaling pathways regulating pluripotency of stem cells

0.0187 35

symbiosis, encompassing mutualism through parasitism

1.06E-12 111 13 Ras signaling pathway 0.0192 54

small molecule metabolic process

1.23E-12 413 13 Protein processing in endoplasmic reticulum

0.0192 42

viral process 3.01E-12 99 13 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

0.0270 7

nucleoplasm 6.20E-12 240 14 Glycosaminoglycan biosynthesis - heparan sulfate / heparin

0.0270 8

Fc-epsilon receptor signaling pathway

1.15E-11 43 13 mTOR signaling pathway 0.0270 20

enzyme binding 1.15E-11 253 14 Oxytocin signaling pathway 0.0271 38

GO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)Cellular component 1.19E-10 2972 14 Circadian rhythm 0.0311 12

protein binding transcription factor activity

1.24E-10 108 13 Adherens junction 0.0311 19

nucleobase-containing compound catabolic process

2.53E-09 175 14 Renal cell carcinoma 0.031096615

18

epidermal growth factor receptor signaling pathway

3.89E-09 55 13 AMPK signaling pathway 0.031096615

32

cellular component assembly 5.51E-09 241 14 Cell adhesion molecules (CAMs) 0.031096615

31

synaptic transmission 3.77E-07 90 13 Basal cell carcinoma 0.036661464

17

mitotic cell cycle 4.93E-07 75 13 Transcriptional misregulation in cancer

0.036661464

47

macromolecular complex assembly

6.93E-07 163 14

cellular protein metabolic process

1.02E-06 83 14

cytosol 2.76E-06 472 14membrane organization 2.97E-06 110 13blood coagulation 3.24E-06 84 13cell death 3.76E-06 170 14

phosphatidylinositol-mediated signaling

4.87E-06 37 13

cytoskeletal protein binding 4.87E-06 146 14

fibroblast growth factor receptor signaling pathway

3.35E-05 45 13

Biological process 3.35E-05 2843 14

post-translational protein modification

6.47E-05 34 13

cell-cell signaling 6.91E-05 123 13

GO Category FDR genes (n) miRNAs (n)transcription, DNA-templated 7.83E-05 451 14

platelet activation 0.0004 41 12transmembrane transporter activity

0.0005 189 13

cellular lipid metabolic process 0.0005 30 13energy reserve metabolic process

0.0006 24 10

DNA metabolic process 0.0007 137 14

small conjugating protein binding 0.0008 25 14toll-like receptor 10 signaling pathway

0.0010 15 9

response to stress 0.0010 364 14toll-like receptor 9 signaling pathway

0.0014 17 10

protein complex assembly 0.0017 131 13

TRIF-dependent toll-like receptor signaling pathway

0.0019 16 10

mRNA metabolic process 0.0020 38 12

cytoskeleton-dependent intracellular transport

0.0021 27 11

toll-like receptor TLR1:TLR2 signaling pathway

0.0021 15 9

toll-like receptor TLR6:TLR2 signaling pathway

0.0021 15 9

Fc-gamma receptor signaling pathway involved in phagocytosis

0.0021 16 10

RNA metabolic process 0.0023 44 13

cellular component disassembly involved in execution phase of apoptosis

0.0025 12 9

GO Category FDR genes (n) miRNAs (n)

toll-like receptor 5 signaling pathway

0.0046 15 9

activation of signaling protein activity involved in unfolded protein response

0.0059 15 8

cell junction assembly 0.0059 15 11microtubule organizing center 0.0059 86 13

MyD88-independent toll-like receptor signaling pathway

0.0070 16 10

integral component of plasma membrane

0.0075 220 13

junctional sarcoplasmic reticulum membrane

0.0092 6 5

toll-like receptor signaling pathway

0.0092 23 13

platelet degranulation 0.0097 16 10

ribonucleoprotein complex assembly

0.0097 32 12

RNA binding 0.0108 305 14


0.0111 20 11

in utero embryonic development 0.0111 74 14C-terminal protein lipidation 0.0114 9 10

transcription initiation from RNA polymerase II promoter

0.0114 43 12

adherens junction organization 0.0122 13 8

post-Golgi vesicle-mediated transport

0.0140 13 8

GO Category FDR genes (n) miRNAs (n)

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

0.0145 15 9


0.0179 16 9

nucleobase-containing small molecule metabolic process

0.0239 14 9


0.0272 16 10

enzyme regulator activity 0.0272 134 13

homeostatic process 0.0290 137 13

vesicle-mediated transport 0.0290 176 13

G2/M transition of mitotic cell cycle

0.0310 29 11

phospholipid metabolic process 0.0353 32 10

chondroitin sulfate metabolic process

0.0360 11 6

protein binding, bridging 0.0366 32 13

cell junction organization 0.0383 29 11sphingolipid biosynthetic process 0.0409 12 8

inositol phosphate metabolic process

0.0435 10 7

cell motility 0.0448 96 13

glycosaminoglycan metabolic process

0.0468 19 8

chromatin organization 0.0486 25 8

insulin receptor signaling pathway

0.0490 33 12

Supplementary Table S3. All miRNAs detected in the skim fraction of pMBM and tMBM

P-value(pMBM v. tMBM)

FDR step up(pMBM v. tMBM)

Ratio(pMBM v. tMBM)


LSMean(pMBM v. tMBM)

4.93E-06 1.58E-04 4.72E-01 -2.12E+00 1.67E+044.23E-05 6.40E-04 5.26E-01 -1.90E+00 2.36E+046.00E-05 6.40E-04 2.50E+00 2.50E+00 2.04E+039.33E-05 7.47E-04 5.66E-01 -1.77E+00 3.25E+041.25E-04 7.84E-04 6.04E-01 -1.66E+00 3.75E+041.71E-04 7.84E-04 5.92E-01 -1.69E+00 2.18E+041.56E-04 7.84E-04 5.99E-01 -1.67E+00 8.15E+032.26E-04 9.03E-04 2.12E+00 2.12E+00 7.27E+034.45E-03 1.58E-02 1.76E+00 1.76E+00 6.36E+035.28E-03 1.69E-02 1.69E+00 1.69E+00 8.55E+031.07E-02 3.11E-02 2.24E+00 2.24E+00 2.98E+031.86E-02 4.97E-02 7.22E-01 -1.39E+00 2.41E+043.27E-02 8.06E-02 7.97E-01 -1.26E+00 1.08E+044.55E-02 9.72E-02 1.20E+00 1.20E+00 9.15E+034.56E-02 9.72E-02 7.14E-01 -1.40E+00 7.65E+035.48E-02 1.10E-01 7.84E-01 -1.28E+00 1.68E+047.68E-02 1.41E-01 7.16E-01 -1.40E+00 8.16E+037.90E-02 1.41E-01 1.49E+00 1.49E+00 6.85E+038.41E-02 1.42E-01 1.64E+00 1.64E+00 5.01E+031.06E-01 1.69E-01 8.48E-01 -1.18E+00 1.09E+041.23E-01 1.87E-01 6.74E-01 -1.48E+00 1.82E+031.57E-01 2.29E-01 9.66E-01 -1.04E+00 4.19E+042.59E-01 3.61E-01 8.38E-01 -1.19E+00 1.05E+033.58E-01 4.77E-01 1.20E+00 1.20E+00 2.47E+033.81E-01 4.87E-01 8.85E-01 -1.13E+00 3.09E+045.06E-01 6.04E-01 9.24E-01 -1.08E+00 1.65E+045.09E-01 6.04E-01 8.53E-01 -1.17E+00 6.31E+045.80E-01 6.63E-01 1.23E+00 1.23E+00 5.38E+036.35E-01 7.01E-01 1.61E+00 1.61E+00 1.81E+038.07E-01 8.60E-01 8.62E-01 -1.16E+00 3.54E+048.96E-01 9.25E-01 1.56E+00 1.56E+00 7.96E+039.54E-01 9.54E-01 8.79E-01 -1.14E+00 3.63E+04

Abbreviations: pMBM = premature maternal breast milk, tMBM = term maternal breast milk

Supplementary Table S4. The miRNAs “altered” in skim pMBM target mRNAs enriched in 10 gene ontology (GO) processes (A) and 9 KEGG Pathways (B), many of which are related to metabolism and biosynthesis.

A B

GO Category FDRgenes (n) miRNAs (n) KEGG pathway FDR

genes (n) miRNAs (n)

cellular nitrogen compound metabolic process

3.60E-62 484 5 Glycosphingolipid biosynthesis - ganglio series

5.24E-09 6 4

organelle 4.10E-44 1108 7 Lysine degradation 0.0144 10 5ion binding 2.10E-13 668 6 Calcium signaling pathway 0.0144 32 5biosynthetic process 4.67E-09 302 3 Adherens junction 0.0144 17 10

nucleic acid binding transcription factor activity

4.06E-06 114 3Circadian entrainment

0.0183 22 6

symbiosis, encompassing mutualism through parasitism

0.0012 32 1 Glycosphingolipid biosynthesis - globo series

0.0226 5 2

cellular protein modification process

0.0024 134 2Oxytocin signaling pathway

0.0226 31 9

viral process 0.0088 26 1 2-Oxocarboxylic acid metabolism 0.0326 4 5

homophilic cell adhesion via plasma membrane adhesion molecules

0.0136 44 2 Arrhythmogenic right ventricular cardiomyopathy (ARVC)

0.0326 16 6

protein binding transcription factor activity 0.0261 30 1

Supplementary Table S5. The nine miRNAs “altered” in both lipid and skim fractions of pMBM target mRNAs enriched in 42 gene ontology (GO) processes (A) and 5 KEGG Pathways (B)

A B

GO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)miRNAs (n)

organelle (GO:0043226) 2.74E-42 1091 8

Glycosphingolipid biosynthesis - ganglio series(hsa00604)

9.32E-09 5 3

cellular nitrogen compound metabolic process (GO:0034641)

9.84E-32 569 8 Lysine

degradation (hsa00310) 0.0037 10 5

ion binding (GO:0043167) 4.30E-28 694 8 Calcium signaling

pathway (hsa04020) 0.0037 32 5

biosynthetic process (GO:0009058)

1.71E-19 468 8 Adherens

junction (hsa04520) 0.0092 16 8

nucleic acid binding transcription factor activity (GO:0001071)

3.28E-12 142 8

Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)

0.0184 16 5

cellular protein modification process (GO:0006464)

4.38E-10 265 8

neurotrophin TRK receptor signaling pathway (GO:0048011)

7.02E-09 41 8

symbiosis, encompassing mutualism through parasitism (GO:0044403)

5.30E-08 70 8

viral process (GO:0016032) 1.74E-07 62 8

molecular_function (GO:0003674)

7.39E-06 1780 8

protein binding transcription factor activity (GO:0000988)

1.36E-05 65 8

gene expression (GO:0010467)

1.96E-05 65 6

small molecule metabolic process (GO:0044281) 0.0001 236 8

nucleoplasm (GO:0005654) 0.0001 136 8

cellular component assembly (GO:0022607) 0.0002 144 8

cellular_component (GO:0005575) 0.0003 1790 8

cytoskeletal protein binding (GO:0008092) 0.0006 92 8

blood coagulation (GO:0007596) 0.0007 53 8

catabolic process (GO:0009056) 0.0008 198 8

homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)

0.0012 52 5

enzyme binding (GO:0019899) 0.0017 138 8

synaptic transmission (GO:0007268) 0.0018 53 8

cell-cell signaling (GO:0007267) 0.0074 76 8

integral component of plasma membrane (GO:0005887) 0.0074 145 8

macromolecular complex assembly (GO:0065003) 0.0080 94 8

mitotic cell cycle (GO:0000278) 0.0083 42 7

protein complex (GO:0043234) 0.0086 379 8

cellular component disassembly involved in execution phase of apoptosis

0.0103 9 5

(GO:0006921)energy reserve metabolic process (GO:0006112)

0.0105 16 6

transcription, DNA-templated (GO:0006351) 0.0112 274 8

epidermal growth factor receptor signaling pathway (GO:0007173)

0.0146 27 7

nucleobase-containing compound catabolic process (GO:0034655)

0.0148 93 8

cell junction assembly (GO:0034329) 0.0188 11 6

Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)

0.0204 11 5

glycosaminoglycan metabolic process (GO:0030203) 0.0275 15 4

protein complex assembly (GO:0006461) 0.0275 82 8

transmembrane transporter activity (GO:0022857) 0.0412 114 8

cell junction organization (GO:0034330) 0.0472 21 6

post-translational protein modification (GO:0043687) 0.0472 19 7

cell death (GO:0008219) 0.0472 95 8

membrane organization (GO:0061024) 0.0473 60 8

inositol phosphate metabolic process (GO:0043647) 0.0495 8 5

Supplementary Table S6. miRNAs with significant differences between pMBM (collected 3-4 weeks post-delivery), tMBM (collected 3-4 weeks post-delivery) and term colostrum

MicroRNA Chi Squared KW pval -Log10 FDRhsa-miR-639 38.173 5.14E-09 8.2892 5.46E-07hsa-miR-6772-3p 38.159 5.17E-09 8.2861 5.46E-07hsa-miR-4668-5p 33.748 4.70E-08 7.3282 2.68E-06hsa-miR-1303 33.282 5.93E-08 7.2271 2.68E-06hsa-miR-3655 33.148 6.34E-08 7.1979 2.68E-06hsa-miR-491-3p 31.825 1.23E-07 6.9107 3.69E-06hsa-miR-2276-3p 31.817 1.23E-07 6.909 3.69E-06hsa-miR-208b-3p 31.567 1.40E-07 6.8547 3.69E-06hsa-miR-15a-5p 30.612 2.25E-07 6.6472 5.28E-06hsa-miR-375 29.358 4.22E-07 6.3751 8.90E-06hsa-miR-30d-5p 28.836 5.47E-07 6.2617 1.05E-05hsa-miR-3934-5p 27.816 9.12E-07 6.0401 1.60E-05hsa-miR-30b-5p 27.3 1.18E-06 5.9282 1.91E-05hsa-miR-3614-3p 27.114 1.30E-06 5.8877 1.95E-05hsa-miR-7641 26.095 2.16E-06 5.6665 3.03E-05hsa-miR-7704 25.326 3.17E-06 5.4995 4.18E-05hsa-let-7d-3p 24.982 3.76E-06 5.4248 4.46E-05hsa-miR-183-5p 24.958 3.81E-06 5.4196 4.46E-05hsa-miR-4687-3p 24.301 5.29E-06 5.2768 5.55E-05hsa-miR-4680-3p 24.146 5.71E-06 5.2433 5.55E-05hsa-miR-3195 24.127 5.77E-06 5.2391 5.55E-05hsa-miR-4286 24.122 5.78E-06 5.2379 5.55E-05hsa-miR-193b-3p 23.636 7.37E-06 5.1325 6.76E-05hsa-miR-4454 22.38 1.38E-05 4.8597 0.0001

hsa-miR-668-3p 22.238 1.48E-05 4.8288 0.0001

hsa-miR-3944-5p 22.136 1.56E-05 4.8067 0.0001

hsa-miR-6871-3p 21.861 1.79E-05 4.7472 0.0001

hsa-miR-6090 21.357 2.30E-05 4.6376 0.0002

hsa-miR-30e-5p 20.171 4.17E-05 4.38 0.0003

hsa-miR-1260a 20.064 4.40E-05 4.3568 0.0003

hsa-miR-499a-5p 19.801 5.02E-05 4.2997 0.0003

hsa-miR-182-5p 19.694 5.29E-05 4.2764 0.0003

hsa-miR-650 19.576 5.61E-05 4.2509 0.0004

hsa-miR-1260b 19.369 6.22E-05 4.2059 0.0004

hsa-miR-4492 19.276 6.52E-05 4.1858 0.0004

hsa-miR-429 19.055 7.28E-05 4.1377 0.0004

hsa-miR-4664-5p 19.018 7.42E-05 4.1297 0.0004

hsa-miR-6757-5p 18.701 8.69E-05 4.061 0.0005

hsa-miR-5010-3p 18.11 0.00011682 3.9325 0.0006

hsa-miR-378a-3p 16.843 0.00022007 3.6574 0.0011

hsa-miR-7977 16.819 0.00022271 3.6523 0.0011

hsa-miR-7975 16.628 0.00024507 3.6107 0.0012

hsa-miR-589-5p 16.595 0.00024917 3.6035 0.0012

hsa-miR-146b-5p 16.585 0.00025037 3.6014 0.0012

hsa-miR-4294 16.162 0.00030932 3.5096 0.0015

hsa-miR-1913 16.097 0.00031961 3.4954 0.0015

hsa-miR-378g 15.935 0.00034652 3.4603 0.0016

hsa-miR-6765-5p 15.404 0.00045198 3.3449 0.0020

hsa-miR-378c 15.277 0.00048153 3.3174 0.0021

hsa-miR-1343-5p 15.04 0.00054215 3.2659 0.0023

hsa-miR-22-3p 14.946 0.00056819 3.2455 0.0024

hsa-miR-212-5p 14.715 0.00063775 3.1954 0.0026

hsa-miR-378i 14.671 0.00065212 3.1857 0.0026

hsa-miR-6821-5p 14.667 0.00065339 3.1848 0.0026

hsa-miR-200b-5p 14.535 0.00069787 3.1562 0.0027

hsa-miR-663a 14.401 0.00074625 3.1271 0.0028

hsa-miR-5787 14.154 0.00084434 3.0735 0.0031

hsa-miR-200a-3p 13.917 0.00095037 3.0221 0.0035

hsa-miR-3134 13.859 0.00097867 3.0094 0.0035

hsa-miR-3907 13.78 0.0010178 2.9923 0.0036

hsa-miR-1180-5p 13.642 0.0010905 2.9624 0.0038

hsa-miR-3621 13.581 0.0011245 2.949 0.0038

hsa-miR-493-5p 13.335 0.0012715 2.8957 0.0043

hsa-miR-21-5p 13.106 0.0014256 2.846 0.0047

hsa-miR-6724-5p 13.087 0.0014393 2.8419 0.0047

hsa-miR-6836-3p 13.018 0.0014899 2.8268 0.0047

hsa-miR-1245a 12.983 0.0015163 2.8192 0.0047

hsa-miR-148b-3p 12.95 0.0015411 2.8122 0.0047

hsa-miR-5196-3p 12.94 0.0015489 2.81 0.0047

hsa-let-7g-3p 12.923 0.0015626 2.8061 0.0047

hsa-miR-4783-3p 12.917 0.001567 2.8049 0.0047

hsa-miR-1908-5p 12.732 0.0017189 2.7647 0.0050

hsa-miR-148a-3p 12.271 0.0021649 2.6646 0.0063

hsa-miR-29a-3p 12.19 0.0022542 2.647 0.0064

hsa-miR-6865-5p 12.05 0.0024178 2.6166 0.0068

hsa-miR-522-3p 11.992 0.0024884 2.6041 0.0069

hsa-let-7g-5p 11.958 0.0025308 2.5967 0.0069

hsa-miR-3181 11.898 0.0026088 2.5836 0.0071

hsa-miR-6804-5p 11.639 0.0029697 2.5273 0.0079

hsa-miR-141-3p 11.56 0.0030886 2.5102 0.0081

hsa-miR-6089 11.509 0.0031682 2.4992 0.0083

hsa-miR-422a 11.478 0.0032178 2.4924 0.0083

hsa-miR-4739 11.449 0.003265 2.4861 0.0083

hsa-miR-378h 11.396 0.0033534 2.4745 0.0084

hsa-miR-7978 11.226 0.0036498 2.4377 0.0091

hsa-miR-4530 11.144 0.0038025 2.4199 0.0093

hsa-miR-103a-3p 11.08 0.0039266 2.406 0.0094

hsa-miR-4695-3p 11.069 0.003948 2.4036 0.0094

hsa-miR-4540 11.067 0.0039513 2.4033 0.0094

hsa-miR-103b 11.022 0.0040421 2.3934 0.0095

hsa-miR-598-5p 10.936 0.0042187 2.3748 0.0098

hsa-miR-1469 10.9 0.004296 2.3669 0.0099

hsa-miR-564 10.804 0.0045078 2.346 0.0102

hsa-miR-4469 10.717 0.0047074 2.3272 0.0106

hsa-miR-3141 10.664 0.0048346 2.3156 0.0107

hsa-miR-5196-5p 10.635 0.0049051 2.3094 0.0108

hsa-miR-301b-5p 10.582 0.0050365 2.2979 0.0110

hsa-miR-1193 10.47 0.0053275 2.2735 0.0115

hsa-miR-3666 10.44 0.0054079 2.267 0.0115

hsa-miR-501-5p 10.433 0.0054266 2.2655 0.0115

hsa-miR-146a-5p 10.23 0.0060057 2.2214 0.0125

hsa-miR-224-3p 10.17 0.0061876 2.2085 0.0128

hsa-miR-146b-3p 10.112 0.006372 2.1957 0.0131

hsa-miR-30c-5p 10.034 0.0066242 2.1789 0.0134

hsa-miR-4632-3p 9.9152 0.0070296 2.1531 0.0141

hsa-miR-4781-3p 9.7575 0.0076066 2.1188 0.0151

hsa-miR-106b-5p 9.6433 0.0080535 2.094 0.0159

hsa-miR-1908-3p 9.43 0.00896 2.0477 0.0175

hsa-miR-578 9.3466 0.0093413 2.0296 0.0181

hsa-miR-499b-3p 9.1417 0.010349 1.9851 0.0199

hsa-miR-27a-3p 8.9238 0.011541 1.9378 0.0219

hsa-miR-3184-5p 8.9118 0.01161 1.9352 0.0219

hsa-miR-6805-3p 8.6761 0.013062 1.884 0.0244

hsa-miR-6790-3p 8.6323 0.013351 1.8745 0.0247

hsa-miR-4787-5p 8.5551 0.013877 1.8577 0.0253

hsa-miR-378a-5p 8.5534 0.013889 1.8573 0.0253

hsa-miR-4298 8.5251 0.014086 1.8512 0.0254

hsa-miR-30a-5p 8.4588 0.014561 1.8368 0.0260

hsa-miR-3196 8.1884 0.016669 1.7781 0.0296

hsa-miR-508-3p 7.8133 0.020108 1.6966 0.0354

hsa-miR-4785 7.6789 0.021505 1.6675 0.0375

hsa-miR-4497 7.5477 0.022963 1.639 0.0397

hsa-miR-335-5p 7.2667 0.026427 1.5779 0.0449

hsa-miR-4693-3p 7.2558 0.026571 1.5756 0.0449

hsa-miR-1237-5p 7.2541 0.026594 1.5752 0.0449

hsa-miR-6765-3p 7.092 0.02884 1.54 0.0483

hsa-miR-4741 7.0091 0.03006 1.522 0.0499

hsa-miR-1299 6.9704 0.030648 1.5136 0.0505

hsa-miR-3922-5p 6.8375 0.032753 1.4847 0.0536

hsa-miR-762 6.5122 0.038539 1.4141 0.0626

hsa-miR-200b-3p 6.4639 0.03948 1.4036 0.0636

hsa-miR-1263 6.439 0.039975 1.3982 0.0639

hsa-miR-4488 6.2978 0.0429 1.3675 0.0681

hsa-miR-6789-3p 6.1721 0.045681 1.3403 0.0719

hsa-miR-4634 6.0672 0.048141 1.3175 0.0752

hsa-miR-8077 5.9958 0.049892 1.302 0.0774

Supplementary Table S7. Twenty-one of the 26 miRNAs “altered” in skim or lipid pMBM show significant correlations with gestational age, but few correlations with other medical/demographic characteristics, aside from method of delivery.

Gestational Age Maternal HTN Infant Sex Delivery Method Maternal Ethnicity Twin GestationPearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR

Gestational Age 1.0000 0.0000 -0.2786 0.2533 0.1583 0.4420 -0.3496 0.0394 0.0458 0.9102 -0.1619 0.4205L miR-4687-3p 0.5472 0.0003 -0.2345 0.3511 0.3323 0.1568 -0.4918 0.0026 0.0792 0.8535 -0.2301 0.2221L miR-1260a 0.5316 0.0004 -0.0295 0.9154 0.1309 0.4750 -0.4034 0.0164 -0.0676 0.8626 -0.0911 0.6501L miR-1260b 0.5123 0.0005 -0.0522 0.8654 0.1379 0.4750 -0.3682 0.0290 -0.0927 0.8295 -0.0732 0.6812L miR-4474-5p -0.5126 0.0005 0.3600 0.1237 -0.0911 0.6264 0.4611 0.0050 -0.0006 0.9963 0.2364 0.2221L miR-378a-3p 0.4925 0.0008 -0.1819 0.5172 0.2005 0.4420 -0.2058 0.2649 -0.1908 0.4241 -0.2639 0.2221L miR-378c 0.4893 0.0008 -0.2179 0.3511 0.1336 0.4750 -0.1751 0.3389 -0.2028 0.4217 -0.2213 0.2321L miR-378g 0.4827 0.0009 -0.2376 0.3511 0.1722 0.4420 -0.2013 0.2649 -0.2068 0.4217 -0.2564 0.2221S miR-4783-3p -0.4810 0.0009 -0.0339 0.9154 0.0115 0.9635 0.4060 0.0164 0.1347 0.6436 0.1161 0.5548L miR-6772-3p -0.4650 0.0013 0.1295 0.5785 -0.0759 0.6901 0.3770 0.0272 -0.0453 0.9102 0.1323 0.5348L miR-4783-3p -0.4470 0.0019 0.1508 0.5415 -0.1930 0.4420 0.3300 0.0543 0.1786 0.4625 0.1392 0.5206S miR-1260a 0.4470 0.0019 -0.0039 0.9777 0.1784 0.4420 -0.2337 0.1958 -0.1255 0.6705 0.0226 0.8982S miR-1260b 0.4242 0.0035 0.0088 0.9777 0.1655 0.4420 -0.2399 0.1901 -0.1660 0.4750 0.0854 0.6512S miR-378a-3p 0.4136 0.0044 -0.1444 0.5415 0.1874 0.4420 -0.1285 0.4500 -0.2568 0.4217 -0.2463 0.2221L miR-4470 -0.4068 0.0050 0.3370 0.1397 -0.0215 0.9340 0.2600 0.1584 -0.0021 0.9963 0.2431 0.2221L miR-6510-5p 0.3977 0.0060 -0.0842 0.7525 -0.1398 0.4750 -0.1655 0.3546 0.2013 0.4217 -0.0273 0.8982S miR-378g 0.3930 0.0064 -0.1536 0.5415 0.1698 0.4420 -0.1556 0.3593 -0.2170 0.4217 -0.2651 0.2221L miR-6763-3p 0.3872 0.0070 -0.2727 0.2533 0.0335 0.8909 -0.1639 0.3546 0.0202 0.9947 -0.2843 0.2221L miR-5585-5p 0.3697 0.0103 -0.1402 0.5415 0.1049 0.5942 -0.1490 0.3727 -0.1036 0.7921 0.1160 0.5548S miR-5787 -0.3530 0.0146 0.1420 0.5415 -0.2527 0.3588 0.2040 0.2649 0.0168 0.9947 0.1200 0.5548Delivery -0.3496 0.0150 0.0903 0.7525 -0.1578 0.4420 1.0000 0.0000 -0.0878 0.8295 0.3051 0.2221S miR-378c 0.3421 0.0170 -0.0790 0.7525 0.2246 0.4230 -0.1062 0.5433 -0.2370 0.4217 -0.3271 0.2221S miR-7975 0.3303 0.0211 -0.0807 0.7525 0.2679 0.3311 -0.3069 0.0746 0.0694 0.8626 -0.1795 0.3767S miR-4454 0.2817 0.0537 -0.2229 0.3511 0.3318 0.1568 -0.2430 0.1901 0.2088 0.4217 -0.1678 0.4128Maternal HTN -0.2786 0.0546 1.0000 0.0000 0.0357 0.8909 0.0903 0.6007 -0.0586 0.8895 0.0945 0.6501L miR-187-5p 0.2512 0.0849 -0.2158 0.3511 -0.0950 0.6264 -0.0485 0.7276 0.0098 0.9963 -0.0826 0.6512S miR-7704 -0.2189 0.1365 0.0160 0.9672 -0.1798 0.4420 0.1891 0.2967 0.1970 0.4217 0.0638 0.7113Twin Gestation -0.1619 0.2853 0.0945 0.7525 -0.2342 0.4160 0.3051 0.0746 -0.2571 0.4217 1.0000 0.0000Infant Sex 0.1583 0.2859 0.0357 0.9154 1.0000 0.0000 -0.1578 0.3593 0.2857 0.4217 -0.2342 0.2221S miR-4784 -0.1560 0.2859 0.3193 0.1536 -0.1354 0.4750 -0.0629 0.6815 -0.0271 0.9947 0.2999 0.2221L miR-1200 0.1524 0.2889 -0.1556 0.5415 0.1692 0.4420 0.0611 0.6815 0.1679 0.4750 -0.2184 0.2321Maternal Ethnicity 0.0458 0.7657 -0.0586 0.8553 0.2857 0.2989 -0.0878 0.6007 1.0000 0.0000 -0.2571 0.2221S miR-4294 -0.0161 0.9078 0.1726 0.5384 -0.0054 0.9689 0.0786 0.6293 0.2256 0.4217 0.0034 0.9807 Significant Pearsons correlations are highlighted in pink. Abbreviations: Hypertension (HTN), Skim fraction (S), Lipid fraction (L), Benjamini Hochberg false discovery rate (FDR)

Supplementary Table S8. Eighteen miRNAs showed nominal differences between lipid fractions of foremilk and hindmilk tMBM, but none survived multiple testing correction.

p.value -Log10(p) FDRhsa-miR-769-3p 0.004629 2.3345 1hsa-miR-3675-5p 0.005083 2.2939 1hsa-miR-6850-3p 0.008625 2.0642 1hsa-miR-6809-5p 0.015606 1.8067 1hsa-miR-181d-5p 0.022741 1.6432 1hsa-miR-3943 0.022741 1.6432 1hsa-miR-487a-3p 0.028859 1.5397 1hsa-miR-296-5p 0.033507 1.4749 1hsa-miR-6742-5p 0.036343 1.4396 1hsa-miR-210-3p 0.037418 1.4269 1hsa-miR-203b-3p 0.03918 1.4069 1hsa-miR-6090 0.042152 1.3752 1hsa-miR-4433a-3p 0.043879 1.3577 1hsa-miR-4433b-5p 0.043879 1.3577 1hsa-miR-6502-5p 0.043879 1.3577 1hsa-miR-3917 0.045368 1.3432 1hsa-miR-3687 0.048844 1.3112 1hsa-miR-6756-5p 0.048844 1.3112 1

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